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Protein

Cilia- and flagella-associated protein 36

Gene

Cfap36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as an effector for ARL3.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 36Imported
Alternative name(s):
Coiled-coil domain-containing protein 104Imported
Gene namesi
Name:Cfap36Imported
Synonyms:Ccdc104Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913994. Cfap36.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell projectionciliumflagellum Curated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Cilia- and flagella-associated protein 36PRO_0000278639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineCombined sources
Modified residuei201 – 2011PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C6E0.
MaxQBiQ8C6E0.
PaxDbiQ8C6E0.
PeptideAtlasiQ8C6E0.
PRIDEiQ8C6E0.

PTM databases

iPTMnetiQ8C6E0.
PhosphoSiteiQ8C6E0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020462.
CleanExiMM_CCDC104.
ExpressionAtlasiQ8C6E0. baseline and differential.
GenevisibleiQ8C6E0. MM.

Interactioni

Subunit structurei

Interacts with ARL3.By similarity

Protein-protein interaction databases

DIPiDIP-61817N.
STRINGi10090.ENSMUSP00000020754.

Structurei

Secondary structure

1
343
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2114Combined sources
Helixi23 – 3614Combined sources
Helixi37 – 393Combined sources
Beta strandi42 – 465Combined sources
Helixi48 – 7225Combined sources
Helixi76 – 849Combined sources
Helixi87 – 915Combined sources
Helixi94 – 10411Combined sources
Helixi106 – 12823Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ZI2X-ray2.20C/D1-133[»]
4ZI3X-ray2.00C/D1-133[»]
ProteinModelPortaliQ8C6E0.
SMRiQ8C6E0. Positions 6-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili147 – 18741Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CFAP36 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4511. Eukaryota.
ENOG41116YE. LUCA.
GeneTreeiENSGT00390000012785.
HOGENOMiHOG000007745.
HOVERGENiHBG062543.
InParanoidiQ8C6E0.
OMAiMTEKPEM.
OrthoDBiEOG091G09GK.
PhylomeDBiQ8C6E0.
TreeFamiTF315143.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C6E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVF DDEEESKLTY
60 70 80 90 100
TEIHQEYKEL VEKLLESYLK EIGINEDQFQ EACTSPLAKT RTSQAILQPV
110 120 130 140 150
LAAEDFTIFK AMMVQKNIEM QLQAIRIIQE RNGVLPDCLT DGADVVSDLE
160 170 180 190 200
QEEMKILREV LRKSKEEYDQ EEERKRKKQS SEAKMEELPV YTSEAEKMSN
210 220 230 240 250
SQGDGEHFVQ PPSEVKVHFA NQSVQPLARK MELLPETSSL TQKGLKIPGL
260 270 280 290 300
EHASMEGPIA NLSALGTEEL RQREHYLKQK RDKLLSMRKD TRTKQIQNTE
310 320 330 340
QKGKPTREAE EMTEKPEMTA EEKQTLLKRR LLAEKLKEEV INK
Length:343
Mass (Da):39,600
Last modified:March 1, 2003 - v1
Checksum:iD276DEDCB7400271
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251Q → H in BAB26962 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010468 mRNA. Translation: BAB26962.1.
AK075858 mRNA. Translation: BAC36009.1.
BX294116, AL935054 Genomic DNA. Translation: CAI35920.1.
AL935054, BX294116 Genomic DNA. Translation: CAI24882.1.
CCDSiCCDS24493.1.
RefSeqiNP_080016.1. NM_025740.3.
UniGeneiMm.128663.

Genome annotation databases

EnsembliENSMUST00000020754; ENSMUSP00000020754; ENSMUSG00000020462.
GeneIDi216618.
KEGGimmu:216618.
UCSCiuc007igu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010468 mRNA. Translation: BAB26962.1.
AK075858 mRNA. Translation: BAC36009.1.
BX294116, AL935054 Genomic DNA. Translation: CAI35920.1.
AL935054, BX294116 Genomic DNA. Translation: CAI24882.1.
CCDSiCCDS24493.1.
RefSeqiNP_080016.1. NM_025740.3.
UniGeneiMm.128663.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ZI2X-ray2.20C/D1-133[»]
4ZI3X-ray2.00C/D1-133[»]
ProteinModelPortaliQ8C6E0.
SMRiQ8C6E0. Positions 6-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61817N.
STRINGi10090.ENSMUSP00000020754.

PTM databases

iPTMnetiQ8C6E0.
PhosphoSiteiQ8C6E0.

Proteomic databases

EPDiQ8C6E0.
MaxQBiQ8C6E0.
PaxDbiQ8C6E0.
PeptideAtlasiQ8C6E0.
PRIDEiQ8C6E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020754; ENSMUSP00000020754; ENSMUSG00000020462.
GeneIDi216618.
KEGGimmu:216618.
UCSCiuc007igu.1. mouse.

Organism-specific databases

CTDi112942.
MGIiMGI:1913994. Cfap36.

Phylogenomic databases

eggNOGiKOG4511. Eukaryota.
ENOG41116YE. LUCA.
GeneTreeiENSGT00390000012785.
HOGENOMiHOG000007745.
HOVERGENiHBG062543.
InParanoidiQ8C6E0.
OMAiMTEKPEM.
OrthoDBiEOG091G09GK.
PhylomeDBiQ8C6E0.
TreeFamiTF315143.

Miscellaneous databases

ChiTaRSiCcdc104. mouse.
PROiQ8C6E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020462.
CleanExiMM_CCDC104.
ExpressionAtlasiQ8C6E0. baseline and differential.
GenevisibleiQ8C6E0. MM.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCFA36_MOUSE
AccessioniPrimary (citable) accession number: Q8C6E0
Secondary accession number(s): Q9CWQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.