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Protein

Protein unc-119 homolog B

Gene

Unc119b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei142LipidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-5624138. Trafficking of myristoylated proteins to the cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-119 homolog B
Gene namesi
Name:Unc119b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2147162. Unc119b.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003372292 – 251Protein unc-119 homolog BAdd BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei24N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8C4B4.
PaxDbiQ8C4B4.
PeptideAtlasiQ8C4B4.
PRIDEiQ8C4B4.

PTM databases

iPTMnetiQ8C4B4.
PhosphoSitePlusiQ8C4B4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046562.
GenevisibleiQ8C4B4. MM.

Interactioni

Subunit structurei

Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8C4B4. 1 interactor.
STRINGi10090.ENSMUSP00000055475.

Structurei

3D structure databases

ProteinModelPortaliQ8C4B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the PDE6D/unc-119 family.Curated

Phylogenomic databases

eggNOGiKOG4037. Eukaryota.
ENOG410YJ3E. LUCA.
GeneTreeiENSGT00390000014595.
HOGENOMiHOG000258286.
HOVERGENiHBG108625.
InParanoidiQ8C4B4.
OMAiDYLCKPE.
OrthoDBiEOG091G0J2K.
PhylomeDBiQ8C4B4.
TreeFamiTF314474.

Family and domain databases

Gene3Di2.70.50.40. 1 hit.
InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR008015. PDED_dom.
IPR037036. PDED_dom_sf.
PfamiView protein in Pfam
PF05351. GMP_PDE_delta. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C4B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSNPKAAT AGSQAGPGGL VAGKEEKKKA GGGVLNRLKA RRQGPPHTPD
60 70 80 90 100
DGSGAAVTEQ ELLALDTIRP EHVLRLNRVT ENYLCKPEDN VYSIDFTRFK
110 120 130 140 150
IRDLETGTVL FEIAKPCISD QDQDAEEESV DVDISVGRFV RYQFTPAFLR
160 170 180 190 200
LRTVGATVEF TVGDRPVTGF RMIERHYFRE RLLKTFDFDF GFCIPSSRNT
210 220 230 240 250
CEHIYEFPQL SEDVIRLMIE NPYETRSDSF YFVDNKLVMH NKADYAYNGG

Q
Length:251
Mass (Da):28,303
Last modified:March 1, 2003 - v1
Checksum:iAC86FFAA553028A2
GO
Isoform 2 (identifier: Q8C4B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-251: DQDQDAEEES...KADYAYNGGQ → GGPGYCGHKP...REYVAGTSVH

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):23,600
Checksum:iBF398298B2879019
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → K in AAI15530 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033985120 – 251DQDQD…YNGGQ → GGPGYCGHKPGRKGPWEAQS FWDAGVCHFHDYFLSACLPV AHQFRALLKGWCVCVCVFEC LCVPECTRWRPGDNFVESGF CFHICGGSREYVAGTSVH in isoform 2. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045128 mRNA. Translation: BAC32235.1.
AK082614 mRNA. Translation: BAC38549.1.
BC008617 mRNA. Translation: AAH08617.1.
BC112388 mRNA. Translation: AAI12389.1.
BC115529 mRNA. Translation: AAI15530.1.
CCDSiCCDS19580.1. [Q8C4B4-1]
RefSeqiNP_780561.1. NM_175352.4. [Q8C4B4-1]
UniGeneiMm.29241.

Genome annotation databases

EnsembliENSMUST00000060798; ENSMUSP00000055475; ENSMUSG00000046562. [Q8C4B4-1]
GeneIDi106840.
KEGGimmu:106840.
UCSCiuc008zdc.1. mouse. [Q8C4B4-1]
uc008zdd.1. mouse. [Q8C4B4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiU119B_MOUSE
AccessioniPrimary (citable) accession number: Q8C4B4
Secondary accession number(s): Q14BY8, Q8BRC4, Q922B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families