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Protein

Transducin beta-like protein 3

Gene

Tbl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 3
Gene namesi
Name:Tbl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384863. Tbl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003629802 – 801Transducin beta-like protein 3Add BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei257PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8C4J7.
MaxQBiQ8C4J7.
PaxDbiQ8C4J7.
PeptideAtlasiQ8C4J7.
PRIDEiQ8C4J7.

PTM databases

iPTMnetiQ8C4J7.
PhosphoSitePlusiQ8C4J7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040688.
ExpressionAtlasiQ8C4J7. baseline and differential.
GenevisibleiQ8C4J7. MM.

Interactioni

Protein-protein interaction databases

BioGridi229469. 2 interactors.
IntActiQ8C4J7. 1 interactor.
MINTiMINT-4114331.
STRINGi10090.ENSMUSP00000120911.

Structurei

3D structure databases

ProteinModelPortaliQ8C4J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 105WD 1Add BLAST42
Repeati107 – 146WD 2Add BLAST40
Repeati149 – 190WD 3Add BLAST42
Repeati193 – 232WD 4Add BLAST40
Repeati245 – 284WD 5Add BLAST40
Repeati290 – 329WD 6Add BLAST40
Repeati332 – 372WD 7Add BLAST41
Repeati374 – 413WD 8Add BLAST40
Repeati419 – 459WD 9Add BLAST41
Repeati477 – 516WD 10Add BLAST40
Repeati519 – 560WD 11Add BLAST42
Repeati562 – 602WD 12Add BLAST41
Repeati604 – 642WD 13Add BLAST39

Sequence similaritiesi

Contains 13 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0319. Eukaryota.
ENOG410XPQD. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
HOVERGENiHBG058869.
InParanoidiQ8C4J7.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG091G029V.
PhylomeDBiQ8C4J7.
TreeFamiTF314872.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C4J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGHYLF CVCGTKVNIL
60 70 80 90 100
DVASGALLRS LEQEDQEDIT SFDLSPDDEV LVTASRALLL AQWAWREGTV
110 120 130 140 150
TRLWKAIHTA PVASMAFDAT STLLATGGCD GAVRVWDIVQ HYGTHHFRGS
160 170 180 190 200
PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW SLQDRSCLAV LTAHYSAVTS
210 220 230 240 250
LSFSEGGHTM LSSGRDKICI VWDLQSYQTT RTVPVFESVE ASVLLPEQPA
260 270 280 290 300
PALGVKSSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMPG LRQELTHCTL
310 320 330 340 350
ARAADLLLTV TADHNLLLYE AHSLQLQKQF AGYSEEVLDV RFLGPSDSHI
360 370 380 390 400
VVASNSPCLK VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI
410 420 430 440 450
RIWKMNKAGQ VACVAQGSGH THSVGTICCS RLKESFLVTG SQDCTVKLWP
460 470 480 490 500
LPEALLAKST AADSGPVLLQ AQTTRRCHDK DINSLAVSPN DKLLATGSQD
510 520 530 540 550
RTAKLWALPQ CQLLGVFTGH RRGLWNVQFS PTDQVLATAS ADGTIKLWAL
560 570 580 590 600
QDFSCLKTFE GHDASVLKVA FVSRGSQLLS SGSDGLLKLW TIKSNECVRT
610 620 630 640 650
LDAHEDKVWG LHCSQLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ
660 670 680 690 700
VIKQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE
710 720 730 740 750
ATVLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR HEAPEELLAY
760 770 780 790 800
DGVRGSLEAL LPYTERHFQR LSRTLQAATF LDFLWHNMKL SPCPAAAPPA

L
Length:801
Mass (Da):88,266
Last modified:March 1, 2003 - v1
Checksum:i1B5AEE0CCB3D1B3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18E → G in BAE29182 (PubMed:16141072).Curated1
Sequence conflicti457A → AN in AAH19504 (PubMed:15489334).Curated1
Sequence conflicti475R → Q in AAH19504 (PubMed:15489334).Curated1
Sequence conflicti483N → K in BAE38045 (PubMed:16141072).Curated1
Sequence conflicti797A → V in AAH19504 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081966 mRNA. Translation: BAC38381.1.
AK137554 mRNA. Translation: BAE23405.1.
AK149940 mRNA. Translation: BAE29182.1.
AK165125 mRNA. Translation: BAE38045.1.
BC019504 mRNA. Translation: AAH19504.1.
CCDSiCCDS28493.1.
RefSeqiNP_663371.2. NM_145396.4.
UniGeneiMm.100353.

Genome annotation databases

EnsembliENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688.
GeneIDi213773.
KEGGimmu:213773.
UCSCiuc008axv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081966 mRNA. Translation: BAC38381.1.
AK137554 mRNA. Translation: BAE23405.1.
AK149940 mRNA. Translation: BAE29182.1.
AK165125 mRNA. Translation: BAE38045.1.
BC019504 mRNA. Translation: AAH19504.1.
CCDSiCCDS28493.1.
RefSeqiNP_663371.2. NM_145396.4.
UniGeneiMm.100353.

3D structure databases

ProteinModelPortaliQ8C4J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229469. 2 interactors.
IntActiQ8C4J7. 1 interactor.
MINTiMINT-4114331.
STRINGi10090.ENSMUSP00000120911.

PTM databases

iPTMnetiQ8C4J7.
PhosphoSitePlusiQ8C4J7.

Proteomic databases

EPDiQ8C4J7.
MaxQBiQ8C4J7.
PaxDbiQ8C4J7.
PeptideAtlasiQ8C4J7.
PRIDEiQ8C4J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688.
GeneIDi213773.
KEGGimmu:213773.
UCSCiuc008axv.1. mouse.

Organism-specific databases

CTDi10607.
MGIiMGI:2384863. Tbl3.

Phylogenomic databases

eggNOGiKOG0319. Eukaryota.
ENOG410XPQD. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
HOVERGENiHBG058869.
InParanoidiQ8C4J7.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG091G029V.
PhylomeDBiQ8C4J7.
TreeFamiTF314872.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ8C4J7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040688.
ExpressionAtlasiQ8C4J7. baseline and differential.
GenevisibleiQ8C4J7. MM.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBL3_MOUSE
AccessioniPrimary (citable) accession number: Q8C4J7
Secondary accession number(s): Q3TNP3, Q3UDS9, Q8VE90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.