Reviewed, UniProtKB/Swiss-Prot Q8C5L6 (INP5K_MOUSE)

Names and origin

Protein names

Recommended name:
    Inositol polyphosphate 5-phosphatase K
    EC=3.1.3.56
Alternative name(s):
    Skeletal muscle and kidney-enriched inositol phosphatase

Gene names

Name:	Inpp5k
Synonyms:	Pps, Skip

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton By similarity. UniProtKB Q9BT40
Catalytic activity	D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate. UniProtKB Q9BT40
Subcellular location	Endoplasmic reticulum. Note: Following stimulation with EGF, translocates to membrane ruffles By similarity.
Sequence similarities	Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	glucose homeostasis Inferred from mutant phenotype. Source: MGI in utero embryonic development Inferred from mutant phenotype. Source: MGI negative regulation of peptidyl-serine phosphorylation Inferred from mutant phenotype. Source: MGI response to insulin stimulus Inferred from mutant phenotype. Source: MGI
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell neuron projection Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	inositol bisphosphate phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB inositol-polyphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Inositol polyphosphate 5-phosphatase K		PRO_0000209728
Regions
	Region	34 – 337	304	Catalytic Potential
	Region	340 – 468	129	Required for ruffle localization UniProtKB Q9BT40
Experimental info
	Sequence conflict	329	1	D → E in BAC37126. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8C5L6-1 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: F2E1CA370B97A8A1	FASTA	468	54,159
	10 20 30 40 50 60 MQHGDRNTPG YREGIMSAVS LRRPSAPKGF ALSVHVVTWN VASAAPTVDL SDLLQLNNQD 70 80 90 100 110 120 LNLDIYIIGL QEMNFGIISL LSDAAFEDPW SSLFMDMLSP LNFVKISQVR MQGLLLLVFA 130 140 150 160 170 180 KYQHLPYIQI ISTKSTPTGL YGYWGNKGGV NVCLKLYGYY VSIINCHLPP HMYNNDQRLE 190 200 210 220 230 240 HFDRILESLT FEGYDVPNIL DHDLILWFGD MNFRIEDFGL LFVQESITRK YYKELWEKDQ 250 260 270 280 290 300 LFIAKKNDQL LREFQEGPLL FPPTYKFDRH SNNYDTSEKK RKPAWTDRIL WRLKRQPSQA 310 320 330 340 350 360 SPLASSVPTS YFLLTLKNYV SHMAYSISDH KPVTGTFDLE LNPLMSVPLI TMMPEHLWTM 370 380 390 400 410 420 ENDMLISYTS TPEFLSSSWD WIGLYKVGMR HINDYVAYVW VGDNQVSYGN NPNQVYINIS 430 440 450 460 AIPDTEDQFL LCYYSNNLHS VVGISQPFKI PIRSFLREDT LYEPEPQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression." Hamilton B.A., Smith D.J., Mueller K.L., Kerrebrock A.W., Bronson R.T., van Berkel V., Daly M.J., Kruglyak L., Reeve M.P., Nemhauser J.L., Hawkins T.L., Rubin E.M., Lander E.S. Neuron 18:711-722(1997) [PubMed: 9182797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ILS and ISS.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Medulla oblongata and Ovary.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96724 mRNA. Translation: AAC53265.1. U96726 Genomic DNA. Translation: AAC60757.1. AF483522 mRNA. Translation: AAL90796.1. AF483523 mRNA. Translation: AAL90797.1. AK054436 mRNA. Translation: BAC35778.1. AK078104 mRNA. Translation: BAC37126.1. BC066112 mRNA. Translation: AAH66112.1.
IPI	IPI00113796.
RefSeq	NP_032942.1.
UniGene	Mm.1458
3D structure databases
HSSP	HSSP built from PDB template 1I9Z based on UniProtKB O43001.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8C5L6.
Proteomic databases
PRIDE	Q8C5L6.
Genome annotation databases
Ensembl	ENSMUST00000006286; ENSMUSP00000006286; ENSMUSG00000006127; Mus musculus. [Genome view]
GeneID	19062.
KEGG	mmu:19062.
UCSC	uc007kek.1. mouse.
Organism-specific databases
CTD	19062.
MGI	MGI:1194899. Inpp5k.
Phylogenomic databases
HOGENOM	Q8C5L6.
HOVERGEN	Q8C5L6.
OMA	DRILEMQ.
Enzyme and pathway databases
BRENDA	3.1.3.56. 244.
Gene expression databases
ArrayExpress	Q8C5L6.
Bgee	Q8C5L6.
Genevestigator	Q8C5L6.
GermOnline	ENSMUSG00000006127. Mus musculus.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295566.
SOURCE	Search...

Entry information

Entry name

INP5K_MOUSE

Accession

Primary (citable) accession number: Q8C5L6
Secondary accession number(s): O09040

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	March 15, 2004
Last modified:	November 3, 2009
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)