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Unreviewed, UniProtKB/TrEMBL Q8C402 (Q8C402_MOUSE)

Last modified January 19, 2010. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAC38867.1
Submitted name:
    Lymphoid enhancer binding factor 1, isoform CRA_b EMBL EDL12205.1
Gene names
Name: Lef1 MGI 96770
ORF Names: mCG_10208 EMBL EDL12205.1
OrganismMus musculus (Mouse) EMBL BAC38867.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

Ontologies

Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

cell development

Inferred from genetic interaction. Source: MGI

chorio-allantoic fusion

Inferred from genetic interaction. Source: MGI

dentate gyrus development

Inferred from mutant phenotype. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction. Source: MGI

mammary gland development

Inferred from mutant phenotype. Source: MGI

negative regulation of striated muscle tissue development

Inferred from direct assay. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

odontogenesis of dentine-containing tooth

Inferred from mutant phenotype. Source: MGI

paraxial mesoderm formation

Inferred from genetic interaction. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

regulation of Wnt receptor signaling pathway

Inferred from genetic interaction. Source: MGI

somitogenesis

Inferred from genetic interaction. Source: MGI

   Cellular componentcytoplasm

Inferred from direct assay. Source: MGI

transcription factor complex

Inferred from physical interaction. Source: MGI

   Molecular functionRNA polymerase II transcription factor activity, enhancer binding

Inferred from genetic interaction. Source: MGI

chromatin binding

Inferred from direct assay. Source: MGI

transcription activator activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8C402-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 383E0F6AA6F7E84F

FASTA33137,041
        10         20         30         40         50         60 
MAGVVRQAPS SQEPYHDKAR EHPDEGKHPD GGLYNKGPSY SSYSGYIMMP NMNSDPYMSN 

        70         80         90        100        110        120 
GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG SHPSHIPSDV NSKQGMSRHP 

       130        140        150        160        170        180 
PAPEIPTFYP LSPGGVGQIT PPIGWQGQPV YPITGGFRQP YPSSLSGDTS MSRFSHHMIP 

       190        200        210        220        230        240 
GPPGPHTTGI PHPAIVTPQV KQEHPHTDSD LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML 

       250        260        270        280        290        300 
YMKEMRANVV AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA 

       310        320        330 
RDNYGKKKKR KREKLQESTS GTGPRMTAAY I 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12205.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12205.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
IPIIPI00230713.
UniGeneMm.255219

3D structure databases

HSSPHSSP built from PDB template 2LEF based on UniProtKB P27782.
SMRQ8C402. Positions 230-305.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8C402.

Genome annotation databases

EnsemblENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985; Mus musculus. [Genome view]
UCSCuc008rjk.1. mouse.

Organism-specific databases

MGIMGI:96770. Lef1.

Phylogenomic databases

HOVERGENQ8C402.

Gene expression databases

ArrayExpressQ8C402.
BgeeQ8C402.
GenevestigatorQ8C402.

Family and domain databases

InterProIPR013558. CTNNB1_bd_N.
IPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
[Graphical view]
Gene3DG3DSA:1.10.30.10. HMG-box. 1 hit.
PfamPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameQ8C402_MOUSE
AccessionPrimary (citable) accession number: Q8C402
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information