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Q8C351

- LAYN_MOUSE

UniProt

Q8C351 - LAYN_MOUSE

Protein

Layilin

Gene

Layn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for hyaluronate.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronic acid binding Source: HGNC

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Layilin
    Gene namesi
    Name:Layn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2685357. Layn.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated
    Note: Colocalizes with TLN1 at the membrane ruffles.By similarity

    GO - Cellular componenti

    1. cell surface Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. ruffle Source: HGNC

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 381357LayilinPRO_0000262509Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 184PROSITE-ProRule annotation
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 176PROSITE-ProRule annotation
    Modified residuei286 – 2861Phosphoserine1 Publication
    Modified residuei299 – 2991Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ8C351.

    PTM databases

    PhosphoSiteiQ8C351.

    Expressioni

    Gene expression databases

    BgeeiQ8C351.
    CleanExiMM_LAYN.
    GenevestigatoriQ8C351.

    Interactioni

    Subunit structurei

    Interacts with TLN1 By similarity. Interacts with NF2 and RDX.By similarity1 Publication

    Structurei

    Secondary structure

    1
    381
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi372 – 3765

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K00NMR-B367-381[»]
    ProteinModelPortaliQ8C351.
    SMRiQ8C351. Positions 46-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8C351.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 235211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 381125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 185141C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Repeati340 – 34451-1
    Repeati350 – 35451-2
    Repeati356 – 35942-1
    Repeati371 – 37551-3
    Repeati377 – 38042-2

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni330 – 37445Interaction with NF2Add
    BLAST
    Regioni337 – 38145Interaction with TLN1By similarityAdd
    BLAST
    Regioni340 – 375363 X 5 AA repeats of E-S-G-X-VAdd
    BLAST
    Regioni356 – 380252 X 4 AA repeats of N-X-I-YAdd
    BLAST

    Domaini

    The C-terminal domain interacts with the N-terminal domain of RDX.

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG315174.
    GeneTreeiENSGT00390000001844.
    HOGENOMiHOG000294068.
    HOVERGENiHBG050945.
    InParanoidiQ8C351.
    KOiK10077.
    OMAiTACQDLY.
    OrthoDBiEOG7FV3RQ.
    TreeFamiTF330715.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C351-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY    50
    KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS 100
    DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFRNWYV DEPSCGSEVC 150
    VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN NFICKYHDDK PSTTPSIWPG 200
    GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP SIPLFLLLVV 250
    TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE 300
    ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME 350
    SGFVTNDIYE FSPDRMGRSK ESGWVENEIY Y 381
    Length:381
    Mass (Da):43,269
    Last modified:July 27, 2011 - v4
    Checksum:iCF20C2EE708A5E07
    GO
    Isoform 2 (identifier: Q8C351-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-137: RN → SG
         138-381: Missing.

    Show »
    Length:137
    Mass (Da):15,321
    Checksum:i7D76C154D4D17262
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei136 – 1372RN → SG in isoform 2. 1 PublicationVSP_021782
    Alternative sequencei138 – 381244Missing in isoform 2. 1 PublicationVSP_021783Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK086930 mRNA. Translation: BAC39765.2.
    AK165695 mRNA. Translation: BAE38343.1.
    AC119831 Genomic DNA. No translation available.
    CCDSiCCDS52791.1. [Q8C351-1]
    RefSeqiNP_001028706.1. NM_001033534.1. [Q8C351-1]
    UniGeneiMm.335152.

    Genome annotation databases

    EnsembliENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594. [Q8C351-1]
    GeneIDi244864.
    KEGGimmu:244864.
    UCSCiuc012gtc.1. mouse. [Q8C351-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK086930 mRNA. Translation: BAC39765.2 .
    AK165695 mRNA. Translation: BAE38343.1 .
    AC119831 Genomic DNA. No translation available.
    CCDSi CCDS52791.1. [Q8C351-1 ]
    RefSeqi NP_001028706.1. NM_001033534.1. [Q8C351-1 ]
    UniGenei Mm.335152.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K00 NMR - B 367-381 [» ]
    ProteinModelPortali Q8C351.
    SMRi Q8C351. Positions 46-179.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8C351.

    Proteomic databases

    PRIDEi Q8C351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098782 ; ENSMUSP00000096379 ; ENSMUSG00000060594 . [Q8C351-1 ]
    GeneIDi 244864.
    KEGGi mmu:244864.
    UCSCi uc012gtc.1. mouse. [Q8C351-1 ]

    Organism-specific databases

    CTDi 143903.
    MGIi MGI:2685357. Layn.

    Phylogenomic databases

    eggNOGi NOG315174.
    GeneTreei ENSGT00390000001844.
    HOGENOMi HOG000294068.
    HOVERGENi HBG050945.
    InParanoidi Q8C351.
    KOi K10077.
    OMAi TACQDLY.
    OrthoDBi EOG7FV3RQ.
    TreeFami TF330715.

    Miscellaneous databases

    EvolutionaryTracei Q8C351.
    NextBioi 386444.
    PROi Q8C351.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C351.
    CleanExi MM_LAYN.
    Genevestigatori Q8C351.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-212 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Lung and Medulla oblongata.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin."
      Bono P., Cordero E., Johnson K., Borowsky M., Ramesh V., Jacks T., Hynes R.O.
      Exp. Cell Res. 308:177-187(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NF2 AND RDX.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLAYN_MOUSE
    AccessioniPrimary (citable) accession number: Q8C351
    Secondary accession number(s): E9QQ23, Q3TMU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 87 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3