Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Active regulator of SIRT1

Gene

Rps19bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:Rps19bp1
Synonyms:Aros
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913788. Rps19bp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleolus Source: HGNC
  • nucleoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523941 – 143Active regulator of SIRT1Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Citrulline1 Publication1
Modified residuei86PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiQ8C6B9.
MaxQBiQ8C6B9.
PaxDbiQ8C6B9.
PeptideAtlasiQ8C6B9.
PRIDEiQ8C6B9.

PTM databases

iPTMnetiQ8C6B9.
PhosphoSitePlusiQ8C6B9.

Expressioni

Tissue specificityi

Widely expressed with higher levels in submaxillary gland and epididymis.1 Publication

Gene expression databases

BgeeiENSMUSG00000051518.
CleanExiMM_RPS19BP1.
GenevisibleiQ8C6B9. MM.

Interactioni

Subunit structurei

Interacts with SIRT1 (By similarity). Interacts with RPS19.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211544. 2 interactors.
IntActiQ8C6B9. 1 interactor.
STRINGi10090.ENSMUSP00000061167.

Structurei

3D structure databases

ProteinModelPortaliQ8C6B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB. Eukaryota.
ENOG41126PZ. LUCA.
GeneTreeiENSGT00390000016774.
HOGENOMiHOG000034068.
HOVERGENiHBG097440.
InParanoidiQ8C6B9.
OMAiKFQREYF.
OrthoDBiEOG091G0YGT.
PhylomeDBiQ8C6B9.
TreeFamiTF333429.

Family and domain databases

InterProiIPR023262. AROS.
[Graphical view]
PfamiPF15684. AROS. 1 hit.
[Graphical view]
PRINTSiPR02029. ACTREGSIRT1.

Sequencei

Sequence statusi: Complete.

Q8C6B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALVRRGL ELLAASEAPR AVPGQVQASG TPAKRTRRAR AKASQALKLR
60 70 80 90 100
NSAKGKAPKS ALAEYQKRQC RDHLKANLKF MTSMRSTVPE SVTQQILQQN
110 120 130 140
QGRKACDRLV AKTKNKKKKK KKAEGTVFTE EDFQKFQREY FGS
Length:143
Mass (Da):15,978
Last modified:March 1, 2003 - v1
Checksum:i6EBBF45EE0668116
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti116Missing .1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB233218 mRNA. Translation: BAE53365.1.
AB233219 Genomic DNA. Translation: BAE53366.1.
AK075974 mRNA. Translation: BAC36088.1.
BC038691 mRNA. Translation: AAH38691.1.
BC050115 mRNA. Translation: AAH50115.1.
CCDSiCCDS27662.1.
RefSeqiNP_780318.1. NM_175109.3.
UniGeneiMm.39485.

Genome annotation databases

EnsembliENSMUST00000052499; ENSMUSP00000061167; ENSMUSG00000051518.
GeneIDi66538.
KEGGimmu:66538.
UCSCiuc007wvm.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB233218 mRNA. Translation: BAE53365.1.
AB233219 Genomic DNA. Translation: BAE53366.1.
AK075974 mRNA. Translation: BAC36088.1.
BC038691 mRNA. Translation: AAH38691.1.
BC050115 mRNA. Translation: AAH50115.1.
CCDSiCCDS27662.1.
RefSeqiNP_780318.1. NM_175109.3.
UniGeneiMm.39485.

3D structure databases

ProteinModelPortaliQ8C6B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211544. 2 interactors.
IntActiQ8C6B9. 1 interactor.
STRINGi10090.ENSMUSP00000061167.

PTM databases

iPTMnetiQ8C6B9.
PhosphoSitePlusiQ8C6B9.

Proteomic databases

EPDiQ8C6B9.
MaxQBiQ8C6B9.
PaxDbiQ8C6B9.
PeptideAtlasiQ8C6B9.
PRIDEiQ8C6B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052499; ENSMUSP00000061167; ENSMUSG00000051518.
GeneIDi66538.
KEGGimmu:66538.
UCSCiuc007wvm.1. mouse.

Organism-specific databases

CTDi91582.
MGIiMGI:1913788. Rps19bp1.

Phylogenomic databases

eggNOGiENOG410J1DB. Eukaryota.
ENOG41126PZ. LUCA.
GeneTreeiENSGT00390000016774.
HOGENOMiHOG000034068.
HOVERGENiHBG097440.
InParanoidiQ8C6B9.
OMAiKFQREYF.
OrthoDBiEOG091G0YGT.
PhylomeDBiQ8C6B9.
TreeFamiTF333429.

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiQ8C6B9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051518.
CleanExiMM_RPS19BP1.
GenevisibleiQ8C6B9. MM.

Family and domain databases

InterProiIPR023262. AROS.
[Graphical view]
PfamiPF15684. AROS. 1 hit.
[Graphical view]
PRINTSiPR02029. ACTREGSIRT1.
ProtoNetiSearch...

Entry informationi

Entry nameiAROS_MOUSE
AccessioniPrimary (citable) accession number: Q8C6B9
Secondary accession number(s): Q2WFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.