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Protein

Axin interactor, dorsalization-associated protein

Gene

Aida

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ventralizing factor during embryogenesis (By similarity). Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.By similarity1 Publication

GO - Molecular functioni

  • phosphatidylinositol binding Source: GO_Central
  • protein domain specific binding Source: MGI

GO - Biological processi

  • determination of ventral identity Source: MGI
  • dorsal/ventral pattern formation Source: UniProtKB
  • negative regulation of determination of dorsal identity Source: MGI
  • negative regulation of JNK cascade Source: UniProtKB
  • negative regulation of JUN kinase activity Source: MGI
  • regulation of protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Axin interactor, dorsalization-associated protein
Alternative name(s):
Axin interaction partner and dorsalization antagonist
Gene namesi
Name:Aida
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919737. Aida.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052791 – 305Axin interactor, dorsalization-associated proteinAdd BLAST305

Proteomic databases

EPDiQ8C4Q6.
PaxDbiQ8C4Q6.
PeptideAtlasiQ8C4Q6.
PRIDEiQ8C4Q6.

2D gel databases

REPRODUCTION-2DPAGEQ8C4Q6.

PTM databases

iPTMnetiQ8C4Q6.
PhosphoSitePlusiQ8C4Q6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042901.
ExpressionAtlasiQ8C4Q6. baseline and differential.
GenevisibleiQ8C4Q6. MM.

Interactioni

Subunit structurei

Interacts with AXIN1.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: MGI

Protein-protein interaction databases

IntActiQ8C4Q6. 1 interactor.

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 25Combined sources22
Helixi28 – 46Combined sources19
Beta strandi49 – 51Combined sources3
Helixi57 – 78Combined sources22
Helixi89 – 92Combined sources4
Helixi94 – 99Combined sources6
Turni100 – 103Combined sources4
Beta strandi167 – 176Combined sources10
Helixi180 – 182Combined sources3
Beta strandi184 – 193Combined sources10
Beta strandi199 – 201Combined sources3
Beta strandi210 – 213Combined sources4
Beta strandi216 – 224Combined sources9
Helixi229 – 231Combined sources3
Beta strandi237 – 246Combined sources10
Turni247 – 250Combined sources4
Beta strandi251 – 261Combined sources11
Helixi262 – 264Combined sources3
Beta strandi267 – 272Combined sources6
Beta strandi275 – 278Combined sources4
Beta strandi291 – 293Combined sources3
Beta strandi296 – 303Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG7NMR-A1-115[»]
2QZ5X-ray2.60A/B151-305[»]
ProteinModelPortaliQ8C4Q6.
SMRiQ8C4Q6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8C4Q6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 220Axin-bindingAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 62Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the AIDA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ07. Eukaryota.
ENOG410YXX7. LUCA.
GeneTreeiENSGT00390000016465.
HOVERGENiHBG057354.
InParanoidiQ8C4Q6.
OMAiATCLEMR.
OrthoDBiEOG091G0GXU.
PhylomeDBiQ8C4Q6.
TreeFamiTF328541.

Family and domain databases

Gene3Di1.20.120.360. 1 hit.
InterProiIPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view]
PfamiPF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view]
SUPFAMiSSF109779. SSF109779. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C4Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVTRSLLQ RWGASLRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH
60 70 80 90 100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN
110 120 130 140 150
ILTYNKEFPF DVQPIPLRRI LAPGEEENLE FEEDEEGGAG AGPPDSFSAR
160 170 180 190 200
VPGTLLPRLP SEPGMTLLTI RIEKIGLKDA GQCIDPYITV SVKDLNGIDL
210 220 230 240 250
TPVQDTPVAS RKEDTYVHFN VDIELQKHVE RLTKGAAIFF EFKHYKPKKR
260 270 280 290 300
FTSTKCFAFM EMDEIKPGPI VIELYKKPTD FKRKKLQLLT KKPLYLHLHQ

SLHKE
Length:305
Mass (Da):34,888
Last modified:March 1, 2003 - v1
Checksum:iA285C564AF5333D0
GO
Isoform 2 (identifier: Q8C4Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-234: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):25,750
Checksum:iF80B8D98D3B0A126
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138G → V in AAH66829 (PubMed:15489334).Curated1
Sequence conflicti171R → K in BAE31624 (PubMed:16141072).Curated1
Sequence conflicti231R → K in BAE34358 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028323153 – 234Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027971 mRNA. Translation: BAC25682.1.
AK081494 mRNA. Translation: BAC38234.1.
AK143716 mRNA. Translation: BAE25512.1.
AK149788 mRNA. Translation: BAE29085.1.
AK150639 mRNA. Translation: BAE29727.1.
AK150702 mRNA. Translation: BAE29781.1.
AK152961 mRNA. Translation: BAE31624.1.
AK153448 mRNA. Translation: BAE32003.1.
AK159318 mRNA. Translation: BAE34985.1.
AK167520 mRNA. Translation: BAE39592.1.
AK172451 mRNA. Translation: BAE43012.1.
AK158103 mRNA. Translation: BAE34358.1.
BC057183 mRNA. Translation: AAH57183.1.
BC066829 mRNA. Translation: AAH66829.1.
BC086763 mRNA. Translation: AAH86763.1.
CCDSiCCDS56663.1. [Q8C4Q6-1]
RefSeqiNP_859421.1. NM_181732.4. [Q8C4Q6-1]
UniGeneiMm.290502.

Genome annotation databases

EnsembliENSMUST00000109166; ENSMUSP00000104795; ENSMUSG00000042901. [Q8C4Q6-1]
ENSMUST00000193625; ENSMUSP00000141649; ENSMUSG00000042901. [Q8C4Q6-2]
GeneIDi108909.
KEGGimmu:108909.
UCSCiuc008icu.2. mouse. [Q8C4Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027971 mRNA. Translation: BAC25682.1.
AK081494 mRNA. Translation: BAC38234.1.
AK143716 mRNA. Translation: BAE25512.1.
AK149788 mRNA. Translation: BAE29085.1.
AK150639 mRNA. Translation: BAE29727.1.
AK150702 mRNA. Translation: BAE29781.1.
AK152961 mRNA. Translation: BAE31624.1.
AK153448 mRNA. Translation: BAE32003.1.
AK159318 mRNA. Translation: BAE34985.1.
AK167520 mRNA. Translation: BAE39592.1.
AK172451 mRNA. Translation: BAE43012.1.
AK158103 mRNA. Translation: BAE34358.1.
BC057183 mRNA. Translation: AAH57183.1.
BC066829 mRNA. Translation: AAH66829.1.
BC086763 mRNA. Translation: AAH86763.1.
CCDSiCCDS56663.1. [Q8C4Q6-1]
RefSeqiNP_859421.1. NM_181732.4. [Q8C4Q6-1]
UniGeneiMm.290502.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG7NMR-A1-115[»]
2QZ5X-ray2.60A/B151-305[»]
ProteinModelPortaliQ8C4Q6.
SMRiQ8C4Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C4Q6. 1 interactor.

PTM databases

iPTMnetiQ8C4Q6.
PhosphoSitePlusiQ8C4Q6.

2D gel databases

REPRODUCTION-2DPAGEQ8C4Q6.

Proteomic databases

EPDiQ8C4Q6.
PaxDbiQ8C4Q6.
PeptideAtlasiQ8C4Q6.
PRIDEiQ8C4Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109166; ENSMUSP00000104795; ENSMUSG00000042901. [Q8C4Q6-1]
ENSMUST00000193625; ENSMUSP00000141649; ENSMUSG00000042901. [Q8C4Q6-2]
GeneIDi108909.
KEGGimmu:108909.
UCSCiuc008icu.2. mouse. [Q8C4Q6-1]

Organism-specific databases

CTDi64853.
MGIiMGI:1919737. Aida.

Phylogenomic databases

eggNOGiENOG410IJ07. Eukaryota.
ENOG410YXX7. LUCA.
GeneTreeiENSGT00390000016465.
HOVERGENiHBG057354.
InParanoidiQ8C4Q6.
OMAiATCLEMR.
OrthoDBiEOG091G0GXU.
PhylomeDBiQ8C4Q6.
TreeFamiTF328541.

Miscellaneous databases

ChiTaRSiAida. mouse.
EvolutionaryTraceiQ8C4Q6.
PROiQ8C4Q6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042901.
ExpressionAtlasiQ8C4Q6. baseline and differential.
GenevisibleiQ8C4Q6. MM.

Family and domain databases

Gene3Di1.20.120.360. 1 hit.
InterProiIPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view]
PfamiPF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view]
SUPFAMiSSF109779. SSF109779. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAIDA_MOUSE
AccessioniPrimary (citable) accession number: Q8C4Q6
Secondary accession number(s): Q3U6V0
, Q3UP85, Q6NXY2, Q6PG77, Q78W09, Q99K80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.