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Protein

RAD51-associated protein 1

Gene

Rad51ap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RAD51-associated protein 1
Alternative name(s):
RAB22
RAD51-interacting protein
Gene namesi
Name:Rad51ap1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098224. Rad51ap1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337RAD51-associated protein 1PRO_0000097141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei23 – 231PhosphoserineCombined sources
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C551.
MaxQBiQ8C551.
PaxDbiQ8C551.
PRIDEiQ8C551.

PTM databases

iPTMnetiQ8C551.
PhosphoSiteiQ8C551.

Expressioni

Tissue specificityi

Most abundantly expressed in testis. Also expressed in spleen, thymus and bone marrow. Not detected in heart, kidney or liver.1 Publication

Gene expression databases

BgeeiQ8C551.
CleanExiMM_RAD51AP1.

Interactioni

Subunit structurei

Interacts (via C-terminal region) with RAD51; the interaction is direct (By similarity). Interacts with RAD51 and PALB2.By similarity1 Publication

Protein-protein interaction databases

BioGridi202565. 1 interaction.
STRINGi10090.ENSMUSP00000107841.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni295 – 33440Interaction with RAD51By similarityAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IICA. Eukaryota.
ENOG4111WAW. LUCA.
HOGENOMiHOG000116153.
HOVERGENiHBG079699.
InParanoidiQ8C551.
OrthoDBiEOG7GQXWK.
PhylomeDBiQ8C551.
TreeFamiTF335955.

Family and domain databases

InterProiIPR031419. RAD51_interact.
[Graphical view]
PfamiPF15696. RAD51_interact. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPTRNRKP INYSQFEDSG NDSDDDFISS STPVNKSKTV PKVLKQDKPK
60 70 80 90 100
PNLKNLQKEE VLPTEPPKKR VALDDKVFQR GLEVALALSV KELPTLTNQV
110 120 130 140 150
KKSKEKSTDK QGKEKTENTG KPPRVSNCSV ASDDVEDLDK ITEEGDASSV
160 170 180 190 200
EGERKSPSQA KAPRRRAPSE GSDGSSANDT ESESATGEGS ESDPDFDESK
210 220 230 240 250
ESDEDFGVRR SKESKKKTVQ KKPAGEKKER KSKPKCEASV TSVDPAPAAI
260 270 280 290 300
KSGSPSLPQA VGLPSEATRK PAIMCSPSAE SKRPKWVPPA ASGSRNSSSN
310 320 330
ALAGTPAKSP SQSLRLGLSR LAPVKRLHPS ATSSQVR
Length:337
Mass (Da):36,227
Last modified:July 5, 2005 - v2
Checksum:i7691E9515079783A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51T → I in BAB27579 (PubMed:16141072).Curated
Sequence conflicti5 – 51T → I in BAC37025 (PubMed:16141072).Curated
Sequence conflicti5 – 51T → I in BAC37671 (PubMed:16141072).Curated
Sequence conflicti39 – 391T → A in AAB91541 (PubMed:9192668).Curated
Sequence conflicti114 – 1141E → G in AAB91541 (PubMed:9192668).Curated
Sequence conflicti120 – 1201G → D in AAB91541 (PubMed:9192668).Curated
Sequence conflicti124 – 1241R → H in BAB27579 (PubMed:16141072).Curated
Sequence conflicti124 – 1241R → H in BAC37025 (PubMed:16141072).Curated
Sequence conflicti124 – 1241R → H in BAC37671 (PubMed:16141072).Curated
Sequence conflicti136 – 1361Missing in BAC37025 (PubMed:16141072).Curated
Sequence conflicti270 – 2701K → R in AAH03738 (PubMed:15489334).Curated
Sequence conflicti336 – 3372VR → SAVAEKDLLGPWDLQAGLSY SAST in BAC37671 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93583 mRNA. Translation: AAB91541.1.
AK011379 mRNA. Translation: BAB27579.1.
AK077829 mRNA. Translation: BAC37025.1.
AK079525 mRNA. Translation: BAC37671.1.
BC003738 mRNA. Translation: AAH03738.1.
CCDSiCCDS39644.1.
RefSeqiNP_033039.2. NM_009013.3.
XP_006505826.1. XM_006505763.2.
UniGeneiMm.204634.

Genome annotation databases

GeneIDi19362.
KEGGimmu:19362.
UCSCiuc009dvi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93583 mRNA. Translation: AAB91541.1.
AK011379 mRNA. Translation: BAB27579.1.
AK077829 mRNA. Translation: BAC37025.1.
AK079525 mRNA. Translation: BAC37671.1.
BC003738 mRNA. Translation: AAH03738.1.
CCDSiCCDS39644.1.
RefSeqiNP_033039.2. NM_009013.3.
XP_006505826.1. XM_006505763.2.
UniGeneiMm.204634.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202565. 1 interaction.
STRINGi10090.ENSMUSP00000107841.

PTM databases

iPTMnetiQ8C551.
PhosphoSiteiQ8C551.

Proteomic databases

EPDiQ8C551.
MaxQBiQ8C551.
PaxDbiQ8C551.
PRIDEiQ8C551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19362.
KEGGimmu:19362.
UCSCiuc009dvi.1. mouse.

Organism-specific databases

CTDi10635.
MGIiMGI:1098224. Rad51ap1.

Phylogenomic databases

eggNOGiENOG410IICA. Eukaryota.
ENOG4111WAW. LUCA.
HOGENOMiHOG000116153.
HOVERGENiHBG079699.
InParanoidiQ8C551.
OrthoDBiEOG7GQXWK.
PhylomeDBiQ8C551.
TreeFamiTF335955.

Miscellaneous databases

NextBioi296425.
PROiQ8C551.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C551.
CleanExiMM_RAD51AP1.

Family and domain databases

InterProiIPR031419. RAD51_interact.
[Graphical view]
PfamiPF15696. RAD51_interact. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein."
    Mizuta R., LaSalle J.M., Cheng H.-L., Shinohara A., Ogawa H., Copeland N.G., Jenkins N.A., Lalande M., Alt F.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:6927-6932(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAD51, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis1 Publication and Thymus1 Publication.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Forelimb and Hypothalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary glandImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiR51A1_MOUSE
AccessioniPrimary (citable) accession number: Q8C551
Secondary accession number(s): O55219
, Q8BP36, Q99L94, Q9D0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 16, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.