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Protein

Natural cytotoxicity triggering receptor 1

Gene

Ncr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.By similarity

GO - Biological processi

  • defense response to virus Source: MGI
  • detection of virus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Activating receptor 1
Short name:
mAR-1
Lymphocyte antigen 94
Natural killer cell p46-related protein
Short name:
NK-p46
Short name:
NKp46
Short name:
mNKp46
CD_antigen: CD335
Gene namesi
Name:Ncr1
Synonyms:Ly94
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336212. Ncr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 255239ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27318HelicalSequence analysisAdd
BLAST
Topological domaini274 – 32552CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 325309Natural cytotoxicity triggering receptor 1PRO_0000015029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 190By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8C567.
PRIDEiQ8C567.

Expressioni

Tissue specificityi

Selectively expressed by NK cells.1 Publication

Gene expression databases

BgeeiQ8C567.
CleanExiMM_NCR1.

Interactioni

Subunit structurei

Interacts with CD3Z and FCER1G.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006792.

Structurei

3D structure databases

ProteinModelPortaliQ8C567.
SMRiQ8C567. Positions 25-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11885Ig-like 1Add
BLAST
Domaini129 – 21183Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8C567.
KOiK06741.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ8C567.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTLTALLC LGLCLSQRIN TEKETLPKPI IWAKPSIMVT NGNSVNIWCQ
60 70 80 90 100
GAQSASEYQL YFEGSFFALE RPKPSRSMNK VRFFISQMTS HTAGIYTCFY
110 120 130 140 150
QSGELWSKSS NPLKLVVTGL YDTPNLWVYP RPEVTLGENV TFFCQLKTAT
160 170 180 190 200
SKFFLLKERG SNHIQNKYGN IQAEFPMGPV TRAHRGTYRC FGSYNDYAWS
210 220 230 240 250
FPSEPVTLLI TGGVENSSLA PTDPTSSLDY WEFDLSTNES GLQKDSAFWD
260 270 280 290 300
HTTQNLIRIG LACIILITLV WLLTEDWLSK RKDHEEANRL TNWECRRRWR
310 320
MQHYFEEEQR NAISMMELKA TPGAL
Length:325
Mass (Da):37,266
Last modified:May 24, 2004 - v2
Checksum:iED24E48ABF22F029
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311R → Q in BAC37635 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223765 mRNA. Translation: CAB39169.1.
AK079401 mRNA. Translation: BAC37635.1.
BC042788 mRNA. Translation: AAH42788.1.
BC115364 mRNA. Translation: AAI15365.1.
CCDSiCCDS20734.1.
RefSeqiNP_034876.2. NM_010746.3.
UniGeneiMm.240231.

Genome annotation databases

GeneIDi17086.
KEGGimmu:17086.
UCSCiuc009exi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223765 mRNA. Translation: CAB39169.1.
AK079401 mRNA. Translation: BAC37635.1.
BC042788 mRNA. Translation: AAH42788.1.
BC115364 mRNA. Translation: AAI15365.1.
CCDSiCCDS20734.1.
RefSeqiNP_034876.2. NM_010746.3.
UniGeneiMm.240231.

3D structure databases

ProteinModelPortaliQ8C567.
SMRiQ8C567. Positions 25-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006792.

Proteomic databases

PaxDbiQ8C567.
PRIDEiQ8C567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17086.
KEGGimmu:17086.
UCSCiuc009exi.1. mouse.

Organism-specific databases

CTDi9437.
MGIiMGI:1336212. Ncr1.

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8C567.
KOiK06741.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ8C567.
TreeFamiTF336644.

Miscellaneous databases

PROiQ8C567.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C567.
CleanExiMM_NCR1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity."
    Biassoni R., Pessino A., Bottino C., Pende D., Moretta L., Moretta A.
    Eur. J. Immunol. 29:1014-1020(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Lymphoid tissue.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiNCTR1_MOUSE
AccessioniPrimary (citable) accession number: Q8C567
Secondary accession number(s): Q1RLN4, Q80UY6, Q9Z0Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.