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Q8C5L6

- INP5K_MOUSE

UniProt

Q8C5L6 - INP5K_MOUSE

Protein

Inositol polyphosphate 5-phosphatase K

Gene

Inpp5k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton By similarity.By similarity

    Catalytic activityi

    D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.By similarity

    GO - Molecular functioni

    1. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
    2. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
    3. inositol bisphosphate phosphatase activity Source: UniProtKB
    4. inositol-polyphosphate 5-phosphatase activity Source: UniProtKB-EC
    5. inositol trisphosphate phosphatase activity Source: UniProtKB
    6. phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
    7. phosphatidylinositol phosphate 5-phosphatase activity Source: UniProtKB
    8. phosphatidylinositol trisphosphate phosphatase activity Source: UniProtKB
    9. vasopressin receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to cAMP Source: UniProtKB
    2. cellular response to epidermal growth factor stimulus Source: UniProtKB
    3. cellular response to hormone stimulus Source: UniProtKB
    4. cellular response to insulin stimulus Source: UniProtKB
    5. cellular response to tumor necrosis factor Source: UniProtKB
    6. dephosphorylation Source: UniProtKB
    7. glucose homeostasis Source: UniProtKB
    8. G-protein coupled receptor signaling pathway Source: UniProtKB
    9. inositol phosphate dephosphorylation Source: MGI
    10. in utero embryonic development Source: MGI
    11. negative regulation by host of viral transcription Source: UniProtKB
    12. negative regulation of calcium ion transport Source: UniProtKB
    13. negative regulation of dephosphorylation Source: UniProtKB
    14. negative regulation of glucose transport Source: UniProtKB
    15. negative regulation of glycogen (starch) synthase activity Source: UniProtKB
    16. negative regulation of glycogen biosynthetic process Source: UniProtKB
    17. negative regulation of insulin receptor signaling pathway Source: UniProtKB
    18. negative regulation of MAP kinase activity Source: UniProtKB
    19. negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
    20. negative regulation of peptidyl-threonine phosphorylation Source: UniProtKB
    21. negative regulation of protein kinase activity Source: UniProtKB
    22. negative regulation of protein kinase B signaling Source: UniProtKB
    23. negative regulation of protein phosphorylation Source: UniProtKB
    24. negative regulation of protein targeting to membrane Source: UniProtKB
    25. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
    26. negative regulation of stress fiber assembly Source: UniProtKB
    27. negative regulation of transcription, DNA-templated Source: UniProtKB
    28. phosphatidylinositol dephosphorylation Source: UniProtKB
    29. positive regulation of renal water transport Source: UniProtKB
    30. positive regulation of transcription, DNA-templated Source: UniProtKB
    31. positive regulation of urine volume Source: UniProtKB
    32. protein targeting to plasma membrane Source: UniProtKB
    33. regulation of glycogen biosynthetic process Source: UniProtKB
    34. response to insulin Source: MGI
    35. ruffle assembly Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol polyphosphate 5-phosphatase K (EC:3.1.3.56)
    Alternative name(s):
    Skeletal muscle and kidney-enriched inositol phosphatase
    Gene namesi
    Name:Inpp5k
    Synonyms:Pps, Skip
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1194899. Inpp5k.

    Subcellular locationi

    Endoplasmic reticulum
    Note: Following stimulation with EGF, translocates to membrane ruffles.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. membrane Source: UniProtKB
    5. neuron projection Source: UniProtKB
    6. nucleus Source: UniProtKB
    7. perinuclear region of cytoplasm Source: UniProtKB
    8. plasma membrane Source: UniProtKB
    9. ruffle Source: UniProtKB
    10. ruffle membrane Source: UniProtKB
    11. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Inositol polyphosphate 5-phosphatase KPRO_0000209728Add
    BLAST

    Proteomic databases

    MaxQBiQ8C5L6.
    PaxDbiQ8C5L6.
    PRIDEiQ8C5L6.

    PTM databases

    PhosphoSiteiQ8C5L6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8C5L6.
    BgeeiQ8C5L6.
    GenevestigatoriQ8C5L6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C5L6.
    SMRiQ8C5L6. Positions 38-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 337304CatalyticSequence AnalysisAdd
    BLAST
    Regioni340 – 468129Required for ruffle localizationAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5411.
    GeneTreeiENSGT00750000117675.
    HOGENOMiHOG000046051.
    HOVERGENiHBG082135.
    InParanoidiQ8C5L6.
    KOiK01106.
    OMAiGLYGYWG.
    OrthoDBiEOG79CXZB.
    PhylomeDBiQ8C5L6.
    TreeFamiTF317034.

    Family and domain databases

    Gene3Di3.60.10.10. 1 hit.
    InterProiIPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view]
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    SMARTiSM00128. IPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8C5L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHGDRNTPG YREGIMSAVS LRRPSAPKGF ALSVHVVTWN VASAAPTVDL    50
    SDLLQLNNQD LNLDIYIIGL QEMNFGIISL LSDAAFEDPW SSLFMDMLSP 100
    LNFVKISQVR MQGLLLLVFA KYQHLPYIQI ISTKSTPTGL YGYWGNKGGV 150
    NVCLKLYGYY VSIINCHLPP HMYNNDQRLE HFDRILESLT FEGYDVPNIL 200
    DHDLILWFGD MNFRIEDFGL LFVQESITRK YYKELWEKDQ LFIAKKNDQL 250
    LREFQEGPLL FPPTYKFDRH SNNYDTSEKK RKPAWTDRIL WRLKRQPSQA 300
    SPLASSVPTS YFLLTLKNYV SHMAYSISDH KPVTGTFDLE LNPLMSVPLI 350
    TMMPEHLWTM ENDMLISYTS TPEFLSSSWD WIGLYKVGMR HINDYVAYVW 400
    VGDNQVSYGN NPNQVYINIS AIPDTEDQFL LCYYSNNLHS VVGISQPFKI 450
    PIRSFLREDT LYEPEPQI 468
    Length:468
    Mass (Da):54,159
    Last modified:March 15, 2004 - v2
    Checksum:iF2E1CA370B97A8A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti329 – 3291D → E in BAC37126. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96724 mRNA. Translation: AAC53265.1.
    U96726 Genomic DNA. Translation: AAC60757.1.
    AF483522 mRNA. Translation: AAL90796.1.
    AF483523 mRNA. Translation: AAL90797.1.
    AK054436 mRNA. Translation: BAC35778.1.
    AK078104 mRNA. Translation: BAC37126.1.
    BC066112 mRNA. Translation: AAH66112.1.
    CCDSiCCDS25053.1.
    RefSeqiNP_032942.1. NM_008916.2.
    UniGeneiMm.1458.

    Genome annotation databases

    EnsembliENSMUST00000006286; ENSMUSP00000006286; ENSMUSG00000006127.
    GeneIDi19062.
    KEGGimmu:19062.
    UCSCiuc007kek.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96724 mRNA. Translation: AAC53265.1 .
    U96726 Genomic DNA. Translation: AAC60757.1 .
    AF483522 mRNA. Translation: AAL90796.1 .
    AF483523 mRNA. Translation: AAL90797.1 .
    AK054436 mRNA. Translation: BAC35778.1 .
    AK078104 mRNA. Translation: BAC37126.1 .
    BC066112 mRNA. Translation: AAH66112.1 .
    CCDSi CCDS25053.1.
    RefSeqi NP_032942.1. NM_008916.2.
    UniGenei Mm.1458.

    3D structure databases

    ProteinModelPortali Q8C5L6.
    SMRi Q8C5L6. Positions 38-339.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C5L6.

    Proteomic databases

    MaxQBi Q8C5L6.
    PaxDbi Q8C5L6.
    PRIDEi Q8C5L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006286 ; ENSMUSP00000006286 ; ENSMUSG00000006127 .
    GeneIDi 19062.
    KEGGi mmu:19062.
    UCSCi uc007kek.1. mouse.

    Organism-specific databases

    CTDi 51763.
    MGIi MGI:1194899. Inpp5k.

    Phylogenomic databases

    eggNOGi COG5411.
    GeneTreei ENSGT00750000117675.
    HOGENOMi HOG000046051.
    HOVERGENi HBG082135.
    InParanoidi Q8C5L6.
    KOi K01106.
    OMAi GLYGYWG.
    OrthoDBi EOG79CXZB.
    PhylomeDBi Q8C5L6.
    TreeFami TF317034.

    Enzyme and pathway databases

    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 295566.
    PROi Q8C5L6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C5L6.
    Bgeei Q8C5L6.
    Genevestigatori Q8C5L6.

    Family and domain databases

    Gene3Di 3.60.10.10. 1 hit.
    InterProi IPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view ]
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    SMARTi SM00128. IPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression."
      Hamilton B.A., Smith D.J., Mueller K.L., Kerrebrock A.W., Bronson R.T., van Berkel V., Daly M.J., Kruglyak L., Reeve M.P., Nemhauser J.L., Hawkins T.L., Rubin E.M., Lander E.S.
      Neuron 18:711-722(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ILSImported and ISSImported.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Medulla oblongata and Ovary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiINP5K_MOUSE
    AccessioniPrimary (citable) accession number: Q8C5L6
    Secondary accession number(s): O09040
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3