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Q8C419

- GP158_MOUSE

UniProt

Q8C419 - GP158_MOUSE

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Protein
Probable G-protein coupled receptor 158
Gene
Gpr158, Kiaa1136
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. protein localization to plasma membrane Source: MGI
  2. regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:Gpr158
Synonyms:Kiaa1136
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2441697. Gpr158.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 417393Extracellular Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini439 – 45113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei452 – 47221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini473 – 48311Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50623Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini507 – 52822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei529 – 54921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini550 – 57930Extracellular Reviewed prediction
Add
BLAST
Transmembranei580 – 60021Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini601 – 61313Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei614 – 63421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini635 – 6439Extracellular Reviewed prediction
Transmembranei644 – 66421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini665 – 1200536Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 12001176Probable G-protein coupled receptor 158
PRO_0000012970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8C419.
PaxDbiQ8C419.
PRIDEiQ8C419.

PTM databases

PhosphoSiteiQ8C419.

Expressioni

Gene expression databases

BgeeiQ8C419.
CleanExiMM_GPR158.
GenevestigatoriQ8C419.

Interactioni

Protein-protein interaction databases

IntActiQ8C419. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8C419.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328237.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ8C419.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG71ZP0V.
PhylomeDBiQ8C419.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C419-1 [UniParc]FASTAAdd to Basket

« Hide

MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP     50
RASAPDPSIP WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS 100
GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV 150
QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR 200
ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW 250
RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF 300
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY 350
QCICKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP 400
FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS 450
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT 500
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ 550
NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV 600
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH 650
AHLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI 700
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL 750
GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG 800
RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE EEATENSTLE 850
SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ 900
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE 950
TIPNSGHMEE PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV 1000
CPWEVYDLTP GPMPSEPKAQ KHVSIAASEV EQNPASFLKE KSYHKSKATE 1050
GLYQANHKSI DKTEVCPWEI HSQSLLEDEN RLISKTPVLP GRAREENGSQ 1100
LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS SVDIIPGSCN 1150
SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK 1200
Length:1,200
Mass (Da):134,426
Last modified:June 7, 2005 - v2
Checksum:i2FCEF8283DE964B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772387, AL928939, AL929311 Genomic DNA. Translation: CAM14703.1.
AL929311, AL772387, AL928939 Genomic DNA. Translation: CAM19923.1.
AL928939, AL772387, AL929311 Genomic DNA. Translation: CAM19976.1.
AK083234 mRNA. Translation: BAC38819.1.
AB093287 mRNA. Translation: BAC41471.1.
CCDSiCCDS15722.1.
RefSeqiNP_001004761.1. NM_001004761.1.
UniGeneiMm.166647.

Genome annotation databases

EnsembliENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
GeneIDi241263.
KEGGimmu:241263.
UCSCiuc008ine.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772387 , AL928939 , AL929311 Genomic DNA. Translation: CAM14703.1 .
AL929311 , AL772387 , AL928939 Genomic DNA. Translation: CAM19923.1 .
AL928939 , AL772387 , AL929311 Genomic DNA. Translation: CAM19976.1 .
AK083234 mRNA. Translation: BAC38819.1 .
AB093287 mRNA. Translation: BAC41471.1 .
CCDSi CCDS15722.1.
RefSeqi NP_001004761.1. NM_001004761.1.
UniGenei Mm.166647.

3D structure databases

ProteinModelPortali Q8C419.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8C419. 1 interaction.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8C419.

Proteomic databases

MaxQBi Q8C419.
PaxDbi Q8C419.
PRIDEi Q8C419.

Protocols and materials databases

DNASUi 241263.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055946 ; ENSMUSP00000049708 ; ENSMUSG00000045967 .
GeneIDi 241263.
KEGGi mmu:241263.
UCSCi uc008ine.1. mouse.

Organism-specific databases

CTDi 57512.
MGIi MGI:2441697. Gpr158.
Rougei Search...

Phylogenomic databases

eggNOGi NOG328237.
GeneTreei ENSGT00390000010934.
HOGENOMi HOG000049235.
HOVERGENi HBG080352.
InParanoidi Q8C419.
KOi K08469.
OMAi ETEWFHG.
OrthoDBi EOG71ZP0V.
PhylomeDBi Q8C419.
TreeFami TF319114.

Miscellaneous databases

NextBioi 384949.
PROi Q8C419.
SOURCEi Search...

Gene expression databases

Bgeei Q8C419.
CleanExi MM_GPR158.
Genevestigatori Q8C419.

Family and domain databases

InterProi IPR017978. GPCR_3_C.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
[Graphical view ]
PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-724.
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1200.
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiGP158_MOUSE
AccessioniPrimary (citable) accession number: Q8C419
Secondary accession number(s): B1AWY4, Q8CHB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi