Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8C3K6

- SC5A1_MOUSE

UniProt

Q8C3K6 - SC5A1_MOUSE

Protein

Sodium/glucose cotransporter 1

Gene

Slc5a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei43 – 431Implicated in sodium couplingBy similarity
    Sitei300 – 3001Implicated in sodium couplingBy similarity
    Binding sitei457 – 4571GlucoseBy similarity
    Sitei460 – 4601Involved in sugar-binding/transport and inhibitor bindingBy similarity

    GO - Molecular functioni

    1. glucose transmembrane transporter activity Source: MGI
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. glucose transport Source: MGI
    2. intestinal absorption Source: MGI
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Sugar transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/glucose cotransporter 1
    Short name:
    Na(+)/glucose cotransporter 1
    Alternative name(s):
    High affinity sodium-glucose cotransporter
    Solute carrier family 5 member 1
    Gene namesi
    Name:Slc5a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107678. Slc5a1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. brush border Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 665665Sodium/glucose cotransporter 1PRO_0000105367Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 611By similarity

    Post-translational modificationi

    N-glycosylation is not necessary for the cotransporter function.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8C3K6.
    PaxDbiQ8C3K6.
    PRIDEiQ8C3K6.

    PTM databases

    PhosphoSiteiQ8C3K6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8C3K6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8C3K6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C3K6.
    SMRiQ8C3K6. Positions 26-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 10520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 2087CytoplasmicSequence Analysis
    Topological domaini230 – 27748ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 38046ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini402 – 42322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini445 – 45511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini477 – 4848CytoplasmicSequence Analysis
    Topological domaini506 – 52621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini564 – 64481ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei527 – 56337HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 20123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei645 – 66521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    HOGENOMiHOG000025422.
    HOVERGENiHBG052859.
    InParanoidiQ8C3K6.
    KOiK14158.
    PhylomeDBiQ8C3K6.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C3K6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSTLSPAV TATDAPIPSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST    50
    NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG 100
    FEWNALVLVV VLGWIFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL 150
    LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV 200
    IYTDTLQTAI MLVGSFILTG FAFNEVGGYE AFMDKYMKAI PTKVSNGNFT 250
    AKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLAILALWY WCTDQVIVQR 300
    CLSAKNMSHV KADCTLCGYL KLLPMFLMVM PGMISRILYT EKIACVLPEE 350
    CQKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS 400
    ASTLFTMDIY TKIRKKASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG 450
    QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEQGAFWGLI LGFLIGISRM 500
    ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFVISVIT ILIISFLTKP 550
    IPDVHLYRWC WSLRNSKEER IDLDAGEEED IPEDSKDTIE IDTEAPQKKK 600
    GCFRRAYDLF CGLDQDKGPK MTKEEEEAMK MKMTDTSEKP LWRTVVNING 650
    IILLAVAVFC HAYFA 665
    Length:665
    Mass (Da):73,449
    Last modified:March 1, 2003 - v1
    Checksum:i70905E30408BE378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK085602 mRNA. Translation: BAC39483.1.
    CCDSiCCDS19199.1.
    RefSeqiNP_062784.3. NM_019810.4.
    UniGeneiMm.25237.

    Genome annotation databases

    GeneIDi20537.
    KEGGimmu:20537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK085602 mRNA. Translation: BAC39483.1 .
    CCDSi CCDS19199.1.
    RefSeqi NP_062784.3. NM_019810.4.
    UniGenei Mm.25237.

    3D structure databases

    ProteinModelPortali Q8C3K6.
    SMRi Q8C3K6. Positions 26-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8C3K6. 1 interaction.

    PTM databases

    PhosphoSitei Q8C3K6.

    Proteomic databases

    MaxQBi Q8C3K6.
    PaxDbi Q8C3K6.
    PRIDEi Q8C3K6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20537.
    KEGGi mmu:20537.

    Organism-specific databases

    CTDi 6523.
    MGIi MGI:107678. Slc5a1.

    Phylogenomic databases

    eggNOGi COG4146.
    HOGENOMi HOG000025422.
    HOVERGENi HBG052859.
    InParanoidi Q8C3K6.
    KOi K14158.
    PhylomeDBi Q8C3K6.

    Miscellaneous databases

    NextBioi 298811.
    PROi Q8C3K6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8C3K6.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.

    Entry informationi

    Entry nameiSC5A1_MOUSE
    AccessioniPrimary (citable) accession number: Q8C3K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3