UniProtKB - Q8C5P3 (Q8C5P3_MOUSE)
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Protein
Nitric oxide synthase
Gene
Nos3
Organism
Mus musculus (Mouse)
Status
Functioni
Produces nitric oxide (NO).UniRule annotation
Catalytic activityi
2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.UniRule annotation
Cofactori
Protein has several cofactor binding sites:- FADUniRule annotationNote: Binds 1 FAD.UniRule annotation
- FMNUniRule annotationNote: Binds 1 FMN.UniRule annotation
- hemeUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 183 | Iron (heme axial ligand)UniRule annotation | 1 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- flavin adenine dinucleotide binding Source: InterPro
- FMN binding Source: InterPro
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- NADP binding Source: InterPro
- nitric-oxide synthase activity Source: UniProtKB-EC
GO - Biological processi
- nitric oxide biosynthetic process Source: InterPro
Keywordsi
Molecular function | Calmodulin-bindingUniRule annotation, OxidoreductaseUniRule annotation |
Ligand | FADUniRule annotation, Flavoprotein, FMNUniRule annotation, HemeUniRule annotationSAAS annotation, Iron, Metal-binding, NADPUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Nos3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97362 Nos3 |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q8C5P3 1 interactor. |
MINTi | Q8C5P3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 519 – 702 | Flavodoxin-likeInterPro annotationAdd BLAST | 184 | |
Domaini | 755 – 1001 | FAD-binding FR-typeInterPro annotationAdd BLAST | 247 |
Sequence similaritiesi
Belongs to the NOS family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1158 Eukaryota COG0369 LUCA COG4362 LUCA |
HOVERGENi | HBG000159 |
KOi | K13242 |
Family and domain databases
Gene3Di | 1.20.990.101 hit 3.40.50.3601 hit |
InterProi | View protein in InterPro IPR003097 FAD-binding_1 IPR017927 Fd_Rdtase_FAD-bd IPR001094 Flavdoxin-like IPR008254 Flavodoxin/NO_synth IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039 Flavoprotein-like_sf IPR023173 NADPH_Cyt_P450_Rdtase_alpha IPR012144 NOS_euk IPR004030 NOS_N IPR036119 NOS_N_sf IPR001433 OxRdtase_FAD/NAD-bd IPR017938 Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667 FAD_binding_1, 1 hit PF00258 Flavodoxin_1, 1 hit PF00175 NAD_binding_1, 1 hit PF02898 NO_synthase, 1 hit |
PIRSFi | PIRSF000333 NOS, 1 hit |
PRINTSi | PR00369 FLAVODOXIN PR00371 FPNCR |
SUPFAMi | SSF52218 SSF52218, 1 hit SSF56512 SSF56512, 1 hit SSF63380 SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384 FAD_FR, 1 hit PS50902 FLAVODOXIN_LIKE, 1 hit PS60001 NOS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8C5P3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APAPPSPTRP
60 70 80 90 100
APDHSPPLTR PPDGPRFPRV KNWEVGSITY DTLSAQAQQD GPCTSRRCLG
110 120 130 140 150
SLVFPRKLQS RPTQGPSPTE QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ
160 170 180 190 200
EVEAEVAATG TYQLRESELV FGAKQAWRNA PRCVGRIQWG KLQVFDARDC
210 220 230 240 250
RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRCPGRGDF RIWNSQLIRY
260 270 280 290 300
AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE
310 320 330 340 350
LFTLPPEMVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA
360 370 380 390 400
PFSGWYMSSE IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE
410 420 430 440 450
INVAVLHSYQ LAKVTIVDHH AATASFMKHL ENEQKARGGC PADWAWIVPP
460 470 480 490 500
ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK GSAAKGAGIT RKKTFKEVAN
510 520 530 540 550
AVKVSASLMG TVMAKRVKAT ILYGSEAGRA QSYAQQLGRL FRKAFDPRVL
560 570 580 590 600
CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP
610 620 630 640 650
RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG
660 670 680 690 700
LGSRAYPHFC AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA
710 720 730 740 750
AFQAACETFC VGEDAKAAAR DIFSPKRSWK RQRYRLSTQA ESLQLLPGLT
760 770 780 790 800
HVHRRKMFQA TILSVENLQS SKSTRATILV RLDTGGQEGL QYQPGDHIGV
810 820 830 840 850
CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP PGWVRDPRLP
860 870 880 890 900
PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE
910 920 930 940 950
EWKWFSCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG
960 970 980 990 1000
EIHLTIAVLA YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL
1010 1020 1030 1040 1050
PPDPNLPCIL VGPGTGIAPF RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS
1060 1070 1080 1090 1100
QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP GSPKTYVQDL LRTELAAEVH
1110 1120 1130 1140 1150
RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGGMELDE AGDVIGVLRD
1160 1170 1180 1190 1200
QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPGPEIP
GS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK077896 mRNA Translation: BAC37052.1 |
RefSeqi | NP_032739.3, NM_008713.4 |
UniGenei | Mm.258415 |
Genome annotation databases
GeneIDi | 18127 |
KEGGi | mmu:18127 |
Similar proteinsi
Entry informationi
Entry namei | Q8C5P3_MOUSE | |
Accessioni | Q8C5P3Primary (citable) accession number: Q8C5P3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |