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Q8C569 (F118B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM118B
Gene names
Name:Fam118b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM118 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C569-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C569-2)

The sequence of this isoform differs from the canonical sequence as follows:
     114-189: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 351350Protein FAM118B
PRO_0000295105

Amino acid modifications

Modified residue21N-acetylalanine Ref.3
Modified residue91Phosphoserine By similarity
Modified residue111N6-acetyllysine Ref.3

Natural variations

Alternative sequence114 – 18976Missing in isoform 2.
VSP_026730

Experimental info

Sequence conflict1941A → D in BAE40129. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8082AF895A40FE32

FASTA35139,508
        10         20         30         40         50         60 
MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG ISAAVAPQVP 

        70         80         90        100        110        120 
ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL VHVAHDLIQK LSPRTSNVRS 

       130        140        150        160        170        180 
TFFKDCLYEV FDDLESKMED SGKQLLQSVL HLMENGALVL TTNFDNLLEL YAADQGKQLE 

       190        200        210        220        230        240 
SLDLTDEKKV LEWAQEKRKL SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE 

       250        260        270        280        290        300 
NKSFLFLGCG WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV 

       310        320        330        340        350 
ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS T 

« Hide

Isoform 2 [UniParc].

Checksum: C25DC8CED9ED8204
Show »

FASTA27530,822

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: BALB/c, C57BL/6J and NOD.
Tissue: Bone, Corpus striatum, Embryo and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Olfactory epithelium.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028018 mRNA. Translation: BAC25701.1.
AK079397 mRNA. Translation: BAC37632.1.
AK081206 mRNA. Translation: BAC38164.1.
AK168168 mRNA. Translation: BAE40129.1.
AK169810 mRNA. Translation: BAE41383.1.
BC051180 mRNA. Translation: AAH51180.1.
CCDSCCDS22960.1. [Q8C569-2]
CCDS22961.1. [Q8C569-1]
RefSeqNP_001273533.1. NM_001286604.1. [Q8C569-1]
NP_780620.1. NM_175411.5. [Q8C569-2]
NP_919233.1. NM_194257.2. [Q8C569-1]
XP_006509999.1. XM_006509936.1. [Q8C569-1]
XP_006510000.1. XM_006509937.1. [Q8C569-1]
UniGeneMm.24197.

3D structure databases

ProteinModelPortalQ8C569.
SMRQ8C569. Positions 39-67, 145-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-5191464.

PTM databases

PhosphoSiteQ8C569.

Proteomic databases

PaxDbQ8C569.
PRIDEQ8C569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
GeneID109229.
KEGGmmu:109229.
UCSCuc009ota.1. mouse. [Q8C569-1]
uc009otb.1. mouse. [Q8C569-2]

Organism-specific databases

CTD79607.
MGIMGI:1924483. Fam118b.

Phylogenomic databases

eggNOGNOG46711.
GeneTreeENSGT00390000010215.
HOGENOMHOG000072713.
HOVERGENHBG055230.
InParanoidQ8C569.
OMALYETKSF.
OrthoDBEOG7RJPRH.
PhylomeDBQ8C569.
TreeFamTF332439.

Gene expression databases

ArrayExpressQ8C569.
BgeeQ8C569.
GenevestigatorQ8C569.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSFAM118B. mouse.
NextBio361801.
PROQ8C569.
SOURCESearch...

Entry information

Entry nameF118B_MOUSE
AccessionPrimary (citable) accession number: Q8C569
Secondary accession number(s): Q3THR7, Q8BNN4, Q8BT26
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot