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Q8C350 (Q8C350_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Fas MGI 95484 Ensembl ENSMUSP00000108091
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell mediated immunity

Inferred from mutant phenotype PubMed 18199416. Source: MGI

T cell homeostasis

Inferred from mutant phenotype PubMed 8640868. Source: MGI

activation-induced cell death of T cells

Inferred from direct assay PubMed 12702495. Source: MGI

apoptotic process

Inferred from mutant phenotype PubMed 8700551. Source: MGI

apoptotic signaling pathway

Inferred from direct assay PubMed 7511063PubMed 8666928. Source: MGI

cellular response to lithium ion

Inferred from mutant phenotype PubMed 20530871. Source: MGI

extrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 17980593. Source: MGI

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 13679421. Source: MGI

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from direct assay PubMed 10588860PubMed 12801066PubMed 15039234PubMed 18363966PubMed 8524870. Source: MGI

gene expression

Inferred from mutant phenotype PubMed 7602121. Source: MGI

immunoglobulin production

Inferred from mutant phenotype PubMed 18199416. Source: MGI

inflammatory cell apoptotic process

Inferred from direct assay PubMed 12801066. Source: MGI

motor neuron apoptotic process

Inferred from mutant phenotype PubMed 13679421. Source: MGI

necroptotic signaling pathway

Inferred from genetic interaction PubMed 21052097. Source: MGI

negative regulation of B cell activation

Inferred from mutant phenotype PubMed 6610701. Source: MGI

negative regulation of apoptotic process

Inferred from direct assay PubMed 7595210. Source: MGI

negative thymic T cell selection

Inferred from mutant phenotype PubMed 10429671. Source: MGI

neuron apoptotic process

Inferred from mutant phenotype PubMed 20530871. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 15039234. Source: MGI

protein homooligomerization

Inferred from direct assay PubMed 8524870. Source: MGI

regulation of lymphocyte differentiation

Inferred from mutant phenotype PubMed 6610701. Source: MGI

regulation of myeloid cell differentiation

Inferred from mutant phenotype PubMed 9697835. Source: MGI

renal system process

Inferred from mutant phenotype PubMed 8640868. Source: MGI

response to glucocorticoid

Inferred from mutant phenotype PubMed 7602121PubMed 8640868. Source: MGI

response to toxic substance

Inferred from mutant phenotype PubMed 8557033. Source: MGI

spleen development

Inferred from mutant phenotype PubMed 18199416. Source: MGI

transformed cell apoptotic process

Inferred from direct assay PubMed 12801066. Source: MGI

   Cellular_componentcell surface

Inferred from direct assay PubMed 7595210. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 12801066PubMed 16365167PubMed 16493007PubMed 23583643PubMed 8788039. Source: MGI

extracellular region

Inferred from direct assay PubMed 7595210. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 8524870. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8C350 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 37283F7401ECAD82

FASTA637,116
        10         20         30         40         50         60 
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ GGPFCCQPCQ 


PEN 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC39766.1.
Tissue: Lung EMBL BAC39766.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000108091.
[10]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000108091.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC102285 Genomic DNA. No translation available.
AK086933 mRNA. Translation: BAC39766.1.
RefSeqNP_001140180.1. NM_001146708.1.
UniGeneMm.1626.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112472; ENSMUSP00000108091; ENSMUSG00000024778.
GeneID14102.
KEGGmmu:14102.
UCSCuc008hgh.2. mouse.

Organism-specific databases

CTD355.
MGIMGI:95484. Fas.

Phylogenomic databases

GeneTreeENSGT00730000111280.
HOGENOMHOG000139681.
InParanoidQ8C350.
KOK04390.

Gene expression databases

GenevestigatorQ8C350.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSFAS. mouse.
NextBio285130.
SOURCESearch...

Entry information

Entry nameQ8C350_MOUSE
AccessionPrimary (citable) accession number: Q8C350
Secondary accession number(s): D3Z6E5
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)