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Protein

Probable G-protein coupled receptor 158

Gene

Gpr158

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:Gpr158
Synonyms:Kiaa1136
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2441697. Gpr158.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 417ExtracellularSequence analysisAdd BLAST393
Transmembranei418 – 438Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini439 – 451CytoplasmicSequence analysisAdd BLAST13
Transmembranei452 – 472Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini473 – 483ExtracellularSequence analysisAdd BLAST11
Transmembranei484 – 506Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini507 – 528CytoplasmicSequence analysisAdd BLAST22
Transmembranei529 – 549Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini550 – 579ExtracellularSequence analysisAdd BLAST30
Transmembranei580 – 600Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini601 – 613CytoplasmicSequence analysisAdd BLAST13
Transmembranei614 – 634Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini635 – 643ExtracellularSequence analysis9
Transmembranei644 – 664Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini665 – 1200CytoplasmicSequence analysisAdd BLAST536

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001297025 – 1200Probable G-protein coupled receptor 158Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Modified residuei694PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei865PhosphoserineCombined sources1
Modified residuei944PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1074PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8C419.
PaxDbiQ8C419.
PeptideAtlasiQ8C419.
PRIDEiQ8C419.

PTM databases

iPTMnetiQ8C419.
PhosphoSitePlusiQ8C419.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045967.
CleanExiMM_GPR158.
GenevisibleiQ8C419. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8C419. 1 interactor.
STRINGi10090.ENSMUSP00000049708.

Structurei

3D structure databases

ProteinModelPortaliQ8C419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ8C419.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG091G0GG1.
PhylomeDBiQ8C419.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP
60 70 80 90 100
RASAPDPSIP WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS
110 120 130 140 150
GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV
160 170 180 190 200
QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW
260 270 280 290 300
RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF
310 320 330 340 350
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
QCICKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP
410 420 430 440 450
FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ
560 570 580 590 600
NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH
660 670 680 690 700
AHLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG
810 820 830 840 850
RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE EEATENSTLE
860 870 880 890 900
SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE
960 970 980 990 1000
TIPNSGHMEE PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV
1010 1020 1030 1040 1050
CPWEVYDLTP GPMPSEPKAQ KHVSIAASEV EQNPASFLKE KSYHKSKATE
1060 1070 1080 1090 1100
GLYQANHKSI DKTEVCPWEI HSQSLLEDEN RLISKTPVLP GRAREENGSQ
1110 1120 1130 1140 1150
LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS SVDIIPGSCN
1160 1170 1180 1190 1200
SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK
Length:1,200
Mass (Da):134,426
Last modified:June 7, 2005 - v2
Checksum:i2FCEF8283DE964B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
AK083234 mRNA. Translation: BAC38819.1.
AB093287 mRNA. Translation: BAC41471.1.
CCDSiCCDS15722.1.
RefSeqiNP_001004761.1. NM_001004761.1.
UniGeneiMm.166647.

Genome annotation databases

EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
GeneIDi241263.
KEGGimmu:241263.
UCSCiuc008ine.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
AK083234 mRNA. Translation: BAC38819.1.
AB093287 mRNA. Translation: BAC41471.1.
CCDSiCCDS15722.1.
RefSeqiNP_001004761.1. NM_001004761.1.
UniGeneiMm.166647.

3D structure databases

ProteinModelPortaliQ8C419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C419. 1 interactor.
STRINGi10090.ENSMUSP00000049708.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8C419.
PhosphoSitePlusiQ8C419.

Proteomic databases

MaxQBiQ8C419.
PaxDbiQ8C419.
PeptideAtlasiQ8C419.
PRIDEiQ8C419.

Protocols and materials databases

DNASUi241263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
GeneIDi241263.
KEGGimmu:241263.
UCSCiuc008ine.1. mouse.

Organism-specific databases

CTDi57512.
MGIiMGI:2441697. Gpr158.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ8C419.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG091G0GG1.
PhylomeDBiQ8C419.
TreeFamiTF319114.

Miscellaneous databases

ChiTaRSiGpr158. mouse.
PROiQ8C419.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045967.
CleanExiMM_GPR158.
GenevisibleiQ8C419. MM.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP158_MOUSE
AccessioniPrimary (citable) accession number: Q8C419
Secondary accession number(s): B1AWY4, Q8CHB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.