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Q8C3X2

- CC90B_MOUSE

UniProt

Q8C3X2 - CC90B_MOUSE

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Protein

Coiled-coil domain-containing protein 90B, mitochondrial

Gene

Ccdc90b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 90B, mitochondrial
Gene namesi
Name:Ccdc90b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1913615. Ccdc90b.

Subcellular locationi

Mitochondrion By similarity. Membrane Curated; Single-pass membrane protein Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei231 – 25323HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionSequence AnalysisAdd
BLAST
Chaini43 – 256214Coiled-coil domain-containing protein 90B, mitochondrialPRO_0000295696Add
BLAST

Proteomic databases

MaxQBiQ8C3X2.
PaxDbiQ8C3X2.
PRIDEiQ8C3X2.

PTM databases

PhosphoSiteiQ8C3X2.

Expressioni

Gene expression databases

BgeeiQ8C3X2.
CleanExiMM_CCDC90B.
GenevestigatoriQ8C3X2.

Interactioni

Protein-protein interaction databases

IntActiQ8C3X2. 2 interactions.
MINTiMINT-4114288.
STRINGi10090.ENSMUSP00000032842.

Structurei

3D structure databases

ProteinModelPortaliQ8C3X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili129 – 16739Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC90 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297085.
GeneTreeiENSGT00390000016409.
HOGENOMiHOG000294135.
HOVERGENiHBG107611.
InParanoidiQ8C3X2.
OMAiTAMAEVI.
OrthoDBiEOG7SR4NS.
PhylomeDBiQ8C3X2.
TreeFamiTF331442.

Family and domain databases

InterProiIPR024461. DUF1640.
[Graphical view]
PfamiPF07798. DUF1640. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C3X2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSRWIWRFL RPDGGGIRWT STPHGRLSPA LRRGFLTTTT KSDYDRRPVD
60 70 80 90 100
ITPLEQRKLT FDTHALVQDL ETHGFDKTQA QTIVSVLSTL SNVSLDTIYK
110 120 130 140 150
EMVTKAQQEI TVQQLMAHLD SIRKDMVILE KSEFANLRAE NEKMKIELDQ
160 170 180 190 200
VKQQLTNETS RIRADNKLDI NLERSRVTDM FTDQEKQLIE ATNEFAKKDT
210 220 230 240 250
QTKSIISETS NKIDTEIASL KTLMESSKLE TIRYLAASVF TCLAIALGFY

RFWKEN
Length:256
Mass (Da):29,597
Last modified:March 1, 2003 - v1
Checksum:i0F5BB3CBDA61994B
GO
Isoform 2 (identifier: Q8C3X2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-142: Missing.

Note: No experimental confirmation available.

Show »
Length:222
Mass (Da):25,642
Checksum:i682028974E38370F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151G → C in BAB26248. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 14234Missing in isoform 2. 1 PublicationVSP_027004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084673 mRNA. Translation: BAC39246.1.
AK009370 mRNA. Translation: BAB26248.1.
BC034878 mRNA. Translation: AAH34878.1.
BC115973 mRNA. Translation: AAI15974.1.
CCDSiCCDS21449.1. [Q8C3X2-1]
CCDS52309.1. [Q8C3X2-2]
RefSeqiNP_001156390.1. NM_001162918.1. [Q8C3X2-2]
NP_079791.2. NM_025515.3. [Q8C3X2-1]
UniGeneiMm.21173.

Genome annotation databases

EnsembliENSMUST00000032842; ENSMUSP00000032842; ENSMUSG00000030613. [Q8C3X2-1]
ENSMUST00000085017; ENSMUSP00000082090; ENSMUSG00000030613. [Q8C3X2-2]
GeneIDi66365.
KEGGimmu:66365.
UCSCiuc009ihv.2. mouse. [Q8C3X2-1]
uc009ihw.2. mouse. [Q8C3X2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084673 mRNA. Translation: BAC39246.1 .
AK009370 mRNA. Translation: BAB26248.1 .
BC034878 mRNA. Translation: AAH34878.1 .
BC115973 mRNA. Translation: AAI15974.1 .
CCDSi CCDS21449.1. [Q8C3X2-1 ]
CCDS52309.1. [Q8C3X2-2 ]
RefSeqi NP_001156390.1. NM_001162918.1. [Q8C3X2-2 ]
NP_079791.2. NM_025515.3. [Q8C3X2-1 ]
UniGenei Mm.21173.

3D structure databases

ProteinModelPortali Q8C3X2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8C3X2. 2 interactions.
MINTi MINT-4114288.
STRINGi 10090.ENSMUSP00000032842.

PTM databases

PhosphoSitei Q8C3X2.

Proteomic databases

MaxQBi Q8C3X2.
PaxDbi Q8C3X2.
PRIDEi Q8C3X2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032842 ; ENSMUSP00000032842 ; ENSMUSG00000030613 . [Q8C3X2-1 ]
ENSMUST00000085017 ; ENSMUSP00000082090 ; ENSMUSG00000030613 . [Q8C3X2-2 ]
GeneIDi 66365.
KEGGi mmu:66365.
UCSCi uc009ihv.2. mouse. [Q8C3X2-1 ]
uc009ihw.2. mouse. [Q8C3X2-2 ]

Organism-specific databases

CTDi 60492.
MGIi MGI:1913615. Ccdc90b.

Phylogenomic databases

eggNOGi NOG297085.
GeneTreei ENSGT00390000016409.
HOGENOMi HOG000294135.
HOVERGENi HBG107611.
InParanoidi Q8C3X2.
OMAi TAMAEVI.
OrthoDBi EOG7SR4NS.
PhylomeDBi Q8C3X2.
TreeFami TF331442.

Miscellaneous databases

NextBioi 321453.
PROi Q8C3X2.
SOURCEi Search...

Gene expression databases

Bgeei Q8C3X2.
CleanExi MM_CCDC90B.
Genevestigatori Q8C3X2.

Family and domain databases

InterProi IPR024461. DUF1640.
[Graphical view ]
Pfami PF07798. DUF1640. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Heart and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary gland.

Entry informationi

Entry nameiCC90B_MOUSE
AccessioniPrimary (citable) accession number: Q8C3X2
Secondary accession number(s): Q8JZY3, Q9D7C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3