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Protein

Collagen alpha-6(VI) chain

Gene

Col6a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-186797. Signaling by PDGF.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-419037. NCAM1 interactions.
R-MMU-8948216. Collagen chain trimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-6(VI) chain
Gene namesi
Name:Col6a6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444259. Col6a6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500025301319 – 2265Collagen alpha-6(VI) chainAdd BLAST2247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi760N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ8C6K9.
PRIDEiQ8C6K9.

PTM databases

iPTMnetiQ8C6K9.
PhosphoSitePlusiQ8C6K9.

Expressioni

Tissue specificityi

In newborn, it is expressed in lung, heart, kidney, muscle, brain, intestine, skin, femur and sternum. In adult, it is expressed in lung, heart, muscle, ovary, brain, liver and sternum.1 Publication

Gene expression databases

BgeeiENSMUSG00000043719.
ExpressionAtlasiQ8C6K9. baseline and differential.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096040.

Structurei

3D structure databases

ProteinModelPortaliQ8C6K9.
SMRiQ8C6K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 205VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini228 – 406VWFA 2PROSITE-ProRule annotationAdd BLAST179
Domaini435 – 605VWFA 3PROSITE-ProRule annotationAdd BLAST171
Domaini621 – 790VWFA 4PROSITE-ProRule annotationAdd BLAST170
Domaini808 – 981VWFA 5PROSITE-ProRule annotationAdd BLAST174
Domaini999 – 1170VWFA 6PROSITE-ProRule annotationAdd BLAST172
Domaini1186 – 1378VWFA 7PROSITE-ProRule annotationAdd BLAST193
Domaini1756 – 1936VWFA 8PROSITE-ProRule annotationAdd BLAST181
Domaini1964 – 2165VWFA 9PROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 1390Nonhelical regionAdd BLAST1372
Regioni1391 – 1724Triple-helical regionAdd BLAST334
Regioni1725 – 2265Nonhelical regionAdd BLAST541

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1507 – 1509Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410Y0KT. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000111864.
HOVERGENiHBG107743.
InParanoidiQ8C6K9.
KOiK06238.
OMAiFQVTNAM.
PhylomeDBiQ8C6K9.

Family and domain databases

Gene3Di3.40.50.410. 8 hits.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PfamiView protein in Pfam
PF01391. Collagen. 1 hit.
PF00092. VWA. 8 hits.
SMARTiView protein in SMART
SM00327. VWA. 9 hits.
SUPFAMiSSF53300. SSF53300. 9 hits.
PROSITEiView protein in PROSITE
PS50234. VWFA. 8 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C6K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLVLCLTMI CFHVCVNQDS GPEYADVVFL VDSSDHLGLK SFPLVKTFIH
60 70 80 90 100
KMISSLPIEA NKYRVALAQY SDALHNEFQL GTFKNRNPML NHLKKNFGFI
110 120 130 140 150
GGSLKIGNAL QEAHRTYFSA PTNGRDKKQF PPILVVLASA ESEDDVEEAA
160 170 180 190 200
KALREDGVKI ISVGVQKASE ENLKAMATSQ FHFNLRTARD LSVFAPNMTE
210 220 230 240 250
IIKDVTQYRE GMADDIIVEA CQGPSVADVV FLLDMAINGS QEDLDHLKAF
260 270 280 290 300
LGESISALDI KENCMRVGLV TYSNETRVIS SLSTGNNKTE VLQRIQDLSP
310 320 330 340 350
QVGQAYTGAA LRKTRKEIFS AQRGSRKNQG VPQIAVLVTH RASEDNVTKA
360 370 380 390 400
AVNLRREGVT IFTMGIEGAN PDELEKIASH PAEQFTSKLG NFSELATHNQ
410 420 430 440 450
TFLKKLRNQI THTVSVFSER TETLKSACVD TEEADIYLLI DGSGSTQPTD
460 470 480 490 500
FHEMKTFLSE VVGMFNIAPH KVRVGAVQYA DTWDLEFEIS KYSNKPDLGK
510 520 530 540 550
AIENIRQMGG NTNTGAALNF TLKLLQRAKK ERGSKVPCHL VVLTNGMSRD
560 570 580 590 600
SVLGPAHKLR EENIRVHAIG VKEANQTQLR EIAGEEKRVY YVHEFDALRN
610 620 630 640 650
IRNQVVQEIC AEEACRDMKA DIMFLVDSSG SIGPENFSKM KMFMKNLVSK
660 670 680 690 700
SQIGADRVQI GVVQFSHENK EEFQLNTFMS QSDIANAIDR MTHIGETTLT
710 720 730 740 750
GSALTFVSQY FSPDKGARPN VRKFLILITD GEAQDIVRDP AIALRKEGVI
760 770 780 790 800
IYSVGVFGSN VTQLEEISGK PEMVFYVENF DILQHIEDDL VLGICSPREE
810 820 830 840 850
CKRIEVLDVV FVIDSSGSID YQEYNIMKDF MIGLVKKADV GKNQVRFGAL
860 870 880 890 900
KYADDPEVLF YLDELGTKLE VVSVLQNDHP MGGNTYTAEA LAFSDHMFTE
910 920 930 940 950
ARGSRLHKGV PQVLIVITDG ESHDAEKLNT TAKALRDKGI LVLAVGIAGA
960 970 980 990 1000
NSWELLAMAG SSDKYYFVET FGGLKGIFSD VSASVCNSSK VDCEIEKVDL
1010 1020 1030 1040 1050
VFLMDGSNSI HPDDFQKMKG FLVSVVQDFD VSLNRVRIGV AQFSDSYRSE
1060 1070 1080 1090 1100
FLLGTFTGER EISTQIEGIQ QIFGYTHIGD ALRKVKYYFQ PDMGSRINAG
1110 1120 1130 1140 1150
TPQVLLVLTD GRSQDEVAQA AEELRHKGVD IYSVGIGDVD DQELVQITGT
1160 1170 1180 1190 1200
AEKKLTVHNF DELKKVKKRI VRNICTSGGE SNCFVDVVVG FDISSLQRGQ
1210 1220 1230 1240 1250
TLLEGQPWMG SYLQDLLRAI SSLNGVSCEV GTETQVSIAF QVTNAMERYP
1260 1270 1280 1290 1300
SKFEIYSENI LSSLQGVTVN GPSRLNANLL SSLWDTFQNK SAARGKVVLL
1310 1320 1330 1340 1350
FSDGLDDGIE KLEQKSDELR KEGLNALITI AVDGAADSSD LADLLYIEFG
1360 1370 1380 1390 1400
KGFEYRTQFT IGMRNLGSQL SRQLINVAER TCCCLLCKCT GGDGAMGDPG
1410 1420 1430 1440 1450
SAGKKGPPGF KGSDGYLGEE GIAGERGASG PMGEQGTKGC FGAKGPKGTR
1460 1470 1480 1490 1500
GLSGEEGEVG EDGLDGLDGE QGDHGIPGRR GEKGDEGSQG NPGRRGAAGD
1510 1520 1530 1540 1550
RGAKGLRGDP GTPGRDSSIQ GPKGLKGDLG RQGRRGWPGS PGTPGSRRKM
1560 1570 1580 1590 1600
VVHGRRGHIG PQGNPGTPGP DGLAGSPGLR GPQGPRGEVG EKGEKGSLGM
1610 1620 1630 1640 1650
KGPQGPPGPG GQAGSQGHLG SQGNKGEPGD LGEKGAAGFP GPRGLQGDDG
1660 1670 1680 1690 1700
SPGYGSIGRK GTKGQEGFPG ESGLKGDIGD PGDPGEAGPK GARGKTVSAG
1710 1720 1730 1740 1750
IPGEPGSPGE PGPPGRKGVK GARGLASFST CDLIQYVRDH SPGRHGKPEC
1760 1770 1780 1790 1800
PVHPTELVFV LDQSRDVTEQ DFERMKGMMV SLVRDVKVRE ANCPVGARVA
1810 1820 1830 1840 1850
ILAYNSHTRH LIRFSDAYRK DQLLTAIKAL PYERSSDSRE IGKAMRFISR
1860 1870 1880 1890 1900
NVFKRTLPGA HVRRIATFFS SGPSADAQTI TTAAMEFSAL DIVPVVIAFS
1910 1920 1930 1940 1950
NVPSVKRAFS IDDTGTFQVI VVPSGSDEGP ALERLQRCTF CYDLCKPDAS
1960 1970 1980 1990 2000
CDQAKPPPIQ SYLDTAFLLD GSRHVGSAEF EDMRDFLEAL LDHFEITSEP
2010 2020 2030 2040 2050
ETSVTGDRVA LLSHAPLDFL PNTQRSPVRT EFNLTSYSSK RLMKRHVDQA
2060 2070 2080 2090 2100
VQQLHGDAFL GHALGWALDN VFLNTPNLRR NKVIFVISAG ETSHLDAETL
2110 2120 2130 2140 2150
KKESLRAKCH GYALFVFSLG PDWDDKELED LASHPVDQHL IQLGRIHKPD
2160 2170 2180 2190 2200
HGYSVKFVKS FINSIRHGIN KYPPVNLKAK CNRLGSRDLK PPPRQFRSFV
2210 2220 2230 2240 2250
PGPQKANLKD HTAEAAKLFQ DKKRLSSMLK GGRATISSLS RSTRYAFKQG
2260
KEAIKATSKL GKRSA
Length:2,265
Mass (Da):246,323
Last modified:May 20, 2008 - v2
Checksum:i30F442032002386A
GO
Isoform 2 (identifier: Q8C6K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1182-1182: N → S
     1183-2265: Missing.

Note: No experimental confirmation available.
Show »
Length:1,182
Mass (Da):130,970
Checksum:iEF42F19311628426
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti923H → N in BAC35749 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339161182N → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_0339171183 – 2265Missing in isoform 2. 1 PublicationAdd BLAST1083

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM748259 mRNA. Translation: CAO01894.1.
AM748260 mRNA. Translation: CAO01895.1.
AM748261 mRNA. Translation: CAO01896.1.
AM748262 mRNA. Translation: CAO01897.1.
AK054356 mRNA. Translation: BAC35749.1.
CCDSiCCDS23468.1. [Q8C6K9-2]
CCDS52906.1. [Q8C6K9-1]
RefSeqiNP_001096077.1. NM_001102607.1. [Q8C6K9-1]
NP_766515.2. NM_172927.3. [Q8C6K9-2]
UniGeneiMm.482507.

Genome annotation databases

EnsembliENSMUST00000060896; ENSMUSP00000060840; ENSMUSG00000043719. [Q8C6K9-2]
ENSMUST00000098441; ENSMUSP00000096040; ENSMUSG00000043719. [Q8C6K9-1]
GeneIDi245026.
KEGGimmu:245026.
UCSCiuc009ris.1. mouse. [Q8C6K9-1]
uc009rit.1. mouse. [Q8C6K9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCO6A6_MOUSE
AccessioniPrimary (citable) accession number: Q8C6K9
Secondary accession number(s): A6H587
, A6H588, A6H589, A6H590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome