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Q8C4U3 (SFRP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secreted frizzled-related protein 1

Short name=sFRP-1
Gene names
Name:Sfrp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels By similarity. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi By similarity. Inhibits WNT1/WNT4-mediated TCF-dependent transcription By similarity. Ref.6

Subunit structure

Interacts with WNT8, WNT1, WNT2, WNT4 and FRZD6 By similarity. Interacts with MYOC. Ref.5 Ref.7

Subcellular location

Secreted By similarity. Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding By similarity.

Tissue specificity

Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus. Ref.1

Developmental stage

In the developing kidney expressed at 13.5 dpc in the periphery of the metanophros and surrounding the uretic and nephrogenic tubules. At 14.5 dpc, expression decreases in the outer cortical cells and becomes visible in the tubular parts of the nephron. From 15.5 dpc, highly expressed in the future loops of Henle. In the developing CNS, expression located to the forebrain and hindbrain. At 8.0 dpc, expressed in the future forebrain and in the ventral portion of the presumptive hindbrain. At 8.5 dpc, expression is maintained in these tissues with a strong signal in rhombomere 4. Until 11.5 dpc, expression continues in the hindbrain with additional expression at 9.5 dpc and 10.5 dpc, in the nasal and epibranchial placodes. In the forbrain, initial expression is found in the proencephalon of the forebrain, and then strong expression in the telencephalic vesicle up to 15.5 dpc. Expression is then found in specific cell populations throughout the brain. In the developing eye, expression, by 10.5 dpc, is confined to ectodermal cells overlying the dorsal part of the optic cup. In later stages, expression limited to the lens fiber cells and the future pigmented retina. By 15.5 dpc, expression is confined to the anterior part of the lens. During limb development, barely expressed until later stages, when it is found in the distal part of the separating phalanges. In other developing structures, expressed in nasal placodes at 9.5 dpc, in medial nasal processes at E10.5 and then in the anterior portion of the invaginating olfactory epithelium. At 15.5 dpc, expressed on the basal side of the nasal epithelium. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. As well, expressed in the ventral body wall, in the mesenchyme derived adrenal cortex, the cochlear epithelium and the branching epithelium of the salivary gland. In the developing heart, weakly expressed from 8.5 dpc in the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5 dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in the common ventricular and atrial chamber of the developing heart, in the aortic sac and in the sinus venosus. High expression found from 11.5 dpc-12.5 dpc, in the trabeculated wall of the ventricular chamber together with the wall of the atrial chamber. Expression also found in the muscular part of the interventricular septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac confined to the inner lining endothelial cell layer. Expression in the developing heart decreases after 14.5 dpc. Ref.4 Ref.5

Domain

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Contains 1 FZ (frizzled) domain.

Contains 1 NTR domain.

Ontologies

Keywords
   Biological processDifferentiation
Wnt signaling pathway
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in somitogenesis

Inferred from genetic interaction PubMed 18257070. Source: MGI

Wnt signaling pathway, planar cell polarity pathway

Inferred from direct assay PubMed 18371946. Source: MGI

actin cytoskeleton organization

Inferred from sequence orthology PubMed 18156211. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 16467359. Source: MGI

apoptotic DNA fragmentation

Inferred from electronic annotation. Source: Ensembl

bone trabecula formation

Inferred from mutant phenotype PubMed 14976225. Source: MGI

brain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to X-ray

Inferred from direct assay PubMed 19778523. Source: UniProtKB

cellular response to estradiol stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to estrogen stimulus

Inferred from direct assay PubMed 18941195. Source: UniProtKB

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to heparin

Inferred from electronic annotation. Source: Ensembl

cellular response to hypoxia

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to prostaglandin E stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to starvation

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cellular response to vitamin D

Inferred from electronic annotation. Source: Ensembl

convergent extension involved in somitogenesis

Inferred from genetic interaction PubMed 18257070. Source: MGI

development of primary male sexual characteristics

Inferred from genetic interaction PubMed 19100252. Source: MGI

digestive tract morphogenesis

Inferred from genetic interaction PubMed 19300477. Source: MGI

dorsal/ventral axis specification

Inferred from electronic annotation. Source: Ensembl

female gonad development

Inferred from genetic interaction PubMed 19100252. Source: MGI

hematopoietic stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

hemopoiesis

Inferred from mutant phenotype PubMed 19664990. Source: MGI

male gonad development

Inferred from genetic interaction PubMed 19100252. Source: MGI

menstrual cycle phase

Inferred from electronic annotation. Source: Ensembl

negative regulation of B cell differentiation

Inferred from mutant phenotype PubMed 18941195. Source: UniProtKB

negative regulation of BMP signaling pathway

Inferred from genetic interaction PubMed 19850029. Source: MGI

negative regulation of JUN kinase activity

Inferred from genetic interaction PubMed 19300477. Source: MGI

negative regulation of Wnt signaling pathway

Inferred from genetic interaction PubMed 19300477. Source: MGI

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Inferred from electronic annotation. Source: Ensembl

negative regulation of androgen receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of bone remodeling

Inferred from electronic annotation. Source: Ensembl

negative regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 16149051. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibroblast apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from mutant phenotype PubMed 19850029. Source: MGI

negative regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of ossification

Inferred from mutant phenotype PubMed 19254787. Source: MGI

negative regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 14976225. Source: MGI

negative regulation of osteoblast proliferation

Inferred from mutant phenotype PubMed 14976225. Source: MGI

negative regulation of osteoclast differentiation

Inferred from mutant phenotype PubMed 14976225. Source: MGI

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of planar cell polarity pathway involved in axis elongation

Inferred from genetic interaction PubMed 18257070. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

neural crest cell fate commitment

Inferred from mutant phenotype PubMed 20130188. Source: MGI

neural tube closure

Inferred from genetic interaction PubMed 19850029. Source: MGI

neural tube development

Inferred from genetic interaction PubMed 19850029. Source: MGI

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in neural tube closure

Inferred from genetic interaction PubMed 18257070. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 14976225. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

positive regulation of fat cell differentiation

Inferred from sequence orthology PubMed 12055200. Source: MGI

positive regulation of fibroblast apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of non-canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

Inferred from mutant phenotype PubMed 18371946. Source: MGI

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 18371946. Source: MGI

regulation of cell cycle process

Inferred from electronic annotation. Source: Ensembl

regulation of establishment of planar polarity

Inferred from genetic interaction PubMed 19300477. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to drug

Inferred from direct assay PubMed 19778523. Source: UniProtKB

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19664990. Source: MGI

somitogenesis

Inferred from expression pattern PubMed 10654605. Source: BHF-UCL

stromal-epithelial cell signaling involved in prostate gland development

Inferred from expression pattern PubMed 16288033. Source: UniProtKB

substrate adhesion-dependent cell spreading

Inferred from sequence orthology PubMed 18156211. Source: MGI

ureteric bud development

Inferred from expression pattern PubMed 16545622. Source: UniProtKB

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytosol

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from sequence orthology PubMed 18156211. Source: MGI

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionPDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from physical interaction PubMed 17462603. Source: MGI

cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: Ensembl

drug binding

Inferred from electronic annotation. Source: Ensembl

heparin binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction Ref.7. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 314283Secreted frizzled-related protein 1
PRO_0000032539

Regions

Domain53 – 169117FZ
Domain186 – 306121NTR

Amino acid modifications

Glycosylation1731N-linked (GlcNAc...) By similarity
Disulfide bond58 ↔ 121 By similarity
Disulfide bond68 ↔ 114 By similarity
Disulfide bond105 ↔ 140 By similarity
Disulfide bond129 ↔ 166 By similarity
Disulfide bond133 ↔ 157 By similarity
Disulfide bond186 ↔ 256 By similarity
Disulfide bond189 ↔ 258 By similarity
Disulfide bond203 ↔ 306 By similarity

Experimental info

Sequence conflict281A → S in AAH24495. Ref.2
Sequence conflict2451R → A in AAC53145. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8C4U3 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 3D98A15127DFA421

FASTA31435,413
        10         20         30         40         50         60 
MGVGRSARGR GGAASGVLLA LAAALLAAGS ASEYDYVSFQ SDIGSYQSGR FYTKPPQCVD 

        70         80         90        100        110        120 
IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHMGTQ VFLCSLFAPV 

       130        140        150        160        170        180 
CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNTTEASKP 

       190        200        210        220        230        240 
QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK 

       250        260        270        280        290        300 
KELKRLVLFL KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR 

       310 
MKNHECPTFQ SVFK 

« Hide

References

« Hide 'large scale' references
[1]"A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors."
Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Embryonic eye.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Colon.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314.
Strain: C57BL/6J.
Tissue: Cerebellum.
[4]"Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family."
Leimeister C., Bach A., Gessler M.
Mech. Dev. 75:29-42(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[5]"Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis."
Jaspard B., Couffinhal T., Dufourcq P., Moreau C., Duplaa C.
Mech. Dev. 90:263-267(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WNT8, DEVELOPMENTAL STAGE.
[6]"FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo."
Ezan J., Leroux L., Barandon L., Dufourcq P., Jaspard B., Moreau C., Allieres C., Daret D., Couffinhal T., Duplaa C.
Cardiovasc. Res. 63:731-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS AN ANGIOGENIC FACTOR.
[7]"Myocilin is a modulator of Wnt signaling."
Kwon H.S., Lee H.S., Ji Y., Rubin J.S., Tomarev S.I.
Mol. Cell. Biol. 29:2139-2154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYOC.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88566 mRNA. Translation: AAC53145.1.
BC024495 mRNA. Translation: AAH24495.1.
BC094662 mRNA. Translation: AAH94662.1.
AK081052 mRNA. Translation: BAC38123.1.
CCDSCCDS22191.1.
RefSeqNP_038862.2. NM_013834.3.
XP_006509105.1. XM_006509042.1.
UniGeneMm.281691.

3D structure databases

ProteinModelPortalQ8C4U3.
SMRQ8C4U3. Positions 63-162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203185. 7 interactions.
STRING10090.ENSMUSP00000033952.

Chemistry

ChEMBLCHEMBL1075304.

Protein family/group databases

MEROPSI93.001.

PTM databases

PhosphoSiteQ8C4U3.

Proteomic databases

MaxQBQ8C4U3.
PRIDEQ8C4U3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033952; ENSMUSP00000033952; ENSMUSG00000031548.
GeneID20377.
KEGGmmu:20377.
UCSCuc009lev.2. mouse.

Organism-specific databases

CTD6422.
MGIMGI:892014. Sfrp1.

Phylogenomic databases

eggNOGNOG240950.
GeneTreeENSGT00750000117588.
HOGENOMHOG000231058.
HOVERGENHBG052928.
InParanoidQ505A2.
KOK02166.
OMADDVCIAM.
OrthoDBEOG789CBZ.
TreeFamTF350133.

Gene expression databases

BgeeQ8C4U3.
CleanExMM_SFRP1.
GenevestigatorQ8C4U3.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
PfamPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSFRP1. mouse.
NextBio298286.
PROQ8C4U3.
SOURCESearch...

Entry information

Entry nameSFRP1_MOUSE
AccessionPrimary (citable) accession number: Q8C4U3
Secondary accession number(s): O08861, Q505A2, Q8R1J4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot