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Protein

Probable G-protein coupled receptor 158

Gene

Gpr158

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • protein localization to plasma membrane Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:Gpr158
Synonyms:Kiaa1136
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2441697 Gpr158

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 417ExtracellularSequence analysisAdd BLAST393
Transmembranei418 – 438Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini439 – 451CytoplasmicSequence analysisAdd BLAST13
Transmembranei452 – 472Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini473 – 483ExtracellularSequence analysisAdd BLAST11
Transmembranei484 – 506Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini507 – 528CytoplasmicSequence analysisAdd BLAST22
Transmembranei529 – 549Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini550 – 579ExtracellularSequence analysisAdd BLAST30
Transmembranei580 – 600Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini601 – 613CytoplasmicSequence analysisAdd BLAST13
Transmembranei614 – 634Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini635 – 643ExtracellularSequence analysis9
Transmembranei644 – 664Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini665 – 1200CytoplasmicSequence analysisAdd BLAST536

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001297025 – 1200Probable G-protein coupled receptor 158Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei694PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei865PhosphoserineCombined sources1
Modified residuei944PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1074PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8C419
PaxDbiQ8C419
PeptideAtlasiQ8C419
PRIDEiQ8C419

PTM databases

iPTMnetiQ8C419
PhosphoSitePlusiQ8C419
SwissPalmiQ8C419

Expressioni

Gene expression databases

BgeeiENSMUSG00000045967
CleanExiMM_GPR158
GenevisibleiQ8C419 MM

Interactioni

Protein-protein interaction databases

BioGridi232299, 1 interactor
IntActiQ8C419, 2 interactors
STRINGi10090.ENSMUSP00000049708

Structurei

3D structure databases

ProteinModelPortaliQ8C419
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4418 Eukaryota
ENOG410XXEC LUCA
GeneTreeiENSGT00390000010934
HOGENOMiHOG000049235
HOVERGENiHBG080352
InParanoidiQ8C419
KOiK08469
OMAiETEWFHG
OrthoDBiEOG091G0GG1
PhylomeDBiQ8C419
TreeFamiTF319114

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP
60 70 80 90 100
RASAPDPSIP WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS
110 120 130 140 150
GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV
160 170 180 190 200
QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW
260 270 280 290 300
RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF
310 320 330 340 350
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
QCICKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP
410 420 430 440 450
FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ
560 570 580 590 600
NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH
660 670 680 690 700
AHLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG
810 820 830 840 850
RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE EEATENSTLE
860 870 880 890 900
SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE
960 970 980 990 1000
TIPNSGHMEE PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV
1010 1020 1030 1040 1050
CPWEVYDLTP GPMPSEPKAQ KHVSIAASEV EQNPASFLKE KSYHKSKATE
1060 1070 1080 1090 1100
GLYQANHKSI DKTEVCPWEI HSQSLLEDEN RLISKTPVLP GRAREENGSQ
1110 1120 1130 1140 1150
LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS SVDIIPGSCN
1160 1170 1180 1190 1200
SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK
Length:1,200
Mass (Da):134,426
Last modified:June 7, 2005 - v2
Checksum:i2FCEF8283DE964B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772387, AL928939, AL929311 Genomic DNA Translation: CAM14703.1
AL929311, AL772387, AL928939 Genomic DNA Translation: CAM19923.1
AL928939, AL772387, AL929311 Genomic DNA Translation: CAM19976.1
AK083234 mRNA Translation: BAC38819.1
AB093287 mRNA Translation: BAC41471.1
CCDSiCCDS15722.1
RefSeqiNP_001004761.1, NM_001004761.1
UniGeneiMm.166647

Genome annotation databases

EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967
GeneIDi241263
KEGGimmu:241263
UCSCiuc008ine.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGP158_MOUSE
AccessioniPrimary (citable) accession number: Q8C419
Secondary accession number(s): B1AWY4, Q8CHB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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