##gff-version 3
Q8C3P7	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Chain	2	580	.	.	.	ID=PRO_0000207631;Note=N6-adenosine-methyltransferase subunit METTL3	
Q8C3P7	UniProtKB	Region	1	70	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8C3P7	UniProtKB	Region	198	217	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8C3P7	UniProtKB	Region	396	410	.	.	.	Note=Gate loop 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Region	450	454	.	.	.	Note=Interaction with METTL14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Region	462	479	.	.	.	Note=Interphase loop;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Region	464	480	.	.	.	Note=Interaction with METTL14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Region	465	478	.	.	.	Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Region	507	515	.	.	.	Note=Gate loop 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Motif	210	215	.	.	.	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Compositional bias	13	34	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8C3P7	UniProtKB	Compositional bias	43	70	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8C3P7	UniProtKB	Binding site	377	378	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Binding site	395	395	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Binding site	513	513	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Binding site	536	539	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Binding site	549	550	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Site	438	438	.	.	.	Note=Interaction with METTL14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Site	441	441	.	.	.	Note=Interaction with METTL14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylserine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	2	2	.	.	.	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	43	43	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	48	48	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	50	50	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	219	219	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
Q8C3P7	UniProtKB	Modified residue	243	243	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Modified residue	350	350	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Cross-link	177	177	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Cross-link	211	211	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Cross-link	212	212	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Cross-link	215	215	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86U44	
Q8C3P7	UniProtKB	Alternative sequence	34	106	.	.	.	ID=VSP_007867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11389549;Dbxref=PMID:11389549	
Q8C3P7	UniProtKB	Alternative sequence	241	299	.	.	.	ID=VSP_007868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11389549;Dbxref=PMID:11389549	
Q8C3P7	UniProtKB	Mutagenesis	395	398	.	.	.	Note=Loss of activity. DPPW->APPA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24209618,ECO:0000269|PubMed:28792938;Dbxref=PMID:24209618,PMID:28792938	
Q8C3P7	UniProtKB	Sequence conflict	162	162	.	.	.	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8C3P7	UniProtKB	Sequence conflict	471	471	.	.	.	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8C3P7	UniProtKB	Sequence conflict	475	475	.	.	.	Note=W->L;Ontology_term=ECO:0000305;evidence=ECO:0000305