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Protein

Signal transducer and activator of transcription

Gene

Stat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1059683. Interleukin-6 signaling.
R-MMU-1169408. ISG15 antiviral mechanism.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-186763. Downstream signal transduction.
R-MMU-877300. Interferon gamma signaling.
R-MMU-877312. Regulation of IFNG signaling.
R-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat1Imported
ORF Names:mCG_123683Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103063. Stat1.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000026104.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini573 – 670SH2InterPro annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 166Sequence analysisAdd BLAST28
Coiled coili263 – 290Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022752. STAT1_TAZ2-bd_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12162. STAT1_TAZ2bind. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C3V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQWFELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV
60 70 80 90 100
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ
110 120 130 140 150
MSMIIYNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK
160 170 180 190 200
DQVMCIEQEI KTLEELQDEY DFKCKTSQNR EGEANGVAKS DQKQEQLLLH
210 220 230 240 250
KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK RRQQSACIGG
260 270 280 290 300
PPNACLDQLQ SWFTIVAETL QQIRQQLKKL EELEQKFTYE PDPITKNKQV
310 320 330 340 350
LSDRTFLLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
360 370 380 390 400
LQELNYNLKV KVSFDKDVNE KNTVKGFRKF NILGTHTKVM NMEESTNGSL
410 420 430 440 450
AAEFRHLQLK EQKNAGNRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET
460 470 480 490 500
TSLPVVVISN VSQLPSGWAS ILWYNMLVTE PRNLSFFLNP PCAWWSQLSE
510 520 530 540 550
VLSWQFSSVT KRGLNADQLS MLGEKLLGPN AGPDGLIPWT RFCKENINDK
560 570 580 590 600
NFSFWPWIDT ILELIKKHLL CLWNDGCIMG FISKERERAL LKDQQPGTFL
610 620 630 640 650
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN
660 670 680 690 700
YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDDPKRTG
710 720 730 740
YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEMSRIVGP EFDSMMSTV
Length:749
Mass (Da):87,315
Last modified:March 1, 2003 - v1
Checksum:iFF7EA8C1734F7C99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA. No translation available.
AK084855 mRNA. Translation: BAC39293.1.
CH466548 Genomic DNA. Translation: EDK99968.1.
RefSeqiNP_001192243.1. NM_001205314.1.
NP_033309.3. NM_009283.4.
XP_006495874.1. XM_006495811.3.
XP_017174952.1. XM_017319463.1.
XP_017174953.1. XM_017319464.1.
UniGeneiMm.277406.
Mm.487336.

Genome annotation databases

EnsembliENSMUST00000070968; ENSMUSP00000066743; ENSMUSG00000026104.
ENSMUST00000186857; ENSMUSP00000140875; ENSMUSG00000026104.
GeneIDi20846.
UCSCiuc007aya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA. No translation available.
AK084855 mRNA. Translation: BAC39293.1.
CH466548 Genomic DNA. Translation: EDK99968.1.
RefSeqiNP_001192243.1. NM_001205314.1.
NP_033309.3. NM_009283.4.
XP_006495874.1. XM_006495811.3.
XP_017174952.1. XM_017319463.1.
XP_017174953.1. XM_017319464.1.
UniGeneiMm.277406.
Mm.487336.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070968; ENSMUSP00000066743; ENSMUSG00000026104.
ENSMUST00000186857; ENSMUSP00000140875; ENSMUSG00000026104.
GeneIDi20846.
UCSCiuc007aya.2. mouse.

Organism-specific databases

CTDi6772.
MGIiMGI:103063. Stat1.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
TreeFamiTF318648.

Enzyme and pathway databases

ReactomeiR-MMU-1059683. Interleukin-6 signaling.
R-MMU-1169408. ISG15 antiviral mechanism.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-186763. Downstream signal transduction.
R-MMU-877300. Interferon gamma signaling.
R-MMU-877312. Regulation of IFNG signaling.
R-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.

Miscellaneous databases

ChiTaRSiStat1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022752. STAT1_TAZ2-bd_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12162. STAT1_TAZ2bind. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8C3V4_MOUSE
AccessioniPrimary (citable) accession number: Q8C3V4
Secondary accession number(s): E9QK78
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.