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Protein

Lipase maturation factor 2

Gene

Lmf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase maturation factor 2
Alternative name(s):
Transmembrane protein 112B
Transmembrane protein 153
Gene namesi
Name:Lmf2
Synonyms:Tmem112b, Tmem153
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146015. Lmf2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Lipase maturation factor 2PRO_0000324511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8C3X8.
MaxQBiQ8C3X8.
PaxDbiQ8C3X8.
PRIDEiQ8C3X8.

PTM databases

PhosphoSiteiQ8C3X8.

Expressioni

Gene expression databases

BgeeiQ8C3X8.
CleanExiMM_LMF2.
GenevisibleiQ8C3X8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023283.

Structurei

3D structure databases

ProteinModelPortaliQ8C3X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lipase maturation factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKQ. Eukaryota.
ENOG410XPYW. LUCA.
GeneTreeiENSGT00530000063702.
HOGENOMiHOG000019333.
HOVERGENiHBG108090.
InParanoidiQ8C3X8.
OMAiWQQRTIH.
OrthoDBiEOG7B31MK.
PhylomeDBiQ8C3X8.
TreeFamiTF314339.

Family and domain databases

InterProiIPR009613. LMF.
[Graphical view]
PfamiPF06762. LMF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRVPQQL FLQGVAAVYL FAFASLYTQI PGLYGPEGIL PARRTLRPQG
60 70 80 90 100
KGLWQQLWET PTLLWEAPRL GLDTAQGLDL LTLLGTVLAL GALLLNSLRH
110 120 130 140 150
PFVYLLLWVA YRSAYQVGQV FLYFQWDSLL LETGFLAILV APLRGPSKHK
160 170 180 190 200
ILQGRLAGAL PHEDLPFWLV RWLLFRLMFA SGVVKLTSRC PTWWGLTALT
210 220 230 240 250
YHYETQCLPT PAAWFAHHLP VWLHKLSVVA TFLIEIAVPP LFFAPIRRLR
260 270 280 290 300
LTAFYAQALL QVLIIITGNY NFFNLLTLVL TTALLDDRHL SAEPGLRCHK
310 320 330 340 350
KMPTSWPKAL LTALSLLLEL TVYGLLAYGT VYYFGLEVDW QQHIILSKTT
360 370 380 390 400
FTFHQFSQWL KTVTLPTVWL GTASLAWELL VVLWRWIQVQ GWSRKFSAGI
410 420 430 440 450
QLSVLGTATV ALFLISLVPY SYVEPGTHGR LWTGAHRLFG SVEHLQLANS
460 470 480 490 500
YGLFRRMTGV GGRPEVVLEG SYDGQHWTEI EFMYKPGNVS RPPPFLTPHQ
510 520 530 540 550
PRLDWQMWFA ALGPHTHSPW FTGLVLRLLQ GKEPVIRLVQ SHVANYPFHE
560 570 580 590 600
RPPTYLRAQR YKYWFSKPGD QSRWWHRQWV EEFFPSVSLG DPTLETLLQQ
610 620 630 640 650
FGLKDKSPPR ARSPSNGLAQ TLNWVRTQLS PLEPPILLWG LFGAVVAIRV
660 670 680 690 700
VQTLLAPRPL QSSKQTREEK RKQTSKKDSR AASEQAAANS NSRDSWAPRR

KK
Length:702
Mass (Da):79,997
Last modified:March 1, 2003 - v1
Checksum:iD6E880D37C517A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084606 mRNA. Translation: BAC39228.1.
AK149916 mRNA. Translation: BAE29164.1.
AK149934 mRNA. Translation: BAE29177.1.
AK171488 mRNA. Translation: BAE42488.1.
BC079532 mRNA. Translation: AAH79532.1.
CCDSiCCDS27746.1.
RefSeqiNP_849250.1. NM_178919.4.
UniGeneiMm.34511.

Genome annotation databases

EnsembliENSMUST00000023283; ENSMUSP00000023283; ENSMUSG00000022614.
GeneIDi105847.
KEGGimmu:105847.
UCSCiuc007xgd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084606 mRNA. Translation: BAC39228.1.
AK149916 mRNA. Translation: BAE29164.1.
AK149934 mRNA. Translation: BAE29177.1.
AK171488 mRNA. Translation: BAE42488.1.
BC079532 mRNA. Translation: AAH79532.1.
CCDSiCCDS27746.1.
RefSeqiNP_849250.1. NM_178919.4.
UniGeneiMm.34511.

3D structure databases

ProteinModelPortaliQ8C3X8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023283.

PTM databases

PhosphoSiteiQ8C3X8.

Proteomic databases

EPDiQ8C3X8.
MaxQBiQ8C3X8.
PaxDbiQ8C3X8.
PRIDEiQ8C3X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023283; ENSMUSP00000023283; ENSMUSG00000022614.
GeneIDi105847.
KEGGimmu:105847.
UCSCiuc007xgd.2. mouse.

Organism-specific databases

CTDi91289.
MGIiMGI:2146015. Lmf2.

Phylogenomic databases

eggNOGiENOG410IFKQ. Eukaryota.
ENOG410XPYW. LUCA.
GeneTreeiENSGT00530000063702.
HOGENOMiHOG000019333.
HOVERGENiHBG108090.
InParanoidiQ8C3X8.
OMAiWQQRTIH.
OrthoDBiEOG7B31MK.
PhylomeDBiQ8C3X8.
TreeFamiTF314339.

Miscellaneous databases

ChiTaRSiLmf2. mouse.
NextBioi357928.
PROiQ8C3X8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C3X8.
CleanExiMM_LMF2.
GenevisibleiQ8C3X8. MM.

Family and domain databases

InterProiIPR009613. LMF.
[Graphical view]
PfamiPF06762. LMF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLMF2_MOUSE
AccessioniPrimary (citable) accession number: Q8C3X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.