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Protein

Lipase maturation factor 2

Gene

Lmf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8963889 Assembly of active LPL and LIPC lipase complexes

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase maturation factor 2
Alternative name(s):
Transmembrane protein 112B
Transmembrane protein 153
Gene namesi
Name:Lmf2
Synonyms:Tmem112b, Tmem153
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146015 Lmf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245111 – 702Lipase maturation factor 2Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8C3X8
MaxQBiQ8C3X8
PaxDbiQ8C3X8
PeptideAtlasiQ8C3X8
PRIDEiQ8C3X8

PTM databases

iPTMnetiQ8C3X8
PhosphoSitePlusiQ8C3X8

Expressioni

Gene expression databases

BgeeiENSMUSG00000022614
CleanExiMM_LMF2
GenevisibleiQ8C3X8 MM

Structurei

3D structure databases

ProteinModelPortaliQ8C3X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lipase maturation factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKQ Eukaryota
ENOG410XPYW LUCA
GeneTreeiENSGT00530000063702
HOGENOMiHOG000019333
HOVERGENiHBG108090
InParanoidiQ8C3X8
OMAiWVEEFFP
OrthoDBiEOG091G05XZ
PhylomeDBiQ8C3X8
TreeFamiTF314339

Family and domain databases

InterProiView protein in InterPro
IPR009613 LMF
PfamiView protein in Pfam
PF06762 LMF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRVPQQL FLQGVAAVYL FAFASLYTQI PGLYGPEGIL PARRTLRPQG
60 70 80 90 100
KGLWQQLWET PTLLWEAPRL GLDTAQGLDL LTLLGTVLAL GALLLNSLRH
110 120 130 140 150
PFVYLLLWVA YRSAYQVGQV FLYFQWDSLL LETGFLAILV APLRGPSKHK
160 170 180 190 200
ILQGRLAGAL PHEDLPFWLV RWLLFRLMFA SGVVKLTSRC PTWWGLTALT
210 220 230 240 250
YHYETQCLPT PAAWFAHHLP VWLHKLSVVA TFLIEIAVPP LFFAPIRRLR
260 270 280 290 300
LTAFYAQALL QVLIIITGNY NFFNLLTLVL TTALLDDRHL SAEPGLRCHK
310 320 330 340 350
KMPTSWPKAL LTALSLLLEL TVYGLLAYGT VYYFGLEVDW QQHIILSKTT
360 370 380 390 400
FTFHQFSQWL KTVTLPTVWL GTASLAWELL VVLWRWIQVQ GWSRKFSAGI
410 420 430 440 450
QLSVLGTATV ALFLISLVPY SYVEPGTHGR LWTGAHRLFG SVEHLQLANS
460 470 480 490 500
YGLFRRMTGV GGRPEVVLEG SYDGQHWTEI EFMYKPGNVS RPPPFLTPHQ
510 520 530 540 550
PRLDWQMWFA ALGPHTHSPW FTGLVLRLLQ GKEPVIRLVQ SHVANYPFHE
560 570 580 590 600
RPPTYLRAQR YKYWFSKPGD QSRWWHRQWV EEFFPSVSLG DPTLETLLQQ
610 620 630 640 650
FGLKDKSPPR ARSPSNGLAQ TLNWVRTQLS PLEPPILLWG LFGAVVAIRV
660 670 680 690 700
VQTLLAPRPL QSSKQTREEK RKQTSKKDSR AASEQAAANS NSRDSWAPRR

KK
Length:702
Mass (Da):79,997
Last modified:March 1, 2003 - v1
Checksum:iD6E880D37C517A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084606 mRNA Translation: BAC39228.1
AK149916 mRNA Translation: BAE29164.1
AK149934 mRNA Translation: BAE29177.1
AK171488 mRNA Translation: BAE42488.1
BC079532 mRNA Translation: AAH79532.1
CCDSiCCDS27746.1
RefSeqiNP_849250.1, NM_178919.4
UniGeneiMm.34511

Genome annotation databases

EnsembliENSMUST00000023283; ENSMUSP00000023283; ENSMUSG00000022614
GeneIDi105847
KEGGimmu:105847
UCSCiuc007xgd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLMF2_MOUSE
AccessioniPrimary (citable) accession number: Q8C3X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health