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Q8C4X2 (KC1G3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Casein kinase I isoform gamma-3

Short name=CKI-gamma 3
EC=2.7.11.1
Gene names
Name:Csnk1g3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity. Regulates fast synaptic transmission mediated by glutamate. Ref.5

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in both the striatum and the neocortex. Ref.5

Post-translational modification

Autophosphorylated By similarity.

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Sequence similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Casein kinase I isoform gamma-3
PRO_0000305924

Regions

Domain43 – 313271Protein kinase
Nucleotide binding49 – 579ATP By similarity
Compositional bias31 – 344Poly-Ser

Sites

Active site1621Proton acceptor By similarity
Binding site721ATP By similarity
Binding site1171Inhibitor triazolodiamine 1; via carbonyl oxygen By similarity
Binding site1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygen By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3821Phosphoserine By similarity

Experimental info

Sequence conflict62 – 8423NLYTN…APQLH → IVLFIPLCEEQFKNEYTCKR VFL in BAC37932. Ref.2
Sequence conflict1191L → V Ref.2
Sequence conflict1381T → A in AK218008. Ref.2
Sequence conflict1671N → K in AK218008. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8C4X2 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: A0A0789CE718F3C0

FASTA42448,938
        10         20         30         40         50         60 
MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 

        70         80         90        100        110        120 
KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 

       130        140        150        160        170        180 
PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKAQQV 

       190        200        210        220        230        240 
IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 

       250        260        270        280        290        300 
YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 

       310        320        330        340        350        360 
DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA HQHRDKIQQS 

       370        380        390        400        410        420 
KNQVVSSTNG ELNTDDPTAG RSNAPITAPT EVEVMDETNC QKVLNMWCCC FFKRRKRKTI 


QRHK 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-210 AND 238-424.
Strain: C57BL/6J.
Tissue: Cerebellum and Embryoid bodies.
[3]"Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas."
Watahiki A., Waki K., Hayatsu N., Shiraki T., Kondo S., Nakamura M., Sasaki D., Arakawa T., Kawai J., Harbers M., Hayashizaki Y., Carninci P.
Nat. Methods 1:233-239(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-210.
Tissue: Melanocyte.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-424.
Tissue: Eye.
[5]"Physiological role for casein kinase 1 in glutamatergic synaptic transmission."
Chergui K., Svenningsson P., Greengard P.
J. Neurosci. 25:6601-6609(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN SYNAPTIC TRANSMISSION, TISSUE SPECIFICITY.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC115124 Genomic DNA. No translation available.
AC127368 Genomic DNA. No translation available.
AK032675 mRNA. Translation: BAC27983.1.
AK034842 mRNA. Translation: BAC28850.1.
AK080491 mRNA. Translation: BAC37932.1.
AK218008 mRNA. No translation available.
BC033601 mRNA. Translation: AAH33601.2.
RefSeqNP_690022.2. NM_152809.2.
UniGeneMm.368668.

3D structure databases

ProteinModelPortalQ8C4X2.
SMRQ8C4X2. Positions 36-402.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8C4X2.

Proteomic databases

PaxDbQ8C4X2.
PRIDEQ8C4X2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069597; ENSMUSP00000070259; ENSMUSG00000073563.
GeneID70425.
KEGGmmu:70425.
UCSCuc008eya.1. mouse.

Organism-specific databases

CTD1456.
MGIMGI:1917675. Csnk1g3.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110718.
HOGENOMHOG000182054.
HOVERGENHBG000176.
InParanoidQ8C4X2.
KOK08958.
OMANREAHPH.
OrthoDBEOG7G1V66.
PhylomeDBQ8C4X2.
TreeFamTF313349.

Gene expression databases

BgeeQ8C4X2.
CleanExMM_CSNK1G3.
GenevestigatorQ8C4X2.

Family and domain databases

InterProIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio331587.
PROQ8C4X2.
SOURCESearch...

Entry information

Entry nameKC1G3_MOUSE
AccessionPrimary (citable) accession number: Q8C4X2
Secondary accession number(s): Q8BM57, Q8C001, Q8K079
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot