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Protein
Submitted name:

Lysosomal membrane glycoprotein 2, isoform CRA_a

Gene

Lamp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal membrane glycoprotein 2, isoform CRA_aImported
Gene namesi
Name:Lamp2Imported
ORF Names:mCG_1450Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96748. Lamp2.

Subcellular locationi

  • Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 404HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

LysosomePROSITE-ProRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501084695626 – 416Sequence analysisAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi149 ↔ 185PROSITE-ProRule annotation
Disulfide bondi336 ↔ 373PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000016534.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000230942.
HOVERGENiHBG052303.
OMAiPIIHTTV.
OrthoDBiEOG091G09EV.

Family and domain databases

InterProiView protein in InterPro
IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C5K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLSPVKGAK LILIFLFLGA VQSNALIVNL TDSKGTCLYA EWEMNFTITY
60 70 80 90 100
ETTNQTNKTI TIAVPDKATH DGSSCGDDRN SAKIMIQFGF AVSWAVNFTK
110 120 130 140 150
EASHYSIHDI VLSYNTSDST VFPGAVAKGV HTVKNPENFK VPLDVIFKCN
160 170 180 190 200
SVLTYNLTPV VQKYWGIHLQ AFVQNGTVSK NEQVCEEDQT PTTVAPIIHT
210 220 230 240 250
TAPSTTTTLT PTSTPTPTPT PTPTVGNYSI RNGNTTCLLA TMGLQLNITE
260 270 280 290 300
EKVPFIFNIN PATTNFTGSC QPQSAQLRLN NSQIKYLDFI FAVKNEKRFY
310 320 330 340 350
LKEVNVYMYL ANGSAFNISN KNLSFWDAPL GSSYMCNKEQ VLSVSRAFQI
360 370 380 390 400
NTFNLKVQPF NVTKGQYSTA EECAADSDLN FLIPVAVGVA LGFLIIAVFI
410
SYMIGRRKSR TGYQSV
Length:416
Mass (Da):45,797
Last modified:March 1, 2003 - v1
Checksum:iF6FE0E2F2B5689E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078193 mRNA. Translation: BAC37169.1.
CH466570 Genomic DNA. Translation: EDL29015.1.
RefSeqiNP_001277414.1. NM_001290485.1.
UniGeneiMm.414016.
Mm.486.

Genome annotation databases

GeneIDi16784.
UCSCiuc009szv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ8C5K0_MOUSE
AccessioniPrimary (citable) accession number: Q8C5K0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation