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Q8C3K6

- SC5A1_MOUSE

UniProt

Q8C3K6 - SC5A1_MOUSE

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Protein

Sodium/glucose cotransporter 1

Gene

Slc5a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei43 – 431Implicated in sodium couplingBy similarity
Sitei300 – 3001Implicated in sodium couplingBy similarity
Binding sitei457 – 4571GlucoseBy similarity
Sitei460 – 4601Involved in sugar-binding/transport and inhibitor bindingBy similarity

GO - Molecular functioni

  1. glucose transmembrane transporter activity Source: MGI
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. glucose transport Source: MGI
  2. intestinal absorption Source: MGI
  3. metanephros development Source: MGI
  4. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
Gene namesi
Name:Slc5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107678. Slc5a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Topological domaini50 – 6415CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Topological domaini86 – 10520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 14216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 17815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei179 – 20123HelicalSequence AnalysisAdd
BLAST
Topological domaini202 – 2087CytoplasmicSequence Analysis
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 27748ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Topological domaini299 – 31315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence AnalysisAdd
BLAST
Topological domaini335 – 38046ExtracellularSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Topological domaini402 – 42322CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST
Topological domaini445 – 45511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Topological domaini477 – 4848CytoplasmicSequence Analysis
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST
Topological domaini506 – 52621ExtracellularSequence AnalysisAdd
BLAST
Intramembranei527 – 56337HelicalSequence AnalysisAdd
BLAST
Topological domaini564 – 64481ExtracellularSequence AnalysisAdd
BLAST
Transmembranei645 – 66521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. brush border Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Sodium/glucose cotransporter 1PRO_0000105367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi255 ↔ 611By similarity

Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8C3K6.
PaxDbiQ8C3K6.
PRIDEiQ8C3K6.

PTM databases

PhosphoSiteiQ8C3K6.

Expressioni

Gene expression databases

GenevestigatoriQ8C3K6.

Interactioni

Protein-protein interaction databases

IntActiQ8C3K6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8C3K6.
SMRiQ8C3K6. Positions 26-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8C3K6.
KOiK14158.
PhylomeDBiQ8C3K6.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C3K6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSSTLSPAV TATDAPIPSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG
110 120 130 140 150
FEWNALVLVV VLGWIFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTAI MLVGSFILTG FAFNEVGGYE AFMDKYMKAI PTKVSNGNFT
260 270 280 290 300
AKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLAILALWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KADCTLCGYL KLLPMFLMVM PGMISRILYT EKIACVLPEE
360 370 380 390 400
CQKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY TKIRKKASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEQGAFWGLI LGFLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFVISVIT ILIISFLTKP
560 570 580 590 600
IPDVHLYRWC WSLRNSKEER IDLDAGEEED IPEDSKDTIE IDTEAPQKKK
610 620 630 640 650
GCFRRAYDLF CGLDQDKGPK MTKEEEEAMK MKMTDTSEKP LWRTVVNING
660
IILLAVAVFC HAYFA
Length:665
Mass (Da):73,449
Last modified:March 1, 2003 - v1
Checksum:i70905E30408BE378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085602 mRNA. Translation: BAC39483.1.
CCDSiCCDS19199.1.
RefSeqiNP_062784.3. NM_019810.4.
UniGeneiMm.25237.

Genome annotation databases

GeneIDi20537.
KEGGimmu:20537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085602 mRNA. Translation: BAC39483.1 .
CCDSi CCDS19199.1.
RefSeqi NP_062784.3. NM_019810.4.
UniGenei Mm.25237.

3D structure databases

ProteinModelPortali Q8C3K6.
SMRi Q8C3K6. Positions 26-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8C3K6. 1 interaction.

PTM databases

PhosphoSitei Q8C3K6.

Proteomic databases

MaxQBi Q8C3K6.
PaxDbi Q8C3K6.
PRIDEi Q8C3K6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20537.
KEGGi mmu:20537.

Organism-specific databases

CTDi 6523.
MGIi MGI:107678. Slc5a1.

Phylogenomic databases

eggNOGi COG4146.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi Q8C3K6.
KOi K14158.
PhylomeDBi Q8C3K6.

Miscellaneous databases

ChiTaRSi Slc5a1. mouse.
NextBioi 298811.
PROi Q8C3K6.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8C3K6.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A1_MOUSE
AccessioniPrimary (citable) accession number: Q8C3K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3