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Protein

Natural cytotoxicity triggering receptor 1

Gene

Ncr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.By similarity

GO - Biological processi

  • defense response to virus Source: MGI
  • detection of virus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Activating receptor 1
Short name:
mAR-1
Lymphocyte antigen 94
Natural killer cell p46-related protein
Short name:
NK-p46
Short name:
NKp46
Short name:
mNKp46
CD_antigen: CD335
Gene namesi
Name:Ncr1
Synonyms:Ly94
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336212. Ncr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 255ExtracellularSequence analysisAdd BLAST239
Transmembranei256 – 273HelicalSequence analysisAdd BLAST18
Topological domaini274 – 325CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001502917 – 325Natural cytotoxicity triggering receptor 1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98By similarity
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 190By similarity
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Glycosylationi238N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8C567.
PRIDEiQ8C567.

PTM databases

PhosphoSitePlusiQ8C567.

Expressioni

Tissue specificityi

Selectively expressed by NK cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000062524.
CleanExiMM_NCR1.

Interactioni

Subunit structurei

Interacts with CD3Z and FCER1G.By similarity

Protein-protein interaction databases

IntActiQ8C567. 1 interactor.
STRINGi10090.ENSMUSP00000006792.

Structurei

3D structure databases

ProteinModelPortaliQ8C567.
SMRiQ8C567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 118Ig-like 1Add BLAST85
Domaini129 – 211Ig-like 2Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8C567.
KOiK06741.
PhylomeDBiQ8C567.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTLTALLC LGLCLSQRIN TEKETLPKPI IWAKPSIMVT NGNSVNIWCQ
60 70 80 90 100
GAQSASEYQL YFEGSFFALE RPKPSRSMNK VRFFISQMTS HTAGIYTCFY
110 120 130 140 150
QSGELWSKSS NPLKLVVTGL YDTPNLWVYP RPEVTLGENV TFFCQLKTAT
160 170 180 190 200
SKFFLLKERG SNHIQNKYGN IQAEFPMGPV TRAHRGTYRC FGSYNDYAWS
210 220 230 240 250
FPSEPVTLLI TGGVENSSLA PTDPTSSLDY WEFDLSTNES GLQKDSAFWD
260 270 280 290 300
HTTQNLIRIG LACIILITLV WLLTEDWLSK RKDHEEANRL TNWECRRRWR
310 320
MQHYFEEEQR NAISMMELKA TPGAL
Length:325
Mass (Da):37,266
Last modified:May 24, 2004 - v2
Checksum:iED24E48ABF22F029
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131R → Q in BAC37635 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223765 mRNA. Translation: CAB39169.1.
AK079401 mRNA. Translation: BAC37635.1.
BC042788 mRNA. Translation: AAH42788.1.
BC115364 mRNA. Translation: AAI15365.1.
CCDSiCCDS20734.1.
RefSeqiNP_034876.2. NM_010746.3.
UniGeneiMm.240231.

Genome annotation databases

GeneIDi17086.
KEGGimmu:17086.
UCSCiuc009exi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223765 mRNA. Translation: CAB39169.1.
AK079401 mRNA. Translation: BAC37635.1.
BC042788 mRNA. Translation: AAH42788.1.
BC115364 mRNA. Translation: AAI15365.1.
CCDSiCCDS20734.1.
RefSeqiNP_034876.2. NM_010746.3.
UniGeneiMm.240231.

3D structure databases

ProteinModelPortaliQ8C567.
SMRiQ8C567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C567. 1 interactor.
STRINGi10090.ENSMUSP00000006792.

PTM databases

PhosphoSitePlusiQ8C567.

Proteomic databases

PaxDbiQ8C567.
PRIDEiQ8C567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17086.
KEGGimmu:17086.
UCSCiuc009exi.1. mouse.

Organism-specific databases

CTDi9437.
MGIiMGI:1336212. Ncr1.

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8C567.
KOiK06741.
PhylomeDBiQ8C567.
TreeFamiTF336644.

Miscellaneous databases

PROiQ8C567.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062524.
CleanExiMM_NCR1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNCTR1_MOUSE
AccessioniPrimary (citable) accession number: Q8C567
Secondary accession number(s): Q1RLN4, Q80UY6, Q9Z0Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.