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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. identical protein binding Source: MGI
  2. kinase binding Source: MGI

GO - Biological processi

  1. activation-induced cell death of T cells Source: MGI
  2. apoptotic process Source: MGI
  3. apoptotic signaling pathway Source: MGI
  4. B cell mediated immunity Source: MGI
  5. cellular response to hyperoxia Source: MGI
  6. cellular response to lithium ion Source: MGI
  7. extrinsic apoptotic signaling pathway Source: MGI
  8. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  9. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  10. gene expression Source: MGI
  11. hepatocyte apoptotic process Source: MGI
  12. immunoglobulin production Source: MGI
  13. inflammatory cell apoptotic process Source: MGI
  14. motor neuron apoptotic process Source: MGI
  15. necroptotic signaling pathway Source: MGI
  16. negative regulation of apoptotic process Source: MGI
  17. negative regulation of B cell activation Source: MGI
  18. negative thymic T cell selection Source: MGI
  19. neuron apoptotic process Source: MGI
  20. positive regulation of apoptotic process Source: MGI
  21. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  22. protein homooligomerization Source: MGI
  23. regulation of lymphocyte differentiation Source: MGI
  24. regulation of myeloid cell differentiation Source: MGI
  25. renal system process Source: MGI
  26. response to glucocorticoid Source: MGI
  27. response to toxic substance Source: MGI
  28. spleen development Source: MGI
  29. T cell homeostasis Source: MGI
  30. transformed cell apoptotic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 6Imported
Gene namesi
Name:FasImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95484. Fas.

Subcellular locationi

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: MGI
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. death-inducing signaling complex Source: MGI
  5. external side of plasma membrane Source: MGI
  6. extracellular region Source: MGI
  7. extracellular vesicular exosome Source: MGI
  8. membrane raft Source: MGI
  9. nucleus Source: MGI
  10. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8C350.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
KOiK04390.

Sequencei

Sequence statusi: Complete.

Q8C350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ
60
GGPFCCQPCQ PEN
Length:63
Mass (Da):7,116
Last modified:March 1, 2003 - v1
Checksum:i37283F7401ECAD82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102285 Genomic DNA. No translation available.
AK086933 mRNA. Translation: BAC39766.1.
RefSeqiNP_001140180.1. NM_001146708.1.
UniGeneiMm.1626.

Genome annotation databases

EnsembliENSMUST00000112472; ENSMUSP00000108091; ENSMUSG00000024778.
GeneIDi14102.
KEGGimmu:14102.
UCSCiuc008hgh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102285 Genomic DNA. No translation available.
AK086933 mRNA. Translation: BAC39766.1.
RefSeqiNP_001140180.1. NM_001146708.1.
UniGeneiMm.1626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112472; ENSMUSP00000108091; ENSMUSG00000024778.
GeneIDi14102.
KEGGimmu:14102.
UCSCiuc008hgh.2. mouse.

Organism-specific databases

CTDi355.
MGIiMGI:95484. Fas.

Phylogenomic databases

GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
KOiK04390.

Miscellaneous databases

NextBioi285130.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8C350.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C350_MOUSE
AccessioniPrimary (citable) accession number: Q8C350
Secondary accession number(s): D3Z6E5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.