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Q8C4U3

- SFRP1_MOUSE

UniProt

Q8C4U3 - SFRP1_MOUSE

Protein

Secreted frizzled-related protein 1

Gene

Sfrp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels By similarity. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi By similarity. Inhibits WNT1/WNT4-mediated TCF-dependent transcription By similarity.By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: Ensembl
    2. drug binding Source: Ensembl
    3. heparin binding Source: Ensembl
    4. PDZ domain binding Source: RefGenome
    5. protein binding Source: UniProtKB
    6. Wnt-activated receptor activity Source: RefGenome
    7. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. apoptotic DNA fragmentation Source: Ensembl
    4. bone trabecula formation Source: MGI
    5. brain development Source: RefGenome
    6. canonical Wnt signaling pathway Source: Ensembl
    7. cellular response to BMP stimulus Source: Ensembl
    8. cellular response to estradiol stimulus Source: Ensembl
    9. cellular response to estrogen stimulus Source: UniProtKB
    10. cellular response to fibroblast growth factor stimulus Source: Ensembl
    11. cellular response to heparin Source: Ensembl
    12. cellular response to hypoxia Source: Ensembl
    13. cellular response to interleukin-1 Source: Ensembl
    14. cellular response to prostaglandin E stimulus Source: Ensembl
    15. cellular response to starvation Source: Ensembl
    16. cellular response to transforming growth factor beta stimulus Source: Ensembl
    17. cellular response to tumor necrosis factor Source: Ensembl
    18. cellular response to vitamin D Source: Ensembl
    19. cellular response to X-ray Source: UniProtKB
    20. convergent extension involved in somitogenesis Source: MGI
    21. development of primary male sexual characteristics Source: MGI
    22. digestive tract morphogenesis Source: MGI
    23. dorsal/ventral axis specification Source: Ensembl
    24. female gonad development Source: MGI
    25. hematopoietic stem cell differentiation Source: Ensembl
    26. hemopoiesis Source: MGI
    27. male gonad development Source: MGI
    28. menstrual cycle phase Source: Ensembl
    29. negative regulation of androgen receptor signaling pathway Source: Ensembl
    30. negative regulation of B cell differentiation Source: UniProtKB
    31. negative regulation of BMP signaling pathway Source: MGI
    32. negative regulation of bone remodeling Source: Ensembl
    33. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    34. negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
    35. negative regulation of cell growth Source: Ensembl
    36. negative regulation of cell migration Source: Ensembl
    37. negative regulation of cysteine-type endopeptidase activity Source: Ensembl
    38. negative regulation of epithelial cell proliferation Source: Ensembl
    39. negative regulation of epithelial to mesenchymal transition Source: Ensembl
    40. negative regulation of fibroblast apoptotic process Source: Ensembl
    41. negative regulation of fibroblast proliferation Source: Ensembl
    42. negative regulation of gene expression Source: MGI
    43. negative regulation of insulin secretion Source: Ensembl
    44. negative regulation of JUN kinase activity Source: MGI
    45. negative regulation of ossification Source: MGI
    46. negative regulation of osteoblast differentiation Source: MGI
    47. negative regulation of osteoblast proliferation Source: MGI
    48. negative regulation of osteoclast differentiation Source: MGI
    49. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    50. negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
    51. negative regulation of transcription, DNA-templated Source: Ensembl
    52. negative regulation of Wnt signaling pathway Source: MGI
    53. negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
    54. neural crest cell fate commitment Source: MGI
    55. neural tube closure Source: MGI
    56. neural tube development Source: MGI
    57. osteoblast differentiation Source: Ensembl
    58. planar cell polarity pathway involved in neural tube closure Source: MGI
    59. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    60. positive regulation of cell growth Source: Ensembl
    61. positive regulation of epithelial cell proliferation Source: Ensembl
    62. positive regulation of extrinsic apoptotic signaling pathway Source: MGI
    63. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    64. positive regulation of fat cell differentiation Source: MGI
    65. positive regulation of fibroblast apoptotic process Source: Ensembl
    66. positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
    67. positive regulation of smoothened signaling pathway Source: Ensembl
    68. positive regulation of transcription, DNA-templated Source: Ensembl
    69. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    70. regulation of branching involved in prostate gland morphogenesis Source: MGI
    71. regulation of cell cycle process Source: Ensembl
    72. regulation of establishment of planar polarity Source: MGI
    73. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    74. response to drug Source: UniProtKB
    75. somatic stem cell maintenance Source: MGI
    76. somitogenesis Source: BHF-UCL
    77. stromal-epithelial cell signaling involved in prostate gland development Source: UniProtKB
    78. substrate adhesion-dependent cell spreading Source: MGI
    79. ureteric bud development Source: UniProtKB
    80. vasculature development Source: RefGenome
    81. Wnt signaling pathway, planar cell polarity pathway Source: MGI
    82. Wnt signaling pathway involved in somitogenesis Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 1
    Short name:
    sFRP-1
    Gene namesi
    Name:Sfrp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:892014. Sfrp1.

    Subcellular locationi

    Secreted By similarity
    Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding By similarity.By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: RefGenome
    3. cytosol Source: Ensembl
    4. extracellular space Source: Ensembl
    5. plasma membrane Source: MGI
    6. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 314283Secreted frizzled-related protein 1PRO_0000032539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 121By similarity
    Disulfide bondi68 ↔ 114By similarity
    Disulfide bondi105 ↔ 140By similarity
    Disulfide bondi129 ↔ 166By similarity
    Disulfide bondi133 ↔ 157By similarity
    Glycosylationi173 – 1731N-linked (GlcNAc...)By similarity
    Disulfide bondi186 ↔ 256By similarity
    Disulfide bondi189 ↔ 258By similarity
    Disulfide bondi203 ↔ 306By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8C4U3.
    PRIDEiQ8C4U3.

    PTM databases

    PhosphoSiteiQ8C4U3.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus.1 Publication

    Developmental stagei

    In the developing kidney expressed at 13.5 dpc in the periphery of the metanophros and surrounding the uretic and nephrogenic tubules. At 14.5 dpc, expression decreases in the outer cortical cells and becomes visible in the tubular parts of the nephron. From 15.5 dpc, highly expressed in the future loops of Henle. In the developing CNS, expression located to the forebrain and hindbrain. At 8.0 dpc, expressed in the future forebrain and in the ventral portion of the presumptive hindbrain. At 8.5 dpc, expression is maintained in these tissues with a strong signal in rhombomere 4. Until 11.5 dpc, expression continues in the hindbrain with additional expression at 9.5 dpc and 10.5 dpc, in the nasal and epibranchial placodes. In the forbrain, initial expression is found in the proencephalon of the forebrain, and then strong expression in the telencephalic vesicle up to 15.5 dpc. Expression is then found in specific cell populations throughout the brain. In the developing eye, expression, by 10.5 dpc, is confined to ectodermal cells overlying the dorsal part of the optic cup. In later stages, expression limited to the lens fiber cells and the future pigmented retina. By 15.5 dpc, expression is confined to the anterior part of the lens. During limb development, barely expressed until later stages, when it is found in the distal part of the separating phalanges. In other developing structures, expressed in nasal placodes at 9.5 dpc, in medial nasal processes at E10.5 and then in the anterior portion of the invaginating olfactory epithelium. At 15.5 dpc, expressed on the basal side of the nasal epithelium. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. As well, expressed in the ventral body wall, in the mesenchyme derived adrenal cortex, the cochlear epithelium and the branching epithelium of the salivary gland. In the developing heart, weakly expressed from 8.5 dpc in the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5 dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in the common ventricular and atrial chamber of the developing heart, in the aortic sac and in the sinus venosus. High expression found from 11.5 dpc-12.5 dpc, in the trabeculated wall of the ventricular chamber together with the wall of the atrial chamber. Expression also found in the muscular part of the interventricular septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac confined to the inner lining endothelial cell layer. Expression in the developing heart decreases after 14.5 dpc.2 Publications

    Gene expression databases

    BgeeiQ8C4U3.
    CleanExiMM_SFRP1.
    GenevestigatoriQ8C4U3.

    Interactioni

    Subunit structurei

    Interacts with WNT8, WNT1, WNT2, WNT4 and FRZD6 By similarity. Interacts with MYOC.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi203185. 7 interactions.
    STRINGi10090.ENSMUSP00000033952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C4U3.
    SMRiQ8C4U3. Positions 63-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 169117FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 306121NTRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240950.
    GeneTreeiENSGT00750000117588.
    HOGENOMiHOG000231058.
    HOVERGENiHBG052928.
    InParanoidiQ505A2.
    KOiK02166.
    OMAiDDVCIAM.
    OrthoDBiEOG789CBZ.
    TreeFamiTF350133.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8C4U3-1 [UniParc]FASTAAdd to Basket

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    MGVGRSARGR GGAASGVLLA LAAALLAAGS ASEYDYVSFQ SDIGSYQSGR    50
    FYTKPPQCVD IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL 100
    LNKNCHMGTQ VFLCSLFAPV CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY 150
    WPEMLKCDKF PEGDVCIAMT PPNTTEASKP QGTTVCPPCD NELKSEAIIE 200
    HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK KELKRLVLFL 250
    KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR 300
    MKNHECPTFQ SVFK 314
    Length:314
    Mass (Da):35,413
    Last modified:July 27, 2011 - v3
    Checksum:i3D98A15127DFA421
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281A → S in AAH24495. (PubMed:15489334)Curated
    Sequence conflicti245 – 2451R → A in AAC53145. (PubMed:9096311)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88566 mRNA. Translation: AAC53145.1.
    BC024495 mRNA. Translation: AAH24495.1.
    BC094662 mRNA. Translation: AAH94662.1.
    AK081052 mRNA. Translation: BAC38123.1.
    CCDSiCCDS22191.1.
    RefSeqiNP_038862.2. NM_013834.3.
    XP_006509105.1. XM_006509042.1.
    UniGeneiMm.281691.

    Genome annotation databases

    EnsembliENSMUST00000033952; ENSMUSP00000033952; ENSMUSG00000031548.
    GeneIDi20377.
    KEGGimmu:20377.
    UCSCiuc009lev.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88566 mRNA. Translation: AAC53145.1 .
    BC024495 mRNA. Translation: AAH24495.1 .
    BC094662 mRNA. Translation: AAH94662.1 .
    AK081052 mRNA. Translation: BAC38123.1 .
    CCDSi CCDS22191.1.
    RefSeqi NP_038862.2. NM_013834.3.
    XP_006509105.1. XM_006509042.1.
    UniGenei Mm.281691.

    3D structure databases

    ProteinModelPortali Q8C4U3.
    SMRi Q8C4U3. Positions 63-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203185. 7 interactions.
    STRINGi 10090.ENSMUSP00000033952.

    Chemistry

    ChEMBLi CHEMBL1075304.

    Protein family/group databases

    MEROPSi I93.001.

    PTM databases

    PhosphoSitei Q8C4U3.

    Proteomic databases

    MaxQBi Q8C4U3.
    PRIDEi Q8C4U3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033952 ; ENSMUSP00000033952 ; ENSMUSG00000031548 .
    GeneIDi 20377.
    KEGGi mmu:20377.
    UCSCi uc009lev.2. mouse.

    Organism-specific databases

    CTDi 6422.
    MGIi MGI:892014. Sfrp1.

    Phylogenomic databases

    eggNOGi NOG240950.
    GeneTreei ENSGT00750000117588.
    HOGENOMi HOG000231058.
    HOVERGENi HBG052928.
    InParanoidi Q505A2.
    KOi K02166.
    OMAi DDVCIAM.
    OrthoDBi EOG789CBZ.
    TreeFami TF350133.

    Enzyme and pathway databases

    Reactomei REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

    Miscellaneous databases

    ChiTaRSi SFRP1. mouse.
    NextBioi 298286.
    PROi Q8C4U3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C4U3.
    CleanExi MM_SFRP1.
    Genevestigatori Q8C4U3.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors."
      Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6J.
      Tissue: Embryonic eye.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Colon.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314.
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    4. "Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family."
      Leimeister C., Bach A., Gessler M.
      Mech. Dev. 75:29-42(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    5. "Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis."
      Jaspard B., Couffinhal T., Dufourcq P., Moreau C., Duplaa C.
      Mech. Dev. 90:263-267(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WNT8, DEVELOPMENTAL STAGE.
    6. "FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo."
      Ezan J., Leroux L., Barandon L., Dufourcq P., Jaspard B., Moreau C., Allieres C., Daret D., Couffinhal T., Duplaa C.
      Cardiovasc. Res. 63:731-738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN ANGIOGENIC FACTOR.
    7. Cited for: INTERACTION WITH MYOC.

    Entry informationi

    Entry nameiSFRP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8C4U3
    Secondary accession number(s): O08861, Q505A2, Q8R1J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3