Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

REST corepressor 2

Gene

Rcor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • enzyme binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: GO_Central
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Alternative name(s):
M-CoREST
Gene namesi
Name:Rcor2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1859854 Rcor2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267771 – 523REST corepressor 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei63PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei202PhosphoserineBy similarity1
Modified residuei479Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C796
MaxQBiQ8C796
PaxDbiQ8C796
PeptideAtlasiQ8C796
PRIDEiQ8C796

PTM databases

iPTMnetiQ8C796
PhosphoSitePlusiQ8C796

Expressioni

Tissue specificityi

Predominantly, but not exclusively, expressed in neural tissue. Strongly expressed in neural domains of the developing brain of the developing mouse CNS.1 Publication

Developmental stagei

During early development (E7 to E8.5), it is uniformly distributed, with a higher expression in the presumptive neural tissue (head region) while it is not expressed in the heart. From E9 on, it becomes increasingly restricted to the developing brain and spinal cord. With the exception of the floor plate, it is expressed in many cell clusters in the neural tube at that stage. Expressed in dorsal root ganglia and in the neural retina (sensory layer of the retina) of embryos from E11 on throughout development. During mid-gestation, it is particularly expressed in neural tissue thereby shifting to the intermediate and distal layers of the expanding intraneural domains. From late gestational stages on, pronounced expression is detectable only in selected areas of the brain such as the retrospinal cortex. Expressed in neural cell layers in the hypothalamic region at postnatal day 5. In adult brains, it is expressed in many neural cells of the differentiated cortex. Expression is also observed in non-neural tissue such as the developing limbs where it becomes restricted to the interdigital areas. Strongly expressed in the odontoblast layer of the developing teeth and the maxillary bone. In the cerebellum, it is already expressed before the lobules form. At E14, it is uniformly distributed in the cerebellar rudiment. When lobulation becomes evident, expression is detectable only in the proliferating granule cells of the outermost layer (external granular layer).1 Publication

Gene expression databases

BgeeiENSMUSG00000024968
CleanExiMM_RCOR2
ExpressionAtlasiQ8C796 baseline and differential
GenevisibleiQ8C796 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hdac2P702882EBI-3043949,EBI-302251

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi222597, 8 interactors
DIPiDIP-59754N
IntActiQ8C796, 7 interactors
MINTiQ8C796
STRINGi10090.ENSMUSP00000108996

Structurei

3D structure databases

ProteinModelPortaliQ8C796
SMRiQ8C796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129ELM2PROSITE-ProRule annotationAdd BLAST86
Domaini130 – 181SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini327 – 378SANT 2PROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 314Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi430 – 521Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the CoREST family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00840000129748
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ8C796
OMAiKCFQRIQ
OrthoDBiEOG091G096Y
PhylomeDBiQ8C796
TreeFamiTF106450

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits

Sequencei

Sequence statusi: Complete.

Q8C796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTAPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKVIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG AVSEGEPDTG DPKREPLPSR PLNARPGPGK KEVQISQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPAAPVPT
410 420 430 440 450
EEARRGAPVP ATALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAASRHS
510 520
ARPGPQPPPT LVGAPLEPPA PSL
Length:523
Mass (Da):57,908
Last modified:March 1, 2003 - v1
Checksum:i46A563C1CC11A7E4
GO

Sequence cautioni

The sequence CAB93943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052295 mRNA Translation: BAC34922.1
BC055719 mRNA Translation: AAH55719.1
X83587 mRNA Translation: CAB93943.1 Different initiation.
CCDSiCCDS29522.2
RefSeqiNP_001307483.1, NM_001320554.1
NP_473389.2, NM_054048.4
UniGeneiMm.283859

Genome annotation databases

EnsembliENSMUST00000066646; ENSMUSP00000063335; ENSMUSG00000024968
GeneIDi104383
KEGGimmu:104383
UCSCiuc008gkn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRCOR2_MOUSE
AccessioniPrimary (citable) accession number: Q8C796
Secondary accession number(s): Q9JMK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health