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Q8C3V4

- Q8C3V4_MOUSE

UniProt

Q8C3V4 - Q8C3V4_MOUSE

Protein

Signal transducer and activator of transcription

Gene

Stat1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    4. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    5. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. sequence-specific DNA binding transcription factor activity Source: MGI
    7. signal transducer activity Source: InterPro

    GO - Biological processi

    1. blood circulation Source: Ensembl
    2. cellular response to insulin stimulus Source: Ensembl
    3. cellular response to interferon-beta Source: Ensembl
    4. cytokine-mediated signaling pathway Source: MGI
    5. JAK-STAT cascade Source: Ensembl
    6. lipopolysaccharide-mediated signaling pathway Source: MGI
    7. negative regulation of angiogenesis Source: Ensembl
    8. negative regulation of endothelial cell proliferation Source: Ensembl
    9. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    10. negative regulation of macrophage fusion Source: MGI
    11. positive regulation of smooth muscle cell proliferation Source: Ensembl
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. renal tubule development Source: Ensembl
    14. response to bacterium Source: MGI
    15. response to cAMP Source: Ensembl
    16. response to drug Source: Ensembl
    17. response to exogenous dsRNA Source: MGI
    18. response to hydrogen peroxide Source: Ensembl
    19. response to lipopolysaccharide Source: MGI
    20. response to mechanical stimulus Source: Ensembl
    21. response to nutrient Source: Ensembl
    22. transcription, DNA-templated Source: MGI
    23. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198533. ISG15 antiviral mechanism.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.
    REACT_199118. Interleukin-6 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcriptionUniRule annotation
    Gene namesi
    Name:Stat1Imported
    ORF Names:mCG_123683Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:103063. Stat1.

    Subcellular locationi

    Cytoplasm UniRule annotation
    Nucleus UniRule annotation

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: MGI
    3. dendrite Source: Ensembl
    4. nuclear chromatin Source: Ensembl
    5. nucleolus Source: Ensembl
    6. nucleus Source: MGI

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8C3V4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.UniRule annotation
    Contains 1 SH2 domain.UniRule annotation

    Keywords - Domaini

    SH2 domainUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117596.
    HOVERGENiHBG055669.
    InParanoidiQ8C3V4.
    KOiK11220.
    OMAiKNKQVLW.
    OrthoDBiEOG73JKTT.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022752. STAT1_TAZ2-bd_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF12162. STAT1_TAZ2bind. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C3V4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQWFELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV    50
    SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ 100
    MSMIIYNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK 150
    DQVMCIEQEI KTLEELQDEY DFKCKTSQNR EGEANGVAKS DQKQEQLLLH 200
    KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK RRQQSACIGG 250
    PPNACLDQLQ SWFTIVAETL QQIRQQLKKL EELEQKFTYE PDPITKNKQV 300
    LSDRTFLLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK 350
    LQELNYNLKV KVSFDKDVNE KNTVKGFRKF NILGTHTKVM NMEESTNGSL 400
    AAEFRHLQLK EQKNAGNRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET 450
    TSLPVVVISN VSQLPSGWAS ILWYNMLVTE PRNLSFFLNP PCAWWSQLSE 500
    VLSWQFSSVT KRGLNADQLS MLGEKLLGPN AGPDGLIPWT RFCKENINDK 550
    NFSFWPWIDT ILELIKKHLL CLWNDGCIMG FISKERERAL LKDQQPGTFL 600
    LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN 650
    YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDDPKRTG 700
    YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEMSRIVGP EFDSMMSTV 749
    Length:749
    Mass (Da):87,315
    Last modified:March 1, 2003 - v1
    Checksum:iFF7EA8C1734F7C99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123752 Genomic DNA. No translation available.
    AK084855 mRNA. Translation: BAC39293.1.
    CH466548 Genomic DNA. Translation: EDK99968.1.
    RefSeqiNP_001192243.1. NM_001205314.1.
    NP_033309.3. NM_009283.4.
    XP_006495874.1. XM_006495811.1.
    XP_006495875.1. XM_006495812.1.
    XP_006495876.1. XM_006495813.1.
    UniGeneiMm.277406.
    Mm.487336.

    Genome annotation databases

    EnsembliENSMUST00000070968; ENSMUSP00000066743; ENSMUSG00000026104.
    GeneIDi20846.
    KEGGimmu:20846.
    UCSCiuc007aya.2. mouse.
    uc007ayc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123752 Genomic DNA. No translation available.
    AK084855 mRNA. Translation: BAC39293.1 .
    CH466548 Genomic DNA. Translation: EDK99968.1 .
    RefSeqi NP_001192243.1. NM_001205314.1.
    NP_033309.3. NM_009283.4.
    XP_006495874.1. XM_006495811.1.
    XP_006495875.1. XM_006495812.1.
    XP_006495876.1. XM_006495813.1.
    UniGenei Mm.277406.
    Mm.487336.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070968 ; ENSMUSP00000066743 ; ENSMUSG00000026104 .
    GeneIDi 20846.
    KEGGi mmu:20846.
    UCSCi uc007aya.2. mouse.
    uc007ayc.2. mouse.

    Organism-specific databases

    CTDi 6772.
    MGIi MGI:103063. Stat1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117596.
    HOVERGENi HBG055669.
    InParanoidi Q8C3V4.
    KOi K11220.
    OMAi KNKQVLW.
    OrthoDBi EOG73JKTT.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198533. ISG15 antiviral mechanism.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.
    REACT_199118. Interleukin-6 signaling.

    Miscellaneous databases

    ChiTaRSi STAT1. mouse.
    NextBioi 299615.
    PROi Q8C3V4.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8C3V4.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022752. STAT1_TAZ2-bd_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF12162. STAT1_TAZ2bind. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    12. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8C3V4_MOUSE
    AccessioniPrimary (citable) accession number: Q8C3V4
    Secondary accession number(s): E9QK78
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3