Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Lymphoid enhancer binding factor 1, isoform CRA_b

Gene

Lef1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • alpha-beta T cell differentiation Source: MGI
  • anatomical structure regression Source: MGI
  • apoptotic process involved in morphogenesis Source: MGI
  • apoptotic process involved in patterning of blood vessels Source: MGI
  • B cell proliferation Source: MGI
  • BMP signaling pathway Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell chemotaxis Source: MGI
  • cell development Source: MGI
  • cellular response to cytokine stimulus Source: MGI
  • cellular response to interleukin-4 Source: MGI
  • chorio-allantoic fusion Source: MGI
  • dentate gyrus development Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • eye pigmentation Source: GO_Central
  • face morphogenesis Source: MGI
  • forebrain neuroblast division Source: MGI
  • forebrain neuron differentiation Source: GO_Central
  • forebrain radial glial cell differentiation Source: MGI
  • formation of radial glial scaffolds Source: MGI
  • generation of neurons Source: GO_Central
  • hippocampus development Source: MGI
  • histone H3 acetylation Source: MGI
  • histone H4 acetylation Source: MGI
  • hypothalamus development Source: GO_Central
  • mammary gland development Source: MGI
  • muscle fiber development Source: GO_Central
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of apoptotic process in bone marrow Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell-cell adhesion Source: MGI
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of DNA binding Source: MGI
  • negative regulation of estrogen receptor binding Source: MGI
  • negative regulation of interleukin-13 production Source: MGI
  • negative regulation of interleukin-4 production Source: MGI
  • negative regulation of interleukin-5 production Source: MGI
  • negative regulation of striated muscle tissue development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neural crest cell migration Source: GO_Central
  • neutrophil differentiation Source: MGI
  • odontoblast differentiation Source: GO_Central
  • odontogenesis of dentin-containing tooth Source: MGI
  • osteoblast differentiation Source: GO_Central
  • paraxial mesoderm formation Source: MGI
  • patterning of blood vessels Source: MGI
  • positive regulation by host of viral transcription Source: MGI
  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of cell cycle process Source: MGI
  • positive regulation of cell growth Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cell proliferation in bone marrow Source: MGI
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of granulocyte differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell-cell adhesion Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of Wnt signaling pathway Source: MGI
  • sensory perception of taste Source: MGI
  • somitogenesis Source: MGI
  • sprouting angiogenesis Source: MGI
  • steroid hormone mediated signaling pathway Source: MGI
  • T cell receptor V(D)J recombination Source: MGI
  • tongue development Source: MGI
  • trachea gland development Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
  • vasculature development Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphoid enhancer binding factor 1, isoform CRA_bImported
Submitted name:
Lymphoid enhancer-binding factor 1Imported
Gene namesi
Name:Lef1Imported
ORF Names:mCG_10208Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96770. Lef1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • protein-DNA complex Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029611.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOVERGENiHBG000419.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVVRQAPS SQEPYHDKAR EHPDEGKHPD GGLYNKGPSY SSYSGYIMMP
60 70 80 90 100
NMNSDPYMSN GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG
110 120 130 140 150
SHPSHIPSDV NSKQGMSRHP PAPEIPTFYP LSPGGVGQIT PPIGWQGQPV
160 170 180 190 200
YPITGGFRQP YPSSLSGDTS MSRFSHHMIP GPPGPHTTGI PHPAIVTPQV
210 220 230 240 250
KQEHPHTDSD LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML YMKEMRANVV
260 270 280 290 300
AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA
310 320 330
RDNYGKKKKR KREKLQESTS GTGPRMTAAY I
Length:331
Mass (Da):37,041
Last modified:March 1, 2003 - v1
Checksum:i383E0F6AA6F7E84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqiNP_001263332.1. NM_001276403.1.
UniGeneiMm.255219.

Genome annotation databases

EnsembliENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneIDi16842.
UCSCiuc008rjk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
AK083328 mRNA. Translation: BAC38867.1.
CH466532 Genomic DNA. Translation: EDL12205.1.
RefSeqiNP_001263332.1. NM_001276403.1.
UniGeneiMm.255219.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098611; ENSMUSP00000096211; ENSMUSG00000027985.
GeneIDi16842.
UCSCiuc008rjk.2. mouse.

Organism-specific databases

CTDi51176.
MGIiMGI:96770. Lef1.

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOVERGENiHBG000419.

Miscellaneous databases

ChiTaRSiLef1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C402_MOUSE
AccessioniPrimary (citable) accession number: Q8C402
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.