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Q8C569

- F118B_MOUSE

UniProt

Q8C569 - F118B_MOUSE

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Protein

Protein FAM118B

Gene

Fam118b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in Cajal bodies formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM118B
Gene namesi
Name:Fam118b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924483. Fam118b.

Subcellular locationi

NucleusCajal body By similarity

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 351350Protein FAM118BPRO_0000295105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei11 – 111N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8C569.
PaxDbiQ8C569.
PRIDEiQ8C569.

PTM databases

PhosphoSiteiQ8C569.

Expressioni

Gene expression databases

BgeeiQ8C569.
ExpressionAtlasiQ8C569. baseline and differential.
GenevestigatoriQ8C569.

Interactioni

Protein-protein interaction databases

MINTiMINT-5191464.

Structurei

3D structure databases

ProteinModelPortaliQ8C569.
SMRiQ8C569. Positions 39-67, 145-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM118 family.Curated

Phylogenomic databases

eggNOGiNOG46711.
GeneTreeiENSGT00390000010215.
HOGENOMiHOG000072713.
HOVERGENiHBG055230.
InParanoidiQ8C569.
OMAiLYETKSF.
OrthoDBiEOG7RJPRH.
PhylomeDBiQ8C569.
TreeFamiTF332439.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C569-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG
60 70 80 90 100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL
110 120 130 140 150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL
160 170 180 190 200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL
210 220 230 240 250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG
260 270 280 290 300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
310 320 330 340 350
ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS

T
Length:351
Mass (Da):39,508
Last modified:March 1, 2003 - v1
Checksum:i8082AF895A40FE32
GO
Isoform 2 (identifier: Q8C569-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-189: Missing.

Show »
Length:275
Mass (Da):30,822
Checksum:iC25DC8CED9ED8204
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941A → D in BAE40129. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 18976Missing in isoform 2. 1 PublicationVSP_026730Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA. Translation: BAC25701.1.
AK079397 mRNA. Translation: BAC37632.1.
AK081206 mRNA. Translation: BAC38164.1.
AK168168 mRNA. Translation: BAE40129.1.
AK169810 mRNA. Translation: BAE41383.1.
BC051180 mRNA. Translation: AAH51180.1.
CCDSiCCDS22960.1. [Q8C569-2]
CCDS22961.1. [Q8C569-1]
RefSeqiNP_001273533.1. NM_001286604.1. [Q8C569-1]
NP_780620.1. NM_175411.5. [Q8C569-2]
NP_919233.1. NM_194257.2. [Q8C569-1]
XP_006509999.1. XM_006509936.1. [Q8C569-1]
XP_006510000.1. XM_006509937.1. [Q8C569-1]
UniGeneiMm.24197.

Genome annotation databases

EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
GeneIDi109229.
KEGGimmu:109229.
UCSCiuc009ota.1. mouse. [Q8C569-1]
uc009otb.1. mouse. [Q8C569-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA. Translation: BAC25701.1 .
AK079397 mRNA. Translation: BAC37632.1 .
AK081206 mRNA. Translation: BAC38164.1 .
AK168168 mRNA. Translation: BAE40129.1 .
AK169810 mRNA. Translation: BAE41383.1 .
BC051180 mRNA. Translation: AAH51180.1 .
CCDSi CCDS22960.1. [Q8C569-2 ]
CCDS22961.1. [Q8C569-1 ]
RefSeqi NP_001273533.1. NM_001286604.1. [Q8C569-1 ]
NP_780620.1. NM_175411.5. [Q8C569-2 ]
NP_919233.1. NM_194257.2. [Q8C569-1 ]
XP_006509999.1. XM_006509936.1. [Q8C569-1 ]
XP_006510000.1. XM_006509937.1. [Q8C569-1 ]
UniGenei Mm.24197.

3D structure databases

ProteinModelPortali Q8C569.
SMRi Q8C569. Positions 39-67, 145-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-5191464.

PTM databases

PhosphoSitei Q8C569.

Proteomic databases

MaxQBi Q8C569.
PaxDbi Q8C569.
PRIDEi Q8C569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059057 ; ENSMUSP00000058377 ; ENSMUSG00000050471 . [Q8C569-1 ]
ENSMUST00000063782 ; ENSMUSP00000066281 ; ENSMUSG00000050471 . [Q8C569-2 ]
ENSMUST00000121564 ; ENSMUSP00000113537 ; ENSMUSG00000050471 . [Q8C569-1 ]
GeneIDi 109229.
KEGGi mmu:109229.
UCSCi uc009ota.1. mouse. [Q8C569-1 ]
uc009otb.1. mouse. [Q8C569-2 ]

Organism-specific databases

CTDi 79607.
MGIi MGI:1924483. Fam118b.

Phylogenomic databases

eggNOGi NOG46711.
GeneTreei ENSGT00390000010215.
HOGENOMi HOG000072713.
HOVERGENi HBG055230.
InParanoidi Q8C569.
OMAi LYETKSF.
OrthoDBi EOG7RJPRH.
PhylomeDBi Q8C569.
TreeFami TF332439.

Miscellaneous databases

ChiTaRSi Fam118b. mouse.
NextBioi 361801.
PROi Q8C569.
SOURCEi Search...

Gene expression databases

Bgeei Q8C569.
ExpressionAtlasi Q8C569. baseline and differential.
Genevestigatori Q8C569.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Bone, Corpus striatum, Embryo and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiF118B_MOUSE
AccessioniPrimary (citable) accession number: Q8C569
Secondary accession number(s): Q3THR7, Q8BNN4, Q8BT26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3