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Q8C419 (GP158_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 158
Gene names
Name:Gpr158
Synonyms:Kiaa1136
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1200 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 12001176Probable G-protein coupled receptor 158
PRO_0000012970

Regions

Topological domain25 – 417393Extracellular Potential
Transmembrane418 – 43821Helical; Name=1; Potential
Topological domain439 – 45113Cytoplasmic Potential
Transmembrane452 – 47221Helical; Name=2; Potential
Topological domain473 – 48311Extracellular Potential
Transmembrane484 – 50623Helical; Name=3; Potential
Topological domain507 – 52822Cytoplasmic Potential
Transmembrane529 – 54921Helical; Name=4; Potential
Topological domain550 – 57930Extracellular Potential
Transmembrane580 – 60021Helical; Name=5; Potential
Topological domain601 – 61313Cytoplasmic Potential
Transmembrane614 – 63421Helical; Name=6; Potential
Topological domain635 – 6439Extracellular Potential
Transmembrane644 – 66421Helical; Name=7; Potential
Topological domain665 – 1200536Cytoplasmic Potential

Amino acid modifications

Modified residue9041Phosphoserine Ref.4
Modified residue9761Phosphoserine Ref.4
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Cross-link774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8C419 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: 2FCEF8283DE964B4

FASTA1,200134,426
        10         20         30         40         50         60 
MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP RASAPDPSIP 

        70         80         90        100        110        120 
WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS GRYELAGLPG KSPSLASSHP 

       130        140        150        160        170        180 
SLHGALDTLT HATNFLNMML QSNKSREQTV QDDLQWYQAL VRSLLEGEPS ISRAAITFST 

       190        200        210        220        230        240 
ESLSTPAPQV FLQATREESR ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN 

       250        260        270        280        290        300 
QGPRGLGHSW RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF 

       310        320        330        340        350        360 
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY QCICKAGFYH 

       370        380        390        400        410        420 
PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP FCADDRPCFV QEDKYLRLAI 

       430        440        450        460        470        480 
ISFQALCMLL DFVSMLVVYH FRKAKSIRAS GLILLETILF GSLLLYFPVV ILYFEPSTFR 

       490        500        510        520        530        540 
CILLRWARLL GFATVYGTVT LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF 

       550        560        570        580        590        600 
LVGWTSSMCQ NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV 

       610        620        630        640        650        660 
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH AHLTVTVTIG 

       670        680        690        700        710        720 
LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI NSAWSEHSLD PEDIRDELKK 

       730        740        750        760        770        780 
LYAQLEIYKR KKMITNNPHL QKKRCSKKGL GRSIMRRITE IPETVSRQCS KEDKEGTDHS 

       790        800        810        820        830        840 
AAKGTGLVRK NPTESSGNTG RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE 

       850        860        870        880        890        900 
EEATENSTLE SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ 

       910        920        930        940        950        960 
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE TIPNSGHMEE 

       970        980        990       1000       1010       1020 
PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV CPWEVYDLTP GPMPSEPKAQ 

      1030       1040       1050       1060       1070       1080 
KHVSIAASEV EQNPASFLKE KSYHKSKATE GLYQANHKSI DKTEVCPWEI HSQSLLEDEN 

      1090       1100       1110       1120       1130       1140 
RLISKTPVLP GRAREENGSQ LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS 

      1150       1160       1170       1180       1190       1200 
SVDIIPGSCN SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK

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References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-724.
Strain: C57BL/6J.
Tissue: Hippocampus.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1200.
Tissue: Brain.
[4]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-904 AND SER-976, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
AK083234 mRNA. Translation: BAC38819.1.
AB093287 mRNA. Translation: BAC41471.1.
IPIIPI00465871.
RefSeqNP_001004761.1. NM_001004761.1.
UniGeneMm.166647.

3D structure databases

ProteinModelPortalQ8C419.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8C419. 1 interaction.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8C419.

Proteomic databases

PaxDbQ8C419.
PRIDEQ8C419.

Protocols and materials databases

DNASU241263.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
GeneID241263.
KEGGmmu:241263.

Organism-specific databases

CTD57512.
MGIMGI:2441697. Gpr158.
RougeSearch...

Phylogenomic databases

eggNOGNOG328237.
GeneTreeENSGT00390000010934.
HOGENOMHOG000049235.
HOVERGENHBG080352.
InParanoidQ8C419.
KOK08469.
OMAYKPGWLV.
OrthoDBEOG4SBDX6.

Gene expression databases

ArrayExpressQ8C419.
BgeeQ8C419.
CleanExMM_GPR158.
GenevestigatorQ8C419.
GermOnlineENSMUSG00000045967. Mus musculus.

Family and domain databases

InterProIPR017978. GPCR_3_C.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. False negative.
PS00981. G_PROTEIN_RECEP_F3_3. False negative.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384949.
SOURCESearch...

Entry information

Entry nameGP158_MOUSE
AccessionPrimary (citable) accession number: Q8C419
Secondary accession number(s): B1AWY4, Q8CHB0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents