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Q8C5N5 (PDD2L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Programmed cell death protein 2-like
Gene names
Name:Pdcd2l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase By similarity.

Ontologies

Keywords
   Biological processCell cycle
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Programmed cell death protein 2-like
PRO_0000272646

Regions

Compositional bias138 – 1414Poly-Pro

Experimental info

Sequence conflict921S → T in BAB22726. Ref.1
Sequence conflict1181L → V in BAB22726. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8C5N5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5CC9853B7B588EFF

FASTA36439,955
        10         20         30         40         50         60 
MAAVRKPVLL GLRDTAVKGC PKGPSAWTSS KLGGVPDALP AVTTPGPQCG RCAQPLTLVV 

        70         80         90        100        110        120 
QVYCPLDGSP FHRLLYVFAC ARPGCGNSQT RSWKVFRSQC LQVPEKETWN AQNQSDSLAA 

       130        140        150        160        170        180 
ENWCEGSQDW GSDTEETPPP PASDLGSDSN DVRALDWTEK LQALRLQDTA LAVTCPSPSG 

       190        200        210        220        230        240 
EGLTVPTAVP QFQPYYICVA EEEDYGSVVD LDHAHSLLQE YQRREGVDME QLLSLGSSDG 

       250        260        270        280        290        300 
DEKYEKTTVS SGDPTFYRFM KRIAACQEQI LRYSWSGEPL FLSCPTFEVS EVPACSGCGG 

       310        320        330        340        350        360 
QRTFEFQLMP ALVSMLSSAN LGLAVEFGTI LVYTCKQSCW PPNQQMPMEE FCVLQEDPDE 


FLFK

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow, Embryo and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK003339 mRNA. Translation: BAB22726.1.
AK077948 mRNA. Translation: BAC37080.1.
AK151495 mRNA. Translation: BAE30447.1.
AK154811 mRNA. Translation: BAE32845.1.
BC025090 mRNA. Translation: AAH25090.1.
BC115797 mRNA. Translation: AAI15798.1.
IPIIPI00225938.
RefSeqNP_080825.1. NM_026549.3.
UniGeneMm.38173.

3D structure databases

ProteinModelPortalQ8C5N5.
ModBaseSearch...

PTM databases

PhosphoSiteQ8C5N5.

Proteomic databases

PaxDbQ8C5N5.
PRIDEQ8C5N5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002710; ENSMUSP00000002710; ENSMUSG00000002635.
GeneID68079.
KEGGmmu:68079.
UCSCuc009giw.1. mouse.

Organism-specific databases

CTD84306.
MGIMGI:1915329. Pdcd2l.

Phylogenomic databases

eggNOGNOG238796.
GeneTreeENSGT00530000063570.
HOGENOMHOG000232160.
HOVERGENHBG060880.
InParanoidQ8C5N5.
KOK14801.
OMADKMFYKF.
OrthoDBEOG45TCPG.

Gene expression databases

ArrayExpressQ8C5N5.
BgeeQ8C5N5.
CleanExMM_PDCD2L.
GenevestigatorQ8C5N5.

Family and domain databases

InterProIPR007320. PDCD2_C.
[Graphical view]
PfamPF04194. PDCD2_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326372.
SOURCESearch...

Entry information

Entry namePDD2L_MOUSE
AccessionPrimary (citable) accession number: Q8C5N5
Secondary accession number(s): Q8R185, Q9D1M3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents