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Protein

PEX5-related protein

Gene

Pex5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PEX5-related protein
Alternative name(s):
PEX2-related protein
PEX5-like protein
Peroxin-5-related protein
Tetratricopeptide repeat-containing Rab8b-interacting protein
Short name:
Pex5Rp
Short name:
TRIP8b
Gene namesi
Name:Pex5l
Synonyms:Pex2, Pex5r, Pxr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916672. Pex5l.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GO_Central
  • dendrite Source: MGI
  • peroxisomal membrane Source: GO_Central
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063181 – 567PEX5-related proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1
Modified residuei194PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C437.
PRIDEiQ8C437.

PTM databases

iPTMnetiQ8C437.
PhosphoSitePlusiQ8C437.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027674.
CleanExiMM_PEX2.
MM_PEX5L.
ExpressionAtlasiQ8C437. baseline and differential.
GenevisibleiQ8C437. MM.

Interactioni

Subunit structurei

Interacts with RAB8B (By similarity). Forms an obligate 4:4 complex with HCN2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208454. 2 interactors.
IntActiQ8C437. 1 interactor.
MINTiMINT-4997685.
STRINGi10090.ENSMUSP00000077353.

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni263 – 266Combined sources4
Helixi270 – 280Combined sources11
Helixi283 – 296Combined sources14
Helixi301 – 313Combined sources13
Helixi317 – 330Combined sources14
Helixi335 – 347Combined sources13
Helixi351 – 364Combined sources14
Helixi366 – 369Combined sources4
Helixi393 – 408Combined sources16
Helixi415 – 428Combined sources14
Helixi431 – 444Combined sources14
Helixi449 – 461Combined sources13
Helixi465 – 478Combined sources14
Helixi483 – 496Combined sources14
Helixi500 – 514Combined sources15
Helixi530 – 542Combined sources13
Helixi545 – 552Combined sources8
Helixi557 – 559Combined sources3
Turni560 – 564Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EQFX-ray3.00A206-567[»]
ProteinModelPortaliQ8C437.
SMRiQ8C437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati267 – 300TPR 1Add BLAST34
Repeati301 – 334TPR 2Add BLAST34
Repeati336 – 368TPR 3Add BLAST33
Repeati415 – 448TPR 4Add BLAST34
Repeati450 – 482TPR 5Add BLAST33
Repeati484 – 516TPR 6Add BLAST33

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ8C437.
KOiK13342.
PhylomeDBiQ8C437.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C437-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQGHMQLVN EQQESRPLLS PSIDDFLCET KSEAIAKPVT SNTAVLTTGL
60 70 80 90 100
DLLDLSEPVS QPQTKAKKSE PSSKSSSLKK KADGSDLISA DAEQRAQALR
110 120 130 140 150
GPETSSLDLD IQTQLEKWDD VKFHGDRTSK GHLMAERKSC SSRTGSKELL
160 170 180 190 200
WSAEHRSQPE LSTGKSALNS ESASELELVA PAQARLTKEH RWGSALLSRN
210 220 230 240 250
HSLEEEFERA KAAVESDTEF WDKMQAEWEE MARRNWISEN QEAQNQVTVS
260 270 280 290 300
ASEKGYYFHT ENPFKDWPGA FEEGLKRLKE GDLPVTILFM EAAILQDPGD
310 320 330 340 350
AEAWQFLGIT QAENENEQAA IVALQRCLEL QPNNLKALMA LAVSYTNTSH
360 370 380 390 400
QQDACEALKN WIKQNPKYKY LVKNKKGSPG LTRRMSKSPV DSSVLEGVKE
410 420 430 440 450
LYLEAAHQNG DMIDPDLQTG LGVLFHLSGE FNRAIDAFNA ALTVRPEDYS
460 470 480 490 500
LWNRLGATLA NGDRSEEAVE AYTRALEIQP GFIRSRYNLG ISCINLGAYR
510 520 530 540 550
EAVSNFLTAL SLQRKSRNQQ QVPHPAISGN IWAALRIALS LMDQPELFQA
560
ANLGDLDVLL RAFNLDP
Length:567
Mass (Da):63,135
Last modified:May 24, 2004 - v2
Checksum:i4955363C5A70FB28
GO
Isoform 3 (identifier: Q8C437-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MYQGHM → MSDSEMDGRTHIPSLLNALLSRNRVMQMSYLKSKEQGYGKLSSDEDLEIIVDQK

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):68,528
Checksum:i3A355AAA227F4273
GO
Isoform 4 (identifier: Q8C437-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):38,529
Checksum:i7CAD0D71968C2991
GO

Sequence cautioni

The sequence BAC38781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62P → T (PubMed:16141072).Curated1
Sequence conflicti564N → K in BAB24376 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0104371 – 223Missing in isoform 4. 1 PublicationAdd BLAST223
Alternative sequenceiVSP_0104391 – 6MYQGHM → MSDSEMDGRTHIPSLLNALL SRNRVMQMSYLKSKEQGYGK LSSDEDLEIIVDQK in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032591 mRNA. Translation: BAA92877.1.
AK006035 mRNA. Translation: BAB24376.1.
AK083141 mRNA. Translation: BAC38781.1. Different initiation.
CCDSiCCDS17302.1. [Q8C437-3]
CCDS50888.1. [Q8C437-4]
CCDS50889.1. [Q8C437-1]
RefSeqiNP_001156988.1. NM_001163516.3.
NP_001156989.1. NM_001163517.3. [Q8C437-4]
UniGeneiMm.151332.
Mm.384357.

Genome annotation databases

EnsembliENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674. [Q8C437-4]
GeneIDi58869.
KEGGimmu:58869.
UCSCiuc008owt.3. mouse. [Q8C437-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032591 mRNA. Translation: BAA92877.1.
AK006035 mRNA. Translation: BAB24376.1.
AK083141 mRNA. Translation: BAC38781.1. Different initiation.
CCDSiCCDS17302.1. [Q8C437-3]
CCDS50888.1. [Q8C437-4]
CCDS50889.1. [Q8C437-1]
RefSeqiNP_001156988.1. NM_001163516.3.
NP_001156989.1. NM_001163517.3. [Q8C437-4]
UniGeneiMm.151332.
Mm.384357.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EQFX-ray3.00A206-567[»]
ProteinModelPortaliQ8C437.
SMRiQ8C437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208454. 2 interactors.
IntActiQ8C437. 1 interactor.
MINTiMINT-4997685.
STRINGi10090.ENSMUSP00000077353.

PTM databases

iPTMnetiQ8C437.
PhosphoSitePlusiQ8C437.

Proteomic databases

PaxDbiQ8C437.
PRIDEiQ8C437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674. [Q8C437-4]
GeneIDi58869.
KEGGimmu:58869.
UCSCiuc008owt.3. mouse. [Q8C437-1]

Organism-specific databases

CTDi51555.
MGIiMGI:1916672. Pex5l.

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ8C437.
KOiK13342.
PhylomeDBiQ8C437.

Miscellaneous databases

PROiQ8C437.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027674.
CleanExiMM_PEX2.
MM_PEX5L.
ExpressionAtlasiQ8C437. baseline and differential.
GenevisibleiQ8C437. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX5R_MOUSE
AccessioniPrimary (citable) accession number: Q8C437
Secondary accession number(s): Q8CA31, Q9DAA1, Q9JMB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.