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Q8C7U7

- GALT6_MOUSE

UniProt

Q8C7U7 - GALT6_MOUSE

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Protein
Polypeptide N-acetylgalactosaminyltransferase 6
Gene
Galnt6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides By similarity.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171Substrate By similarity
Binding sitei246 – 2461Substrate By similarity
Metal bindingi269 – 2691Manganese By similarity
Metal bindingi271 – 2711Manganese By similarity
Binding sitei379 – 3791Substrate By similarity
Metal bindingi407 – 4071Manganese By similarity
Binding sitei410 – 4101Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. polypeptide N-acetylgalactosaminyltransferase activity Source: MGI

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198517. O-linked glycosylation of mucins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Polypeptide N-acetylgalactosaminyltransferase 6 (EC:2.4.1.41)
Alternative name(s):
Polypeptide GalNAc transferase 6
Short name:
GalNAc-T6
Short name:
pp-GaNTase 6
Protein-UDP acetylgalactosaminyltransferase 6
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
Gene namesi
Name:Galnt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1891640. Galnt6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2820Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini29 – 622594Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Polypeptide N-acetylgalactosaminyltransferase 6
PRO_0000059115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi165 ↔ 402 By similarity
Disulfide bondi393 ↔ 474 By similarity
Glycosylationi476 – 4761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi509 ↔ 527 By similarity
Disulfide bondi553 ↔ 566 By similarity
Disulfide bondi597 ↔ 610 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8C7U7.
PaxDbiQ8C7U7.
PRIDEiQ8C7U7.

PTM databases

PhosphoSiteiQ8C7U7.

Expressioni

Gene expression databases

BgeeiQ8C7U7.
GenevestigatoriQ8C7U7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056705.

Structurei

3D structure databases

ProteinModelPortaliQ8C7U7.
SMRiQ8C7U7. Positions 117-621.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini496 – 622127Ricin B-type lectin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 285110Catalytic subdomain A
Add
BLAST
Regioni348 – 41063Catalytic subdomain B
Add
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239675.
GeneTreeiENSGT00750000117451.
HOGENOMiHOG000038227.
HOVERGENiHBG051699.
InParanoidiQ0VE84.
KOiK00710.
OMAiNQCLDVG.
OrthoDBiEOG7J9VP2.
PhylomeDBiQ8C7U7.
TreeFamiTF313267.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C7U7-1 [UniParc]FASTAAdd to Basket

« Hide

MRLLRRRHMS LRLAMLGSVF MLFLFIRQKD VSNQEQAMEK PWLKSLAGQK    50
DQVLDFMLGA VNNIRDVMPK LQIRAPEPPQ TLVSTNHSCL PGFYTPAELK 100
PFWDRPPQDP NSPGADGKAF QKKEWTNLET KEKEEGYKKH CFNAFASDRI 150
SLQRSLGPDT RPPECVDQKF RRCPPLPTTS VIIVFHNEAW STLLRTVYSV 200
LHTSPAILLK EIILVDDAST DEHLKERLEQ YVQQLQIVRV VRQRERKGLI 250
TARLLGASVA QAEVLTFLDA HCECFHGWLE PLLARIAEDK TAVVSPDIVT 300
IDLNTFQFSR PVQRGKAHSR GNFDWSLTFG WEMLPEHEKQ RRKDETYPIK 350
SPTFAGGLFS ISKAYFEHIG TYDNQMEIWG GENVEMSFRV WQCGGQLEII 400
PCSVVGHVFR TKSPHTFPKG TSVIARNQVR LAEVWMDDYK KIFYRRNLQA 450
AKMVQENNFG DISERLRLRE QLRCHNFSWY LHNVYPEMFV PDLNPTFYGA 500
IKNLGTNQCL DVGENNRGGK PLIMYVCHNL GGNQYFEYTS QRDLRHNIGK 550
QLCLHASGST LGLRSCQFVG KNSRVPKDEE WELTQDQLIR NSGSGTCLTS 600
QDKKPAMAPC NPRDPYQLWL FV 622
Length:622
Mass (Da):71,537
Last modified:March 1, 2003 - v1
Checksum:i6DBCA3A2CCFDBDAA
GO

Sequence cautioni

The sequence CAB55352.1 differs from that shown. Reason: Frameshift at position 622.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → T in CAB55352. 1 Publication
Sequence conflicti100 – 1001K → R in CAB55352. 1 Publication
Sequence conflicti210 – 2101K → N in BAC25984. 1 Publication
Sequence conflicti215 – 2151V → M in BAC25984. 1 Publication
Sequence conflicti247 – 2471K → G in BAC25984. 1 Publication
Sequence conflicti263 – 27513EVLTF…HCECF → KGAHVSWTPTVSVS1 Publication
Add
BLAST
Sequence conflicti292 – 2921A → P in CAB55352. 1 Publication
Sequence conflicti336 – 3361E → Q in CAB55352. 1 Publication
Sequence conflicti398 – 3981E → G in BAC25984. 1 Publication
Sequence conflicti467 – 4671R → Q in CAB55352. 1 Publication
Sequence conflicti562 – 5621G → S in CAB55352. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133523 mRNA. Translation: CAB55352.1. Frameshift.
AK028506 mRNA. Translation: BAC25984.1.
AK049222 mRNA. Translation: BAC33618.1.
AK155008 mRNA. Translation: BAE32989.1.
AK159721 mRNA. Translation: BAE35316.1.
BC119324 mRNA. Translation: AAI19325.1.
BC119326 mRNA. Translation: AAI19327.1.
CCDSiCCDS27843.1.
RefSeqiNP_001155239.1. NM_001161767.1.
NP_001155240.1. NM_001161768.1.
NP_766039.2. NM_172451.3.
UniGeneiMm.22969.

Genome annotation databases

EnsembliENSMUST00000052069; ENSMUSP00000056705; ENSMUSG00000037280.
ENSMUST00000159715; ENSMUSP00000123848; ENSMUSG00000037280.
ENSMUST00000161514; ENSMUSP00000124793; ENSMUSG00000037280.
GeneIDi207839.
KEGGimmu:207839.
UCSCiuc007xrz.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Polypeptide N-acetylgalactosaminyltransferase 6

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133523 mRNA. Translation: CAB55352.1 . Frameshift.
AK028506 mRNA. Translation: BAC25984.1 .
AK049222 mRNA. Translation: BAC33618.1 .
AK155008 mRNA. Translation: BAE32989.1 .
AK159721 mRNA. Translation: BAE35316.1 .
BC119324 mRNA. Translation: AAI19325.1 .
BC119326 mRNA. Translation: AAI19327.1 .
CCDSi CCDS27843.1.
RefSeqi NP_001155239.1. NM_001161767.1.
NP_001155240.1. NM_001161768.1.
NP_766039.2. NM_172451.3.
UniGenei Mm.22969.

3D structure databases

ProteinModelPortali Q8C7U7.
SMRi Q8C7U7. Positions 117-621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000056705.

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

PTM databases

PhosphoSitei Q8C7U7.

Proteomic databases

MaxQBi Q8C7U7.
PaxDbi Q8C7U7.
PRIDEi Q8C7U7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052069 ; ENSMUSP00000056705 ; ENSMUSG00000037280 .
ENSMUST00000159715 ; ENSMUSP00000123848 ; ENSMUSG00000037280 .
ENSMUST00000161514 ; ENSMUSP00000124793 ; ENSMUSG00000037280 .
GeneIDi 207839.
KEGGi mmu:207839.
UCSCi uc007xrz.2. mouse.

Organism-specific databases

CTDi 11226.
MGIi MGI:1891640. Galnt6.

Phylogenomic databases

eggNOGi NOG239675.
GeneTreei ENSGT00750000117451.
HOGENOMi HOG000038227.
HOVERGENi HBG051699.
InParanoidi Q0VE84.
KOi K00710.
OMAi NQCLDVG.
OrthoDBi EOG7J9VP2.
PhylomeDBi Q8C7U7.
TreeFami TF313267.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_198517. O-linked glycosylation of mucins.

Miscellaneous databases

NextBioi 372071.
PROi Q8C7U7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C7U7.
Genevestigatori Q8C7U7.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a close homologue of human UDP-N-acetyl--D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy."
    Bennett E.P., Hassan H., Mandel U., Hollingsworth M.A., Akisawa N., Ikematsu Y., Merkx G., Geurts van Kessel A., Olofsson S., Clausen H.
    J. Biol. Chem. 274:25362-25370(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gastric carcinoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGALT6_MOUSE
AccessioniPrimary (citable) accession number: Q8C7U7
Secondary accession number(s): Q0VE84
, Q3TWF0, Q8CED2, Q9QZ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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