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Protein
Submitted name:

Lymphoid enhancer binding factor 1, isoform CRA_b

Gene

Lef1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. armadillo repeat domain binding Source: MGI
  2. beta-catenin binding Source: MGI
  3. C2H2 zinc finger domain binding Source: MGI
  4. chromatin binding Source: MGI
  5. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: MGI
  6. DNA binding Source: MGI
  7. enhancer binding Source: MGI
  8. estrogen receptor activity Source: MGI
  9. estrogen receptor binding Source: MGI
  10. gamma-catenin binding Source: MGI
  11. histone binding Source: MGI
  12. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  13. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  14. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  15. sequence-specific DNA binding Source: MGI
  16. sequence-specific DNA binding transcription factor activity Source: MGI
  17. transcription factor binding Source: MGI
  18. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. alpha-beta T cell differentiation Source: MGI
  2. anatomical structure regression Source: MGI
  3. apoptotic process involved in morphogenesis Source: MGI
  4. apoptotic process involved in patterning of blood vessels Source: MGI
  5. B cell proliferation Source: MGI
  6. BMP signaling pathway Source: MGI
  7. canonical Wnt signaling pathway Source: MGI
  8. cell chemotaxis Source: MGI
  9. cell development Source: MGI
  10. cellular response to cytokine stimulus Source: MGI
  11. cellular response to interleukin-4 Source: MGI
  12. chorio-allantoic fusion Source: MGI
  13. dentate gyrus development Source: MGI
  14. embryonic limb morphogenesis Source: MGI
  15. eye pigmentation Source: GO_Central
  16. face morphogenesis Source: MGI
  17. forebrain neuroblast division Source: MGI
  18. forebrain neuron differentiation Source: GO_Central
  19. forebrain radial glial cell differentiation Source: MGI
  20. formation of radial glial scaffolds Source: MGI
  21. hippocampus development Source: MGI
  22. histone H3 acetylation Source: MGI
  23. histone H4 acetylation Source: MGI
  24. hypothalamus development Source: GO_Central
  25. mammary gland development Source: MGI
  26. muscle fiber development Source: GO_Central
  27. negative regulation of apoptotic process Source: MGI
  28. negative regulation of apoptotic process in bone marrow Source: MGI
  29. negative regulation of canonical Wnt signaling pathway Source: MGI
  30. negative regulation of cell-cell adhesion Source: MGI
  31. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  32. negative regulation of DNA binding Source: MGI
  33. negative regulation of estrogen receptor binding Source: MGI
  34. negative regulation of interleukin-13 production Source: MGI
  35. negative regulation of interleukin-4 production Source: MGI
  36. negative regulation of interleukin-5 production Source: MGI
  37. negative regulation of striated muscle tissue development Source: MGI
  38. negative regulation of transcription, DNA-templated Source: MGI
  39. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  40. neural crest cell migration Source: GO_Central
  41. neutrophil differentiation Source: MGI
  42. odontoblast differentiation Source: GO_Central
  43. odontogenesis of dentin-containing tooth Source: MGI
  44. osteoblast differentiation Source: GO_Central
  45. paraxial mesoderm formation Source: MGI
  46. patterning of blood vessels Source: MGI
  47. positive regulation by host of viral transcription Source: MGI
  48. positive regulation of cell-cell adhesion Source: MGI
  49. positive regulation of cell cycle process Source: MGI
  50. positive regulation of cell growth Source: MGI
  51. positive regulation of cell migration Source: MGI
  52. positive regulation of cell proliferation Source: MGI
  53. positive regulation of cell proliferation in bone marrow Source: MGI
  54. positive regulation of epithelial to mesenchymal transition Source: MGI
  55. positive regulation of gene expression Source: MGI
  56. positive regulation of granulocyte differentiation Source: MGI
  57. positive regulation of transcription, DNA-templated Source: MGI
  58. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  59. regulation of cell-cell adhesion Source: MGI
  60. regulation of transcription from RNA polymerase II promoter Source: MGI
  61. regulation of Wnt signaling pathway Source: MGI
  62. sensory perception of taste Source: MGI
  63. somitogenesis Source: MGI
  64. sprouting angiogenesis Source: MGI
  65. steroid hormone mediated signaling pathway Source: MGI
  66. T cell receptor V(D)J recombination Source: MGI
  67. tongue development Source: MGI
  68. trachea gland development Source: MGI
  69. transcription from RNA polymerase II promoter Source: MGI
  70. vasculature development Source: MGI
  71. Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphoid enhancer binding factor 1, isoform CRA_bImported
Submitted name:
Lymphoid enhancer-binding factor 1Imported
Gene namesi
Name:Lef1Imported
ORF Names:mCG_10208Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96770. Lef1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. protein-DNA complex Source: MGI
  4. transcription factor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8C402.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029611.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOVERGENiHBG000419.
KOiK04492.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVVRQAPS SQEPYHDKAR EHPDEGKHPD GGLYNKGPSY SSYSGYIMMP
60 70 80 90 100
NMNSDPYMSN GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG
110 120 130 140 150
SHPSHIPSDV NSKQGMSRHP PAPEIPTFYP LSPGGVGQIT PPIGWQGQPV
160 170 180 190 200
YPITGGFRQP YPSSLSGDTS MSRFSHHMIP GPPGPHTTGI PHPAIVTPQV
210 220 230 240 250
KQEHPHTDSD LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML YMKEMRANVV
260 270 280 290 300
AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA
310 320 330
RDNYGKKKKR KREKLQESTS GTGPRMTAAY I
Length:331
Mass (Da):37,041
Last modified:March 1, 2003 - v1
Checksum:i383E0F6AA6F7E84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqiNP_001263332.1. NM_001276403.1.
UniGeneiMm.255219.

Genome annotation databases

EnsembliENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneIDi16842.
KEGGimmu:16842.
UCSCiuc008rjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqiNP_001263332.1. NM_001276403.1.
UniGeneiMm.255219.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneIDi16842.
KEGGimmu:16842.
UCSCiuc008rjk.1. mouse.

Organism-specific databases

CTDi51176.
MGIiMGI:96770. Lef1.

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOVERGENiHBG000419.
KOiK04492.

Miscellaneous databases

ChiTaRSiLef1. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8C402.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C402_MOUSE
AccessioniPrimary (citable) accession number: Q8C402
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.