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Protein

Protein phosphatase 1 regulatory subunit 3B

Gene

Ppp1r3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3B
Alternative name(s):
Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
Protein phosphatase 1 regulatory subunit 4
Short name:
PP1 subunit R4
Protein phosphatase 1 subunit GL
Short name:
PTG
Gene namesi
Name:Ppp1r3b
Synonyms:Ppp1r4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2177268 Ppp1r3b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245441 – 284Protein phosphatase 1 regulatory subunit 3BAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C767
PaxDbiQ8C767
PRIDEiQ8C767

PTM databases

iPTMnetiQ8C767
PhosphoSitePlusiQ8C767

Expressioni

Tissue specificityi

Highly expressed in liver (at protein level). Expressed predominantly in liver. Expressed moderately in heart. Expressed weakly in prostate, stomach, thyroid, lung, kidney, spleen and skeletal muscle.2 Publications

Developmental stagei

Expressed in lung at 12.5 and 16.5 dpc and declines thereafter. Expressed in epithelial cells of the bronchus and smooth muscle of the pulmonary artery at 13.5 and 16.5 dpc.1 Publication

Inductioni

Up-regulated by TITF1.1 Publication

Gene expression databases

BgeeiENSMUSG00000046794
GenevisibleiQ8C767 MM

Interactioni

Subunit structurei

Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232645, 9 interactors
IntActiQ8C767, 10 interactors
STRINGi10090.ENSMUSP00000065679

Structurei

3D structure databases

ProteinModelPortaliQ8C767
SMRiQ8C767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 232CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 64PP1-binding motif4

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.By similarity

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000026799
HOVERGENiHBG052744
InParanoidiQ8C767
KOiK07189
OMAiMVKVFSE
OrthoDBiEOG091G0GB5
PhylomeDBiQ8C767
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
IPR030682 PP1_3B
PANTHERiPTHR12307:SF13 PTHR12307:SF13, 1 hit
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDIQYSYS SMAPSLRRER FTFKISPKLS KPLRPCIQLG SKDEASGMVA
60 70 80 90 100
PAVQEKKVKK RVSFADNQGL ALTMVKVFSE FDDPLDIPFN ITELLDNIVS
110 120 130 140 150
LTTAESESFV LDFPQPSADY LDFRNRLQTN HVCLENCVLK DKAIAGTVKV
160 170 180 190 200
QNLAFEKVVK IRMTFDTWKS FTDFPCQYVK DTYAGSDRDT FSFDISLPEK
210 220 230 240 250
IQSYERMEFA VCYECNGQAY WDSNKGKNYR ITRAELRSSP GKIEPYNGPD
260 270 280
FGISFDQFGS PRCSFGLFPE WPSYLGYEKL GPYY
Length:284
Mass (Da):32,433
Last modified:March 1, 2003 - v1
Checksum:i193C1BAC1286D344
GO

Sequence cautioni

The sequence AAH60261 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052438 mRNA Translation: BAC34990.1
BC060261 mRNA Translation: AAH60261.1 Different initiation.
BC079666 mRNA Translation: AAH79666.1
CCDSiCCDS22243.1
RefSeqiNP_808409.1, NM_177741.3
XP_006509181.1, XM_006509118.3
XP_017168286.1, XM_017312797.1
XP_017168287.1, XM_017312798.1
UniGeneiMm.247126

Genome annotation databases

EnsembliENSMUST00000070481; ENSMUSP00000065679; ENSMUSG00000046794
ENSMUST00000210337; ENSMUSP00000147736; ENSMUSG00000046794
ENSMUST00000211648; ENSMUSP00000147633; ENSMUSG00000046794
GeneIDi244416
KEGGimmu:244416
UCSCiuc009lkw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPR3B_MOUSE
AccessioniPrimary (citable) accession number: Q8C767
Secondary accession number(s): Q6PAJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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