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Q8C7G5

- APOA5_MOUSE

UniProt

Q8C7G5 - APOA5_MOUSE

Protein

Apolipoprotein A-V

Gene

Apoa5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. lipoprotein lipase activator activity Source: Ensembl
    3. phosphatidylcholine binding Source: Ensembl

    GO - Biological processi

    1. acylglycerol homeostasis Source: BHF-UCL
    2. cholesterol homeostasis Source: Ensembl
    3. lipid transport Source: UniProtKB-KW
    4. lipoprotein metabolic process Source: InterPro
    5. organ regeneration Source: Ensembl
    6. positive regulation of fatty acid biosynthetic process Source: Ensembl
    7. positive regulation of lipoprotein lipase activity Source: Ensembl
    8. positive regulation of triglyceride catabolic process Source: Ensembl
    9. positive regulation of very-low-density lipoprotein particle remodeling Source: Ensembl
    10. response to hormone Source: Ensembl
    11. tissue regeneration Source: Ensembl
    12. triglyceride catabolic process Source: Ensembl
    13. triglyceride homeostasis Source: Ensembl
    14. triglyceride metabolic process Source: MGI
    15. triglyceride-rich lipoprotein particle remodeling Source: MGI

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.
    REACT_216017. Chylomicron-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-V
    Short name:
    Apo-AV
    Short name:
    ApoA-V
    Alternative name(s):
    Apolipoprotein A5
    Regeneration-associated protein 3
    Gene namesi
    Name:Apoa5
    Synonyms:Rap3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1913363. Apoa5.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. chylomicron Source: UniProtKB-KW
    2. high-density lipoprotein particle Source: UniProtKB-KW
    3. very-low-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chylomicron, HDL, Secreted, VLDL

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 368348Apolipoprotein A-VPRO_0000001982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8C7G5.
    PaxDbiQ8C7G5.
    PRIDEiQ8C7G5.

    PTM databases

    PhosphoSiteiQ8C7G5.

    Expressioni

    Tissue specificityi

    Liver.2 Publications

    Inductioni

    Induced in early phase of liver regeneration.

    Gene expression databases

    BgeeiQ8C7G5.
    CleanExiMM_APOA5.
    GenevestigatoriQ8C7G5.

    Interactioni

    Subunit structurei

    Interacts with GPIHBP1.By similarity

    Protein-protein interaction databases

    IntActiQ8C7G5. 3 interactions.
    MINTiMINT-1858746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C7G5.
    SMRiQ8C7G5. Positions 80-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili231 – 25525Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein A1/A4/E family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG46095.
    GeneTreeiENSGT00740000115662.
    HOGENOMiHOG000253942.
    HOVERGENiHBG050545.
    InParanoidiQ8C7G5.
    KOiK09025.
    OMAiHRSVAPH.
    OrthoDBiEOG7K9K48.
    PhylomeDBiQ8C7G5.
    TreeFamiTF334458.

    Family and domain databases

    InterProiIPR000074. ApoA1_A4_E.
    [Graphical view]
    PfamiPF01442. Apolipoprotein. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8C7G5-1 [UniParc]FASTAAdd to Basket

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    MAAVITWALA LLAVFASTQA RKSLWDYFSQ NSWSKGVMGQ PQKLAQENLK    50
    GSFEQDLYNM NNYLEKLGPL RGPGKEPPLL AQDPEGIRKQ LQQELGEVSS 100
    RLEPYMAAKH QQVGWNLEGL RQQLKPYTAE LMEQVGLSVQ ELQEQLRVVG 150
    EDTKAQLLGG VDEALNLLQD MQSRVLHHTD RVKELFHPYA ERLVTGIGHH 200
    VQELHRSVAP HAAASPARLS RCVQTLSHKL TRKAKDLHTS IQRNLDQLRD 250
    ELSAFIRVST DGAEDGDSLD PQALSEEVRQ RLQAFRHDTY LQIAAFTQAI 300
    DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY 350
    GLQDQGHSHL SDPEGHSG 368
    Length:368
    Mass (Da):41,262
    Last modified:March 1, 2003 - v1
    Checksum:iB5B2F1982C47475B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861G → D in AAG49600. (PubMed:11577099)Curated
    Sequence conflicti178 – 1792HT → QA in AAH11198. (PubMed:15489334)Curated
    Sequence conflicti278 – 2781V → L in AAH11198. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF327059 mRNA. Translation: AAG49600.1.
    AK050280 mRNA. Translation: BAC34163.1.
    BC011198 mRNA. Translation: AAH11198.1.
    CCDSiCCDS23143.1.
    RefSeqiNP_536682.2. NM_080434.3.
    XP_006510601.1. XM_006510538.1.
    UniGeneiMm.29738.

    Genome annotation databases

    EnsembliENSMUST00000034584; ENSMUSP00000034584; ENSMUSG00000032079.
    ENSMUST00000121598; ENSMUSP00000113413; ENSMUSG00000032079.
    GeneIDi66113.
    KEGGimmu:66113.
    UCSCiuc009phf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF327059 mRNA. Translation: AAG49600.1 .
    AK050280 mRNA. Translation: BAC34163.1 .
    BC011198 mRNA. Translation: AAH11198.1 .
    CCDSi CCDS23143.1.
    RefSeqi NP_536682.2. NM_080434.3.
    XP_006510601.1. XM_006510538.1.
    UniGenei Mm.29738.

    3D structure databases

    ProteinModelPortali Q8C7G5.
    SMRi Q8C7G5. Positions 80-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8C7G5. 3 interactions.
    MINTi MINT-1858746.

    PTM databases

    PhosphoSitei Q8C7G5.

    Proteomic databases

    MaxQBi Q8C7G5.
    PaxDbi Q8C7G5.
    PRIDEi Q8C7G5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034584 ; ENSMUSP00000034584 ; ENSMUSG00000032079 .
    ENSMUST00000121598 ; ENSMUSP00000113413 ; ENSMUSG00000032079 .
    GeneIDi 66113.
    KEGGi mmu:66113.
    UCSCi uc009phf.1. mouse.

    Organism-specific databases

    CTDi 116519.
    MGIi MGI:1913363. Apoa5.

    Phylogenomic databases

    eggNOGi NOG46095.
    GeneTreei ENSGT00740000115662.
    HOGENOMi HOG000253942.
    HOVERGENi HBG050545.
    InParanoidi Q8C7G5.
    KOi K09025.
    OMAi HRSVAPH.
    OrthoDBi EOG7K9K48.
    PhylomeDBi Q8C7G5.
    TreeFami TF334458.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.
    REACT_216017. Chylomicron-mediated lipid transport.

    Miscellaneous databases

    NextBioi 320666.
    PROi Q8C7G5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C7G5.
    CleanExi MM_APOA5.
    Genevestigatori Q8C7G5.

    Family and domain databases

    InterProi IPR000074. ApoA1_A4_E.
    [Graphical view ]
    Pfami PF01442. Apolipoprotein. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration."
      van Der Vliet H.N., Sammels M.G., Leegwater A.C.J., Levels J.H.M., Reitsma P.H., Boers W., Chamuleau R.A.F.M.
      J. Biol. Chem. 276:44512-44520(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Strain: C57BL/6.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing."
      Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.-C., Krauss R.M., Rubin E.M.
      Science 294:169-173(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis."
      Schaap F.G., Rensen P.C.N., Voshol P.J., Vrins C., van der Vliet H.N., Chamuleau R.A.F.M., Havekes L.M., Groen A.K., van Dijk K.W.
      J. Biol. Chem. 279:27941-27947(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiAPOA5_MOUSE
    AccessioniPrimary (citable) accession number: Q8C7G5
    Secondary accession number(s): Q91X90, Q99P64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3