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Q8C419

- GP158_MOUSE

UniProt

Q8C419 - GP158_MOUSE

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Protein

Probable G-protein coupled receptor 158

Gene

Gpr158

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. protein localization to plasma membrane Source: MGI
  2. regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:Gpr158
Synonyms:Kiaa1136
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2441697. Gpr158.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 417393ExtracellularSequence AnalysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini439 – 45113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini473 – 48311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei484 – 50623Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini507 – 52822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini550 – 57930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei580 – 60021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini601 – 61313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei614 – 63421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini635 – 6439ExtracellularSequence Analysis
Transmembranei644 – 66421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini665 – 1200536CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 12001176Probable G-protein coupled receptor 158PRO_0000012970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8C419.
PaxDbiQ8C419.
PRIDEiQ8C419.

PTM databases

PhosphoSiteiQ8C419.

Expressioni

Gene expression databases

BgeeiQ8C419.
CleanExiMM_GPR158.
ExpressionAtlasiQ8C419. baseline and differential.
GenevestigatoriQ8C419.

Interactioni

Protein-protein interaction databases

IntActiQ8C419. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8C419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328237.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ8C419.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG71ZP0V.
PhylomeDBiQ8C419.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C419-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP
60 70 80 90 100
RASAPDPSIP WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS
110 120 130 140 150
GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV
160 170 180 190 200
QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW
260 270 280 290 300
RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF
310 320 330 340 350
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
QCICKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP
410 420 430 440 450
FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ
560 570 580 590 600
NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH
660 670 680 690 700
AHLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG
810 820 830 840 850
RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE EEATENSTLE
860 870 880 890 900
SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE
960 970 980 990 1000
TIPNSGHMEE PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV
1010 1020 1030 1040 1050
CPWEVYDLTP GPMPSEPKAQ KHVSIAASEV EQNPASFLKE KSYHKSKATE
1060 1070 1080 1090 1100
GLYQANHKSI DKTEVCPWEI HSQSLLEDEN RLISKTPVLP GRAREENGSQ
1110 1120 1130 1140 1150
LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS SVDIIPGSCN
1160 1170 1180 1190 1200
SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK
Length:1,200
Mass (Da):134,426
Last modified:June 7, 2005 - v2
Checksum:i2FCEF8283DE964B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
AK083234 mRNA. Translation: BAC38819.1.
AB093287 mRNA. Translation: BAC41471.1.
CCDSiCCDS15722.1.
RefSeqiNP_001004761.1. NM_001004761.1.
UniGeneiMm.166647.

Genome annotation databases

EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
GeneIDi241263.
KEGGimmu:241263.
UCSCiuc008ine.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772387 , AL928939 , AL929311 Genomic DNA. Translation: CAM14703.1 .
AL929311 , AL772387 , AL928939 Genomic DNA. Translation: CAM19923.1 .
AL928939 , AL772387 , AL929311 Genomic DNA. Translation: CAM19976.1 .
AK083234 mRNA. Translation: BAC38819.1 .
AB093287 mRNA. Translation: BAC41471.1 .
CCDSi CCDS15722.1.
RefSeqi NP_001004761.1. NM_001004761.1.
UniGenei Mm.166647.

3D structure databases

ProteinModelPortali Q8C419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8C419. 1 interaction.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8C419.

Proteomic databases

MaxQBi Q8C419.
PaxDbi Q8C419.
PRIDEi Q8C419.

Protocols and materials databases

DNASUi 241263.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055946 ; ENSMUSP00000049708 ; ENSMUSG00000045967 .
GeneIDi 241263.
KEGGi mmu:241263.
UCSCi uc008ine.1. mouse.

Organism-specific databases

CTDi 57512.
MGIi MGI:2441697. Gpr158.
Rougei Search...

Phylogenomic databases

eggNOGi NOG328237.
GeneTreei ENSGT00390000010934.
HOGENOMi HOG000049235.
HOVERGENi HBG080352.
InParanoidi Q8C419.
KOi K08469.
OMAi ETEWFHG.
OrthoDBi EOG71ZP0V.
PhylomeDBi Q8C419.
TreeFami TF319114.

Miscellaneous databases

ChiTaRSi Gpr158. mouse.
NextBioi 384949.
PROi Q8C419.
SOURCEi Search...

Gene expression databases

Bgeei Q8C419.
CleanExi MM_GPR158.
ExpressionAtlasi Q8C419. baseline and differential.
Genevestigatori Q8C419.

Family and domain databases

InterProi IPR017978. GPCR_3_C.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
[Graphical view ]
PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-724.
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1200.
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiGP158_MOUSE
AccessioniPrimary (citable) accession number: Q8C419
Secondary accession number(s): B1AWY4, Q8CHB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3