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Protein

Kelch repeat and BTB domain-containing protein 13

Gene

Kbtbd13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 13
Gene namesi
Name:Kbtbd13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921742 Kbtbd13

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939071 – 458Kelch repeat and BTB domain-containing protein 13Add BLAST458

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8C828
PRIDEiQ8C828

PTM databases

PhosphoSitePlusiQ8C828

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000054978
GenevisibleiQ8C828 MM

Interactioni

Subunit structurei

Component of the BCR(KBTBD13) E3 ubiquitin ligase complex, at least composed of CUL3 and KBTBD13 and RBX1. Interacts with CUL3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136872

Structurei

3D structure databases

ProteinModelPortaliQ8C828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 74BTBPROSITE-ProRule annotationAdd BLAST68
Repeati159 – 209Kelch 1Add BLAST51
Repeati210 – 258Kelch 2Add BLAST49
Repeati259 – 305Kelch 3Add BLAST47
Repeati307 – 350Kelch 4Add BLAST44
Repeati352 – 400Kelch 5Add BLAST49

Domaini

The BCB domain mediates the interaction with CUL3.By similarity

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00900000140914
HOGENOMiHOG000147850
HOVERGENiHBG070203
InParanoidiQ8C828
KOiK21913
OMAiAHRDSLY
OrthoDBiEOG091G05A3
PhylomeDBiQ8C828
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGPEVPVQ VWVDGQLFQA EQSLLVEHCG FFRGLFRSGM REARAAEVRL
60 70 80 90 100
GALSASGFRT ALRVLRGERP ALAAEDELLQ AVECAAFLQA PALARFLEHS
110 120 130 140 150
VTSDNCSLLC DAAAAFGLRD VLHSAALFIR DGSHELVAQL ELPEARAYVA
160 170 180 190 200
ALRPSTYVAV STHTPTPGFL EDASRTMCFL DEEEDAWRTL AALPLEASTL
210 220 230 240 250
LAGVATLGNK LYIVGGVCGA SKEVVELGFC YDPEGGTWCE FPSPHQPRYD
260 270 280 290 300
MALAGFEGRL YAIGGEFQRT PMSSVECYDP ATGCWSFVAD LPQPATGVPC
310 320 330 340 350
AQARGRLFVC LWRPADITAV VEYVVQMDKW LPVAELCRSQ SYGHFMVAHR
360 370 380 390 400
DSLYVVRNGP SDDFLHCAID CLNLVTGQWT SLPGQFVNSK GALFTSVVRG
410 420 430 440 450
DTVYTVNRVS TLVYAIEDGT WRLLREKAGF PRPGSLQTFL LRLPPGTTGP

VATALPEL
Length:458
Mass (Da):49,769
Last modified:May 18, 2010 - v2
Checksum:i6A9D89487D21B81F
GO

Sequence cautioni

The sequence BAC33390 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114645 Genomic DNA No translation available.
AK048611 mRNA Translation: BAC33390.1 Different initiation.
CCDSiCCDS57682.1
RefSeqiNP_083250.1, NM_028974.1
UniGeneiMm.159223

Genome annotation databases

EnsembliENSMUST00000068307; ENSMUSP00000136872; ENSMUSG00000054978
GeneIDi74492
KEGGimmu:74492
UCSCiuc009qde.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKBTBD_MOUSE
AccessioniPrimary (citable) accession number: Q8C828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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