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Q8C3F2

- F120C_MOUSE

UniProt

Q8C3F2 - F120C_MOUSE

Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

Fam120c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Constitutive coactivator of PPAR-gamma-like protein 2
    Alternative name(s):
    Protein FAM120C
    Gene namesi
    Name:Fam120c
    Synonyms:ORF34
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2387687. Fam120c.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10911091Constitutive coactivator of PPAR-gamma-like protein 2PRO_0000221629Add
    BLAST

    Proteomic databases

    MaxQBiQ8C3F2.
    PaxDbiQ8C3F2.
    PRIDEiQ8C3F2.

    PTM databases

    PhosphoSiteiQ8C3F2.

    Expressioni

    Gene expression databases

    BgeeiQ8C3F2.
    CleanExiMM_ORF34.
    GenevestigatoriQ8C3F2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000073082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C3F2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG40155.
    GeneTreeiENSGT00530000063168.
    HOGENOMiHOG000112430.
    HOVERGENiHBG050957.
    InParanoidiQ3U0F6.
    OMAiQACAYPG.
    OrthoDBiEOG7G4QD9.
    TreeFamiTF328642.

    Family and domain databases

    InterProiIPR026785. Coact_PPARg-like_2.
    IPR029060. PIN_domain-like.
    [Graphical view]
    PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
    SUPFAMiSSF88723. SSF88723. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C3F2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP     50
    GAPRITRGSA PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG 100
    LHPPPPPPLP GARVLVDAGS ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC 150
    QACAYPGGDG LELVVMFPGG LGKDRLAEWG RRCQAERQTA QLIVGHVGNK 200
    GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE VVAFFRENGF 250
    HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK 300
    RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC 350
    DVVIKAVSEY VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS 400
    VTTKLSSLPV GPSFLGFRNN RLGNPPLPRN QMGPISPGKP MFSRQVPQKM 450
    KYPPPFPMGP NSSLLFSHSV GESHAFSEDA MLQDNSFANW AVSYDSNTSQ 500
    FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV QQQPGWEDPN 550
    GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP 600
    EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR 650
    SARQYVYGVL FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ 700
    TPELVSALTF REWTCPNLKK LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN 750
    PANVPTHLLL MCCVLRYMVQ WPGGRILHRH ELDTFLAQAV STQLYEPDQL 800
    QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE HCCPWIYFDG 850
    KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS 900
    ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG 950
    GKLEIAGMVV GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG 1000
    HKKGNKQGSS DVISKAVELH QSRARSQVNG NNGTLIVEEK SDPLPAPSQC 1050
    ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ ELEAVAQQKE E 1091
    Length:1,091
    Mass (Da):119,718
    Last modified:July 27, 2011 - v3
    Checksum:i765E9226F3DFA344
    GO
    Isoform 2 (identifier: Q8C3F2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-236: FQSLED → REGLDF
         237-1091: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):25,329
    Checksum:iE5704682CB84DD5E
    GO
    Isoform 3 (identifier: Q8C3F2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-997: HGKEQAGRG → YVPECVGMS
         998-1091: Missing.

    Show »
    Length:997
    Mass (Da):109,580
    Checksum:i67993EE8083EB38E
    GO

    Sequence cautioni

    The sequence BAC39601.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti241 – 2411V → M in AAO24120. (PubMed:14585507)Curated
    Sequence conflicti730 – 7301K → R in AAO24119. (PubMed:14585507)Curated
    Sequence conflicti874 – 8741Q → R in AAO24120. (PubMed:14585507)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei231 – 2366FQSLED → REGLDF in isoform 2. 1 PublicationVSP_010521
    Alternative sequencei237 – 1091855Missing in isoform 2. 1 PublicationVSP_010522Add
    BLAST
    Alternative sequencei989 – 9979HGKEQAGRG → YVPECVGMS in isoform 3. 1 PublicationVSP_010523
    Alternative sequencei998 – 109194Missing in isoform 3. 1 PublicationVSP_010524Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY150023 mRNA. Translation: AAO24119.1.
    AY150024 mRNA. Translation: AAO24120.1.
    AK086058 mRNA. Translation: BAC39601.1. Different initiation.
    AK156920 mRNA. Translation: BAE33898.1.
    AL807396, AL662922 Genomic DNA. Translation: CAM13455.1.
    AL662922, AL807396 Genomic DNA. Translation: CAM17157.1.
    BC137973 mRNA. Translation: AAI37974.1.
    CCDSiCCDS41175.1. [Q8C3F2-1]
    RefSeqiNP_932773.2. NM_198105.2. [Q8C3F2-1]
    UniGeneiMm.391339.

    Genome annotation databases

    EnsembliENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
    GeneIDi207375.
    KEGGimmu:207375.
    UCSCiuc009upb.1. mouse. [Q8C3F2-2]
    uc009upc.1. mouse. [Q8C3F2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY150023 mRNA. Translation: AAO24119.1 .
    AY150024 mRNA. Translation: AAO24120.1 .
    AK086058 mRNA. Translation: BAC39601.1 . Different initiation.
    AK156920 mRNA. Translation: BAE33898.1 .
    AL807396 , AL662922 Genomic DNA. Translation: CAM13455.1 .
    AL662922 , AL807396 Genomic DNA. Translation: CAM17157.1 .
    BC137973 mRNA. Translation: AAI37974.1 .
    CCDSi CCDS41175.1. [Q8C3F2-1 ]
    RefSeqi NP_932773.2. NM_198105.2. [Q8C3F2-1 ]
    UniGenei Mm.391339.

    3D structure databases

    ProteinModelPortali Q8C3F2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000073082.

    PTM databases

    PhosphoSitei Q8C3F2.

    Proteomic databases

    MaxQBi Q8C3F2.
    PaxDbi Q8C3F2.
    PRIDEi Q8C3F2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073364 ; ENSMUSP00000073082 ; ENSMUSG00000025262 . [Q8C3F2-1 ]
    GeneIDi 207375.
    KEGGi mmu:207375.
    UCSCi uc009upb.1. mouse. [Q8C3F2-2 ]
    uc009upc.1. mouse. [Q8C3F2-1 ]

    Organism-specific databases

    CTDi 54954.
    MGIi MGI:2387687. Fam120c.

    Phylogenomic databases

    eggNOGi NOG40155.
    GeneTreei ENSGT00530000063168.
    HOGENOMi HOG000112430.
    HOVERGENi HBG050957.
    InParanoidi Q3U0F6.
    OMAi QACAYPG.
    OrthoDBi EOG7G4QD9.
    TreeFami TF328642.

    Miscellaneous databases

    NextBioi 371937.
    PROi Q8C3F2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C3F2.
    CleanExi MM_ORF34.
    Genevestigatori Q8C3F2.

    Family and domain databases

    InterProi IPR026785. Coact_PPARg-like_2.
    IPR029060. PIN_domain-like.
    [Graphical view ]
    PANTHERi PTHR15976:SF15. PTHR15976:SF15. 1 hit.
    SUPFAMi SSF88723. SSF88723. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
      Holden S., Raymond F.L.
      Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J and NOD.
      Tissue: Head and Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiF120C_MOUSE
    AccessioniPrimary (citable) accession number: Q8C3F2
    Secondary accession number(s): Q3U0F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3