Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase I isoform gamma-3

Gene

Csnk1g3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Regulates fast synaptic transmission mediated by glutamate.By similarity1 Publication

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPPROSITE-ProRule annotation1
Binding sitei117Inhibitor triazolodiamine 1; via carbonyl oxygenBy similarity1
Binding sitei119Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygenBy similarity1
Active sitei162Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 57ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
Gene namesi
Name:Csnk1g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1917675 Csnk1g3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059241 – 424Casein kinase I isoform gamma-3Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei382PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8C4X2
MaxQBiQ8C4X2
PaxDbiQ8C4X2
PeptideAtlasiQ8C4X2
PRIDEiQ8C4X2

PTM databases

iPTMnetiQ8C4X2
PhosphoSitePlusiQ8C4X2
SwissPalmiQ8C4X2

Expressioni

Tissue specificityi

Expressed in both the striatum and the neocortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000073563
CleanExiMM_CSNK1G3
GenevisibleiQ8C4X2 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070259

Structurei

3D structure databases

ProteinModelPortaliQ8C4X2
SMRiQ8C4X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 34Poly-Ser4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1165 Eukaryota
ENOG410XNXP LUCA
GeneTreeiENSGT00760000119040
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ8C4X2
KOiK08958
OMAiTYKHLQG
OrthoDBiEOG091G0F3Z
PhylomeDBiQ8C4X2
TreeFamiTF313349

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C4X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG
60 70 80 90 100
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP
110 120 130 140 150
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM
160 170 180 190 200
EYVHSKNLIY RDVKPENFLI GRPGNKAQQV IHIIDFGLAK EYIDPETKKH
210 220 230 240 250
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ
260 270 280 290 300
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP
310 320 330 340 350
DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA
360 370 380 390 400
HQHRDKIQQS KNQVVSSTNG ELNTDDPTAG RSNAPITAPT EVEVMDETNC
410 420
QKVLNMWCCC FFKRRKRKTI QRHK
Length:424
Mass (Da):48,938
Last modified:October 2, 2007 - v2
Checksum:iA0A0789CE718F3C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62 – 84NLYTN…APQLH → IVLFIPLCEEQFKNEYTCKR VFL in BAC37932 (PubMed:16141072).CuratedAdd BLAST23
Sequence conflicti119L → V (PubMed:16141072).Curated1
Sequence conflicti138T → A in AK218008 (PubMed:16141072).Curated1
Sequence conflicti167N → K in AK218008 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115124 Genomic DNA No translation available.
AC127368 Genomic DNA No translation available.
AK032675 mRNA Translation: BAC27983.1
AK034842 mRNA Translation: BAC28850.1
AK080491 mRNA Translation: BAC37932.1
AK218008 mRNA No translation available.
BC033601 mRNA Translation: AAH33601.2
CCDSiCCDS37823.1
RefSeqiNP_690022.2, NM_152809.2
UniGeneiMm.368668

Genome annotation databases

EnsembliENSMUST00000069597; ENSMUSP00000070259; ENSMUSG00000073563
GeneIDi70425
KEGGimmu:70425
UCSCiuc008eya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKC1G3_MOUSE
AccessioniPrimary (citable) accession number: Q8C4X2
Secondary accession number(s): Q8BM57, Q8C001, Q8K079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health