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Protein

Protein LEG1 homolog

Gene

Leg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in early liver development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LEG1 homologBy similarity
Gene namesi
Name:Leg1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914969. 2310057J18Rik.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025238621 – 337Protein LEG1 homologAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C6C9.
PeptideAtlasiQ8C6C9.
PRIDEiQ8C6C9.

PTM databases

PhosphoSitePlusiQ8C6C9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015519.
CleanExiMM_2310057J18RIK.
ExpressionAtlasiQ8C6C9. baseline and differential.
GenevisibleiQ8C6C9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015663.

Structurei

3D structure databases

SMRiQ8C6C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LEG1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ51. Eukaryota.
ENOG4111MHP. LUCA.
GeneTreeiENSGT00390000004904.
HOVERGENiHBG081098.
InParanoidiQ8C6C9.
OMAiSWWADMN.
OrthoDBiEOG091G0HCG.
PhylomeDBiQ8C6C9.
TreeFamiTF332991.

Family and domain databases

InterProiView protein in InterPro
IPR008499. Leg1.
PANTHERiPTHR18820. PTHR18820. 1 hit.
PfamiView protein in Pfam
PF05612. Leg1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C6C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLASWVWV LAGCFCAAVA EVSDSSDPYP PLWEDSPEQL SDYMMEDGNY
60 70 80 90 100
IINPWVYTDR MGMYRILLEE TAMYFAKYGP ENEQNLLWGL PLQFGWQYQS
110 120 130 140 150
GRLADPTGMT DCGNELNESL CVSVDSWWAD INYYLSVIPF LAAVDSGITG
160 170 180 190 200
ISPNQITILP PPKDQMRFCY NVSDCQSAVP GTMNRWRDFF QYMQLNSSDF
210 220 230 240 250
DGLLNYLWEA HASSLDYPTS AFGDRYNFYS EKEANFEENW AIAVNYLAAA
260 270 280 290 300
RLPTTQNRTY SFQRGLPPRV LVDTDIAPFI PDFTPLQNEV LVSLKLLGDT
310 320 330
DRNSGSLSLT LWENLMSTKL ARTLFLKAFE EFLATSS
Length:337
Mass (Da):38,284
Last modified:October 17, 2006 - v2
Checksum:iC3F366FAC48436B2
GO

Sequence cautioni

The sequence AAH21783 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26664 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → S in BAB26334 (PubMed:16141072).Curated1
Sequence conflicti20A → S in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti21E → G in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti51I → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti60R → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti65R → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti111D → N in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti157T → M in BAB26334 (PubMed:16141072).Curated1
Sequence conflicti157T → M in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti262F → C in BAB26189 (PubMed:16141072).Curated1
Sequence conflicti274T → A in BAB26391 (PubMed:16141072).Curated1
Sequence conflicti301D → E in BAB25653 (PubMed:16141072).Curated1
Sequence conflicti332F → S in BAB26653 (PubMed:16141072).Curated1
Sequence conflicti334A → V in AAH21783 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008407 mRNA. Translation: BAB25653.1.
AK009278 mRNA. Translation: BAB26189.1.
AK009369 mRNA. Translation: BAB26247.1.
AK009472 mRNA. Translation: BAB26311.1. Different initiation.
AK009516 mRNA. Translation: BAB26334.1.
AK009594 mRNA. Translation: BAB26380.1.
AK009610 mRNA. Translation: BAB26391.1.
AK009872 mRNA. Translation: BAB26555.1.
AK009911 mRNA. Translation: BAB26580.1.
AK009921 mRNA. Translation: BAB26585.1.
AK010028 mRNA. Translation: BAB26653.1.
AK010037 mRNA. Translation: BAB26657.1.
AK010047 mRNA. Translation: BAB26664.1. Different initiation.
AK010108 mRNA. Translation: BAB26706.1.
AK010222 mRNA. Translation: BAB26777.1.
AK075881 mRNA. Translation: BAC36026.1.
AK075892 mRNA. Translation: BAC36034.1.
AK075901 mRNA. Translation: BAC36041.1.
BC021783 mRNA. Translation: AAH21783.1. Different initiation.
CCDSiCCDS23759.1.
RefSeqiNP_080612.1. NM_026336.3.
UniGeneiMm.440480.

Genome annotation databases

EnsembliENSMUST00000015663; ENSMUSP00000015663; ENSMUSG00000015519.
GeneIDi67719.
KEGGimmu:67719.
UCSCiuc007esr.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiLEG1H_MOUSE
AccessioniPrimary (citable) accession number: Q8C6C9
Secondary accession number(s): Q8C6D2
, Q8C6D6, Q8VDJ0, Q9CPV8, Q9CQ55, Q9D6S4, Q9D745, Q9D775, Q9D7F4, Q9D865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: February 28, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome