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Protein

Starch-binding domain-containing protein 1

Gene

Stbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Starch-binding domain-containing protein 11 Publication
Alternative name(s):
Genethonin-11 Publication
Glycophagy cargo receptor stbd1Curated
Gene namesi
Name:Stbd11 Publication
Synonyms:D5Ertd593e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1261768. Stbd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence analysis
Transmembranei7 – 2317HelicalSequence analysisAdd
BLAST
Topological domaini24 – 338315CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Starch-binding domain-containing protein 1PRO_0000238961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681PhosphoserineBy similarity
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineCombined sources
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei195 – 1951PhosphoserineBy similarity
Modified residuei196 – 1961PhosphoserineCombined sources
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei209 – 2091PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineBy similarity
Modified residuei220 – 2201PhosphoserineCombined sources
Modified residuei223 – 2231PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated, which leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8C7E7.
PaxDbiQ8C7E7.
PRIDEiQ8C7E7.

PTM databases

iPTMnetiQ8C7E7.
PhosphoSiteiQ8C7E7.

Expressioni

Tissue specificityi

Expressed at high level in glycogen-accumulating organs such as muscle and liver. Trace signals are also found in brain, kidney, and pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000047963.
CleanExiMM_STBD1.
ExpressionAtlasiQ8C7E7. baseline and differential.
GenevisibleiQ8C7E7. MM.

Interactioni

Subunit structurei

Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (By similarity). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8C7E7. 2 interactions.
MINTiMINT-1864909.
STRINGi10090.ENSMUSP00000054322.

Structurei

3D structure databases

ProteinModelPortaliQ8C7E7.
SMRiQ8C7E7. Positions 238-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 337100CBM20PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi185 – 1917LIRBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 6252Gly-richAdd
BLAST

Domaini

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.By similarity
The C-terminal CBM20 domain is required for the interaction with glycogen.1 Publication

Sequence similaritiesi

Contains 1 CBM20 (carbohydrate binding type-20) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ19. Eukaryota.
ENOG410Y3IB. LUCA.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiQ8C7E7.
OMAiMGAVWSA.
OrthoDBiEOG091G0LFT.
PhylomeDBiQ8C7E7.
TreeFamiTF338505.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C7E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVWSALLV GGGLAGALIL WLLRGDSGAP GKDGVAEPPQ KGAPPGEAAA
60 70 80 90 100
PGDGPGGGGS GGLSPEPSDR ELVSKAEHLR ESNGHLISES KDLGNLPEAQ
110 120 130 140 150
RLQNVGADWV NAREFVPVGK IPDTHSRADS EAARNQSPGS HGGEWRLPKG
160 170 180 190 200
QETAVKVAGS VAAKLPSSSL LVDRAKAVSQ DQAGHEDWEV VSRHSSWGSV
210 220 230 240 250
GLGGSLEASR LSLNQRMDDS TNSLVGGRGW EVDGKVASLK PQQVSIQFQV
260 270 280 290 300
HYTTNTDVQF IAVTGDHESL GRWNTYIPLH YCKDGLWSHS VFLPADTVVE
310 320 330
WKFVLVENKE VTRWEECSNR FLQTGHEDKV VHGWWGIH
Length:338
Mass (Da):36,127
Last modified:March 1, 2003 - v1
Checksum:i66C12554D9C9EC59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050416 mRNA. Translation: BAC34244.1.
BC118661 mRNA. Translation: AAI18662.1.
CCDSiCCDS19433.1.
RefSeqiNP_780305.1. NM_175096.3.
UniGeneiMm.21965.

Genome annotation databases

EnsembliENSMUST00000050952; ENSMUSP00000054322; ENSMUSG00000047963.
GeneIDi52331.
KEGGimmu:52331.
UCSCiuc008ydp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050416 mRNA. Translation: BAC34244.1.
BC118661 mRNA. Translation: AAI18662.1.
CCDSiCCDS19433.1.
RefSeqiNP_780305.1. NM_175096.3.
UniGeneiMm.21965.

3D structure databases

ProteinModelPortaliQ8C7E7.
SMRiQ8C7E7. Positions 238-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C7E7. 2 interactions.
MINTiMINT-1864909.
STRINGi10090.ENSMUSP00000054322.

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

PTM databases

iPTMnetiQ8C7E7.
PhosphoSiteiQ8C7E7.

Proteomic databases

MaxQBiQ8C7E7.
PaxDbiQ8C7E7.
PRIDEiQ8C7E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050952; ENSMUSP00000054322; ENSMUSG00000047963.
GeneIDi52331.
KEGGimmu:52331.
UCSCiuc008ydp.1. mouse.

Organism-specific databases

CTDi8987.
MGIiMGI:1261768. Stbd1.

Phylogenomic databases

eggNOGiENOG410IJ19. Eukaryota.
ENOG410Y3IB. LUCA.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiQ8C7E7.
OMAiMGAVWSA.
OrthoDBiEOG091G0LFT.
PhylomeDBiQ8C7E7.
TreeFamiTF338505.

Miscellaneous databases

PROiQ8C7E7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047963.
CleanExiMM_STBD1.
ExpressionAtlasiQ8C7E7. baseline and differential.
GenevisibleiQ8C7E7. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTBD1_MOUSE
AccessioniPrimary (citable) accession number: Q8C7E7
Secondary accession number(s): Q147T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.