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Protein

REST corepressor 2

Gene

Rcor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcription factor binding Source: GO_Central
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Alternative name(s):
M-CoREST
Gene namesi
Name:Rcor2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1859854. Rcor2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
  • transcriptional repressor complex Source: GO_Central
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267771 – 523REST corepressor 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei63PhosphoserineCombined sources1
Modified residuei202PhosphoserineBy similarity1
Modified residuei479Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8C796.
MaxQBiQ8C796.
PaxDbiQ8C796.
PeptideAtlasiQ8C796.
PRIDEiQ8C796.

PTM databases

iPTMnetiQ8C796.
PhosphoSitePlusiQ8C796.

Expressioni

Tissue specificityi

Predominantly, but not exclusively, expressed in neural tissue. Strongly expressed in neural domains of the developing brain of the developing mouse CNS.1 Publication

Developmental stagei

During early development (E7 to E8.5), it is uniformly distributed, with a higher expression in the presumptive neural tissue (head region) while it is not expressed in the heart. From E9 on, it becomes increasingly restricted to the developing brain and spinal cord. With the exception of the floor plate, it is expressed in many cell clusters in the neural tube at that stage. Expressed in dorsal root ganglia and in the neural retina (sensory layer of the retina) of embryos from E11 on throughout development. During mid-gestation, it is particularly expressed in neural tissue thereby shifting to the intermediate and distal layers of the expanding intraneural domains. From late gestational stages on, pronounced expression is detectable only in selected areas of the brain such as the retrospinal cortex. Expressed in neural cell layers in the hypothalamic region at postnatal day 5. In adult brains, it is expressed in many neural cells of the differentiated cortex. Expression is also observed in non-neural tissue such as the developing limbs where it becomes restricted to the interdigital areas. Strongly expressed in the odontoblast layer of the developing teeth and the maxillary bone. In the cerebellum, it is already expressed before the lobules form. At E14, it is uniformly distributed in the cerebellar rudiment. When lobulation becomes evident, expression is detectable only in the proliferating granule cells of the outermost layer (external granular layer).1 Publication

Gene expression databases

BgeeiENSMUSG00000024968.
CleanExiMM_RCOR2.
ExpressionAtlasiQ8C796. baseline and differential.
GenevisibleiQ8C796. MM.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi222597. 6 interactors.
DIPiDIP-59754N.
IntActiQ8C796. 4 interactors.
STRINGi10090.ENSMUSP00000108996.

Structurei

3D structure databases

ProteinModelPortaliQ8C796.
SMRiQ8C796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129ELM2PROSITE-ProRule annotationAdd BLAST86
Domaini130 – 181SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini327 – 378SANT 2PROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 314Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi430 – 521Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the CoREST family.Curated
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8C796.
OMAiSPARYSN.
OrthoDBiEOG091G096Y.
PhylomeDBiQ8C796.
TreeFamiTF106450.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTAPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKVIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG AVSEGEPDTG DPKREPLPSR PLNARPGPGK KEVQISQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPAAPVPT
410 420 430 440 450
EEARRGAPVP ATALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAASRHS
510 520
ARPGPQPPPT LVGAPLEPPA PSL
Length:523
Mass (Da):57,908
Last modified:March 1, 2003 - v1
Checksum:i46A563C1CC11A7E4
GO

Sequence cautioni

The sequence CAB93943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052295 mRNA. Translation: BAC34922.1.
BC055719 mRNA. Translation: AAH55719.1.
X83587 mRNA. Translation: CAB93943.1. Different initiation.
CCDSiCCDS29522.1.
RefSeqiNP_001307483.1. NM_001320554.1.
NP_473389.2. NM_054048.4.
UniGeneiMm.283859.

Genome annotation databases

EnsembliENSMUST00000066646; ENSMUSP00000063335; ENSMUSG00000024968.
GeneIDi104383.
KEGGimmu:104383.
UCSCiuc008gkn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052295 mRNA. Translation: BAC34922.1.
BC055719 mRNA. Translation: AAH55719.1.
X83587 mRNA. Translation: CAB93943.1. Different initiation.
CCDSiCCDS29522.1.
RefSeqiNP_001307483.1. NM_001320554.1.
NP_473389.2. NM_054048.4.
UniGeneiMm.283859.

3D structure databases

ProteinModelPortaliQ8C796.
SMRiQ8C796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222597. 6 interactors.
DIPiDIP-59754N.
IntActiQ8C796. 4 interactors.
STRINGi10090.ENSMUSP00000108996.

PTM databases

iPTMnetiQ8C796.
PhosphoSitePlusiQ8C796.

Proteomic databases

EPDiQ8C796.
MaxQBiQ8C796.
PaxDbiQ8C796.
PeptideAtlasiQ8C796.
PRIDEiQ8C796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066646; ENSMUSP00000063335; ENSMUSG00000024968.
GeneIDi104383.
KEGGimmu:104383.
UCSCiuc008gkn.1. mouse.

Organism-specific databases

CTDi283248.
MGIiMGI:1859854. Rcor2.

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8C796.
OMAiSPARYSN.
OrthoDBiEOG091G096Y.
PhylomeDBiQ8C796.
TreeFamiTF106450.

Miscellaneous databases

ChiTaRSiRcor2. mouse.
PROiQ8C796.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024968.
CleanExiMM_RCOR2.
ExpressionAtlasiQ8C796. baseline and differential.
GenevisibleiQ8C796. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCOR2_MOUSE
AccessioniPrimary (citable) accession number: Q8C796
Secondary accession number(s): Q9JMK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.