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Protein

Transducin beta-like protein 3

Gene

Tbl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 3
Gene namesi
Name:Tbl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384863 Tbl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003629802 – 801Transducin beta-like protein 3Add BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei257PhosphoserineBy similarity1
Cross-linki407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C4J7
MaxQBiQ8C4J7
PaxDbiQ8C4J7
PeptideAtlasiQ8C4J7
PRIDEiQ8C4J7

PTM databases

iPTMnetiQ8C4J7
PhosphoSitePlusiQ8C4J7
SwissPalmiQ8C4J7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040688
ExpressionAtlasiQ8C4J7 baseline and differential
GenevisibleiQ8C4J7 MM

Interactioni

Protein-protein interaction databases

BioGridi229469, 4 interactors
IntActiQ8C4J7, 1 interactor
MINTiQ8C4J7
STRINGi10090.ENSMUSP00000120911

Structurei

3D structure databases

ProteinModelPortaliQ8C4J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 105WD 1Add BLAST42
Repeati107 – 146WD 2Add BLAST40
Repeati149 – 190WD 3Add BLAST42
Repeati193 – 232WD 4Add BLAST40
Repeati245 – 284WD 5Add BLAST40
Repeati290 – 329WD 6Add BLAST40
Repeati332 – 372WD 7Add BLAST41
Repeati374 – 413WD 8Add BLAST40
Repeati419 – 459WD 9Add BLAST41
Repeati477 – 516WD 10Add BLAST40
Repeati519 – 560WD 11Add BLAST42
Repeati562 – 602WD 12Add BLAST41
Repeati604 – 642WD 13Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0319 Eukaryota
ENOG410XPQD LUCA
GeneTreeiENSGT00910000144102
HOGENOMiHOG000188765
HOVERGENiHBG058869
InParanoidiQ8C4J7
KOiK14555
OMAiDFLWHNM
OrthoDBiEOG091G029V
PhylomeDBiQ8C4J7
TreeFamiTF314872

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013934 SSU_processome_Utp13
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08625 Utp13, 1 hit
PF00400 WD40, 9 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 13 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 9 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C4J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGHYLF CVCGTKVNIL
60 70 80 90 100
DVASGALLRS LEQEDQEDIT SFDLSPDDEV LVTASRALLL AQWAWREGTV
110 120 130 140 150
TRLWKAIHTA PVASMAFDAT STLLATGGCD GAVRVWDIVQ HYGTHHFRGS
160 170 180 190 200
PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW SLQDRSCLAV LTAHYSAVTS
210 220 230 240 250
LSFSEGGHTM LSSGRDKICI VWDLQSYQTT RTVPVFESVE ASVLLPEQPA
260 270 280 290 300
PALGVKSSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMPG LRQELTHCTL
310 320 330 340 350
ARAADLLLTV TADHNLLLYE AHSLQLQKQF AGYSEEVLDV RFLGPSDSHI
360 370 380 390 400
VVASNSPCLK VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI
410 420 430 440 450
RIWKMNKAGQ VACVAQGSGH THSVGTICCS RLKESFLVTG SQDCTVKLWP
460 470 480 490 500
LPEALLAKST AADSGPVLLQ AQTTRRCHDK DINSLAVSPN DKLLATGSQD
510 520 530 540 550
RTAKLWALPQ CQLLGVFTGH RRGLWNVQFS PTDQVLATAS ADGTIKLWAL
560 570 580 590 600
QDFSCLKTFE GHDASVLKVA FVSRGSQLLS SGSDGLLKLW TIKSNECVRT
610 620 630 640 650
LDAHEDKVWG LHCSQLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ
660 670 680 690 700
VIKQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE
710 720 730 740 750
ATVLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR HEAPEELLAY
760 770 780 790 800
DGVRGSLEAL LPYTERHFQR LSRTLQAATF LDFLWHNMKL SPCPAAAPPA

L
Length:801
Mass (Da):88,266
Last modified:March 1, 2003 - v1
Checksum:i1B5AEE0CCB3D1B3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18E → G in BAE29182 (PubMed:16141072).Curated1
Sequence conflicti457A → AN in AAH19504 (PubMed:15489334).Curated1
Sequence conflicti475R → Q in AAH19504 (PubMed:15489334).Curated1
Sequence conflicti483N → K in BAE38045 (PubMed:16141072).Curated1
Sequence conflicti797A → V in AAH19504 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081966 mRNA Translation: BAC38381.1
AK137554 mRNA Translation: BAE23405.1
AK149940 mRNA Translation: BAE29182.1
AK165125 mRNA Translation: BAE38045.1
BC019504 mRNA Translation: AAH19504.1
CCDSiCCDS28493.1
RefSeqiNP_663371.2, NM_145396.4
UniGeneiMm.100353

Genome annotation databases

EnsembliENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688
GeneIDi213773
KEGGimmu:213773
UCSCiuc008axv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBL3_MOUSE
AccessioniPrimary (citable) accession number: Q8C4J7
Secondary accession number(s): Q3TNP3, Q3UDS9, Q8VE90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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