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Protein

Sodium/glucose cotransporter 1

Gene

Slc5a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1
Binding sitei457GlucoseBy similarity1
Sitei460Involved in sugar-binding/transport and inhibitor bindingBy similarity1

GO - Molecular functioni

  • glucose:sodium symporter activity Source: MGI
  • glucose transmembrane transporter activity Source: MGI

GO - Biological processi

  • glucose transport Source: MGI
  • intestinal absorption Source: MGI
  • intestinal D-glucose absorption Source: GO_Central
  • metanephros development Source: MGI
  • sodium ion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
Gene namesi
Name:Slc5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107678. Slc5a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 64CytoplasmicSequence analysisAdd BLAST15
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 142CytoplasmicSequence analysisAdd BLAST16
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 201HelicalSequence analysisAdd BLAST23
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 277ExtracellularSequence analysisAdd BLAST48
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 313CytoplasmicSequence analysisAdd BLAST15
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 380ExtracellularSequence analysisAdd BLAST46
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 423CytoplasmicSequence analysisAdd BLAST22
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 484CytoplasmicSequence analysis8
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 526ExtracellularSequence analysisAdd BLAST21
Intramembranei527 – 563HelicalSequence analysisAdd BLAST37
Topological domaini564 – 644ExtracellularSequence analysisAdd BLAST81
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • brush border Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053671 – 665Sodium/glucose cotransporter 1Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 611By similarity
Modified residuei585PhosphoserineCombined sources1
Modified residuei588PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8C3K6.
PaxDbiQ8C3K6.
PeptideAtlasiQ8C3K6.
PRIDEiQ8C3K6.

PTM databases

iPTMnetiQ8C3K6.
PhosphoSitePlusiQ8C3K6.

Interactioni

Protein-protein interaction databases

IntActiQ8C3K6. 1 interactor.
STRINGi10090.ENSMUSP00000011178.

Structurei

3D structure databases

ProteinModelPortaliQ8C3K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8C3K6.
KOiK14158.
PhylomeDBiQ8C3K6.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C3K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTLSPAV TATDAPIPSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG
110 120 130 140 150
FEWNALVLVV VLGWIFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTAI MLVGSFILTG FAFNEVGGYE AFMDKYMKAI PTKVSNGNFT
260 270 280 290 300
AKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLAILALWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KADCTLCGYL KLLPMFLMVM PGMISRILYT EKIACVLPEE
360 370 380 390 400
CQKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY TKIRKKASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEQGAFWGLI LGFLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFVISVIT ILIISFLTKP
560 570 580 590 600
IPDVHLYRWC WSLRNSKEER IDLDAGEEED IPEDSKDTIE IDTEAPQKKK
610 620 630 640 650
GCFRRAYDLF CGLDQDKGPK MTKEEEEAMK MKMTDTSEKP LWRTVVNING
660
IILLAVAVFC HAYFA
Length:665
Mass (Da):73,449
Last modified:March 1, 2003 - v1
Checksum:i70905E30408BE378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085602 mRNA. Translation: BAC39483.1.
CCDSiCCDS19199.1.
RefSeqiNP_062784.3. NM_019810.4.
UniGeneiMm.25237.

Genome annotation databases

GeneIDi20537.
KEGGimmu:20537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085602 mRNA. Translation: BAC39483.1.
CCDSiCCDS19199.1.
RefSeqiNP_062784.3. NM_019810.4.
UniGeneiMm.25237.

3D structure databases

ProteinModelPortaliQ8C3K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C3K6. 1 interactor.
STRINGi10090.ENSMUSP00000011178.

PTM databases

iPTMnetiQ8C3K6.
PhosphoSitePlusiQ8C3K6.

Proteomic databases

MaxQBiQ8C3K6.
PaxDbiQ8C3K6.
PeptideAtlasiQ8C3K6.
PRIDEiQ8C3K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20537.
KEGGimmu:20537.

Organism-specific databases

CTDi6523.
MGIiMGI:107678. Slc5a1.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8C3K6.
KOiK14158.
PhylomeDBiQ8C3K6.

Miscellaneous databases

ChiTaRSiSlc5a1. mouse.
PROiQ8C3K6.
SOURCEiSearch...

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A1_MOUSE
AccessioniPrimary (citable) accession number: Q8C3K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.