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Q8C5L6

- INP5K_MOUSE

UniProt

Q8C5L6 - INP5K_MOUSE

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Protein

Inositol polyphosphate 5-phosphatase K

Gene

Inpp5k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton (By similarity).By similarity

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.By similarity

GO - Molecular functioni

  1. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
  2. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
  3. inositol bisphosphate phosphatase activity Source: UniProtKB
  4. inositol-polyphosphate 5-phosphatase activity Source: UniProtKB-EC
  5. inositol trisphosphate phosphatase activity Source: UniProtKB
  6. phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
  7. phosphatidylinositol phosphate 5-phosphatase activity Source: UniProtKB
  8. phosphatidylinositol trisphosphate phosphatase activity Source: UniProtKB
  9. vasopressin receptor activity Source: UniProtKB

GO - Biological processi

  1. cellular response to cAMP Source: UniProtKB
  2. cellular response to epidermal growth factor stimulus Source: UniProtKB
  3. cellular response to hormone stimulus Source: UniProtKB
  4. cellular response to insulin stimulus Source: UniProtKB
  5. cellular response to tumor necrosis factor Source: UniProtKB
  6. dephosphorylation Source: UniProtKB
  7. glucose homeostasis Source: UniProtKB
  8. G-protein coupled receptor signaling pathway Source: UniProtKB
  9. inositol phosphate dephosphorylation Source: MGI
  10. in utero embryonic development Source: MGI
  11. negative regulation by host of viral transcription Source: UniProtKB
  12. negative regulation of calcium ion transport Source: UniProtKB
  13. negative regulation of dephosphorylation Source: UniProtKB
  14. negative regulation of glucose transport Source: UniProtKB
  15. negative regulation of glycogen (starch) synthase activity Source: UniProtKB
  16. negative regulation of glycogen biosynthetic process Source: UniProtKB
  17. negative regulation of insulin receptor signaling pathway Source: UniProtKB
  18. negative regulation of MAP kinase activity Source: UniProtKB
  19. negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
  20. negative regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  21. negative regulation of protein kinase activity Source: UniProtKB
  22. negative regulation of protein kinase B signaling Source: UniProtKB
  23. negative regulation of protein phosphorylation Source: UniProtKB
  24. negative regulation of protein targeting to membrane Source: UniProtKB
  25. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
  26. negative regulation of stress fiber assembly Source: UniProtKB
  27. negative regulation of transcription, DNA-templated Source: UniProtKB
  28. phosphatidylinositol dephosphorylation Source: UniProtKB
  29. positive regulation of renal water transport Source: UniProtKB
  30. positive regulation of transcription, DNA-templated Source: UniProtKB
  31. positive regulation of urine volume Source: UniProtKB
  32. protein targeting to plasma membrane Source: UniProtKB
  33. regulation of glycogen biosynthetic process Source: UniProtKB
  34. response to insulin Source: MGI
  35. ruffle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 5-phosphatase K (EC:3.1.3.56)
Alternative name(s):
Skeletal muscle and kidney-enriched inositol phosphatase
Gene namesi
Name:Inpp5k
Synonyms:Pps, Skip
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1194899. Inpp5k.

Subcellular locationi

Endoplasmic reticulum
Note: Following stimulation with EGF, translocates to membrane ruffles.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. membrane Source: UniProtKB
  5. neuron projection Source: UniProtKB
  6. nucleus Source: UniProtKB
  7. perinuclear region of cytoplasm Source: UniProtKB
  8. plasma membrane Source: UniProtKB
  9. ruffle Source: UniProtKB
  10. ruffle membrane Source: UniProtKB
  11. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Inositol polyphosphate 5-phosphatase KPRO_0000209728Add
BLAST

Proteomic databases

MaxQBiQ8C5L6.
PaxDbiQ8C5L6.
PRIDEiQ8C5L6.

PTM databases

PhosphoSiteiQ8C5L6.

Expressioni

Gene expression databases

BgeeiQ8C5L6.
ExpressionAtlasiQ8C5L6. baseline and differential.
GenevestigatoriQ8C5L6.

Structurei

3D structure databases

ProteinModelPortaliQ8C5L6.
SMRiQ8C5L6. Positions 38-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 337304CatalyticSequence AnalysisAdd
BLAST
Regioni340 – 468129Required for ruffle localizationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5411.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000046051.
HOVERGENiHBG082135.
InParanoidiQ8C5L6.
KOiK01106.
OMAiGLYGYWG.
OrthoDBiEOG79CXZB.
PhylomeDBiQ8C5L6.
TreeFamiTF317034.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C5L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQHGDRNTPG YREGIMSAVS LRRPSAPKGF ALSVHVVTWN VASAAPTVDL
60 70 80 90 100
SDLLQLNNQD LNLDIYIIGL QEMNFGIISL LSDAAFEDPW SSLFMDMLSP
110 120 130 140 150
LNFVKISQVR MQGLLLLVFA KYQHLPYIQI ISTKSTPTGL YGYWGNKGGV
160 170 180 190 200
NVCLKLYGYY VSIINCHLPP HMYNNDQRLE HFDRILESLT FEGYDVPNIL
210 220 230 240 250
DHDLILWFGD MNFRIEDFGL LFVQESITRK YYKELWEKDQ LFIAKKNDQL
260 270 280 290 300
LREFQEGPLL FPPTYKFDRH SNNYDTSEKK RKPAWTDRIL WRLKRQPSQA
310 320 330 340 350
SPLASSVPTS YFLLTLKNYV SHMAYSISDH KPVTGTFDLE LNPLMSVPLI
360 370 380 390 400
TMMPEHLWTM ENDMLISYTS TPEFLSSSWD WIGLYKVGMR HINDYVAYVW
410 420 430 440 450
VGDNQVSYGN NPNQVYINIS AIPDTEDQFL LCYYSNNLHS VVGISQPFKI
460
PIRSFLREDT LYEPEPQI
Length:468
Mass (Da):54,159
Last modified:March 15, 2004 - v2
Checksum:iF2E1CA370B97A8A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291D → E in BAC37126. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96724 mRNA. Translation: AAC53265.1.
U96726 Genomic DNA. Translation: AAC60757.1.
AF483522 mRNA. Translation: AAL90796.1.
AF483523 mRNA. Translation: AAL90797.1.
AK054436 mRNA. Translation: BAC35778.1.
AK078104 mRNA. Translation: BAC37126.1.
BC066112 mRNA. Translation: AAH66112.1.
CCDSiCCDS25053.1.
RefSeqiNP_032942.1. NM_008916.2.
UniGeneiMm.1458.

Genome annotation databases

EnsembliENSMUST00000006286; ENSMUSP00000006286; ENSMUSG00000006127.
GeneIDi19062.
KEGGimmu:19062.
UCSCiuc007kek.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96724 mRNA. Translation: AAC53265.1 .
U96726 Genomic DNA. Translation: AAC60757.1 .
AF483522 mRNA. Translation: AAL90796.1 .
AF483523 mRNA. Translation: AAL90797.1 .
AK054436 mRNA. Translation: BAC35778.1 .
AK078104 mRNA. Translation: BAC37126.1 .
BC066112 mRNA. Translation: AAH66112.1 .
CCDSi CCDS25053.1.
RefSeqi NP_032942.1. NM_008916.2.
UniGenei Mm.1458.

3D structure databases

ProteinModelPortali Q8C5L6.
SMRi Q8C5L6. Positions 38-339.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C5L6.

Proteomic databases

MaxQBi Q8C5L6.
PaxDbi Q8C5L6.
PRIDEi Q8C5L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006286 ; ENSMUSP00000006286 ; ENSMUSG00000006127 .
GeneIDi 19062.
KEGGi mmu:19062.
UCSCi uc007kek.1. mouse.

Organism-specific databases

CTDi 51763.
MGIi MGI:1194899. Inpp5k.

Phylogenomic databases

eggNOGi COG5411.
GeneTreei ENSGT00760000119075.
HOGENOMi HOG000046051.
HOVERGENi HBG082135.
InParanoidi Q8C5L6.
KOi K01106.
OMAi GLYGYWG.
OrthoDBi EOG79CXZB.
PhylomeDBi Q8C5L6.
TreeFami TF317034.

Enzyme and pathway databases

Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi 295566.
PROi Q8C5L6.
SOURCEi Search...

Gene expression databases

Bgeei Q8C5L6.
ExpressionAtlasi Q8C5L6. baseline and differential.
Genevestigatori Q8C5L6.

Family and domain databases

Gene3Di 3.60.10.10. 1 hit.
InterProi IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view ]
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
SMARTi SM00128. IPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression."
    Hamilton B.A., Smith D.J., Mueller K.L., Kerrebrock A.W., Bronson R.T., van Berkel V., Daly M.J., Kruglyak L., Reeve M.P., Nemhauser J.L., Hawkins T.L., Rubin E.M., Lander E.S.
    Neuron 18:711-722(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ILSImported and ISSImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Ovary.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiINP5K_MOUSE
AccessioniPrimary (citable) accession number: Q8C5L6
Secondary accession number(s): O09040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 15, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3