Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

Fam120c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Gene namesi
Name:Fam120c
Synonyms:ORF34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2387687 Fam120c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002216291 – 1091Constitutive coactivator of PPAR-gamma-like protein 2Add BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57Omega-N-methylarginineCombined sources1
Modified residuei972Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ8C3F2
PaxDbiQ8C3F2
PeptideAtlasiQ8C3F2
PRIDEiQ8C3F2

PTM databases

iPTMnetiQ8C3F2
PhosphoSitePlusiQ8C3F2
SwissPalmiQ8C3F2

Expressioni

Gene expression databases

BgeeiENSMUSG00000025262
CleanExiMM_ORF34
GenevisibleiQ8C3F2 MM

Interactioni

Protein-protein interaction databases

BioGridi228896, 2 interactors
IntActiQ8C3F2, 2 interactors
STRINGi10090.ENSMUSP00000073082

Structurei

3D structure databases

ProteinModelPortaliQ8C3F2
SMRiQ8C3F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE6R Eukaryota
ENOG410XPY7 LUCA
GeneTreeiENSGT00530000063168
HOGENOMiHOG000112430
HOVERGENiHBG050957
InParanoidiQ8C3F2
OMAiELVVMFP
OrthoDBiEOG091G030W
TreeFamiTF328642

Family and domain databases

InterProiView protein in InterPro
IPR026784 Coact_PPARg
IPR026785 Coact_PPARg-like_2
IPR029060 PIN-like_dom_sf
PANTHERiPTHR15976 PTHR15976, 1 hit
PTHR15976:SF15 PTHR15976:SF15, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C3F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP
60 70 80 90 100
GAPRITRGSA PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG
110 120 130 140 150
LHPPPPPPLP GARVLVDAGS ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC
160 170 180 190 200
QACAYPGGDG LELVVMFPGG LGKDRLAEWG RRCQAERQTA QLIVGHVGNK
210 220 230 240 250
GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE VVAFFRENGF
260 270 280 290 300
HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK
310 320 330 340 350
RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC
360 370 380 390 400
DVVIKAVSEY VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS
410 420 430 440 450
VTTKLSSLPV GPSFLGFRNN RLGNPPLPRN QMGPISPGKP MFSRQVPQKM
460 470 480 490 500
KYPPPFPMGP NSSLLFSHSV GESHAFSEDA MLQDNSFANW AVSYDSNTSQ
510 520 530 540 550
FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV QQQPGWEDPN
560 570 580 590 600
GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP
610 620 630 640 650
EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR
660 670 680 690 700
SARQYVYGVL FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ
710 720 730 740 750
TPELVSALTF REWTCPNLKK LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN
760 770 780 790 800
PANVPTHLLL MCCVLRYMVQ WPGGRILHRH ELDTFLAQAV STQLYEPDQL
810 820 830 840 850
QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE HCCPWIYFDG
860 870 880 890 900
KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS
910 920 930 940 950
ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG
960 970 980 990 1000
GKLEIAGMVV GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG
1010 1020 1030 1040 1050
HKKGNKQGSS DVISKAVELH QSRARSQVNG NNGTLIVEEK SDPLPAPSQC
1060 1070 1080 1090
ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ ELEAVAQQKE E
Length:1,091
Mass (Da):119,718
Last modified:July 27, 2011 - v3
Checksum:i765E9226F3DFA344
GO
Isoform 2 (identifier: Q8C3F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-236: FQSLED → REGLDF
     237-1091: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,329
Checksum:iE5704682CB84DD5E
GO
Isoform 3 (identifier: Q8C3F2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-997: HGKEQAGRG → YVPECVGMS
     998-1091: Missing.

Show »
Length:997
Mass (Da):109,580
Checksum:i67993EE8083EB38E
GO

Sequence cautioni

The sequence BAC39601 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241V → M in AAO24120 (PubMed:14585507).Curated1
Sequence conflicti730K → R in AAO24119 (PubMed:14585507).Curated1
Sequence conflicti874Q → R in AAO24120 (PubMed:14585507).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010521231 – 236FQSLED → REGLDF in isoform 2. 1 Publication6
Alternative sequenceiVSP_010522237 – 1091Missing in isoform 2. 1 PublicationAdd BLAST855
Alternative sequenceiVSP_010523989 – 997HGKEQAGRG → YVPECVGMS in isoform 3. 1 Publication9
Alternative sequenceiVSP_010524998 – 1091Missing in isoform 3. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150023 mRNA Translation: AAO24119.1
AY150024 mRNA Translation: AAO24120.1
AK086058 mRNA Translation: BAC39601.1 Different initiation.
AK156920 mRNA Translation: BAE33898.1
AL807396, AL662922 Genomic DNA Translation: CAM13455.1
AL662922, AL807396 Genomic DNA Translation: CAM17157.1
BC137973 mRNA Translation: AAI37974.1
CCDSiCCDS41175.1 [Q8C3F2-1]
RefSeqiNP_932773.2, NM_198105.2 [Q8C3F2-1]
UniGeneiMm.391339

Genome annotation databases

EnsembliENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262 [Q8C3F2-1]
GeneIDi207375
KEGGimmu:207375
UCSCiuc009upb.1 mouse [Q8C3F2-2]
uc009upc.1 mouse [Q8C3F2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF120C_MOUSE
AccessioniPrimary (citable) accession number: Q8C3F2
Secondary accession number(s): Q3U0F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health