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Protein
Submitted name:

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor type 1Imported
Gene namesi
Name:Il1r1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96545 Il1r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501458886217 – 573Sequence analysisAdd BLAST557

Expressioni

Gene expression databases

BgeeiENSMUSG00000026072

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 112Ig-likeInterPro annotationAdd BLAST70
Domaini118 – 210Ig-likeInterPro annotationAdd BLAST93
Domaini226 – 326Ig-likeInterPro annotationAdd BLAST101
Domaini383 – 541TIRInterPro annotationAdd BLAST159

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
GeneTreeiENSGT00760000119071
HOVERGENiHBG052103

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLGLICL MVPLLSLEID VCTEYPNQIV LFLSVNEIDI RKCPLTPNKM
60 70 80 90 100
HGDTIIWYKN DSKTPISADR DSRIHQQNEH LWFVPAKVED SGYYYCIVRN
110 120 130 140 150
STYCLKTKVT VTVLENDPGL CYSTQATFPQ RLHIAGDGSL VCPYVSYFKD
160 170 180 190 200
ENNELPEVQW YKNCKPLLLD NVSFFGVKDK LLVRNVAEEH RGDYICRMSY
210 220 230 240 250
TFRGKQYPVT RVIQFITIDE NKRDRPVILS PRNETIEADP GSMIQLICNV
260 270 280 290 300
TGQFSDLVYW KWNGSEIEWN DPFLAEDYQF VEHPSTKRKY TLITTLNISE
310 320 330 340 350
VKSQFYRYPF ICVVKNTNIF ESAHVQLIYP VPDFKNYLIG GFIILTATIV
360 370 380 390 400
CCVCIYKVFK VDIVLWYRDS CSGFLPSKAS DGKTYDAYIL YPKTLGEGSF
410 420 430 440 450
SDLDTFVFKL LPEVLEGQFG YKLFIYGRDD YVGEDTIEVT NENVKKSRRL
460 470 480 490 500
IIILVRDMGG FSWLGQSSEE QIAIYNALIQ EGIKIVLLEL EKIQDYEKMP
510 520 530 540 550
DSIQFIKQKH GVICWSGDFQ ERPQSAKTRF WKNLRYQMPA QRRSPLSKHR
560 570
LLTLDPVRDT KEKLPAATHL PLG
Length:573
Mass (Da):66,323
Last modified:March 1, 2003 - v1
Checksum:i3B750CBD0F49C14D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135085 Genomic DNA No translation available.
AC167168 Genomic DNA No translation available.
AK048550 mRNA Translation: BAC33372.1
RefSeqiNP_001116854.1, NM_001123382.1
XP_006495777.1, XM_006495714.3
XP_006495778.1, XM_006495715.3
XP_006495780.1, XM_006495717.2
XP_006495782.1, XM_006495719.2
XP_006495783.1, XM_006495720.3
XP_006495784.1, XM_006495721.3
XP_006495785.1, XM_006495722.2
XP_006495786.1, XM_006495723.3
XP_011236738.1, XM_011238436.2
XP_017173084.1, XM_017317595.1
XP_017173102.1, XM_017317613.1
UniGeneiMm.896

Genome annotation databases

EnsembliENSMUST00000114795; ENSMUSP00000110443; ENSMUSG00000026072
GeneIDi16177

Similar proteinsi

Entry informationi

Entry nameiQ8C833_MOUSE
AccessioniPrimary (citable) accession number: Q8C833
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health