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Protein

Aquaporin-6

Gene

Aqp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • odontogenesis Source: Ensembl
  • water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-6
Short name:
AQP-6
Gene namesi
Name:Aqp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1341204. Aqp6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 45HelicalSequence analysisAdd BLAST18
Topological domaini46 – 51ExtracellularSequence analysis6
Transmembranei52 – 70HelicalSequence analysisAdd BLAST19
Topological domaini71 – 96CytoplasmicSequence analysisAdd BLAST26
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Topological domaini119 – 138ExtracellularSequence analysisAdd BLAST20
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 165CytoplasmicSequence analysis6
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 211ExtracellularSequence analysisAdd BLAST26
Transmembranei212 – 233HelicalSequence analysisAdd BLAST22
Topological domaini234 – 293CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • apical plasma membrane Source: GO_Central
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639561 – 293Aquaporin-6Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C4A0.
PRIDEiQ8C4A0.

PTM databases

PhosphoSitePlusiQ8C4A0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043144.
CleanExiMM_AQP6.
GenevisibleiQ8C4A0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023754.

Structurei

3D structure databases

ProteinModelPortaliQ8C4A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 81NPA 13
Motifi193 – 195NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ8C4A0.
KOiK09868.
OMAiNSEDTEC.
OrthoDBiEOG091G166T.
PhylomeDBiQ8C4A0.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023254. Aquaporin_6.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02018. AQUAPORIN6.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C4A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLCSRAY LLVGGLWTAI SKALFAEFLA TGLYVFFGVG SVLPWPVALP
60 70 80 90 100
SVLQIAITFN LATATAVQIS WKTSGAHANP AVTLAYLVGS HISLPRAMAY
110 120 130 140 150
IAAQLAGATA GAALLYGVTP GGIRETLGVN VVHNSTSTGQ AVAVELVLTL
160 170 180 190 200
QLVLCVFASM DGRQTLASPA AMIGTSVALG HLIGIYFTGC SMNPARSFGP
210 220 230 240 250
AVIVGKFAVH WIFWVGPLTG AVLASLIYNF ILFPDTKTVA QRLAILVGTT
260 270 280 290
KVEKVVDLEP QKKESQTNSE DTECLTSPCE EAVRSFSFTL GLC
Length:293
Mass (Da):30,709
Last modified:March 1, 2003 - v1
Checksum:iA48282992451ECEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082699 mRNA. Translation: BAC38576.1.
CCDSiCCDS27824.1.
RefSeqiNP_780296.1. NM_175087.4.
UniGeneiMm.202309.

Genome annotation databases

EnsembliENSMUST00000023754; ENSMUSP00000023754; ENSMUSG00000043144.
GeneIDi11831.
KEGGimmu:11831.
UCSCiuc007xpw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082699 mRNA. Translation: BAC38576.1.
CCDSiCCDS27824.1.
RefSeqiNP_780296.1. NM_175087.4.
UniGeneiMm.202309.

3D structure databases

ProteinModelPortaliQ8C4A0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023754.

PTM databases

PhosphoSitePlusiQ8C4A0.

Proteomic databases

PaxDbiQ8C4A0.
PRIDEiQ8C4A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023754; ENSMUSP00000023754; ENSMUSG00000043144.
GeneIDi11831.
KEGGimmu:11831.
UCSCiuc007xpw.1. mouse.

Organism-specific databases

CTDi363.
MGIiMGI:1341204. Aqp6.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ8C4A0.
KOiK09868.
OMAiNSEDTEC.
OrthoDBiEOG091G166T.
PhylomeDBiQ8C4A0.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiQ8C4A0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043144.
CleanExiMM_AQP6.
GenevisibleiQ8C4A0. MM.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023254. Aquaporin_6.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02018. AQUAPORIN6.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP6_MOUSE
AccessioniPrimary (citable) accession number: Q8C4A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.