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Protein

Transmembrane channel-like protein 7

Gene

Tmc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 7
Gene namesi
Name:Tmc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443317. Tmc7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 166ExtracellularSequence analysisAdd BLAST166
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 217CytoplasmicSequence analysisAdd BLAST30
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 261ExtracellularSequence analysisAdd BLAST23
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 360CytoplasmicSequence analysisAdd BLAST78
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 402ExtracellularSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 492CytoplasmicSequence analysisAdd BLAST69
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 553ExtracellularSequence analysisAdd BLAST40
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 598CytoplasmicSequence analysisAdd BLAST24
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 663ExtracellularSequence analysisAdd BLAST44
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 726CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871671 – 726Transmembrane channel-like protein 7Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Modified residuei87PhosphoserineBy similarity1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi636N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8C428.
PRIDEiQ8C428.

PTM databases

iPTMnetiQ8C428.
PhosphoSitePlusiQ8C428.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000042246.
CleanExiMM_TMC7.
GenevisibleiQ8C428. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046927.

Structurei

3D structure databases

ProteinModelPortaliQ8C428.
SMRiQ8C428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154634.
HOVERGENiHBG101778.
InParanoidiQ8C428.
OMAiQEHMKKE.
OrthoDBiEOG091G04K4.
PhylomeDBiQ8C428.
TreeFamiTF313462.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C428-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEGSAGDPG HGSSRQRAVH PENLSLGSSC FSPPVNFLQE LPSYRSVARR
60 70 80 90 100
RTNILSRDKQ SGTLLKPTDS FSCQLDGGIT ENLNSQSIRK YALNISEKRR
110 120 130 140 150
LRDIQETQMK YLSEWDQWKR YSSKSWKRFL EKAREMTTHL ELWRKDIRSI
160 170 180 190 200
EGKFGTGIQS YFSFLRFLVV LNLVIFLIIF MLVLLPILLT KYKITNSTFV
210 220 230 240 250
LIPFKDMDIQ CTLYPISSSG LIYFYSYIID LLSGTGFLEE TSLFYGHYTI
260 270 280 290 300
DGVKFQSFTY DLPLAYLIST IAYLALSLLW IVKRSVEGFK INLIRSEEHF
310 320 330 340 350
QSYCNKIFAG WDFCITNRSM AELKHSSLRY ELRADLEEER IRQKIAERTS
360 370 380 390 400
EETIRIYTLR LFLNCIVLAV LAACFYAIYL ATAFSQEHMK KEIDKMVFGE
410 420 430 440 450
NLLILYLPSI VITLANFITP IIFAKIIHYE DYSPGFEIRL TILRCVFMRL
460 470 480 490 500
ATICVLVFTL GSKITSCGDS TCELCGYNQK LYPCWETQVG QEMYKLMIFD
510 520 530 540 550
FIIILAVTLF VDFPRKLLVT YCASSKLIQC WGQQEFAIPD NVLGIVYGQT
560 570 580 590 600
ICWIGAFFSP LLPAIATLKF VIIFYVKELS LLYTCRPSPR QFRASNSNFF
610 620 630 640 650
FLLVLLIGLC LAIIPLTISM ARIPSSKACG PFTNFNTTWE VIPQTVSTFP
660 670 680 690 700
SSLQTLIHAV TSEAFAVPFF MIICLVMFYF IALAGAHKQV VVQLREQLSL
710 720
ESRDKRYLIQ KLTEAQREVR SQPASA
Length:726
Mass (Da):83,337
Last modified:March 1, 2003 - v1
Checksum:i89C397C9CAD5CE59
GO
Isoform 2 (identifier: Q8C428-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-726: Missing.

Show »
Length:516
Mass (Da):59,800
Checksum:i1AE9CE234787CBAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti447F → I in AAP69877 (PubMed:12906855).Curated1
Sequence conflicti691 – 692VV → AA in AAP78776 (PubMed:12812529).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025348517 – 726Missing in isoform 2. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263161 mRNA. Translation: AAP78776.1.
AY236499 mRNA. Translation: AAP69877.1.
AK082562 mRNA. Translation: BAC38531.1.
AK083189 mRNA. Translation: BAC38802.1.
CCDSiCCDS21772.1. [Q8C428-1]
RefSeqiNP_766064.2. NM_172476.4. [Q8C428-1]
UniGeneiMm.69380.

Genome annotation databases

EnsembliENSMUST00000044195; ENSMUSP00000046927; ENSMUSG00000042246. [Q8C428-1]
GeneIDi209760.
KEGGimmu:209760.
UCSCiuc009jka.1. mouse. [Q8C428-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263161 mRNA. Translation: AAP78776.1.
AY236499 mRNA. Translation: AAP69877.1.
AK082562 mRNA. Translation: BAC38531.1.
AK083189 mRNA. Translation: BAC38802.1.
CCDSiCCDS21772.1. [Q8C428-1]
RefSeqiNP_766064.2. NM_172476.4. [Q8C428-1]
UniGeneiMm.69380.

3D structure databases

ProteinModelPortaliQ8C428.
SMRiQ8C428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046927.

PTM databases

iPTMnetiQ8C428.
PhosphoSitePlusiQ8C428.

Proteomic databases

PaxDbiQ8C428.
PRIDEiQ8C428.

Protocols and materials databases

DNASUi209760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044195; ENSMUSP00000046927; ENSMUSG00000042246. [Q8C428-1]
GeneIDi209760.
KEGGimmu:209760.
UCSCiuc009jka.1. mouse. [Q8C428-1]

Organism-specific databases

CTDi79905.
MGIiMGI:2443317. Tmc7.

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154634.
HOVERGENiHBG101778.
InParanoidiQ8C428.
OMAiQEHMKKE.
OrthoDBiEOG091G04K4.
PhylomeDBiQ8C428.
TreeFamiTF313462.

Miscellaneous databases

PROiQ8C428.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042246.
CleanExiMM_TMC7.
GenevisibleiQ8C428. MM.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMC7_MOUSE
AccessioniPrimary (citable) accession number: Q8C428
Secondary accession number(s): Q7TN59, Q7TQ66, Q8C4C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.