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Q8C351 (LAYN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Layilin
Gene names
Name:Layn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for hyaluronate By similarity.

Subunit structure

Interacts with TLN1 By similarity. Interacts with NF2 and RDX. Ref.3

Subcellular location

Membrane; Single-pass type I membrane protein Potential. Note: Colocalizes with TLN1 at the membrane ruffles By similarity.

Domain

The C-terminal domain interacts with the N-terminal domain of RDX.

Sequence similarities

Contains 1 C-type lectin domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C351-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C351-2)

The sequence of this isoform differs from the canonical sequence as follows:
     136-137: RN → SG
     138-381: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 381357Layilin
PRO_0000262509

Regions

Topological domain25 – 235211Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 381125Cytoplasmic Potential
Domain45 – 185141C-type lectin
Repeat340 – 34451-1
Repeat350 – 35451-2
Repeat356 – 35942-1
Repeat371 – 37551-3
Repeat377 – 38042-2
Region330 – 37445Interaction with NF2
Region337 – 38145Interaction with TLN1 By similarity
Region340 – 375363 X 5 AA repeats of E-S-G-X-V
Region356 – 380252 X 4 AA repeats of N-X-I-Y

Amino acid modifications

Modified residue2861Phosphoserine Ref.4
Modified residue2991Phosphoserine Ref.4
Glycosylation1171N-linked (GlcNAc...) Potential
Disulfide bond71 ↔ 184 By similarity
Disulfide bond150 ↔ 176 By similarity

Natural variations

Alternative sequence136 – 1372RN → SG in isoform 2.
VSP_021782
Alternative sequence138 – 381244Missing in isoform 2.
VSP_021783

Secondary structure

... 381
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: CF20C2EE708A5E07

FASTA38143,269
        10         20         30         40         50         60 
MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY KVIYFHDAFQ 

        70         80         90        100        110        120 
RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS DGDFWIGLKR LEEKQSNNTA 

       130        140        150        160        170        180 
CQDLYAWTDG STSQFRNWYV DEPSCGSEVC VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN 

       190        200        210        220        230        240 
NFICKYHDDK PSTTPSIWPG GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP 

       250        260        270        280        290        300 
SIPLFLLLVV TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE 

       310        320        330        340        350        360 
ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME SGFVTNDIYE 

       370        380 
FSPDRMGRSK ESGWVENEIY Y 

« Hide

Isoform 2 [UniParc].

Checksum: 7D76C154D4D17262
Show »

FASTA13715,321

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-212 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Lung and Medulla oblongata.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin."
Bono P., Cordero E., Johnson K., Borowsky M., Ramesh V., Jacks T., Hynes R.O.
Exp. Cell Res. 308:177-187(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NF2 AND RDX.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK086930 mRNA. Translation: BAC39765.2.
AK165695 mRNA. Translation: BAE38343.1.
AC119831 Genomic DNA. No translation available.
RefSeqNP_001028706.1. NM_001033534.1.
UniGeneMm.335152.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2K00NMR-B367-381[»]
ProteinModelPortalQ8C351.
SMRQ8C351. Positions 46-179.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8C351.

Proteomic databases

PRIDEQ8C351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594. [Q8C351-1]
GeneID244864.
KEGGmmu:244864.
UCSCuc012gtc.1. mouse. [Q8C351-1]

Organism-specific databases

CTD143903.
MGIMGI:2685357. Layn.

Phylogenomic databases

eggNOGNOG315174.
GeneTreeENSGT00390000001844.
HOGENOMHOG000294068.
HOVERGENHBG050945.
InParanoidQ8C351.
KOK10077.
OMATACQDLY.
OrthoDBEOG7FV3RQ.
TreeFamTF330715.

Gene expression databases

BgeeQ8C351.
CleanExMM_LAYN.
GenevestigatorQ8C351.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8C351.
NextBio386444.
PROQ8C351.
SOURCESearch...

Entry information

Entry nameLAYN_MOUSE
AccessionPrimary (citable) accession number: Q8C351
Secondary accession number(s): E9QQ23, Q3TMU7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot