Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8C569

- F118B_MOUSE

UniProt

Q8C569 - F118B_MOUSE

Protein

Protein FAM118B

Gene

Fam118b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM118B
    Gene namesi
    Name:Fam118b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1924483. Fam118b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 351350Protein FAM118BPRO_0000295105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei11 – 111N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ8C569.
    PRIDEiQ8C569.

    PTM databases

    PhosphoSiteiQ8C569.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8C569.
    BgeeiQ8C569.
    GenevestigatoriQ8C569.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-5191464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C569.
    SMRiQ8C569. Positions 39-67, 145-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM118 family.Curated

    Phylogenomic databases

    eggNOGiNOG46711.
    GeneTreeiENSGT00390000010215.
    HOGENOMiHOG000072713.
    HOVERGENiHBG055230.
    InParanoidiQ8C569.
    OMAiLYETKSF.
    OrthoDBiEOG7RJPRH.
    PhylomeDBiQ8C569.
    TreeFamiTF332439.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C569-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG    50
    ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL 100
    VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL 150
    HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL 200
    SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG 250
    WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV 300
    ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS 350
    T 351
    Length:351
    Mass (Da):39,508
    Last modified:March 1, 2003 - v1
    Checksum:i8082AF895A40FE32
    GO
    Isoform 2 (identifier: Q8C569-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         114-189: Missing.

    Show »
    Length:275
    Mass (Da):30,822
    Checksum:iC25DC8CED9ED8204
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti194 – 1941A → D in BAE40129. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei114 – 18976Missing in isoform 2. 1 PublicationVSP_026730Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028018 mRNA. Translation: BAC25701.1.
    AK079397 mRNA. Translation: BAC37632.1.
    AK081206 mRNA. Translation: BAC38164.1.
    AK168168 mRNA. Translation: BAE40129.1.
    AK169810 mRNA. Translation: BAE41383.1.
    BC051180 mRNA. Translation: AAH51180.1.
    CCDSiCCDS22960.1. [Q8C569-2]
    CCDS22961.1. [Q8C569-1]
    RefSeqiNP_001273533.1. NM_001286604.1. [Q8C569-1]
    NP_780620.1. NM_175411.5. [Q8C569-2]
    NP_919233.1. NM_194257.2. [Q8C569-1]
    XP_006509999.1. XM_006509936.1. [Q8C569-1]
    XP_006510000.1. XM_006509937.1. [Q8C569-1]
    UniGeneiMm.24197.

    Genome annotation databases

    EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
    ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
    ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
    GeneIDi109229.
    KEGGimmu:109229.
    UCSCiuc009ota.1. mouse. [Q8C569-1]
    uc009otb.1. mouse. [Q8C569-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028018 mRNA. Translation: BAC25701.1 .
    AK079397 mRNA. Translation: BAC37632.1 .
    AK081206 mRNA. Translation: BAC38164.1 .
    AK168168 mRNA. Translation: BAE40129.1 .
    AK169810 mRNA. Translation: BAE41383.1 .
    BC051180 mRNA. Translation: AAH51180.1 .
    CCDSi CCDS22960.1. [Q8C569-2 ]
    CCDS22961.1. [Q8C569-1 ]
    RefSeqi NP_001273533.1. NM_001286604.1. [Q8C569-1 ]
    NP_780620.1. NM_175411.5. [Q8C569-2 ]
    NP_919233.1. NM_194257.2. [Q8C569-1 ]
    XP_006509999.1. XM_006509936.1. [Q8C569-1 ]
    XP_006510000.1. XM_006509937.1. [Q8C569-1 ]
    UniGenei Mm.24197.

    3D structure databases

    ProteinModelPortali Q8C569.
    SMRi Q8C569. Positions 39-67, 145-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-5191464.

    PTM databases

    PhosphoSitei Q8C569.

    Proteomic databases

    PaxDbi Q8C569.
    PRIDEi Q8C569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059057 ; ENSMUSP00000058377 ; ENSMUSG00000050471 . [Q8C569-1 ]
    ENSMUST00000063782 ; ENSMUSP00000066281 ; ENSMUSG00000050471 . [Q8C569-2 ]
    ENSMUST00000121564 ; ENSMUSP00000113537 ; ENSMUSG00000050471 . [Q8C569-1 ]
    GeneIDi 109229.
    KEGGi mmu:109229.
    UCSCi uc009ota.1. mouse. [Q8C569-1 ]
    uc009otb.1. mouse. [Q8C569-2 ]

    Organism-specific databases

    CTDi 79607.
    MGIi MGI:1924483. Fam118b.

    Phylogenomic databases

    eggNOGi NOG46711.
    GeneTreei ENSGT00390000010215.
    HOGENOMi HOG000072713.
    HOVERGENi HBG055230.
    InParanoidi Q8C569.
    OMAi LYETKSF.
    OrthoDBi EOG7RJPRH.
    PhylomeDBi Q8C569.
    TreeFami TF332439.

    Miscellaneous databases

    ChiTaRSi FAM118B. mouse.
    NextBioi 361801.
    PROi Q8C569.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C569.
    Bgeei Q8C569.
    Genevestigatori Q8C569.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: BALB/c, C57BL/6J and NOD.
      Tissue: Bone, Corpus striatum, Embryo and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Olfactory epithelium.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiF118B_MOUSE
    AccessioniPrimary (citable) accession number: Q8C569
    Secondary accession number(s): Q3THR7, Q8BNN4, Q8BT26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3