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Protein

WD repeat-containing protein 26

Gene

Wdr26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in MAPK pathways.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 26
Gene namesi
Name:Wdr26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923825. Wdr26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641WD repeat-containing protein 26PRO_0000051374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei103 – 1031PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C6G8.
MaxQBiQ8C6G8.
PaxDbiQ8C6G8.
PRIDEiQ8C6G8.

PTM databases

iPTMnetiQ8C6G8.
PhosphoSiteiQ8C6G8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038733.
CleanExiMM_WDR26.
ExpressionAtlasiQ8C6G8. baseline and differential.
GenevisibleiQ8C6G8. MM.

Interactioni

Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes.By similarity

Protein-protein interaction databases

BioGridi230551. 1 interaction.
IntActiQ8C6G8. 1 interaction.
STRINGi10090.ENSMUSP00000124592.

Structurei

3D structure databases

ProteinModelPortaliQ8C6G8.
SMRiQ8C6G8. Positions 102-319, 324-621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 13533LisHPROSITE-ProRule annotationAdd
BLAST
Domaini136 – 21176CTLHPROSITE-ProRule annotationAdd
BLAST
Repeati333 – 37240WD 1Add
BLAST
Repeati379 – 41840WD 2Add
BLAST
Repeati424 – 46441WD 3Add
BLAST
Repeati504 – 54340WD 4Add
BLAST
Repeati546 – 58843WD 5Add
BLAST
Repeati591 – 63141WD 6Add
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0293. Eukaryota.
ENOG410XQ2U. LUCA.
GeneTreeiENSGT00730000111021.
HOVERGENiHBG083958.
InParanoidiQ8C6G8.
OMAiWEAKFLI.
OrthoDBiEOG091G05NI.
TreeFamiTF314869.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C6G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQANGAGGGG GGGGGGQGQT PELACLSAQN GESSPSATSA GDLAHANGLL
60 70 80 90 100
PAAPSAAGNN SNSLSVNNGV PGGAAAASAT AAAAQATPEL GSSLKKKKRL
110 120 130 140 150
SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG
160 170 180 190 200
DWDKAENDLN ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY
210 220 230 240 250
LEYLEDGKVL EALQVLRCEL TPLKYNTERI HVLSGYLMCS HAEDLRAKAE
260 270 280 290 300
WEGKGTASRS KLLDKLQTYL PPSVMLPPRR LQTLLRQAVE LQRDRCLYHN
310 320 330 340 350
TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF CKFSNDGTKL
360 370 380 390 400
ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDSYLVACG
410 420 430 440 450
PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF
460 470 480 490 500
YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV LASDTHQRVR GYNFEDLTDR
510 520 530 540 550
NIVQEDHPIM SFTISKNGRL ALLNVATQGV HLWDLQDRVL VRKYQGVTQG
560 570 580 590 600
FYTIHSCFGG HNEDFIASGS EDHKVYIWHK RSELPIAELT GHTRTVNCVS
610 620 630 640
WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD S
Length:641
Mass (Da):70,543
Last modified:July 27, 2011 - v3
Checksum:i053BAFF901088CFA
GO

Sequence cautioni

The sequence BAC35923 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113084 Genomic DNA. No translation available.
AK075743 mRNA. Translation: BAC35923.1. Different initiation.
AK167116 mRNA. Translation: BAE39264.1.
AK167017 mRNA. Translation: BAE39191.1.
BC020044 mRNA. Translation: AAH20044.2.
BC058601 mRNA. Translation: AAH58601.1.
CCDSiCCDS15583.2.
RefSeqiNP_663489.4. NM_145514.5.
UniGeneiMm.289082.

Genome annotation databases

EnsembliENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733.
GeneIDi226757.
KEGGimmu:226757.
UCSCiuc007dxf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113084 Genomic DNA. No translation available.
AK075743 mRNA. Translation: BAC35923.1. Different initiation.
AK167116 mRNA. Translation: BAE39264.1.
AK167017 mRNA. Translation: BAE39191.1.
BC020044 mRNA. Translation: AAH20044.2.
BC058601 mRNA. Translation: AAH58601.1.
CCDSiCCDS15583.2.
RefSeqiNP_663489.4. NM_145514.5.
UniGeneiMm.289082.

3D structure databases

ProteinModelPortaliQ8C6G8.
SMRiQ8C6G8. Positions 102-319, 324-621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230551. 1 interaction.
IntActiQ8C6G8. 1 interaction.
STRINGi10090.ENSMUSP00000124592.

PTM databases

iPTMnetiQ8C6G8.
PhosphoSiteiQ8C6G8.

Proteomic databases

EPDiQ8C6G8.
MaxQBiQ8C6G8.
PaxDbiQ8C6G8.
PRIDEiQ8C6G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733.
GeneIDi226757.
KEGGimmu:226757.
UCSCiuc007dxf.2. mouse.

Organism-specific databases

CTDi80232.
MGIiMGI:1923825. Wdr26.

Phylogenomic databases

eggNOGiKOG0293. Eukaryota.
ENOG410XQ2U. LUCA.
GeneTreeiENSGT00730000111021.
HOVERGENiHBG083958.
InParanoidiQ8C6G8.
OMAiWEAKFLI.
OrthoDBiEOG091G05NI.
TreeFamiTF314869.

Miscellaneous databases

ChiTaRSiWdr26. mouse.
PROiQ8C6G8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038733.
CleanExiMM_WDR26.
ExpressionAtlasiQ8C6G8. baseline and differential.
GenevisibleiQ8C6G8. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR26_MOUSE
AccessioniPrimary (citable) accession number: Q8C6G8
Secondary accession number(s): E9PX83
, Q3TK81, Q8C4F3, Q8VDZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.