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Q8C3K6

- SC5A1_MOUSE

UniProt

Q8C3K6 - SC5A1_MOUSE

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Protein
Sodium/glucose cotransporter 1
Gene
Slc5a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei43 – 431Implicated in sodium coupling By similarity
Sitei300 – 3001Implicated in sodium coupling By similarity
Binding sitei457 – 4571Glucose By similarity
Sitei460 – 4601Involved in sugar-binding/transport and inhibitor binding By similarity

GO - Molecular functioni

  1. glucose transmembrane transporter activity Source: MGI
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. glucose transport Source: MGI
  2. intestinal absorption Source: MGI
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
Gene namesi
Name:Slc5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107678. Slc5a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed prediction
Add
BLAST
Transmembranei29 – 4921Helical; Reviewed prediction
Add
BLAST
Topological domaini50 – 6415Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Topological domaini86 – 10520Extracellular Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 14216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 17815Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 20123Helical; Reviewed prediction
Add
BLAST
Topological domaini202 – 2087Cytoplasmic Reviewed prediction
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 27748Extracellular Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Reviewed prediction
Add
BLAST
Topological domaini299 – 31315Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei314 – 33421Helical; Reviewed prediction
Add
BLAST
Topological domaini335 – 38046Extracellular Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Topological domaini402 – 42322Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei424 – 44421Helical; Reviewed prediction
Add
BLAST
Topological domaini445 – 45511Extracellular Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST
Topological domaini477 – 4848Cytoplasmic Reviewed prediction
Transmembranei485 – 50521Helical; Reviewed prediction
Add
BLAST
Topological domaini506 – 52621Extracellular Reviewed prediction
Add
BLAST
Intramembranei527 – 56337Helical; Reviewed prediction
Add
BLAST
Topological domaini564 – 64481Extracellular Reviewed prediction
Add
BLAST
Transmembranei645 – 66521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. brush border Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Sodium/glucose cotransporter 1
PRO_0000105367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi255 ↔ 611 By similarity

Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8C3K6.
PaxDbiQ8C3K6.
PRIDEiQ8C3K6.

PTM databases

PhosphoSiteiQ8C3K6.

Expressioni

Gene expression databases

GenevestigatoriQ8C3K6.

Interactioni

Protein-protein interaction databases

IntActiQ8C3K6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8C3K6.
SMRiQ8C3K6. Positions 26-553.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8C3K6.
KOiK14158.
PhylomeDBiQ8C3K6.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C3K6-1 [UniParc]FASTAAdd to Basket

« Hide

MDSSTLSPAV TATDAPIPSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST    50
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG 100
FEWNALVLVV VLGWIFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL 150
LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV 200
IYTDTLQTAI MLVGSFILTG FAFNEVGGYE AFMDKYMKAI PTKVSNGNFT 250
AKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLAILALWY WCTDQVIVQR 300
CLSAKNMSHV KADCTLCGYL KLLPMFLMVM PGMISRILYT EKIACVLPEE 350
CQKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS 400
ASTLFTMDIY TKIRKKASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG 450
QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEQGAFWGLI LGFLIGISRM 500
ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFVISVIT ILIISFLTKP 550
IPDVHLYRWC WSLRNSKEER IDLDAGEEED IPEDSKDTIE IDTEAPQKKK 600
GCFRRAYDLF CGLDQDKGPK MTKEEEEAMK MKMTDTSEKP LWRTVVNING 650
IILLAVAVFC HAYFA 665
Length:665
Mass (Da):73,449
Last modified:March 1, 2003 - v1
Checksum:i70905E30408BE378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK085602 mRNA. Translation: BAC39483.1.
CCDSiCCDS19199.1.
RefSeqiNP_062784.3. NM_019810.4.
UniGeneiMm.25237.

Genome annotation databases

GeneIDi20537.
KEGGimmu:20537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK085602 mRNA. Translation: BAC39483.1 .
CCDSi CCDS19199.1.
RefSeqi NP_062784.3. NM_019810.4.
UniGenei Mm.25237.

3D structure databases

ProteinModelPortali Q8C3K6.
SMRi Q8C3K6. Positions 26-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8C3K6. 1 interaction.

PTM databases

PhosphoSitei Q8C3K6.

Proteomic databases

MaxQBi Q8C3K6.
PaxDbi Q8C3K6.
PRIDEi Q8C3K6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20537.
KEGGi mmu:20537.

Organism-specific databases

CTDi 6523.
MGIi MGI:107678. Slc5a1.

Phylogenomic databases

eggNOGi COG4146.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi Q8C3K6.
KOi K14158.
PhylomeDBi Q8C3K6.

Miscellaneous databases

NextBioi 298811.
PROi Q8C3K6.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8C3K6.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A1_MOUSE
AccessioniPrimary (citable) accession number: Q8C3K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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