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Q8C351

- LAYN_MOUSE

UniProt

Q8C351 - LAYN_MOUSE

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Protein

Layilin

Gene
Layn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for hyaluronate By similarity.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronic acid binding Source: HGNC
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Layilin
Gene namesi
Name:Layn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2685357. Layn.

Subcellular locationi

Membrane; Single-pass type I membrane protein Reviewed prediction
Note: Colocalizes with TLN1 at the membrane ruffles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 235211Extracellular Reviewed predictionAdd
BLAST
Transmembranei236 – 25621Helical; Reviewed predictionAdd
BLAST
Topological domaini257 – 381125Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. ruffle Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 381357LayilinPRO_0000262509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 184 By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi150 ↔ 176 By similarity
Modified residuei286 – 2861Phosphoserine1 Publication
Modified residuei299 – 2991Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ8C351.

PTM databases

PhosphoSiteiQ8C351.

Expressioni

Gene expression databases

BgeeiQ8C351.
CleanExiMM_LAYN.
GenevestigatoriQ8C351.

Interactioni

Subunit structurei

Interacts with TLN1 By similarity. Interacts with NF2 and RDX.1 Publication

Structurei

Secondary structure

1
381
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi372 – 3765

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K00NMR-B367-381[»]
ProteinModelPortaliQ8C351.
SMRiQ8C351. Positions 46-179.

Miscellaneous databases

EvolutionaryTraceiQ8C351.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 185141C-type lectinAdd
BLAST
Repeati340 – 34451-1
Repeati350 – 35451-2
Repeati356 – 35942-1
Repeati371 – 37551-3
Repeati377 – 38042-2

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 37445Interaction with NF2Add
BLAST
Regioni337 – 38145Interaction with TLN1 By similarityAdd
BLAST
Regioni340 – 375363 X 5 AA repeats of E-S-G-X-VAdd
BLAST
Regioni356 – 380252 X 4 AA repeats of N-X-I-YAdd
BLAST

Domaini

The C-terminal domain interacts with the N-terminal domain of RDX.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315174.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ8C351.
KOiK10077.
OMAiTACQDLY.
OrthoDBiEOG7FV3RQ.
TreeFamiTF330715.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C351-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY    50
KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS 100
DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFRNWYV DEPSCGSEVC 150
VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN NFICKYHDDK PSTTPSIWPG 200
GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP SIPLFLLLVV 250
TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE 300
ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME 350
SGFVTNDIYE FSPDRMGRSK ESGWVENEIY Y 381
Length:381
Mass (Da):43,269
Last modified:July 27, 2011 - v4
Checksum:iCF20C2EE708A5E07
GO
Isoform 2 (identifier: Q8C351-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-137: RN → SG
     138-381: Missing.

Show »
Length:137
Mass (Da):15,321
Checksum:i7D76C154D4D17262
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 1372RN → SG in isoform 2. VSP_021782
Alternative sequencei138 – 381244Missing in isoform 2. VSP_021783Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK086930 mRNA. Translation: BAC39765.2.
AK165695 mRNA. Translation: BAE38343.1.
AC119831 Genomic DNA. No translation available.
CCDSiCCDS52791.1. [Q8C351-1]
RefSeqiNP_001028706.1. NM_001033534.1. [Q8C351-1]
UniGeneiMm.335152.

Genome annotation databases

EnsembliENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594. [Q8C351-1]
GeneIDi244864.
KEGGimmu:244864.
UCSCiuc012gtc.1. mouse. [Q8C351-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK086930 mRNA. Translation: BAC39765.2 .
AK165695 mRNA. Translation: BAE38343.1 .
AC119831 Genomic DNA. No translation available.
CCDSi CCDS52791.1. [Q8C351-1 ]
RefSeqi NP_001028706.1. NM_001033534.1. [Q8C351-1 ]
UniGenei Mm.335152.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2K00 NMR - B 367-381 [» ]
ProteinModelPortali Q8C351.
SMRi Q8C351. Positions 46-179.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8C351.

Proteomic databases

PRIDEi Q8C351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098782 ; ENSMUSP00000096379 ; ENSMUSG00000060594 . [Q8C351-1 ]
GeneIDi 244864.
KEGGi mmu:244864.
UCSCi uc012gtc.1. mouse. [Q8C351-1 ]

Organism-specific databases

CTDi 143903.
MGIi MGI:2685357. Layn.

Phylogenomic databases

eggNOGi NOG315174.
GeneTreei ENSGT00390000001844.
HOGENOMi HOG000294068.
HOVERGENi HBG050945.
InParanoidi Q8C351.
KOi K10077.
OMAi TACQDLY.
OrthoDBi EOG7FV3RQ.
TreeFami TF330715.

Miscellaneous databases

EvolutionaryTracei Q8C351.
NextBioi 386444.
PROi Q8C351.
SOURCEi Search...

Gene expression databases

Bgeei Q8C351.
CleanExi MM_LAYN.
Genevestigatori Q8C351.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-212 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung and Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin."
    Bono P., Cordero E., Johnson K., Borowsky M., Ramesh V., Jacks T., Hynes R.O.
    Exp. Cell Res. 308:177-187(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NF2 AND RDX.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLAYN_MOUSE
AccessioniPrimary (citable) accession number: Q8C351
Secondary accession number(s): E9QQ23, Q3TMU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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