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Q8C4X2

- KC1G3_MOUSE

UniProt

Q8C4X2 - KC1G3_MOUSE

Protein

Casein kinase I isoform gamma-3

Gene

Csnk1g3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity. Regulates fast synaptic transmission mediated by glutamate.By similarity1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPPROSITE-ProRule annotation
    Binding sitei117 – 1171Inhibitor triazolodiamine 1; via carbonyl oxygenBy similarity
    Binding sitei119 – 1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform gamma-3 (EC:2.7.11.1)
    Short name:
    CKI-gamma 3
    Gene namesi
    Name:Csnk1g3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1917675. Csnk1g3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Casein kinase I isoform gamma-3PRO_0000305924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei382 – 3821PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8C4X2.
    PaxDbiQ8C4X2.
    PRIDEiQ8C4X2.

    PTM databases

    PhosphoSiteiQ8C4X2.

    Expressioni

    Tissue specificityi

    Expressed in both the striatum and the neocortex.1 Publication

    Gene expression databases

    BgeeiQ8C4X2.
    CleanExiMM_CSNK1G3.
    GenevestigatoriQ8C4X2.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C4X2.
    SMRiQ8C4X2. Positions 36-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 313271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 344Poly-Ser

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110718.
    HOGENOMiHOG000182054.
    HOVERGENiHBG000176.
    InParanoidiQ8C4X2.
    KOiK08958.
    OMAiNREAHPH.
    OrthoDBiEOG7G1V66.
    PhylomeDBiQ8C4X2.
    TreeFamiTF313349.

    Family and domain databases

    InterProiIPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C4X2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG    50
    CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP 100
    QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM 150
    EYVHSKNLIY RDVKPENFLI GRPGNKAQQV IHIIDFGLAK EYIDPETKKH 200
    IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ 250
    GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 300
    DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA 350
    HQHRDKIQQS KNQVVSSTNG ELNTDDPTAG RSNAPITAPT EVEVMDETNC 400
    QKVLNMWCCC FFKRRKRKTI QRHK 424
    Length:424
    Mass (Da):48,938
    Last modified:October 2, 2007 - v2
    Checksum:iA0A0789CE718F3C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 8423NLYTN…APQLH → IVLFIPLCEEQFKNEYTCKR VFL in BAC37932. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti119 – 1191L → V(PubMed:16141072)Curated
    Sequence conflicti138 – 1381T → A in AK218008. (PubMed:16141072)Curated
    Sequence conflicti167 – 1671N → K in AK218008. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115124 Genomic DNA. No translation available.
    AC127368 Genomic DNA. No translation available.
    AK032675 mRNA. Translation: BAC27983.1.
    AK034842 mRNA. Translation: BAC28850.1.
    AK080491 mRNA. Translation: BAC37932.1.
    AK218008 mRNA. No translation available.
    BC033601 mRNA. Translation: AAH33601.2.
    CCDSiCCDS37823.1.
    RefSeqiNP_690022.2. NM_152809.2.
    UniGeneiMm.368668.

    Genome annotation databases

    EnsembliENSMUST00000069597; ENSMUSP00000070259; ENSMUSG00000073563.
    GeneIDi70425.
    KEGGimmu:70425.
    UCSCiuc008eya.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115124 Genomic DNA. No translation available.
    AC127368 Genomic DNA. No translation available.
    AK032675 mRNA. Translation: BAC27983.1 .
    AK034842 mRNA. Translation: BAC28850.1 .
    AK080491 mRNA. Translation: BAC37932.1 .
    AK218008 mRNA. No translation available.
    BC033601 mRNA. Translation: AAH33601.2 .
    CCDSi CCDS37823.1.
    RefSeqi NP_690022.2. NM_152809.2.
    UniGenei Mm.368668.

    3D structure databases

    ProteinModelPortali Q8C4X2.
    SMRi Q8C4X2. Positions 36-368.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C4X2.

    Proteomic databases

    MaxQBi Q8C4X2.
    PaxDbi Q8C4X2.
    PRIDEi Q8C4X2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069597 ; ENSMUSP00000070259 ; ENSMUSG00000073563 .
    GeneIDi 70425.
    KEGGi mmu:70425.
    UCSCi uc008eya.1. mouse.

    Organism-specific databases

    CTDi 1456.
    MGIi MGI:1917675. Csnk1g3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110718.
    HOGENOMi HOG000182054.
    HOVERGENi HBG000176.
    InParanoidi Q8C4X2.
    KOi K08958.
    OMAi NREAHPH.
    OrthoDBi EOG7G1V66.
    PhylomeDBi Q8C4X2.
    TreeFami TF313349.

    Miscellaneous databases

    NextBioi 331587.
    PROi Q8C4X2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C4X2.
    CleanExi MM_CSNK1G3.
    Genevestigatori Q8C4X2.

    Family and domain databases

    InterProi IPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-210 AND 238-424.
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryoid bodies.
    3. "Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas."
      Watahiki A., Waki K., Hayatsu N., Shiraki T., Kondo S., Nakamura M., Sasaki D., Arakawa T., Kawai J., Harbers M., Hayashizaki Y., Carninci P.
      Nat. Methods 1:233-239(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-210.
      Tissue: Melanocyte.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-424.
      Tissue: Eye.
    5. "Physiological role for casein kinase 1 in glutamatergic synaptic transmission."
      Chergui K., Svenningsson P., Greengard P.
      J. Neurosci. 25:6601-6609(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SYNAPTIC TRANSMISSION, TISSUE SPECIFICITY.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKC1G3_MOUSE
    AccessioniPrimary (citable) accession number: Q8C4X2
    Secondary accession number(s): Q8BM57, Q8C001, Q8K079
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3