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Q8C402 (Q8C402_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Lymphoid enhancer-binding factor 1 Ensembl ENSMUSP00000096211
Gene names
Name:Lef1 MGI 96770 Ensembl ENSMUSP00000096211 EMBL EDL12205.1
ORF Names:mCG_10208 EMBL EDL12205.1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell proliferation

Inferred from mutant phenotype PubMed 10933391. Source: MGI

BMP signaling pathway

Inferred from direct assay PubMed 9769173. Source: MGI

T cell receptor V(D)J recombination

Inferred from genetic interaction PubMed 9462507. Source: MGI

Wnt signaling pathway

Inferred from direct assay PubMed 9769173. Source: MGI

alpha-beta T cell differentiation

Inferred from genetic interaction PubMed 9462507. Source: MGI

anatomical structure regression

Inferred from mutant phenotype PubMed 16163358. Source: MGI

apoptotic process involved in morphogenesis

Inferred from mutant phenotype PubMed 15649466. Source: MGI

apoptotic process involved in patterning of blood vessels

Inferred from mutant phenotype PubMed 16163358. Source: MGI

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell development

Inferred from genetic interaction PubMed 15729346. Source: MGI

chorio-allantoic fusion

Inferred from genetic interaction PubMed 10090727. Source: MGI

dentate gyrus development

Inferred from mutant phenotype PubMed 10631168. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 10090727. Source: MGI

eye pigmentation

Inferred from Biological aspect of Ancestor. Source: RefGenome

face morphogenesis

Inferred from genetic interaction PubMed 17699607. Source: MGI

forebrain neuroblast division

Inferred from genetic interaction PubMed 14715945. Source: MGI

forebrain neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

forebrain radial glial cell differentiation

Inferred from genetic interaction PubMed 14715945. Source: MGI

formation of radial glial scaffolds

Inferred from genetic interaction PubMed 14715945. Source: MGI

hippocampus development

Inferred from mutant phenotype PubMed 10631168. Source: MGI

hypothalamus development

Inferred from Biological aspect of Ancestor. Source: RefGenome

mammary gland development

Inferred from mutant phenotype PubMed 16678815. Source: MGI

muscle fiber development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of apoptotic process in bone marrow

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of interleukin-13 production

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of interleukin-4 production

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of interleukin-5 production

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of striated muscle tissue development

Inferred from direct assay PubMed 16936075. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16678101PubMed 19056892. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12551949. Source: MGI

neural crest cell migration

Inferred from Biological aspect of Ancestor. Source: RefGenome

neutrophil differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

odontoblast differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 12502739PubMed 15649466. Source: MGI

osteoblast differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

paraxial mesoderm formation

Inferred from genetic interaction PubMed 10090727. Source: MGI

patterning of blood vessels

Inferred from mutant phenotype PubMed 19154719. Source: MGI

positive regulation of cell proliferation in bone marrow

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12475749PubMed 15545629. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 10631168. Source: MGI

regulation of Wnt signaling pathway

Inferred from genetic interaction PubMed 10090727. Source: MGI

regulation of cell-cell adhesion

Inferred from mutant phenotype PubMed 19154719. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 11696550. Source: MGI

sensory perception of taste

Inferred from mutant phenotype PubMed 17284610. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 15545629. Source: MGI

sprouting angiogenesis

Inferred from mutant phenotype PubMed 19154719. Source: MGI

tongue development

Inferred from mutant phenotype PubMed 17284610. Source: MGI

trachea gland development

Inferred from mutant phenotype PubMed 10498680. Source: MGI

transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15729346. Source: GOC

vasculature development

Inferred from mutant phenotype PubMed 16163358. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 14623238. Source: MGI

nucleus

Inferred from direct assay PubMed 10498690PubMed 12551949PubMed 14623238PubMed 16510873PubMed 18202148PubMed 21464233PubMed 22935613PubMed 7537238. Source: MGI

transcription factor complex

Inferred from physical interaction PubMed 11696550. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15545629PubMed 16936075. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from genetic interaction PubMed 15729346. Source: MGI

armadillo repeat domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

beta-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

chromatin binding

Inferred from direct assay PubMed 15024079PubMed 16678101PubMed 16818445PubMed 18202148. Source: MGI

enhancer binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

estrogen receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

gamma-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 11696550PubMed 15545629PubMed 16936075. Source: MGI

transcription factor binding

Inferred from physical interaction PubMed 12551949. Source: MGI

transcription regulatory region DNA binding

Inferred from direct assay PubMed 12551949PubMed 19056892PubMed 7537238. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8C402 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 383E0F6AA6F7E84F

FASTA33137,041
        10         20         30         40         50         60 
MAGVVRQAPS SQEPYHDKAR EHPDEGKHPD GGLYNKGPSY SSYSGYIMMP NMNSDPYMSN 

        70         80         90        100        110        120 
GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG SHPSHIPSDV NSKQGMSRHP 

       130        140        150        160        170        180 
PAPEIPTFYP LSPGGVGQIT PPIGWQGQPV YPITGGFRQP YPSSLSGDTS MSRFSHHMIP 

       190        200        210        220        230        240 
GPPGPHTTGI PHPAIVTPQV KQEHPHTDSD LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML 

       250        260        270        280        290        300 
YMKEMRANVV AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA 

       310        320        330 
RDNYGKKKKR KREKLQESTS GTGPRMTAAY I 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12205.1.
[7]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38867.1.
Tissue: Thymus EMBL BAC38867.1.
[10]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12205.1.
[11]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000096211.
[12]Ensembl
Submitted (JUN-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000096211.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqNP_001263332.1. NM_001276403.1.
UniGeneMm.255219.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneID16842.
KEGGmmu:16842.
UCSCuc008rjk.1. mouse.

Organism-specific databases

CTD51176.
MGIMGI:96770. Lef1.

Phylogenomic databases

GeneTreeENSGT00390000009964.
HOVERGENHBG000419.
KOK04492.

Gene expression databases

GenevestigatorQ8C402.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR028769. LEF1.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF11. PTHR10373:SF11. 1 hit.
PfamPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLEF1. mouse.
SOURCESearch...

Entry information

Entry nameQ8C402_MOUSE
AccessionPrimary (citable) accession number: Q8C402
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)