ID   F120C_MOUSE             Reviewed;        1091 AA.
AC   Q8C3F2; Q3U0F6;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   24-JAN-2024, entry version 126.
DE   RecName: Full=Constitutive coactivator of PPAR-gamma-like protein 2;
DE   AltName: Full=Protein FAM120C;
GN   Name=Fam120c; Synonyms=ORF34;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=14585507; DOI=10.1016/s0378-1119(03)00770-4;
RA   Holden S., Raymond F.L.;
RT   "The human gene CXorf17 encodes a member of a novel family of putative
RT   transmembrane proteins: cDNA cloning and characterization of CXorf17 and
RT   its mouse ortholog orf34.";
RL   Gene 318:149-161(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Head, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Liver, Lung, and Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-57 AND ARG-972, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Embryo;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8C3F2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8C3F2-2; Sequence=VSP_010521, VSP_010522;
CC       Name=3;
CC         IsoId=Q8C3F2-3; Sequence=VSP_010523, VSP_010524;
CC   -!- SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC39601.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY150023; AAO24119.1; -; mRNA.
DR   EMBL; AY150024; AAO24120.1; -; mRNA.
DR   EMBL; AK086058; BAC39601.1; ALT_INIT; mRNA.
DR   EMBL; AK156920; BAE33898.1; -; mRNA.
DR   EMBL; AL662922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL807396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137973; AAI37974.1; -; mRNA.
DR   CCDS; CCDS41175.1; -. [Q8C3F2-1]
DR   RefSeq; NP_932773.2; NM_198105.2. [Q8C3F2-1]
DR   AlphaFoldDB; Q8C3F2; -.
DR   BioGRID; 228896; 8.
DR   IntAct; Q8C3F2; 4.
DR   MINT; Q8C3F2; -.
DR   STRING; 10090.ENSMUSP00000073082; -.
DR   iPTMnet; Q8C3F2; -.
DR   PhosphoSitePlus; Q8C3F2; -.
DR   SwissPalm; Q8C3F2; -.
DR   EPD; Q8C3F2; -.
DR   MaxQB; Q8C3F2; -.
DR   PaxDb; 10090-ENSMUSP00000073082; -.
DR   PeptideAtlas; Q8C3F2; -.
DR   ProteomicsDB; 275818; -. [Q8C3F2-1]
DR   ProteomicsDB; 275819; -. [Q8C3F2-2]
DR   ProteomicsDB; 275820; -. [Q8C3F2-3]
DR   Pumba; Q8C3F2; -.
DR   Antibodypedia; 26758; 79 antibodies from 16 providers.
DR   DNASU; 207375; -.
DR   Ensembl; ENSMUST00000073364.6; ENSMUSP00000073082.6; ENSMUSG00000025262.9. [Q8C3F2-1]
DR   GeneID; 207375; -.
DR   KEGG; mmu:207375; -.
DR   UCSC; uc009upb.1; mouse. [Q8C3F2-2]
DR   UCSC; uc009upc.1; mouse. [Q8C3F2-1]
DR   AGR; MGI:2387687; -.
DR   CTD; 54954; -.
DR   MGI; MGI:2387687; Fam120c.
DR   VEuPathDB; HostDB:ENSMUSG00000025262; -.
DR   eggNOG; ENOG502QQNQ; Eukaryota.
DR   GeneTree; ENSGT00530000063168; -.
DR   HOGENOM; CLU_008339_0_0_1; -.
DR   InParanoid; Q8C3F2; -.
DR   OMA; SRDSNVC; -.
DR   OrthoDB; 20093at2759; -.
DR   PhylomeDB; Q8C3F2; -.
DR   TreeFam; TF328642; -.
DR   BioGRID-ORCS; 207375; 5 hits in 79 CRISPR screens.
DR   ChiTaRS; Fam120c; mouse.
DR   PRO; PR:Q8C3F2; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q8C3F2; Protein.
DR   Bgee; ENSMUSG00000025262; Expressed in humerus cartilage element and 202 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR026784; Coact_PPARg.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR15976; CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; 1.
DR   PANTHER; PTHR15976:SF15; CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 2; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   Genevisible; Q8C3F2; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Methylation; Reference proteome.
FT   CHAIN           1..1091
FT                   /note="Constitutive coactivator of PPAR-gamma-like protein
FT                   2"
FT                   /id="PRO_0000221629"
FT   REGION          35..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1010
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1037..1077
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..71
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        992..1008
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         57
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
FT   MOD_RES         972
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
FT   VAR_SEQ         231..236
FT                   /note="FQSLED -> REGLDF (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_010521"
FT   VAR_SEQ         237..1091
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_010522"
FT   VAR_SEQ         989..997
FT                   /note="HGKEQAGRG -> YVPECVGMS (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14585507"
FT                   /id="VSP_010523"
FT   VAR_SEQ         998..1091
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14585507"
FT                   /id="VSP_010524"
FT   CONFLICT        241
FT                   /note="V -> M (in Ref. 1; AAO24120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        730
FT                   /note="K -> R (in Ref. 1; AAO24119)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        874
FT                   /note="Q -> R (in Ref. 1; AAO24120)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1091 AA;  119718 MW;  765E9226F3DFA344 CRC64;
     MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP GAPRITRGSA
     PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG LHPPPPPPLP GARVLVDAGS
     ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC QACAYPGGDG LELVVMFPGG LGKDRLAEWG
     RRCQAERQTA QLIVGHVGNK GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE
     VVAFFRENGF HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK
     RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC DVVIKAVSEY
     VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS VTTKLSSLPV GPSFLGFRNN
     RLGNPPLPRN QMGPISPGKP MFSRQVPQKM KYPPPFPMGP NSSLLFSHSV GESHAFSEDA
     MLQDNSFANW AVSYDSNTSQ FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV
     QQQPGWEDPN GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP
     EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR SARQYVYGVL
     FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ TPELVSALTF REWTCPNLKK
     LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN PANVPTHLLL MCCVLRYMVQ WPGGRILHRH
     ELDTFLAQAV STQLYEPDQL QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE
     HCCPWIYFDG KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS
     ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG GKLEIAGMVV
     GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG HKKGNKQGSS DVISKAVELH
     QSRARSQVNG NNGTLIVEEK SDPLPAPSQC ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ
     ELEAVAQQKE E
//