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Protein

RAD51-associated protein 1

Gene

Rad51ap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RAD51-associated protein 1
Alternative name(s):
RAB22
RAD51-interacting protein
Gene namesi
Name:Rad51ap1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098224. Rad51ap1.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971411 – 337RAD51-associated protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei103PhosphoserineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C551.
MaxQBiQ8C551.
PaxDbiQ8C551.
PeptideAtlasiQ8C551.
PRIDEiQ8C551.

PTM databases

iPTMnetiQ8C551.
PhosphoSitePlusiQ8C551.

Expressioni

Tissue specificityi

Most abundantly expressed in testis. Also expressed in spleen, thymus and bone marrow. Not detected in heart, kidney or liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000030346.
CleanExiMM_RAD51AP1.

Interactioni

Subunit structurei

Interacts (via C-terminal region) with RAD51; the interaction is direct (By similarity). Interacts with RAD51 and PALB2.By similarity1 Publication

Protein-protein interaction databases

BioGridi202565. 1 interactor.
STRINGi10090.ENSMUSP00000107841.

Structurei

3D structure databases

ProteinModelPortaliQ8C551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni295 – 334Interaction with RAD51By similarityAdd BLAST40

Phylogenomic databases

eggNOGiENOG410IICA. Eukaryota.
ENOG4111WAW. LUCA.
HOGENOMiHOG000116153.
HOVERGENiHBG079699.
InParanoidiQ8C551.
KOiK20778.
PhylomeDBiQ8C551.
TreeFamiTF335955.

Family and domain databases

InterProiIPR031419. RAD51_interact.
[Graphical view]
PfamiPF15696. RAD51_interact. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPTRNRKP INYSQFEDSG NDSDDDFISS STPVNKSKTV PKVLKQDKPK
60 70 80 90 100
PNLKNLQKEE VLPTEPPKKR VALDDKVFQR GLEVALALSV KELPTLTNQV
110 120 130 140 150
KKSKEKSTDK QGKEKTENTG KPPRVSNCSV ASDDVEDLDK ITEEGDASSV
160 170 180 190 200
EGERKSPSQA KAPRRRAPSE GSDGSSANDT ESESATGEGS ESDPDFDESK
210 220 230 240 250
ESDEDFGVRR SKESKKKTVQ KKPAGEKKER KSKPKCEASV TSVDPAPAAI
260 270 280 290 300
KSGSPSLPQA VGLPSEATRK PAIMCSPSAE SKRPKWVPPA ASGSRNSSSN
310 320 330
ALAGTPAKSP SQSLRLGLSR LAPVKRLHPS ATSSQVR
Length:337
Mass (Da):36,227
Last modified:July 5, 2005 - v2
Checksum:i7691E9515079783A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5T → I in BAB27579 (PubMed:16141072).Curated1
Sequence conflicti5T → I in BAC37025 (PubMed:16141072).Curated1
Sequence conflicti5T → I in BAC37671 (PubMed:16141072).Curated1
Sequence conflicti39T → A in AAB91541 (PubMed:9192668).Curated1
Sequence conflicti114E → G in AAB91541 (PubMed:9192668).Curated1
Sequence conflicti120G → D in AAB91541 (PubMed:9192668).Curated1
Sequence conflicti124R → H in BAB27579 (PubMed:16141072).Curated1
Sequence conflicti124R → H in BAC37025 (PubMed:16141072).Curated1
Sequence conflicti124R → H in BAC37671 (PubMed:16141072).Curated1
Sequence conflicti136Missing in BAC37025 (PubMed:16141072).Curated1
Sequence conflicti270K → R in AAH03738 (PubMed:15489334).Curated1
Sequence conflicti336 – 337VR → SAVAEKDLLGPWDLQAGLSY SAST in BAC37671 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93583 mRNA. Translation: AAB91541.1.
AK011379 mRNA. Translation: BAB27579.1.
AK077829 mRNA. Translation: BAC37025.1.
AK079525 mRNA. Translation: BAC37671.1.
BC003738 mRNA. Translation: AAH03738.1.
CCDSiCCDS39644.1.
RefSeqiNP_033039.2. NM_009013.3.
XP_006505826.1. XM_006505763.3.
UniGeneiMm.204634.

Genome annotation databases

GeneIDi19362.
KEGGimmu:19362.
UCSCiuc009dvi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93583 mRNA. Translation: AAB91541.1.
AK011379 mRNA. Translation: BAB27579.1.
AK077829 mRNA. Translation: BAC37025.1.
AK079525 mRNA. Translation: BAC37671.1.
BC003738 mRNA. Translation: AAH03738.1.
CCDSiCCDS39644.1.
RefSeqiNP_033039.2. NM_009013.3.
XP_006505826.1. XM_006505763.3.
UniGeneiMm.204634.

3D structure databases

ProteinModelPortaliQ8C551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202565. 1 interactor.
STRINGi10090.ENSMUSP00000107841.

PTM databases

iPTMnetiQ8C551.
PhosphoSitePlusiQ8C551.

Proteomic databases

EPDiQ8C551.
MaxQBiQ8C551.
PaxDbiQ8C551.
PeptideAtlasiQ8C551.
PRIDEiQ8C551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19362.
KEGGimmu:19362.
UCSCiuc009dvi.1. mouse.

Organism-specific databases

CTDi10635.
MGIiMGI:1098224. Rad51ap1.

Phylogenomic databases

eggNOGiENOG410IICA. Eukaryota.
ENOG4111WAW. LUCA.
HOGENOMiHOG000116153.
HOVERGENiHBG079699.
InParanoidiQ8C551.
KOiK20778.
PhylomeDBiQ8C551.
TreeFamiTF335955.

Miscellaneous databases

PROiQ8C551.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030346.
CleanExiMM_RAD51AP1.

Family and domain databases

InterProiIPR031419. RAD51_interact.
[Graphical view]
PfamiPF15696. RAD51_interact. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR51A1_MOUSE
AccessioniPrimary (citable) accession number: Q8C551
Secondary accession number(s): O55219
, Q8BP36, Q99L94, Q9D0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.