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Protein

U3 small nucleolar RNA-associated protein 15 homolog

Gene

Utp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15 homolog
Alternative name(s):
Src-associated protein SAW
Gene namesi
Name:Utp15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145443. Utp15.

Subcellular locationi

  • Nucleusnucleolus By similarity

  • Note: Found predominantly at the fibrillar center.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000513222 – 528U3 small nucleolar RNA-associated protein 15 homologAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8C7V3.
MaxQBiQ8C7V3.
PaxDbiQ8C7V3.
PeptideAtlasiQ8C7V3.
PRIDEiQ8C7V3.

PTM databases

iPTMnetiQ8C7V3.
PhosphoSitePlusiQ8C7V3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041747.
GenevisibleiQ8C7V3. MM.

Interactioni

Subunit structurei

Forms a complex with UTP4, NOL11, WDR43 and WDR75.By similarity

Protein-protein interaction databases

BioGridi222829. 1 interactor.
IntActiQ8C7V3. 1 interactor.
STRINGi10090.ENSMUSP00000048204.

Structurei

3D structure databases

ProteinModelPortaliQ8C7V3.
SMRiQ8C7V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati78 – 117WD 2Add BLAST40
Repeati120 – 159WD 3Add BLAST40
Repeati162 – 202WD 4Add BLAST41
Repeati204 – 242WD 5Add BLAST39
Repeati246 – 285WD 6Add BLAST40
Repeati287 – 326WD 7Add BLAST40

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
HOVERGENiHBG080690.
InParanoidiQ8C7V3.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG091G0524.
PhylomeDBiQ8C7V3.
TreeFamiTF319494.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C7V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYKPVAIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQL
60 70 80 90 100
PYNYAVTASS RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE
110 120 130 140 150
DGVVQLFDIN GRAPLRQFEG HTKAVHTVDF TADNYHVVSG ADDYTVKLWD
160 170 180 190 200
IPNSKEILTF KEHSDYVRCG CASKLNPDLF VTGSYDHTVK IFDARTNKNV
210 220 230 240 250
LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT
260 270 280 290 300
VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALSHQ
310 320 330 340 350
DETIVVGMTN GILSVKHRKS EAKKTSLPRR RRPAYRTFIK GKNYLKQRDD
360 370 380 390 400
IMVSRPAKKH LEGYDKDLKS FRVSQALDRV LEPKCVIRTP EVTVSIIKEL
410 420 430 440 450
TRRGVLANAL AGRDEKEVTR VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL
460 470 480 490 500
PVIGQSSVVD KKFIVLQELV EKEIDYQREL LETLGMMDML FATMTRNDSD
510 520
PVPEHVPAEL PEEKTESPTQ PSDTDKNS
Length:528
Mass (Da):59,375
Last modified:March 1, 2003 - v1
Checksum:i6C1691522D1919C5
GO

Sequence cautioni

The sequence AAH34372 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti479E → K in AAH34372 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151261 mRNA. Translation: AAN71642.1.
AK049186 mRNA. Translation: BAC33596.1.
AK162794 mRNA. Translation: BAE37061.1.
BC034372 mRNA. Translation: AAH34372.1. Different initiation.
BC065057 mRNA. Translation: AAH65057.1.
CCDSiCCDS26712.1.
RefSeqiNP_849249.1. NM_178918.3.
UniGeneiMm.28221.
Mm.297905.

Genome annotation databases

EnsembliENSMUST00000040972; ENSMUSP00000048204; ENSMUSG00000041747.
GeneIDi105372.
KEGGimmu:105372.
UCSCiuc007rom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151261 mRNA. Translation: AAN71642.1.
AK049186 mRNA. Translation: BAC33596.1.
AK162794 mRNA. Translation: BAE37061.1.
BC034372 mRNA. Translation: AAH34372.1. Different initiation.
BC065057 mRNA. Translation: AAH65057.1.
CCDSiCCDS26712.1.
RefSeqiNP_849249.1. NM_178918.3.
UniGeneiMm.28221.
Mm.297905.

3D structure databases

ProteinModelPortaliQ8C7V3.
SMRiQ8C7V3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222829. 1 interactor.
IntActiQ8C7V3. 1 interactor.
STRINGi10090.ENSMUSP00000048204.

PTM databases

iPTMnetiQ8C7V3.
PhosphoSitePlusiQ8C7V3.

Proteomic databases

EPDiQ8C7V3.
MaxQBiQ8C7V3.
PaxDbiQ8C7V3.
PeptideAtlasiQ8C7V3.
PRIDEiQ8C7V3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040972; ENSMUSP00000048204; ENSMUSG00000041747.
GeneIDi105372.
KEGGimmu:105372.
UCSCiuc007rom.1. mouse.

Organism-specific databases

CTDi84135.
MGIiMGI:2145443. Utp15.

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
HOVERGENiHBG080690.
InParanoidiQ8C7V3.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG091G0524.
PhylomeDBiQ8C7V3.
TreeFamiTF319494.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiUtp15. mouse.
PROiQ8C7V3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041747.
GenevisibleiQ8C7V3. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTP15_MOUSE
AccessioniPrimary (citable) accession number: Q8C7V3
Secondary accession number(s): Q3TRG8, Q8K231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.