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Protein

mRNA export factor

Gene

Rae1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:Rae1
Synonyms:Mrnp41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913929. Rae1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375861 – 368mRNA export factorAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C570.
MaxQBiQ8C570.
PaxDbiQ8C570.
PeptideAtlasiQ8C570.
PRIDEiQ8C570.

PTM databases

iPTMnetiQ8C570.
PhosphoSitePlusiQ8C570.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027509.
CleanExiMM_RAE1.
ExpressionAtlasiQ8C570. baseline and differential.
GenevisibleiQ8C570. MM.

Interactioni

Subunit structurei

Interacts with NUP98 (PubMed:10209021). Interacts with MYCBP2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211639. 1 interactor.
IntActiQ8C570. 2 interactors.
MINTiMINT-4989876.
STRINGi10090.ENSMUSP00000029013.

Structurei

3D structure databases

ProteinModelPortaliQ8C570.
SMRiQ8C570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1Add BLAST43
Repeati84 – 114WD 2Add BLAST31
Repeati125 – 157WD 3Add BLAST33
Repeati168 – 206WD 4Add BLAST39
Repeati215 – 255WD 5Add BLAST41
Repeati271 – 301WD 6Add BLAST31
Repeati310 – 346WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ8C570.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG091G09GO.
PhylomeDBiQ8C570.
TreeFamiTF105481.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGSTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLNSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPIAA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,965
Last modified:March 1, 2003 - v1
Checksum:i5B1AA677E67F2C85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232A → T in BAE26867 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079383 mRNA. Translation: BAC37627.1.
AK146058 mRNA. Translation: BAE26867.1.
AK156681 mRNA. Translation: BAE33805.1.
BC059051 mRNA. Translation: AAH59051.1.
CCDSiCCDS17138.1.
RefSeqiNP_780321.1. NM_175112.5.
XP_006500086.1. XM_006500023.1.
XP_006500087.1. XM_006500024.3.
UniGeneiMm.4113.

Genome annotation databases

EnsembliENSMUST00000029013; ENSMUSP00000029013; ENSMUSG00000027509.
GeneIDi66679.
KEGGimmu:66679.
UCSCiuc008odg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079383 mRNA. Translation: BAC37627.1.
AK146058 mRNA. Translation: BAE26867.1.
AK156681 mRNA. Translation: BAE33805.1.
BC059051 mRNA. Translation: AAH59051.1.
CCDSiCCDS17138.1.
RefSeqiNP_780321.1. NM_175112.5.
XP_006500086.1. XM_006500023.1.
XP_006500087.1. XM_006500024.3.
UniGeneiMm.4113.

3D structure databases

ProteinModelPortaliQ8C570.
SMRiQ8C570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211639. 1 interactor.
IntActiQ8C570. 2 interactors.
MINTiMINT-4989876.
STRINGi10090.ENSMUSP00000029013.

PTM databases

iPTMnetiQ8C570.
PhosphoSitePlusiQ8C570.

Proteomic databases

EPDiQ8C570.
MaxQBiQ8C570.
PaxDbiQ8C570.
PeptideAtlasiQ8C570.
PRIDEiQ8C570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029013; ENSMUSP00000029013; ENSMUSG00000027509.
GeneIDi66679.
KEGGimmu:66679.
UCSCiuc008odg.2. mouse.

Organism-specific databases

CTDi8480.
MGIiMGI:1913929. Rae1.

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ8C570.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG091G09GO.
PhylomeDBiQ8C570.
TreeFamiTF105481.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ8C570.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027509.
CleanExiMM_RAE1.
ExpressionAtlasiQ8C570. baseline and differential.
GenevisibleiQ8C570. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAE1L_MOUSE
AccessioniPrimary (citable) accession number: Q8C570
Secondary accession number(s): Q3UKD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.