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Q8C3F2 (F120C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Gene names
Name:Fam120c
Synonyms:ORF34
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1091 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the constitutive coactivator of PPAR-gamma family.

Sequence caution

The sequence BAC39601.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C3F2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C3F2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-236: FQSLED → REGLDF
     237-1091: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8C3F2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     989-997: HGKEQAGRG → YVPECVGMS
     998-1091: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10911091Constitutive coactivator of PPAR-gamma-like protein 2
PRO_0000221629

Natural variations

Alternative sequence231 – 2366FQSLED → REGLDF in isoform 2.
VSP_010521
Alternative sequence237 – 1091855Missing in isoform 2.
VSP_010522
Alternative sequence989 – 9979HGKEQAGRG → YVPECVGMS in isoform 3.
VSP_010523
Alternative sequence998 – 109194Missing in isoform 3.
VSP_010524

Experimental info

Sequence conflict2411V → M in AAO24120. Ref.1
Sequence conflict7301K → R in AAO24119. Ref.1
Sequence conflict8741Q → R in AAO24120. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 765E9226F3DFA344

FASTA1,091119,718
        10         20         30         40         50         60 
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP GAPRITRGSA 

        70         80         90        100        110        120 
PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG LHPPPPPPLP GARVLVDAGS 

       130        140        150        160        170        180 
ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC QACAYPGGDG LELVVMFPGG LGKDRLAEWG 

       190        200        210        220        230        240 
RRCQAERQTA QLIVGHVGNK GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE 

       250        260        270        280        290        300 
VVAFFRENGF HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK 

       310        320        330        340        350        360 
RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC DVVIKAVSEY 

       370        380        390        400        410        420 
VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS VTTKLSSLPV GPSFLGFRNN 

       430        440        450        460        470        480 
RLGNPPLPRN QMGPISPGKP MFSRQVPQKM KYPPPFPMGP NSSLLFSHSV GESHAFSEDA 

       490        500        510        520        530        540 
MLQDNSFANW AVSYDSNTSQ FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV 

       550        560        570        580        590        600 
QQQPGWEDPN GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP 

       610        620        630        640        650        660 
EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR SARQYVYGVL 

       670        680        690        700        710        720 
FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ TPELVSALTF REWTCPNLKK 

       730        740        750        760        770        780 
LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN PANVPTHLLL MCCVLRYMVQ WPGGRILHRH 

       790        800        810        820        830        840 
ELDTFLAQAV STQLYEPDQL QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE 

       850        860        870        880        890        900 
HCCPWIYFDG KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS 

       910        920        930        940        950        960 
ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG GKLEIAGMVV 

       970        980        990       1000       1010       1020 
GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG HKKGNKQGSS DVISKAVELH 

      1030       1040       1050       1060       1070       1080 
QSRARSQVNG NNGTLIVEEK SDPLPAPSQC ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ 

      1090 
ELEAVAQQKE E 

« Hide

Isoform 2 [UniParc].

Checksum: E5704682CB84DD5E
Show »

FASTA23625,329
Isoform 3 [UniParc].

Checksum: 67993EE8083EB38E
Show »

FASTA997109,580

References

« Hide 'large scale' references
[1]"The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
Holden S., Raymond F.L.
Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
Strain: BALB/c.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J and NOD.
Tissue: Head and Spleen.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY150023 mRNA. Translation: AAO24119.1.
AY150024 mRNA. Translation: AAO24120.1.
AK086058 mRNA. Translation: BAC39601.1. Different initiation.
AK156920 mRNA. Translation: BAE33898.1.
AL807396, AL662922 Genomic DNA. Translation: CAM13455.1.
AL662922, AL807396 Genomic DNA. Translation: CAM17157.1.
BC137973 mRNA. Translation: AAI37974.1.
CCDSCCDS41175.1. [Q8C3F2-1]
RefSeqNP_932773.2. NM_198105.2. [Q8C3F2-1]
UniGeneMm.391339.

3D structure databases

ProteinModelPortalQ8C3F2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000073082.

PTM databases

PhosphoSiteQ8C3F2.

Proteomic databases

MaxQBQ8C3F2.
PaxDbQ8C3F2.
PRIDEQ8C3F2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
GeneID207375.
KEGGmmu:207375.
UCSCuc009upb.1. mouse. [Q8C3F2-2]
uc009upc.1. mouse. [Q8C3F2-1]

Organism-specific databases

CTD54954.
MGIMGI:2387687. Fam120c.

Phylogenomic databases

eggNOGNOG40155.
GeneTreeENSGT00530000063168.
HOGENOMHOG000112430.
HOVERGENHBG050957.
InParanoidQ3U0F6.
OMAQACAYPG.
OrthoDBEOG7G4QD9.
TreeFamTF328642.

Gene expression databases

BgeeQ8C3F2.
CleanExMM_ORF34.
GenevestigatorQ8C3F2.

Family and domain databases

InterProIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMSSF88723. SSF88723. 1 hit.
ProtoNetSearch...

Other

NextBio371937.
PROQ8C3F2.
SOURCESearch...

Entry information

Entry nameF120C_MOUSE
AccessionPrimary (citable) accession number: Q8C3F2
Secondary accession number(s): Q3U0F6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot