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Protein

F-box and leucine-rich protein 22

Gene

Fbxl22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box and leucine-rich protein 22
Gene namesi
Name:Fbxl22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921415. Fbxl22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236F-box and leucine-rich protein 22PRO_0000247150Add
BLAST

Proteomic databases

PaxDbiQ8C7B6.
PRIDEiQ8C7B6.

Expressioni

Tissue specificityi

Enriched in cardiac muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ8C7B6.
CleanExiMM_FBXL22.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.

Structurei

3D structure databases

ProteinModelPortaliQ8C7B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4646F-boxAdd
BLAST
Repeati15 – 4026LRR 1Add
BLAST
Repeati43 – 7230LRR 2Add
BLAST
Repeati98 – 12326LRR 3Add
BLAST
Repeati124 – 14926LRR 4Add
BLAST
Repeati150 – 17526LRR 5Add
BLAST
Repeati176 – 20126LRR 6Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410JR3A. Eukaryota.
ENOG410ZQWR. LUCA.
GeneTreeiENSGT00390000003748.
HOGENOMiHOG000112678.
HOVERGENiHBG055305.
InParanoidiQ8C7B6.
KOiK10288.
OMAiGCGHVTD.
OrthoDBiEOG7BW0KN.
PhylomeDBiQ8C7B6.
TreeFamiTF332457.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C7B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHITQLNREC LLCLFSFLDK DSRRSLSRTC SQLRDVFEDP TLWPLLHFHS
60 70 80 90 100
LAELKKDNFR LSPALRSLSI CWHSSRVQVC SIEDWLKSAL QRSICSQHES
110 120 130 140 150
LVNDFLLQVC NRCPNLTSVT LSGCGHVTDD CLARLLLSCP RLRTLRLENC
160 170 180 190 200
ARVTNRTLAA VAAHGRALQT LHVDFCRNVS AAGLLRLRAA CPNLRLSAER
210 220 230
SAAMIPDQPP RARVCAASAF SAAPGRQSMP HPTGSY
Length:236
Mass (Da):26,320
Last modified:March 1, 2003 - v1
Checksum:i1AC2A66D54A53B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052175 mRNA. Translation: BAC34870.1.
AK084845 mRNA. Translation: BAC39291.1.
AK085980 mRNA. Translation: BAC39583.1.
BC100535 mRNA. Translation: AAI00536.1.
CCDSiCCDS23304.1.
RefSeqiNP_780415.1. NM_175206.4.
UniGeneiMm.297998.
Mm.479391.

Genome annotation databases

EnsembliENSMUST00000056890; ENSMUSP00000060137; ENSMUSG00000050503.
GeneIDi74165.
KEGGimmu:74165.
UCSCiuc009qex.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052175 mRNA. Translation: BAC34870.1.
AK084845 mRNA. Translation: BAC39291.1.
AK085980 mRNA. Translation: BAC39583.1.
BC100535 mRNA. Translation: AAI00536.1.
CCDSiCCDS23304.1.
RefSeqiNP_780415.1. NM_175206.4.
UniGeneiMm.297998.
Mm.479391.

3D structure databases

ProteinModelPortaliQ8C7B6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ8C7B6.
PRIDEiQ8C7B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056890; ENSMUSP00000060137; ENSMUSG00000050503.
GeneIDi74165.
KEGGimmu:74165.
UCSCiuc009qex.2. mouse.

Organism-specific databases

CTDi283807.
MGIiMGI:1921415. Fbxl22.

Phylogenomic databases

eggNOGiENOG410JR3A. Eukaryota.
ENOG410ZQWR. LUCA.
GeneTreeiENSGT00390000003748.
HOGENOMiHOG000112678.
HOVERGENiHBG055305.
InParanoidiQ8C7B6.
KOiK10288.
OMAiGCGHVTD.
OrthoDBiEOG7BW0KN.
PhylomeDBiQ8C7B6.
TreeFamiTF332457.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi339964.
PROiQ8C7B6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C7B6.
CleanExiMM_FBXL22.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Jaw and Limb.
  3. "F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo."
    Spaich S., Will R.D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M., Wiemann S., Korn B., Koegl M., Backs J., Katus H.A., Rottbauer W., Frey N.
    Circ. Res. 111:1504-1516(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFXL22_MOUSE
AccessioniPrimary (citable) accession number: Q8C7B6
Secondary accession number(s): Q8C3G3, Q8C3V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.