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Q8C3F2

- F120C_MOUSE

UniProt

Q8C3F2 - F120C_MOUSE

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Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene
Fam120c, ORF34
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Gene namesi
Name:Fam120c
Synonyms:ORF34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2387687. Fam120c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091Constitutive coactivator of PPAR-gamma-like protein 2PRO_0000221629Add
BLAST

Proteomic databases

MaxQBiQ8C3F2.
PaxDbiQ8C3F2.
PRIDEiQ8C3F2.

PTM databases

PhosphoSiteiQ8C3F2.

Expressioni

Gene expression databases

BgeeiQ8C3F2.
CleanExiMM_ORF34.
GenevestigatoriQ8C3F2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073082.

Structurei

3D structure databases

ProteinModelPortaliQ8C3F2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40155.
GeneTreeiENSGT00530000063168.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ3U0F6.
OMAiQACAYPG.
OrthoDBiEOG7G4QD9.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C3F2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP     50
GAPRITRGSA PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG 100
LHPPPPPPLP GARVLVDAGS ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC 150
QACAYPGGDG LELVVMFPGG LGKDRLAEWG RRCQAERQTA QLIVGHVGNK 200
GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE VVAFFRENGF 250
HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK 300
RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC 350
DVVIKAVSEY VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS 400
VTTKLSSLPV GPSFLGFRNN RLGNPPLPRN QMGPISPGKP MFSRQVPQKM 450
KYPPPFPMGP NSSLLFSHSV GESHAFSEDA MLQDNSFANW AVSYDSNTSQ 500
FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV QQQPGWEDPN 550
GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP 600
EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR 650
SARQYVYGVL FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ 700
TPELVSALTF REWTCPNLKK LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN 750
PANVPTHLLL MCCVLRYMVQ WPGGRILHRH ELDTFLAQAV STQLYEPDQL 800
QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE HCCPWIYFDG 850
KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS 900
ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG 950
GKLEIAGMVV GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG 1000
HKKGNKQGSS DVISKAVELH QSRARSQVNG NNGTLIVEEK SDPLPAPSQC 1050
ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ ELEAVAQQKE E 1091
Length:1,091
Mass (Da):119,718
Last modified:July 27, 2011 - v3
Checksum:i765E9226F3DFA344
GO
Isoform 2 (identifier: Q8C3F2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-236: FQSLED → REGLDF
     237-1091: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):25,329
Checksum:iE5704682CB84DD5E
GO
Isoform 3 (identifier: Q8C3F2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-997: HGKEQAGRG → YVPECVGMS
     998-1091: Missing.

Show »
Length:997
Mass (Da):109,580
Checksum:i67993EE8083EB38E
GO

Sequence cautioni

The sequence BAC39601.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 2366FQSLED → REGLDF in isoform 2. VSP_010521
Alternative sequencei237 – 1091855Missing in isoform 2. VSP_010522Add
BLAST
Alternative sequencei989 – 9979HGKEQAGRG → YVPECVGMS in isoform 3. VSP_010523
Alternative sequencei998 – 109194Missing in isoform 3. VSP_010524Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411V → M in AAO24120. 1 Publication
Sequence conflicti730 – 7301K → R in AAO24119. 1 Publication
Sequence conflicti874 – 8741Q → R in AAO24120. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150023 mRNA. Translation: AAO24119.1.
AY150024 mRNA. Translation: AAO24120.1.
AK086058 mRNA. Translation: BAC39601.1. Different initiation.
AK156920 mRNA. Translation: BAE33898.1.
AL807396, AL662922 Genomic DNA. Translation: CAM13455.1.
AL662922, AL807396 Genomic DNA. Translation: CAM17157.1.
BC137973 mRNA. Translation: AAI37974.1.
CCDSiCCDS41175.1. [Q8C3F2-1]
RefSeqiNP_932773.2. NM_198105.2. [Q8C3F2-1]
UniGeneiMm.391339.

Genome annotation databases

EnsembliENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
GeneIDi207375.
KEGGimmu:207375.
UCSCiuc009upb.1. mouse. [Q8C3F2-2]
uc009upc.1. mouse. [Q8C3F2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150023 mRNA. Translation: AAO24119.1 .
AY150024 mRNA. Translation: AAO24120.1 .
AK086058 mRNA. Translation: BAC39601.1 . Different initiation.
AK156920 mRNA. Translation: BAE33898.1 .
AL807396 , AL662922 Genomic DNA. Translation: CAM13455.1 .
AL662922 , AL807396 Genomic DNA. Translation: CAM17157.1 .
BC137973 mRNA. Translation: AAI37974.1 .
CCDSi CCDS41175.1. [Q8C3F2-1 ]
RefSeqi NP_932773.2. NM_198105.2. [Q8C3F2-1 ]
UniGenei Mm.391339.

3D structure databases

ProteinModelPortali Q8C3F2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000073082.

PTM databases

PhosphoSitei Q8C3F2.

Proteomic databases

MaxQBi Q8C3F2.
PaxDbi Q8C3F2.
PRIDEi Q8C3F2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073364 ; ENSMUSP00000073082 ; ENSMUSG00000025262 . [Q8C3F2-1 ]
GeneIDi 207375.
KEGGi mmu:207375.
UCSCi uc009upb.1. mouse. [Q8C3F2-2 ]
uc009upc.1. mouse. [Q8C3F2-1 ]

Organism-specific databases

CTDi 54954.
MGIi MGI:2387687. Fam120c.

Phylogenomic databases

eggNOGi NOG40155.
GeneTreei ENSGT00530000063168.
HOGENOMi HOG000112430.
HOVERGENi HBG050957.
InParanoidi Q3U0F6.
OMAi QACAYPG.
OrthoDBi EOG7G4QD9.
TreeFami TF328642.

Miscellaneous databases

NextBioi 371937.
PROi Q8C3F2.
SOURCEi Search...

Gene expression databases

Bgeei Q8C3F2.
CleanExi MM_ORF34.
Genevestigatori Q8C3F2.

Family and domain databases

InterProi IPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view ]
PANTHERi PTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMi SSF88723. SSF88723. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
    Holden S., Raymond F.L.
    Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF120C_MOUSE
AccessioniPrimary (citable) accession number: Q8C3F2
Secondary accession number(s): Q3U0F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi