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Protein

PEX5-related protein

Gene

Pex5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PEX5-related protein
Alternative name(s):
PEX2-related protein
PEX5-like protein
Peroxin-5-related protein
Tetratricopeptide repeat-containing Rab8b-interacting protein
Short name:
Pex5Rp
Short name:
TRIP8b
Gene namesi
Name:Pex5l
Synonyms:Pex2, Pex5r, Pxr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916672. Pex5l.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendrite Source: MGI
  • peroxisomal membrane Source: GO_Central
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567PEX5-related proteinPRO_0000106318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei194 – 1941PhosphoserineBy similarity
Modified residuei198 – 1981PhosphoserineBy similarity
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei386 – 3861PhosphoserineCombined sources
Modified residuei388 – 3881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C437.
PaxDbiQ8C437.
PRIDEiQ8C437.

PTM databases

iPTMnetiQ8C437.
PhosphoSiteiQ8C437.

Expressioni

Gene expression databases

BgeeiQ8C437.
CleanExiMM_PEX2.
MM_PEX5L.
ExpressionAtlasiQ8C437. baseline and differential.
GenevisibleiQ8C437. MM.

Interactioni

Subunit structurei

Interacts with RAB8B (By similarity). Forms an obligate 4:4 complex with HCN2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208454. 2 interactions.
IntActiQ8C437. 1 interaction.
MINTiMINT-4997685.
STRINGi10090.ENSMUSP00000077353.

Structurei

Secondary structure

1
567
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni263 – 2664Combined sources
Helixi270 – 28011Combined sources
Helixi283 – 29614Combined sources
Helixi301 – 31313Combined sources
Helixi317 – 33014Combined sources
Helixi335 – 34713Combined sources
Helixi351 – 36414Combined sources
Helixi366 – 3694Combined sources
Helixi393 – 40816Combined sources
Helixi415 – 42814Combined sources
Helixi431 – 44414Combined sources
Helixi449 – 46113Combined sources
Helixi465 – 47814Combined sources
Helixi483 – 49614Combined sources
Helixi500 – 51415Combined sources
Helixi530 – 54213Combined sources
Helixi545 – 5528Combined sources
Helixi557 – 5593Combined sources
Turni560 – 5645Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EQFX-ray3.00A206-567[»]
ProteinModelPortaliQ8C437.
SMRiQ8C437. Positions 255-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati267 – 30034TPR 1Add
BLAST
Repeati301 – 33434TPR 2Add
BLAST
Repeati336 – 36833TPR 3Add
BLAST
Repeati415 – 44834TPR 4Add
BLAST
Repeati450 – 48233TPR 5Add
BLAST
Repeati484 – 51633TPR 6Add
BLAST

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ8C437.
KOiK13342.
OrthoDBiEOG793B77.
PhylomeDBiQ8C437.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C437-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQGHMQLVN EQQESRPLLS PSIDDFLCET KSEAIAKPVT SNTAVLTTGL
60 70 80 90 100
DLLDLSEPVS QPQTKAKKSE PSSKSSSLKK KADGSDLISA DAEQRAQALR
110 120 130 140 150
GPETSSLDLD IQTQLEKWDD VKFHGDRTSK GHLMAERKSC SSRTGSKELL
160 170 180 190 200
WSAEHRSQPE LSTGKSALNS ESASELELVA PAQARLTKEH RWGSALLSRN
210 220 230 240 250
HSLEEEFERA KAAVESDTEF WDKMQAEWEE MARRNWISEN QEAQNQVTVS
260 270 280 290 300
ASEKGYYFHT ENPFKDWPGA FEEGLKRLKE GDLPVTILFM EAAILQDPGD
310 320 330 340 350
AEAWQFLGIT QAENENEQAA IVALQRCLEL QPNNLKALMA LAVSYTNTSH
360 370 380 390 400
QQDACEALKN WIKQNPKYKY LVKNKKGSPG LTRRMSKSPV DSSVLEGVKE
410 420 430 440 450
LYLEAAHQNG DMIDPDLQTG LGVLFHLSGE FNRAIDAFNA ALTVRPEDYS
460 470 480 490 500
LWNRLGATLA NGDRSEEAVE AYTRALEIQP GFIRSRYNLG ISCINLGAYR
510 520 530 540 550
EAVSNFLTAL SLQRKSRNQQ QVPHPAISGN IWAALRIALS LMDQPELFQA
560
ANLGDLDVLL RAFNLDP
Length:567
Mass (Da):63,135
Last modified:May 24, 2004 - v2
Checksum:i4955363C5A70FB28
GO
Isoform 3 (identifier: Q8C437-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MYQGHM → MSDSEMDGRTHIPSLLNALLSRNRVMQMSYLKSKEQGYGKLSSDEDLEIIVDQK

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):68,528
Checksum:i3A355AAA227F4273
GO
Isoform 4 (identifier: Q8C437-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):38,529
Checksum:i7CAD0D71968C2991
GO

Sequence cautioni

The sequence BAC38781.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621P → T (PubMed:16141072).Curated
Sequence conflicti564 – 5641N → K in BAB24376 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 223223Missing in isoform 4. 1 PublicationVSP_010437Add
BLAST
Alternative sequencei1 – 66MYQGHM → MSDSEMDGRTHIPSLLNALL SRNRVMQMSYLKSKEQGYGK LSSDEDLEIIVDQK in isoform 3. 1 PublicationVSP_010439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032591 mRNA. Translation: BAA92877.1.
AK006035 mRNA. Translation: BAB24376.1.
AK083141 mRNA. Translation: BAC38781.1. Different initiation.
CCDSiCCDS17302.1. [Q8C437-3]
CCDS50888.1. [Q8C437-4]
CCDS50889.1. [Q8C437-1]
RefSeqiNP_001156988.1. NM_001163516.3.
NP_001156989.1. NM_001163517.3. [Q8C437-4]
UniGeneiMm.151332.
Mm.384357.

Genome annotation databases

EnsembliENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674. [Q8C437-4]
GeneIDi58869.
KEGGimmu:58869.
UCSCiuc008owt.3. mouse. [Q8C437-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032591 mRNA. Translation: BAA92877.1.
AK006035 mRNA. Translation: BAB24376.1.
AK083141 mRNA. Translation: BAC38781.1. Different initiation.
CCDSiCCDS17302.1. [Q8C437-3]
CCDS50888.1. [Q8C437-4]
CCDS50889.1. [Q8C437-1]
RefSeqiNP_001156988.1. NM_001163516.3.
NP_001156989.1. NM_001163517.3. [Q8C437-4]
UniGeneiMm.151332.
Mm.384357.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EQFX-ray3.00A206-567[»]
ProteinModelPortaliQ8C437.
SMRiQ8C437. Positions 255-566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208454. 2 interactions.
IntActiQ8C437. 1 interaction.
MINTiMINT-4997685.
STRINGi10090.ENSMUSP00000077353.

PTM databases

iPTMnetiQ8C437.
PhosphoSiteiQ8C437.

Proteomic databases

MaxQBiQ8C437.
PaxDbiQ8C437.
PRIDEiQ8C437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674. [Q8C437-4]
GeneIDi58869.
KEGGimmu:58869.
UCSCiuc008owt.3. mouse. [Q8C437-1]

Organism-specific databases

CTDi51555.
MGIiMGI:1916672. Pex5l.

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ8C437.
KOiK13342.
OrthoDBiEOG793B77.
PhylomeDBiQ8C437.

Miscellaneous databases

PROiQ8C437.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C437.
CleanExiMM_PEX2.
MM_PEX5L.
ExpressionAtlasiQ8C437. baseline and differential.
GenevisibleiQ8C437. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel peroxisomal targeting signal 1 receptor-like gene, PXR2, preferentially expressed in brain."
    Sano H., Snider J., Ohta M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Strain: C57BL/6J.
    Tissue: Hippocampus and Testis.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; SER-202; SER-386 AND SER-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.
  5. "Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels."
    Bankston J.R., Camp S.S., DiMaio F., Lewis A.S., Chetkovich D.M., Zagotta W.N.
    Proc. Natl. Acad. Sci. U.S.A. 109:7899-7904(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 206-567 IN COMPLEX WITH HCN2, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiPEX5R_MOUSE
AccessioniPrimary (citable) accession number: Q8C437
Secondary accession number(s): Q8CA31, Q9DAA1, Q9JMB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.