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Protein

Amphoterin-induced protein 3

Gene

Amigo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • positive regulation of synapse assembly Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:Amigo3Imported
Synonyms:Ali3Imported, Kiaa1851Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444854 Amigo3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 383ExtracellularSequence analysisAdd BLAST364
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 508CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001451420 – 508Amphoterin-induced protein 3Sequence analysisAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8C2S7
PRIDEiQ8C2S7

PTM databases

iPTMnetiQ8C2S7
PhosphoSitePlusiQ8C2S7

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000032593
CleanExiMM_AMIGO3

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8C2S7
SMRiQ8C2S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 61LRRNTAdd BLAST37
Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 133LRR 3Add BLAST24
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 178LRR 5Add BLAST21
Repeati184 – 207LRR 6Add BLAST24
Domaini219 – 275LRRCTAdd BLAST57
Domaini279 – 370Ig-like C2-typeSequence analysisAdd BLAST92

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGMJ Eukaryota
ENOG410YSS0 LUCA
GeneTreeiENSGT00530000063545
HOGENOMiHOG000231327
HOVERGENiHBG080231
InParanoidiQ8C2S7
KOiK22529
OMAiLYLGCNE
OrthoDBiEOG091G09BC
PhylomeDBiQ8C2S7
TreeFamiTF326838

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283 AMIGO
IPR031285 AMIGO3
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR24368 PTHR24368, 1 hit
PTHR24368:SF62 PTHR24368:SF62, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 6 hits
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C2S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLVLSGIL LCMLGAGLGT SDLEDVLPPA PHNCPDICIC AADVLSCAGR
60 70 80 90 100
GLQDLPVALP TTAAELDLSH NALKRLHPGW LAPLSRLRAL HLGYNKLEVL
110 120 130 140 150
GHGAFTNASG LRTLDLSSNM LRMLHTHDLD GLEELEKLLL FNNSLMHLDL
160 170 180 190 200
DAFQGLRMLS HLYLSCNELS SFSFNHLHGL GLTRLRTLDL SSNWLKHISI
210 220 230 240 250
PELAALPTYL KNRLYLHNNP LPCDCSLYHL LRRWHQRGLS ALHDFEREYT
260 270 280 290 300
CLVFKVSESR VRFFEHSRVF KNCSVAAAPG LELPEEQLHA QVGQSLRLFC
310 320 330 340 350
NTSVPATRVA WVSPKNELLV APASQDGSIA VLADGSLAIG RVQEQHAGVF
360 370 380 390 400
VCLASGPRLH HNQTLEYNVS VQKARPEPET FNTGFTTLLG CIVGLVLVLL
410 420 430 440 450
YLFAPPCRGC CHCCQRACRN RCWPRASSPL QELSAQSSML STTPPDAPSR
460 470 480 490 500
KASVHKHVVF LEPGKKGLNG RVQLAVAEDF DLCNPMGLQL KAGSESASST

GSEGLVMS
Length:508
Mass (Da):55,625
Last modified:March 1, 2003 - v1
Checksum:i31334E42F91810C5
GO

Sequence cautioni

The sequence BAC26035 differs from that shown. Reason: Frameshift at position 224.Curated
The sequence BAC98266 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237004 mRNA Translation: AAO48945.1
AB167510 mRNA Translation: BAD12542.1
AK028619 mRNA Translation: BAC26035.1 Frameshift.
AK088051 mRNA Translation: BAC40120.1
AK129456 mRNA Translation: BAC98266.1 Different initiation.
CCDSiCCDS23516.1
RefSeqiNP_796249.1, NM_177275.4
UniGeneiMm.449806

Genome annotation databases

EnsembliENSMUST00000085060; ENSMUSP00000082137; ENSMUSG00000032593
GeneIDi320844
KEGGimmu:320844
UCSCiuc009rom.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAMGO3_MOUSE
AccessioniPrimary (citable) accession number: Q8C2S7
Secondary accession number(s): Q6ZPH1, Q8CEB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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