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Protein

Ankyrin repeat and SOCS box protein 14

Gene

Asb14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 14
Gene namesi
Name:Asb14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2655107. Asb14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003703661 – 587Ankyrin repeat and SOCS box protein 14Add BLAST587

Proteomic databases

PaxDbiQ8C6Y6.
PRIDEiQ8C6Y6.

PTM databases

iPTMnetiQ8C6Y6.
PhosphoSitePlusiQ8C6Y6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021898.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087810.

Structurei

3D structure databases

ProteinModelPortaliQ8C6Y6.
SMRiQ8C6Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 110ANK 1Add BLAST30
Repeati116 – 145ANK 2Add BLAST30
Repeati149 – 178ANK 3Add BLAST30
Repeati182 – 211ANK 4Add BLAST30
Repeati215 – 244ANK 5Add BLAST30
Repeati248 – 277ANK 6Add BLAST30
Repeati281 – 310ANK 7Add BLAST30
Repeati313 – 342ANK 8Add BLAST30
Repeati355 – 384ANK 9Add BLAST30
Repeati385 – 414ANK 10Add BLAST30
Repeati416 – 449ANK 11Add BLAST34
Domaini521 – 576SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000034086.
InParanoidiQ8C6Y6.
KOiK10336.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C6Y6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPSGSDEDA DADFDTQVII QQSLLDVYKP GIAQHTPEAA RLHSFPSDDY
60 70 80 90 100
KKIAEAIETG KEDALAGFAK YHPAFDEANG NGWLPLHKAA VQLNKNILEI
110 120 130 140 150
TMNASEPSTW ERTTHNGETA LFLAVSSSLL ENAHFLLLKG CNPNAKTSEG
160 170 180 190 200
NSPLLTAVLK DAYDMATLLI SHGADVNLRC ANERTALHEA AKLGRLDMVK
210 220 230 240 250
LMLASGAYPD ARSSYGFTPL ALAAQGGHTG IMQLLLQKGA DVHSQASDSS
260 270 280 290 300
SVLLEAVRGG NPEAVSLLLE YGADANIPKS SGHLPIHVAA DKGHFLALKV
310 320 330 340 350
LVPVTDIAAI KKSGISPVHC AAAGAHPHCL ELLIQAGFDV NFMLDQRIRK
360 370 380 390 400
HYDDQRKSAL YFAVSNGDLP SVKLLLSAGA LPNQDPVNCL QIALRMGNYE
410 420 430 440 450
LISLLLRHGA NVNYFCRVNP LHFPSALQYT LKDEVMLRML LNYGYDTERC
460 470 480 490 500
FDCPHGERVH RFCTFEGWTS TVIKDTMFCE VITLSWLQHL SGKVVRVMLD
510 520 530 540 550
YVDQVQICSK LKAVLEKQRL WPEIHFILAN PRSLQHLCRL KIRKCMGRLR
560 570 580
LRCPVFMSFL PLPNLLKAYV LYKEYDLFGQ ERSTGTW
Length:587
Mass (Da):64,883
Last modified:April 14, 2009 - v2
Checksum:i3A9395532FA6712C
GO
Isoform 2 (identifier: Q8C6Y6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     239-239: G → GKAYLMVDYRG

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):48,301
Checksum:iA8C78D6DBB3B716B
GO

Sequence cautioni

The sequence BAC35189 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310I → V in AAL57361 (Ref. 1) Curated1
Sequence conflicti529 – 587ANPRS…STGTW → SEYRSHRKFLPKH in BAC35189 (PubMed:16141072).CuratedAdd BLAST59
Sequence conflicti529A → T in AAL57361 (Ref. 1) Curated1
Sequence conflicti529A → T in AAI45003 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0369291 – 164Missing in isoform 2. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_036930239G → GKAYLMVDYRG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403042 mRNA. Translation: AAL57361.1.
AK052884 mRNA. Translation: BAC35189.1. Different initiation.
AC133179 Genomic DNA. No translation available.
AC124603 Genomic DNA. No translation available.
BC145002 mRNA. Translation: AAI45003.1.
RefSeqiNP_001164219.1. NM_001170748.1.
NP_543132.3. NM_080856.4.
UniGeneiMm.138259.

Genome annotation databases

GeneIDi142687.
KEGGimmu:142687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403042 mRNA. Translation: AAL57361.1.
AK052884 mRNA. Translation: BAC35189.1. Different initiation.
AC133179 Genomic DNA. No translation available.
AC124603 Genomic DNA. No translation available.
BC145002 mRNA. Translation: AAI45003.1.
RefSeqiNP_001164219.1. NM_001170748.1.
NP_543132.3. NM_080856.4.
UniGeneiMm.138259.

3D structure databases

ProteinModelPortaliQ8C6Y6.
SMRiQ8C6Y6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087810.

PTM databases

iPTMnetiQ8C6Y6.
PhosphoSitePlusiQ8C6Y6.

Proteomic databases

PaxDbiQ8C6Y6.
PRIDEiQ8C6Y6.

Protocols and materials databases

DNASUi142687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi142687.
KEGGimmu:142687.

Organism-specific databases

CTDi142686.
MGIiMGI:2655107. Asb14.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000034086.
InParanoidiQ8C6Y6.
KOiK10336.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8C6Y6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021898.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB14_MOUSE
AccessioniPrimary (citable) accession number: Q8C6Y6
Secondary accession number(s): B7ZN45, Q8VHS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.