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Q8C419

- GP158_MOUSE

UniProt

Q8C419 - GP158_MOUSE

Protein

Probable G-protein coupled receptor 158

Gene

Gpr158

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. protein localization to plasma membrane Source: MGI
    2. regulation of G-protein coupled receptor protein signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 158
    Gene namesi
    Name:Gpr158
    Synonyms:Kiaa1136
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2441697. Gpr158.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 12001176Probable G-protein coupled receptor 158PRO_0000012970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ8C419.
    PaxDbiQ8C419.
    PRIDEiQ8C419.

    PTM databases

    PhosphoSiteiQ8C419.

    Expressioni

    Gene expression databases

    BgeeiQ8C419.
    CleanExiMM_GPR158.
    GenevestigatoriQ8C419.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8C419. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C419.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 417393ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini439 – 45113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini473 – 48311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini507 – 52822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini550 – 57930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini601 – 61313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini635 – 6439ExtracellularSequence Analysis
    Topological domaini665 – 1200536CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei418 – 43821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei484 – 50623Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei580 – 60021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei614 – 63421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328237.
    GeneTreeiENSGT00390000010934.
    HOGENOMiHOG000049235.
    HOVERGENiHBG080352.
    InParanoidiQ8C419.
    KOiK08469.
    OMAiETEWFHG.
    OrthoDBiEOG71ZP0V.
    PhylomeDBiQ8C419.
    TreeFamiTF319114.

    Family and domain databases

    InterProiIPR017978. GPCR_3_C.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    [Graphical view]
    PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8C419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP     50
    RASAPDPSIP WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS 100
    GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV 150
    QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR 200
    ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW 250
    RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF 300
    RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY 350
    QCICKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP 400
    FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS 450
    GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT 500
    LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ 550
    NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV 600
    RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH 650
    AHLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI 700
    NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL 750
    GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG 800
    RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE EEATENSTLE 850
    SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ 900
    KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE 950
    TIPNSGHMEE PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV 1000
    CPWEVYDLTP GPMPSEPKAQ KHVSIAASEV EQNPASFLKE KSYHKSKATE 1050
    GLYQANHKSI DKTEVCPWEI HSQSLLEDEN RLISKTPVLP GRAREENGSQ 1100
    LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS SVDIIPGSCN 1150
    SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK 1200
    Length:1,200
    Mass (Da):134,426
    Last modified:June 7, 2005 - v2
    Checksum:i2FCEF8283DE964B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
    AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
    AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
    AK083234 mRNA. Translation: BAC38819.1.
    AB093287 mRNA. Translation: BAC41471.1.
    CCDSiCCDS15722.1.
    RefSeqiNP_001004761.1. NM_001004761.1.
    UniGeneiMm.166647.

    Genome annotation databases

    EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
    GeneIDi241263.
    KEGGimmu:241263.
    UCSCiuc008ine.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772387 , AL928939 , AL929311 Genomic DNA. Translation: CAM14703.1 .
    AL929311 , AL772387 , AL928939 Genomic DNA. Translation: CAM19923.1 .
    AL928939 , AL772387 , AL929311 Genomic DNA. Translation: CAM19976.1 .
    AK083234 mRNA. Translation: BAC38819.1 .
    AB093287 mRNA. Translation: BAC41471.1 .
    CCDSi CCDS15722.1.
    RefSeqi NP_001004761.1. NM_001004761.1.
    UniGenei Mm.166647.

    3D structure databases

    ProteinModelPortali Q8C419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8C419. 1 interaction.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8C419.

    Proteomic databases

    MaxQBi Q8C419.
    PaxDbi Q8C419.
    PRIDEi Q8C419.

    Protocols and materials databases

    DNASUi 241263.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055946 ; ENSMUSP00000049708 ; ENSMUSG00000045967 .
    GeneIDi 241263.
    KEGGi mmu:241263.
    UCSCi uc008ine.1. mouse.

    Organism-specific databases

    CTDi 57512.
    MGIi MGI:2441697. Gpr158.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG328237.
    GeneTreei ENSGT00390000010934.
    HOGENOMi HOG000049235.
    HOVERGENi HBG080352.
    InParanoidi Q8C419.
    KOi K08469.
    OMAi ETEWFHG.
    OrthoDBi EOG71ZP0V.
    PhylomeDBi Q8C419.
    TreeFami TF319114.

    Miscellaneous databases

    NextBioi 384949.
    PROi Q8C419.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C419.
    CleanExi MM_GPR158.
    Genevestigatori Q8C419.

    Family and domain databases

    InterProi IPR017978. GPCR_3_C.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-724.
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
      DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1200.
      Tissue: Brain.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiGP158_MOUSE
    AccessioniPrimary (citable) accession number: Q8C419
    Secondary accession number(s): B1AWY4, Q8CHB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3