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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation-induced cell death of T cells Source: MGI
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: MGI
  • B cell mediated immunity Source: MGI
  • brain development Source: GO_Central
  • cellular response to hyperoxia Source: MGI
  • cellular response to lithium ion Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • gene expression Source: MGI
  • hepatocyte apoptotic process Source: MGI
  • immunoglobulin production Source: MGI
  • inflammatory cell apoptotic process Source: MGI
  • inflammatory response Source: GO_Central
  • motor neuron apoptotic process Source: MGI
  • necroptotic signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of B cell activation Source: MGI
  • negative thymic T cell selection Source: MGI
  • neuron apoptotic process Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • positive regulation of lymphocyte apoptotic process Source: MGI
  • positive regulation of MAPK cascade Source: GO_Central
  • protein homooligomerization Source: MGI
  • regulation of cell proliferation Source: GO_Central
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  • regulation of lymphocyte differentiation Source: MGI
  • regulation of myeloid cell differentiation Source: MGI
  • renal system process Source: MGI
  • response to glucocorticoid Source: MGI
  • response to lipopolysaccharide Source: GO_Central
  • response to toxic substance Source: MGI
  • spleen development Source: MGI
  • T cell homeostasis Source: MGI
  • transformed cell apoptotic process Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 6Imported
Gene namesi
Name:FasImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95484. Fas.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence analysisAdd
BLAST
Chaini14 – 6350Sequence analysisPRO_5005940257Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025691.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J23A. Eukaryota.
ENOG4112ADB. LUCA.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
KOiK04390.

Sequencei

Sequence statusi: Complete.

Q8C350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ
60
GGPFCCQPCQ PEN
Length:63
Mass (Da):7,116
Last modified:March 1, 2003 - v1
Checksum:i37283F7401ECAD82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102285 Genomic DNA. No translation available.
AK086933 mRNA. Translation: BAC39766.1.
RefSeqiNP_001140180.1. NM_001146708.1.
UniGeneiMm.1626.

Genome annotation databases

EnsembliENSMUST00000112472; ENSMUSP00000108091; ENSMUSG00000024778.
GeneIDi14102.
KEGGimmu:14102.
UCSCiuc008hgh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102285 Genomic DNA. No translation available.
AK086933 mRNA. Translation: BAC39766.1.
RefSeqiNP_001140180.1. NM_001146708.1.
UniGeneiMm.1626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112472; ENSMUSP00000108091; ENSMUSG00000024778.
GeneIDi14102.
KEGGimmu:14102.
UCSCiuc008hgh.2. mouse.

Organism-specific databases

CTDi355.
MGIiMGI:95484. Fas.

Phylogenomic databases

eggNOGiENOG410J23A. Eukaryota.
ENOG4112ADB. LUCA.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
KOiK04390.

Miscellaneous databases

NextBioi285130.
SOURCEiSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C350_MOUSE
AccessioniPrimary (citable) accession number: Q8C350
Secondary accession number(s): D3Z6E5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.