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Protein

Secreted frizzled-related protein 1

Gene

Sfrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • bone trabecula formation Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cellular response to BMP stimulus Source: Ensembl
  • cellular response to estradiol stimulus Source: Ensembl
  • cellular response to estrogen stimulus Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: MGI
  • cellular response to growth factor stimulus Source: MGI
  • cellular response to heparin Source: MGI
  • cellular response to hypoxia Source: Ensembl
  • cellular response to interleukin-1 Source: Ensembl
  • cellular response to prostaglandin E stimulus Source: Ensembl
  • cellular response to starvation Source: Ensembl
  • cellular response to transforming growth factor beta stimulus Source: Ensembl
  • cellular response to tumor necrosis factor Source: MGI
  • cellular response to vitamin D Source: Ensembl
  • cellular response to X-ray Source: UniProtKB
  • convergent extension involved in somitogenesis Source: MGI
  • development of primary male sexual characteristics Source: MGI
  • digestive tract morphogenesis Source: MGI
  • dorsal/ventral axis specification Source: MGI
  • female gonad development Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • hematopoietic stem cell differentiation Source: MGI
  • hemopoiesis Source: MGI
  • male gonad development Source: MGI
  • negative regulation of androgen receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of B cell differentiation Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of bone remodeling Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of epithelial to mesenchymal transition Source: MGI
  • negative regulation of fibroblast apoptotic process Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of insulin secretion Source: MGI
  • negative regulation of JUN kinase activity Source: MGI
  • negative regulation of ossification Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of osteoblast proliferation Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
  • neural crest cell fate commitment Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • osteoblast differentiation Source: Ensembl
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell growth Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of fibroblast apoptotic process Source: MGI
  • positive regulation of non-canonical Wnt signaling pathway Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  • proteolysis Source: MGI
  • regulation of branching involved in prostate gland morphogenesis Source: MGI
  • regulation of cell cycle process Source: MGI
  • regulation of establishment of planar polarity Source: MGI
  • response to drug Source: UniProtKB
  • response to organic cyclic compound Source: MGI
  • somatic stem cell maintenance Source: MGI
  • somitogenesis Source: BHF-UCL
  • stromal-epithelial cell signaling involved in prostate gland development Source: UniProtKB
  • substrate adhesion-dependent cell spreading Source: MGI
  • ureteric bud development Source: UniProtKB
  • Wnt signaling pathway, planar cell polarity pathway Source: MGI
  • Wnt signaling pathway involved in somitogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_305098. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 1
Short name:
sFRP-1
Gene namesi
Name:Sfrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:892014. Sfrp1.

Subcellular locationi

  • Secreted By similarity

  • Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 314283Secreted frizzled-related protein 1PRO_0000032539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 121By similarity
Disulfide bondi68 ↔ 114By similarity
Disulfide bondi105 ↔ 140By similarity
Disulfide bondi129 ↔ 166By similarity
Disulfide bondi133 ↔ 157By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)By similarity
Disulfide bondi186 ↔ 256By similarity
Disulfide bondi189 ↔ 258By similarity
Disulfide bondi203 ↔ 306By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8C4U3.
PRIDEiQ8C4U3.

PTM databases

PhosphoSiteiQ8C4U3.

Expressioni

Tissue specificityi

Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus.1 Publication

Developmental stagei

In the developing kidney expressed at 13.5 dpc in the periphery of the metanophros and surrounding the uretic and nephrogenic tubules. At 14.5 dpc, expression decreases in the outer cortical cells and becomes visible in the tubular parts of the nephron. From 15.5 dpc, highly expressed in the future loops of Henle. In the developing CNS, expression located to the forebrain and hindbrain. At 8.0 dpc, expressed in the future forebrain and in the ventral portion of the presumptive hindbrain. At 8.5 dpc, expression is maintained in these tissues with a strong signal in rhombomere 4. Until 11.5 dpc, expression continues in the hindbrain with additional expression at 9.5 dpc and 10.5 dpc, in the nasal and epibranchial placodes. In the forbrain, initial expression is found in the proencephalon of the forebrain, and then strong expression in the telencephalic vesicle up to 15.5 dpc. Expression is then found in specific cell populations throughout the brain. In the developing eye, expression, by 10.5 dpc, is confined to ectodermal cells overlying the dorsal part of the optic cup. In later stages, expression limited to the lens fiber cells and the future pigmented retina. By 15.5 dpc, expression is confined to the anterior part of the lens. During limb development, barely expressed until later stages, when it is found in the distal part of the separating phalanges. In other developing structures, expressed in nasal placodes at 9.5 dpc, in medial nasal processes at E10.5 and then in the anterior portion of the invaginating olfactory epithelium. At 15.5 dpc, expressed on the basal side of the nasal epithelium. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. As well, expressed in the ventral body wall, in the mesenchyme derived adrenal cortex, the cochlear epithelium and the branching epithelium of the salivary gland. In the developing heart, weakly expressed from 8.5 dpc in the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5 dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in the common ventricular and atrial chamber of the developing heart, in the aortic sac and in the sinus venosus. High expression found from 11.5 dpc-12.5 dpc, in the trabeculated wall of the ventricular chamber together with the wall of the atrial chamber. Expression also found in the muscular part of the interventricular septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac confined to the inner lining endothelial cell layer. Expression in the developing heart decreases after 14.5 dpc.2 Publications

Gene expression databases

BgeeiQ8C4U3.
CleanExiMM_SFRP1.
GenevisibleiQ8C4U3. MM.

Interactioni

Subunit structurei

Interacts with WNT8, WNT1, WNT2, WNT4 and FRZD6 (By similarity). Interacts with MYOC.By similarity2 Publications

Protein-protein interaction databases

BioGridi203185. 7 interactions.
STRINGi10090.ENSMUSP00000033952.

Structurei

3D structure databases

ProteinModelPortaliQ8C4U3.
SMRiQ8C4U3. Positions 63-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 169117FZPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 306121NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ8C4U3.
KOiK02166.
OMAiDDVCIAM.
OrthoDBiEOG789CBZ.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C4U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVGRSARGR GGAASGVLLA LAAALLAAGS ASEYDYVSFQ SDIGSYQSGR
60 70 80 90 100
FYTKPPQCVD IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL
110 120 130 140 150
LNKNCHMGTQ VFLCSLFAPV CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY
160 170 180 190 200
WPEMLKCDKF PEGDVCIAMT PPNTTEASKP QGTTVCPPCD NELKSEAIIE
210 220 230 240 250
HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK KELKRLVLFL
260 270 280 290 300
KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR
310
MKNHECPTFQ SVFK
Length:314
Mass (Da):35,413
Last modified:July 27, 2011 - v3
Checksum:i3D98A15127DFA421
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281A → S in AAH24495 (PubMed:15489334).Curated
Sequence conflicti245 – 2451R → A in AAC53145 (PubMed:9096311).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88566 mRNA. Translation: AAC53145.1.
BC024495 mRNA. Translation: AAH24495.1.
BC094662 mRNA. Translation: AAH94662.1.
AK081052 mRNA. Translation: BAC38123.1.
CCDSiCCDS22191.1.
RefSeqiNP_038862.2. NM_013834.3.
XP_011240430.1. XM_011242128.1.
UniGeneiMm.281691.

Genome annotation databases

EnsembliENSMUST00000033952; ENSMUSP00000033952; ENSMUSG00000031548.
GeneIDi20377.
KEGGimmu:20377.
UCSCiuc009lev.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88566 mRNA. Translation: AAC53145.1.
BC024495 mRNA. Translation: AAH24495.1.
BC094662 mRNA. Translation: AAH94662.1.
AK081052 mRNA. Translation: BAC38123.1.
CCDSiCCDS22191.1.
RefSeqiNP_038862.2. NM_013834.3.
XP_011240430.1. XM_011242128.1.
UniGeneiMm.281691.

3D structure databases

ProteinModelPortaliQ8C4U3.
SMRiQ8C4U3. Positions 63-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203185. 7 interactions.
STRINGi10090.ENSMUSP00000033952.

Chemistry

ChEMBLiCHEMBL1075304.

Protein family/group databases

MEROPSiI93.001.

PTM databases

PhosphoSiteiQ8C4U3.

Proteomic databases

MaxQBiQ8C4U3.
PRIDEiQ8C4U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033952; ENSMUSP00000033952; ENSMUSG00000031548.
GeneIDi20377.
KEGGimmu:20377.
UCSCiuc009lev.2. mouse.

Organism-specific databases

CTDi6422.
MGIiMGI:892014. Sfrp1.

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ8C4U3.
KOiK02166.
OMAiDDVCIAM.
OrthoDBiEOG789CBZ.
TreeFamiTF350133.

Enzyme and pathway databases

ReactomeiREACT_305098. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

ChiTaRSiSfrp1. mouse.
NextBioi298286.
PROiQ8C4U3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C4U3.
CleanExiMM_SFRP1.
GenevisibleiQ8C4U3. MM.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors."
    Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Embryonic eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Colon.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314.
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. "Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family."
    Leimeister C., Bach A., Gessler M.
    Mech. Dev. 75:29-42(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. "Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis."
    Jaspard B., Couffinhal T., Dufourcq P., Moreau C., Duplaa C.
    Mech. Dev. 90:263-267(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WNT8, DEVELOPMENTAL STAGE.
  6. "FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo."
    Ezan J., Leroux L., Barandon L., Dufourcq P., Jaspard B., Moreau C., Allieres C., Daret D., Couffinhal T., Duplaa C.
    Cardiovasc. Res. 63:731-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN ANGIOGENIC FACTOR.
  7. Cited for: INTERACTION WITH MYOC.

Entry informationi

Entry nameiSFRP1_MOUSE
AccessioniPrimary (citable) accession number: Q8C4U3
Secondary accession number(s): O08861, Q505A2, Q8R1J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.