##gff-version 3 Q8C7W7 UniProtKB Chain 1 541 . . . ID=PRO_0000209120;Note=5' exonuclease Apollo Q8C7W7 UniProtKB Region 455 475 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8C7W7 UniProtKB Motif 492 507 . . . Note=TBM Q8C7W7 UniProtKB Cross-link 334 334 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9H816 Q8C7W7 UniProtKB Alternative sequence 1 126 . . . ID=VSP_015174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16141072;Dbxref=PMID:15489334,PMID:16141072 Q8C7W7 UniProtKB Alternative sequence 181 213 . . . ID=VSP_015175;Note=In isoform 3. LYSLGKESLLEQLALEFRTWVVLSPQRLELVQL->ERFPFFFHSCLVNQNSLKVLIVFQIFVPCSPFL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16141072;Dbxref=PMID:16141072 Q8C7W7 UniProtKB Alternative sequence 214 541 . . . ID=VSP_015176;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16141072;Dbxref=PMID:16141072 Q8C7W7 UniProtKB Mutagenesis 14 14 . . . Note=Abolishes exonuclease activity without affecting the telomere localization%2C leading to impaired 3'-overhang at the leading end telomeres. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20551906;Dbxref=PMID:20551906 Q8C7W7 UniProtKB Mutagenesis 31 35 . . . Note=Abolishes exonuclease activity%2C leading to activate the ATM signaling pathway%3B when associated with A-230. HMHCD->AMACN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20619712;Dbxref=PMID:20619712 Q8C7W7 UniProtKB Mutagenesis 230 230 . . . Note=Abolishes exonuclease activity%2C leading to activate the ATM signaling pathway%3B when associated with 31-A--N-35. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20619712;Dbxref=PMID:20619712 Q8C7W7 UniProtKB Mutagenesis 500 504 . . . Note=Abolishes interaction with TERF2 and localization to telomeres%2C leading to activate the ATM signaling pathway. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20619712;Dbxref=PMID:20619712 Q8C7W7 UniProtKB Sequence conflict 49 49 . . . Note=Y->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8C7W7 UniProtKB Sequence conflict 162 162 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8C7W7 UniProtKB Sequence conflict 327 327 . . . Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8C7W7 UniProtKB Sequence conflict 412 412 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8C7W7 UniProtKB Sequence conflict 540 540 . . . Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305