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Q8C7G5 (APOA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein A-V

Short name=Apo-AV
Short name=ApoA-V
Alternative name(s):
Apolipoprotein A5
Regeneration-associated protein 3
Gene names
Name:Apoa5
Synonyms:Rap3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages By similarity. Ref.4 Ref.5

Subunit structure

Interacts with GPIHBP1 By similarity.

Subcellular location

Secreted Ref.1.

Tissue specificity

Liver. Ref.1 Ref.4

Induction

Induced in early phase of liver regeneration.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Miscellaneous

Mice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG.

Sequence similarities

Belongs to the apolipoprotein A1/A4/E family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentChylomicron
HDL
Secreted
VLDL
   DomainCoiled coil
Signal
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacylglycerol homeostasis

Inferred from mutant phenotype Ref.4. Source: BHF-UCL

cholesterol homeostasis

Inferred from electronic annotation. Source: Ensembl

lipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

lipoprotein metabolic process

Inferred from electronic annotation. Source: InterPro

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of fatty acid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of lipoprotein lipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of triglyceride catabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of very-low-density lipoprotein particle remodeling

Inferred from electronic annotation. Source: Ensembl

response to hormone

Inferred from electronic annotation. Source: Ensembl

tissue regeneration

Inferred from electronic annotation. Source: Ensembl

triglyceride catabolic process

Inferred from electronic annotation. Source: Ensembl

triglyceride homeostasis

Inferred from electronic annotation. Source: Ensembl

triglyceride metabolic process

Inferred from mutant phenotype PubMed 16166565. Source: MGI

triglyceride-rich lipoprotein particle remodeling

Inferred from mutant phenotype PubMed 16166565. Source: MGI

   Cellular_componentchylomicron

Inferred from electronic annotation. Source: UniProtKB-KW

high-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: Ensembl

lipoprotein lipase activator activity

Inferred from electronic annotation. Source: Ensembl

phosphatidylcholine binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 368348Apolipoprotein A-V
PRO_0000001982

Regions

Coiled coil231 – 25525 Potential

Amino acid modifications

Modified residue521Phosphoserine Ref.6

Experimental info

Sequence conflict861G → D in AAG49600. Ref.1
Sequence conflict178 – 1792HT → QA in AAH11198. Ref.3
Sequence conflict2781V → L in AAH11198. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8C7G5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B5B2F1982C47475B

FASTA36841,262
        10         20         30         40         50         60 
MAAVITWALA LLAVFASTQA RKSLWDYFSQ NSWSKGVMGQ PQKLAQENLK GSFEQDLYNM 

        70         80         90        100        110        120 
NNYLEKLGPL RGPGKEPPLL AQDPEGIRKQ LQQELGEVSS RLEPYMAAKH QQVGWNLEGL 

       130        140        150        160        170        180 
RQQLKPYTAE LMEQVGLSVQ ELQEQLRVVG EDTKAQLLGG VDEALNLLQD MQSRVLHHTD 

       190        200        210        220        230        240 
RVKELFHPYA ERLVTGIGHH VQELHRSVAP HAAASPARLS RCVQTLSHKL TRKAKDLHTS 

       250        260        270        280        290        300 
IQRNLDQLRD ELSAFIRVST DGAEDGDSLD PQALSEEVRQ RLQAFRHDTY LQIAAFTQAI 

       310        320        330        340        350        360 
DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY GLQDQGHSHL 


SDPEGHSG 

« Hide

References

« Hide 'large scale' references
[1]"Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration."
van Der Vliet H.N., Sammels M.G., Leegwater A.C.J., Levels J.H.M., Reitsma P.H., Boers W., Chamuleau R.A.F.M.
J. Biol. Chem. 276:44512-44520(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Strain: C57BL/6.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[4]"An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing."
Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.-C., Krauss R.M., Rubin E.M.
Science 294:169-173(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis."
Schaap F.G., Rensen P.C.N., Voshol P.J., Vrins C., van der Vliet H.N., Chamuleau R.A.F.M., Havekes L.M., Groen A.K., van Dijk K.W.
J. Biol. Chem. 279:27941-27947(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF327059 mRNA. Translation: AAG49600.1.
AK050280 mRNA. Translation: BAC34163.1.
BC011198 mRNA. Translation: AAH11198.1.
CCDSCCDS23143.1.
RefSeqNP_536682.2. NM_080434.3.
XP_006510601.1. XM_006510538.1.
UniGeneMm.29738.

3D structure databases

ProteinModelPortalQ8C7G5.
SMRQ8C7G5. Positions 80-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8C7G5. 3 interactions.
MINTMINT-1858746.

PTM databases

PhosphoSiteQ8C7G5.

Proteomic databases

MaxQBQ8C7G5.
PaxDbQ8C7G5.
PRIDEQ8C7G5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034584; ENSMUSP00000034584; ENSMUSG00000032079.
ENSMUST00000121598; ENSMUSP00000113413; ENSMUSG00000032079.
GeneID66113.
KEGGmmu:66113.
UCSCuc009phf.1. mouse.

Organism-specific databases

CTD116519.
MGIMGI:1913363. Apoa5.

Phylogenomic databases

eggNOGNOG46095.
GeneTreeENSGT00740000115662.
HOGENOMHOG000253942.
HOVERGENHBG050545.
InParanoidQ8C7G5.
KOK09025.
OMAHRSVAPH.
OrthoDBEOG7K9K48.
PhylomeDBQ8C7G5.
TreeFamTF334458.

Gene expression databases

BgeeQ8C7G5.
CleanExMM_APOA5.
GenevestigatorQ8C7G5.

Family and domain databases

InterProIPR000074. ApoA1_A4_E.
[Graphical view]
PfamPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320666.
PROQ8C7G5.
SOURCESearch...

Entry information

Entry nameAPOA5_MOUSE
AccessionPrimary (citable) accession number: Q8C7G5
Secondary accession number(s): Q91X90, Q99P64
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot