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Q8C402

- Q8C402_MOUSE

UniProt

Q8C402 - Q8C402_MOUSE

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Protein
Submitted name:

Lymphoid enhancer binding factor 1, isoform CRA_b

Gene

Lef1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. armadillo repeat domain binding Source: RefGenome
  2. beta-catenin binding Source: RefGenome
  3. chromatin binding Source: MGI
  4. DNA binding Source: MGI
  5. enhancer binding Source: RefGenome
  6. estrogen receptor binding Source: RefGenome
  7. gamma-catenin binding Source: RefGenome
  8. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  9. sequence-specific DNA binding Source: MGI
  10. sequence-specific DNA binding transcription factor activity Source: MGI
  11. transcription factor binding Source: MGI
  12. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. alpha-beta T cell differentiation Source: MGI
  2. anatomical structure regression Source: MGI
  3. apoptotic process involved in morphogenesis Source: MGI
  4. apoptotic process involved in patterning of blood vessels Source: MGI
  5. B cell proliferation Source: MGI
  6. BMP signaling pathway Source: MGI
  7. canonical Wnt signaling pathway Source: RefGenome
  8. cell development Source: MGI
  9. chorio-allantoic fusion Source: MGI
  10. dentate gyrus development Source: MGI
  11. embryonic limb morphogenesis Source: MGI
  12. eye pigmentation Source: RefGenome
  13. face morphogenesis Source: MGI
  14. forebrain neuroblast division Source: MGI
  15. forebrain neuron differentiation Source: RefGenome
  16. forebrain radial glial cell differentiation Source: MGI
  17. formation of radial glial scaffolds Source: MGI
  18. hippocampus development Source: MGI
  19. hypothalamus development Source: RefGenome
  20. mammary gland development Source: MGI
  21. muscle fiber development Source: RefGenome
  22. negative regulation of apoptotic process in bone marrow Source: RefGenome
  23. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RefGenome
  24. negative regulation of interleukin-13 production Source: RefGenome
  25. negative regulation of interleukin-4 production Source: RefGenome
  26. negative regulation of interleukin-5 production Source: RefGenome
  27. negative regulation of striated muscle tissue development Source: MGI
  28. negative regulation of transcription, DNA-templated Source: MGI
  29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  30. neural crest cell migration Source: RefGenome
  31. neutrophil differentiation Source: RefGenome
  32. odontoblast differentiation Source: RefGenome
  33. odontogenesis of dentin-containing tooth Source: MGI
  34. osteoblast differentiation Source: RefGenome
  35. paraxial mesoderm formation Source: MGI
  36. patterning of blood vessels Source: MGI
  37. positive regulation of cell proliferation in bone marrow Source: RefGenome
  38. positive regulation of transcription, DNA-templated Source: MGI
  39. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  40. regulation of cell-cell adhesion Source: MGI
  41. regulation of transcription from RNA polymerase II promoter Source: MGI
  42. regulation of Wnt signaling pathway Source: MGI
  43. sensory perception of taste Source: MGI
  44. somitogenesis Source: MGI
  45. sprouting angiogenesis Source: MGI
  46. T cell receptor V(D)J recombination Source: MGI
  47. tongue development Source: MGI
  48. trachea gland development Source: MGI
  49. transcription from RNA polymerase II promoter Source: GOC
  50. vasculature development Source: MGI
  51. Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphoid enhancer binding factor 1, isoform CRA_bImported
Submitted name:
Lymphoid enhancer-binding factor 1Imported
Gene namesi
Name:Lef1Imported
ORF Names:mCG_10208Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96770. Lef1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. transcription factor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8C402.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029611.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOVERGENiHBG000419.
KOiK04492.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C402-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGVVRQAPS SQEPYHDKAR EHPDEGKHPD GGLYNKGPSY SSYSGYIMMP
60 70 80 90 100
NMNSDPYMSN GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG
110 120 130 140 150
SHPSHIPSDV NSKQGMSRHP PAPEIPTFYP LSPGGVGQIT PPIGWQGQPV
160 170 180 190 200
YPITGGFRQP YPSSLSGDTS MSRFSHHMIP GPPGPHTTGI PHPAIVTPQV
210 220 230 240 250
KQEHPHTDSD LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML YMKEMRANVV
260 270 280 290 300
AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA
310 320 330
RDNYGKKKKR KREKLQESTS GTGPRMTAAY I
Length:331
Mass (Da):37,041
Last modified:March 1, 2003 - v1
Checksum:i383E0F6AA6F7E84F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqiNP_001263332.1. NM_001276403.1.
UniGeneiMm.255219.

Genome annotation databases

EnsembliENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneIDi16842.
KEGGimmu:16842.
UCSCiuc008rjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1 .
CH466532 Genomic DNA. Translation: EDL12205.1 .
RefSeqi NP_001263332.1. NM_001276403.1.
UniGenei Mm.255219.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098611 ; ENSMUSP00000096211 ; ENSMUSG00000027985 .
GeneIDi 16842.
KEGGi mmu:16842.
UCSCi uc008rjk.1. mouse.

Organism-specific databases

CTDi 51176.
MGIi MGI:96770. Lef1.

Phylogenomic databases

GeneTreei ENSGT00390000009964.
HOVERGENi HBG000419.
KOi K04492.

Miscellaneous databases

ChiTaRSi LEF1. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8C402.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view ]
PANTHERi PTHR10373. PTHR10373. 1 hit.
Pfami PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C402_MOUSE
AccessioniPrimary (citable) accession number: Q8C402
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3