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Protein

Protein FAM118B

Gene

Fam118b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in Cajal bodies formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM118B
Gene namesi
Name:Fam118b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924483. Fam118b.

Subcellular locationi

NucleusCajal body By similarity

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 351350Protein FAM118BPRO_0000295105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei11 – 111N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8C569.
PaxDbiQ8C569.
PRIDEiQ8C569.

PTM databases

PhosphoSiteiQ8C569.

Expressioni

Gene expression databases

BgeeiQ8C569.
ExpressionAtlasiQ8C569. baseline and differential.
GenevestigatoriQ8C569.

Interactioni

Protein-protein interaction databases

MINTiMINT-5191464.

Structurei

3D structure databases

ProteinModelPortaliQ8C569.
SMRiQ8C569. Positions 39-67, 145-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM118 family.Curated

Phylogenomic databases

eggNOGiNOG46711.
GeneTreeiENSGT00390000010215.
HOGENOMiHOG000072713.
HOVERGENiHBG055230.
InParanoidiQ8C569.
OMAiLYETKSF.
OrthoDBiEOG7RJPRH.
PhylomeDBiQ8C569.
TreeFamiTF332439.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C569-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG
60 70 80 90 100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL
110 120 130 140 150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL
160 170 180 190 200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL
210 220 230 240 250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG
260 270 280 290 300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
310 320 330 340 350
ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS

T
Length:351
Mass (Da):39,508
Last modified:March 1, 2003 - v1
Checksum:i8082AF895A40FE32
GO
Isoform 2 (identifier: Q8C569-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-189: Missing.

Show »
Length:275
Mass (Da):30,822
Checksum:iC25DC8CED9ED8204
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941A → D in BAE40129. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 18976Missing in isoform 2. 1 PublicationVSP_026730Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA. Translation: BAC25701.1.
AK079397 mRNA. Translation: BAC37632.1.
AK081206 mRNA. Translation: BAC38164.1.
AK168168 mRNA. Translation: BAE40129.1.
AK169810 mRNA. Translation: BAE41383.1.
BC051180 mRNA. Translation: AAH51180.1.
CCDSiCCDS22960.1. [Q8C569-2]
CCDS22961.1. [Q8C569-1]
RefSeqiNP_001273533.1. NM_001286604.1. [Q8C569-1]
NP_780620.1. NM_175411.5. [Q8C569-2]
NP_919233.1. NM_194257.2. [Q8C569-1]
XP_006509999.1. XM_006509936.1. [Q8C569-1]
XP_006510000.1. XM_006509937.1. [Q8C569-1]
UniGeneiMm.24197.

Genome annotation databases

EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
GeneIDi109229.
KEGGimmu:109229.
UCSCiuc009ota.1. mouse. [Q8C569-1]
uc009otb.1. mouse. [Q8C569-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA. Translation: BAC25701.1.
AK079397 mRNA. Translation: BAC37632.1.
AK081206 mRNA. Translation: BAC38164.1.
AK168168 mRNA. Translation: BAE40129.1.
AK169810 mRNA. Translation: BAE41383.1.
BC051180 mRNA. Translation: AAH51180.1.
CCDSiCCDS22960.1. [Q8C569-2]
CCDS22961.1. [Q8C569-1]
RefSeqiNP_001273533.1. NM_001286604.1. [Q8C569-1]
NP_780620.1. NM_175411.5. [Q8C569-2]
NP_919233.1. NM_194257.2. [Q8C569-1]
XP_006509999.1. XM_006509936.1. [Q8C569-1]
XP_006510000.1. XM_006509937.1. [Q8C569-1]
UniGeneiMm.24197.

3D structure databases

ProteinModelPortaliQ8C569.
SMRiQ8C569. Positions 39-67, 145-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5191464.

PTM databases

PhosphoSiteiQ8C569.

Proteomic databases

MaxQBiQ8C569.
PaxDbiQ8C569.
PRIDEiQ8C569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
GeneIDi109229.
KEGGimmu:109229.
UCSCiuc009ota.1. mouse. [Q8C569-1]
uc009otb.1. mouse. [Q8C569-2]

Organism-specific databases

CTDi79607.
MGIiMGI:1924483. Fam118b.

Phylogenomic databases

eggNOGiNOG46711.
GeneTreeiENSGT00390000010215.
HOGENOMiHOG000072713.
HOVERGENiHBG055230.
InParanoidiQ8C569.
OMAiLYETKSF.
OrthoDBiEOG7RJPRH.
PhylomeDBiQ8C569.
TreeFamiTF332439.

Miscellaneous databases

ChiTaRSiFam118b. mouse.
NextBioi361801.
PROiQ8C569.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C569.
ExpressionAtlasiQ8C569. baseline and differential.
GenevestigatoriQ8C569.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Bone, Corpus striatum, Embryo and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiF118B_MOUSE
AccessioniPrimary (citable) accession number: Q8C569
Secondary accession number(s): Q3THR7, Q8BNN4, Q8BT26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.