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Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

Fam120c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Gene namesi
Name:Fam120c
Synonyms:ORF34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2387687. Fam120c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091Constitutive coactivator of PPAR-gamma-like protein 2PRO_0000221629Add
BLAST

Proteomic databases

MaxQBiQ8C3F2.
PaxDbiQ8C3F2.
PRIDEiQ8C3F2.

PTM databases

PhosphoSiteiQ8C3F2.

Expressioni

Gene expression databases

BgeeiQ8C3F2.
CleanExiMM_ORF34.
GenevestigatoriQ8C3F2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073082.

Structurei

3D structure databases

ProteinModelPortaliQ8C3F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40155.
GeneTreeiENSGT00530000063168.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ8C3F2.
OMAiQACAYPG.
OrthoDBiEOG7G4QD9.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C3F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP
60 70 80 90 100
GAPRITRGSA PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG
110 120 130 140 150
LHPPPPPPLP GARVLVDAGS ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC
160 170 180 190 200
QACAYPGGDG LELVVMFPGG LGKDRLAEWG RRCQAERQTA QLIVGHVGNK
210 220 230 240 250
GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE VVAFFRENGF
260 270 280 290 300
HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK
310 320 330 340 350
RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC
360 370 380 390 400
DVVIKAVSEY VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS
410 420 430 440 450
VTTKLSSLPV GPSFLGFRNN RLGNPPLPRN QMGPISPGKP MFSRQVPQKM
460 470 480 490 500
KYPPPFPMGP NSSLLFSHSV GESHAFSEDA MLQDNSFANW AVSYDSNTSQ
510 520 530 540 550
FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV QQQPGWEDPN
560 570 580 590 600
GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP
610 620 630 640 650
EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR
660 670 680 690 700
SARQYVYGVL FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ
710 720 730 740 750
TPELVSALTF REWTCPNLKK LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN
760 770 780 790 800
PANVPTHLLL MCCVLRYMVQ WPGGRILHRH ELDTFLAQAV STQLYEPDQL
810 820 830 840 850
QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE HCCPWIYFDG
860 870 880 890 900
KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS
910 920 930 940 950
ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG
960 970 980 990 1000
GKLEIAGMVV GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG
1010 1020 1030 1040 1050
HKKGNKQGSS DVISKAVELH QSRARSQVNG NNGTLIVEEK SDPLPAPSQC
1060 1070 1080 1090
ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ ELEAVAQQKE E
Length:1,091
Mass (Da):119,718
Last modified:July 27, 2011 - v3
Checksum:i765E9226F3DFA344
GO
Isoform 2 (identifier: Q8C3F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-236: FQSLED → REGLDF
     237-1091: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):25,329
Checksum:iE5704682CB84DD5E
GO
Isoform 3 (identifier: Q8C3F2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-997: HGKEQAGRG → YVPECVGMS
     998-1091: Missing.

Show »
Length:997
Mass (Da):109,580
Checksum:i67993EE8083EB38E
GO

Sequence cautioni

The sequence BAC39601.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411V → M in AAO24120 (PubMed:14585507).Curated
Sequence conflicti730 – 7301K → R in AAO24119 (PubMed:14585507).Curated
Sequence conflicti874 – 8741Q → R in AAO24120 (PubMed:14585507).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 2366FQSLED → REGLDF in isoform 2. 1 PublicationVSP_010521
Alternative sequencei237 – 1091855Missing in isoform 2. 1 PublicationVSP_010522Add
BLAST
Alternative sequencei989 – 9979HGKEQAGRG → YVPECVGMS in isoform 3. 1 PublicationVSP_010523
Alternative sequencei998 – 109194Missing in isoform 3. 1 PublicationVSP_010524Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150023 mRNA. Translation: AAO24119.1.
AY150024 mRNA. Translation: AAO24120.1.
AK086058 mRNA. Translation: BAC39601.1. Different initiation.
AK156920 mRNA. Translation: BAE33898.1.
AL807396, AL662922 Genomic DNA. Translation: CAM13455.1.
AL662922, AL807396 Genomic DNA. Translation: CAM17157.1.
BC137973 mRNA. Translation: AAI37974.1.
CCDSiCCDS41175.1. [Q8C3F2-1]
RefSeqiNP_932773.2. NM_198105.2. [Q8C3F2-1]
UniGeneiMm.391339.

Genome annotation databases

EnsembliENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
GeneIDi207375.
KEGGimmu:207375.
UCSCiuc009upb.1. mouse. [Q8C3F2-2]
uc009upc.1. mouse. [Q8C3F2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150023 mRNA. Translation: AAO24119.1.
AY150024 mRNA. Translation: AAO24120.1.
AK086058 mRNA. Translation: BAC39601.1. Different initiation.
AK156920 mRNA. Translation: BAE33898.1.
AL807396, AL662922 Genomic DNA. Translation: CAM13455.1.
AL662922, AL807396 Genomic DNA. Translation: CAM17157.1.
BC137973 mRNA. Translation: AAI37974.1.
CCDSiCCDS41175.1. [Q8C3F2-1]
RefSeqiNP_932773.2. NM_198105.2. [Q8C3F2-1]
UniGeneiMm.391339.

3D structure databases

ProteinModelPortaliQ8C3F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073082.

PTM databases

PhosphoSiteiQ8C3F2.

Proteomic databases

MaxQBiQ8C3F2.
PaxDbiQ8C3F2.
PRIDEiQ8C3F2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
GeneIDi207375.
KEGGimmu:207375.
UCSCiuc009upb.1. mouse. [Q8C3F2-2]
uc009upc.1. mouse. [Q8C3F2-1]

Organism-specific databases

CTDi54954.
MGIiMGI:2387687. Fam120c.

Phylogenomic databases

eggNOGiNOG40155.
GeneTreeiENSGT00530000063168.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ8C3F2.
OMAiQACAYPG.
OrthoDBiEOG7G4QD9.
TreeFamiTF328642.

Miscellaneous databases

NextBioi371937.
PROiQ8C3F2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C3F2.
CleanExiMM_ORF34.
GenevestigatoriQ8C3F2.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
    Holden S., Raymond F.L.
    Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF120C_MOUSE
AccessioniPrimary (citable) accession number: Q8C3F2
Secondary accession number(s): Q3U0F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.