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Protein

Amphoterin-induced protein 3

Gene

Amigo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • positive regulation of synapse assembly Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:Amigo3Imported
Synonyms:Ali3Imported, Kiaa1851Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444854. Amigo3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 383ExtracellularSequence analysisAdd BLAST364
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 508CytoplasmicSequence analysisAdd BLAST104

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001451420 – 508Amphoterin-induced protein 3Sequence analysisAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8C2S7.
PRIDEiQ8C2S7.

PTM databases

iPTMnetiQ8C2S7.
PhosphoSitePlusiQ8C2S7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000032593.
CleanExiMM_AMIGO3.

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8C2S7.
SMRiQ8C2S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 61LRRNTAdd BLAST37
Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 133LRR 3Add BLAST24
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 178LRR 5Add BLAST21
Repeati184 – 207LRR 6Add BLAST24
Domaini219 – 275LRRCTAdd BLAST57
Domaini279 – 370Ig-like C2-typeSequence analysisAdd BLAST92

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGMJ. Eukaryota.
ENOG410YSS0. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ8C2S7.
OMAiVCLATGP.
OrthoDBiEOG091G09BC.
PhylomeDBiQ8C2S7.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C2S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLVLSGIL LCMLGAGLGT SDLEDVLPPA PHNCPDICIC AADVLSCAGR
60 70 80 90 100
GLQDLPVALP TTAAELDLSH NALKRLHPGW LAPLSRLRAL HLGYNKLEVL
110 120 130 140 150
GHGAFTNASG LRTLDLSSNM LRMLHTHDLD GLEELEKLLL FNNSLMHLDL
160 170 180 190 200
DAFQGLRMLS HLYLSCNELS SFSFNHLHGL GLTRLRTLDL SSNWLKHISI
210 220 230 240 250
PELAALPTYL KNRLYLHNNP LPCDCSLYHL LRRWHQRGLS ALHDFEREYT
260 270 280 290 300
CLVFKVSESR VRFFEHSRVF KNCSVAAAPG LELPEEQLHA QVGQSLRLFC
310 320 330 340 350
NTSVPATRVA WVSPKNELLV APASQDGSIA VLADGSLAIG RVQEQHAGVF
360 370 380 390 400
VCLASGPRLH HNQTLEYNVS VQKARPEPET FNTGFTTLLG CIVGLVLVLL
410 420 430 440 450
YLFAPPCRGC CHCCQRACRN RCWPRASSPL QELSAQSSML STTPPDAPSR
460 470 480 490 500
KASVHKHVVF LEPGKKGLNG RVQLAVAEDF DLCNPMGLQL KAGSESASST

GSEGLVMS
Length:508
Mass (Da):55,625
Last modified:March 1, 2003 - v1
Checksum:i31334E42F91810C5
GO

Sequence cautioni

The sequence BAC26035 differs from that shown. Reason: Frameshift at position 224.Curated
The sequence BAC98266 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237004 mRNA. Translation: AAO48945.1.
AB167510 mRNA. Translation: BAD12542.1.
AK028619 mRNA. Translation: BAC26035.1. Frameshift.
AK088051 mRNA. Translation: BAC40120.1.
AK129456 mRNA. Translation: BAC98266.1. Different initiation.
CCDSiCCDS23516.1.
RefSeqiNP_796249.1. NM_177275.4.
UniGeneiMm.449806.

Genome annotation databases

EnsembliENSMUST00000085060; ENSMUSP00000082137; ENSMUSG00000032593.
GeneIDi320844.
KEGGimmu:320844.
UCSCiuc009rom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237004 mRNA. Translation: AAO48945.1.
AB167510 mRNA. Translation: BAD12542.1.
AK028619 mRNA. Translation: BAC26035.1. Frameshift.
AK088051 mRNA. Translation: BAC40120.1.
AK129456 mRNA. Translation: BAC98266.1. Different initiation.
CCDSiCCDS23516.1.
RefSeqiNP_796249.1. NM_177275.4.
UniGeneiMm.449806.

3D structure databases

ProteinModelPortaliQ8C2S7.
SMRiQ8C2S7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8C2S7.
PhosphoSitePlusiQ8C2S7.

Proteomic databases

PaxDbiQ8C2S7.
PRIDEiQ8C2S7.

Protocols and materials databases

DNASUi320844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085060; ENSMUSP00000082137; ENSMUSG00000032593.
GeneIDi320844.
KEGGimmu:320844.
UCSCiuc009rom.1. mouse.

Organism-specific databases

CTDi386724.
MGIiMGI:2444854. Amigo3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGMJ. Eukaryota.
ENOG410YSS0. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ8C2S7.
OMAiVCLATGP.
OrthoDBiEOG091G09BC.
PhylomeDBiQ8C2S7.
TreeFamiTF326838.

Miscellaneous databases

PROiQ8C2S7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032593.
CleanExiMM_AMIGO3.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMGO3_MOUSE
AccessioniPrimary (citable) accession number: Q8C2S7
Secondary accession number(s): Q6ZPH1, Q8CEB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.