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Protein

Kelch repeat and BTB domain-containing protein 13

Gene

Kbtbd13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 13
Gene namesi
Name:Kbtbd13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921742. Kbtbd13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Kelch repeat and BTB domain-containing protein 13PRO_0000393907Add
BLAST

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8C828.
PRIDEiQ8C828.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart and lung.1 Publication

Gene expression databases

BgeeiQ8C828.
GenevisibleiQ8C828. MM.

Interactioni

Subunit structurei

Component of the BCR(KBTBD13) E3 ubiquitin ligase complex, at least composed of CUL3 and KBTBD13 and RBX1. Interacts with CUL3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136872.

Structurei

3D structure databases

ProteinModelPortaliQ8C828.
SMRiQ8C828. Positions 7-100, 154-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 7468BTBPROSITE-ProRule annotationAdd
BLAST
Repeati159 – 20951Kelch 1Add
BLAST
Repeati210 – 25849Kelch 2Add
BLAST
Repeati259 – 30547Kelch 3Add
BLAST
Repeati307 – 35044Kelch 4Add
BLAST
Repeati352 – 40049Kelch 5Add
BLAST

Domaini

The BCB domain mediates the interaction with CUL3.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000147850.
HOVERGENiHBG070203.
InParanoidiQ8C828.
OMAiTSDNCAL.
OrthoDBiEOG7X9G6R.
PhylomeDBiQ8C828.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGPEVPVQ VWVDGQLFQA EQSLLVEHCG FFRGLFRSGM REARAAEVRL
60 70 80 90 100
GALSASGFRT ALRVLRGERP ALAAEDELLQ AVECAAFLQA PALARFLEHS
110 120 130 140 150
VTSDNCSLLC DAAAAFGLRD VLHSAALFIR DGSHELVAQL ELPEARAYVA
160 170 180 190 200
ALRPSTYVAV STHTPTPGFL EDASRTMCFL DEEEDAWRTL AALPLEASTL
210 220 230 240 250
LAGVATLGNK LYIVGGVCGA SKEVVELGFC YDPEGGTWCE FPSPHQPRYD
260 270 280 290 300
MALAGFEGRL YAIGGEFQRT PMSSVECYDP ATGCWSFVAD LPQPATGVPC
310 320 330 340 350
AQARGRLFVC LWRPADITAV VEYVVQMDKW LPVAELCRSQ SYGHFMVAHR
360 370 380 390 400
DSLYVVRNGP SDDFLHCAID CLNLVTGQWT SLPGQFVNSK GALFTSVVRG
410 420 430 440 450
DTVYTVNRVS TLVYAIEDGT WRLLREKAGF PRPGSLQTFL LRLPPGTTGP

VATALPEL
Length:458
Mass (Da):49,769
Last modified:May 18, 2010 - v2
Checksum:i6A9D89487D21B81F
GO

Sequence cautioni

The sequence BAC33390.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114645 Genomic DNA. No translation available.
AK048611 mRNA. Translation: BAC33390.1. Different initiation.
CCDSiCCDS57682.1.
RefSeqiNP_083250.1. NM_028974.1.
UniGeneiMm.159223.

Genome annotation databases

EnsembliENSMUST00000068307; ENSMUSP00000136872; ENSMUSG00000054978.
GeneIDi74492.
KEGGimmu:74492.
UCSCiuc009qde.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114645 Genomic DNA. No translation available.
AK048611 mRNA. Translation: BAC33390.1. Different initiation.
CCDSiCCDS57682.1.
RefSeqiNP_083250.1. NM_028974.1.
UniGeneiMm.159223.

3D structure databases

ProteinModelPortaliQ8C828.
SMRiQ8C828. Positions 7-100, 154-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136872.

Proteomic databases

PaxDbiQ8C828.
PRIDEiQ8C828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068307; ENSMUSP00000136872; ENSMUSG00000054978.
GeneIDi74492.
KEGGimmu:74492.
UCSCiuc009qde.2. mouse.

Organism-specific databases

CTDi390594.
MGIiMGI:1921742. Kbtbd13.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000147850.
HOVERGENiHBG070203.
InParanoidiQ8C828.
OMAiTSDNCAL.
OrthoDBiEOG7X9G6R.
PhylomeDBiQ8C828.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi340944.
PROiQ8C828.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C828.
GenevisibleiQ8C828. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-458.
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKBTBD_MOUSE
AccessioniPrimary (citable) accession number: Q8C828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.