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Protein

Apolipoprotein A-V

Gene

Apoa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_314625. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-V
Short name:
Apo-AV
Short name:
ApoA-V
Alternative name(s):
Apolipoprotein A5
Regeneration-associated protein 3
Gene namesi
Name:Apoa5
Synonyms:Rap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913363. Apoa5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 368348Apolipoprotein A-VPRO_0000001982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C7G5.
PaxDbiQ8C7G5.
PRIDEiQ8C7G5.

PTM databases

PhosphoSiteiQ8C7G5.

Expressioni

Tissue specificityi

Liver.2 Publications

Inductioni

Induced in early phase of liver regeneration.

Gene expression databases

BgeeiQ8C7G5.
CleanExiMM_APOA5.
GenevisibleiQ8C7G5. MM.

Interactioni

Subunit structurei

Interacts with GPIHBP1.By similarity

Protein-protein interaction databases

IntActiQ8C7G5. 3 interactions.
MINTiMINT-1858746.
STRINGi10090.ENSMUSP00000034584.

Structurei

3D structure databases

ProteinModelPortaliQ8C7G5.
SMRiQ8C7G5. Positions 80-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili231 – 25525Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG46095.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000253942.
HOVERGENiHBG050545.
InParanoidiQ8C7G5.
KOiK09025.
OMAiHRSVAPH.
OrthoDBiEOG7K9K48.
PhylomeDBiQ8C7G5.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C7G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVITWALA LLAVFASTQA RKSLWDYFSQ NSWSKGVMGQ PQKLAQENLK
60 70 80 90 100
GSFEQDLYNM NNYLEKLGPL RGPGKEPPLL AQDPEGIRKQ LQQELGEVSS
110 120 130 140 150
RLEPYMAAKH QQVGWNLEGL RQQLKPYTAE LMEQVGLSVQ ELQEQLRVVG
160 170 180 190 200
EDTKAQLLGG VDEALNLLQD MQSRVLHHTD RVKELFHPYA ERLVTGIGHH
210 220 230 240 250
VQELHRSVAP HAAASPARLS RCVQTLSHKL TRKAKDLHTS IQRNLDQLRD
260 270 280 290 300
ELSAFIRVST DGAEDGDSLD PQALSEEVRQ RLQAFRHDTY LQIAAFTQAI
310 320 330 340 350
DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY
360
GLQDQGHSHL SDPEGHSG
Length:368
Mass (Da):41,262
Last modified:March 1, 2003 - v1
Checksum:iB5B2F1982C47475B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861G → D in AAG49600 (PubMed:11577099).Curated
Sequence conflicti178 – 1792HT → QA in AAH11198 (PubMed:15489334).Curated
Sequence conflicti278 – 2781V → L in AAH11198 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327059 mRNA. Translation: AAG49600.1.
AK050280 mRNA. Translation: BAC34163.1.
BC011198 mRNA. Translation: AAH11198.1.
CCDSiCCDS23143.1.
RefSeqiNP_536682.2. NM_080434.3.
XP_006510601.1. XM_006510538.2.
UniGeneiMm.29738.

Genome annotation databases

EnsembliENSMUST00000034584; ENSMUSP00000034584; ENSMUSG00000032079.
ENSMUST00000121598; ENSMUSP00000113413; ENSMUSG00000032079.
GeneIDi66113.
KEGGimmu:66113.
UCSCiuc009phf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327059 mRNA. Translation: AAG49600.1.
AK050280 mRNA. Translation: BAC34163.1.
BC011198 mRNA. Translation: AAH11198.1.
CCDSiCCDS23143.1.
RefSeqiNP_536682.2. NM_080434.3.
XP_006510601.1. XM_006510538.2.
UniGeneiMm.29738.

3D structure databases

ProteinModelPortaliQ8C7G5.
SMRiQ8C7G5. Positions 80-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C7G5. 3 interactions.
MINTiMINT-1858746.
STRINGi10090.ENSMUSP00000034584.

PTM databases

PhosphoSiteiQ8C7G5.

Proteomic databases

MaxQBiQ8C7G5.
PaxDbiQ8C7G5.
PRIDEiQ8C7G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034584; ENSMUSP00000034584; ENSMUSG00000032079.
ENSMUST00000121598; ENSMUSP00000113413; ENSMUSG00000032079.
GeneIDi66113.
KEGGimmu:66113.
UCSCiuc009phf.1. mouse.

Organism-specific databases

CTDi116519.
MGIiMGI:1913363. Apoa5.

Phylogenomic databases

eggNOGiNOG46095.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000253942.
HOVERGENiHBG050545.
InParanoidiQ8C7G5.
KOiK09025.
OMAiHRSVAPH.
OrthoDBiEOG7K9K48.
PhylomeDBiQ8C7G5.
TreeFamiTF334458.

Enzyme and pathway databases

ReactomeiREACT_314625. Chylomicron-mediated lipid transport.

Miscellaneous databases

NextBioi320666.
PROiQ8C7G5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C7G5.
CleanExiMM_APOA5.
GenevisibleiQ8C7G5. MM.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration."
    van Der Vliet H.N., Sammels M.G., Leegwater A.C.J., Levels J.H.M., Reitsma P.H., Boers W., Chamuleau R.A.F.M.
    J. Biol. Chem. 276:44512-44520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing."
    Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.-C., Krauss R.M., Rubin E.M.
    Science 294:169-173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis."
    Schaap F.G., Rensen P.C.N., Voshol P.J., Vrins C., van der Vliet H.N., Chamuleau R.A.F.M., Havekes L.M., Groen A.K., van Dijk K.W.
    J. Biol. Chem. 279:27941-27947(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiAPOA5_MOUSE
AccessioniPrimary (citable) accession number: Q8C7G5
Secondary accession number(s): Q91X90, Q99P64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.