SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8C2S7

- AMGO3_MOUSE

UniProt

Q8C2S7 - AMGO3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Amphoterin-induced protein 3

Gene
Amigo3, Ali3, Kiaa1851
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain By similarity.By similarity

GO - Biological processi

  1. cell adhesion Source: MGI
  2. heterophilic cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:Amigo3
Synonyms:Ali3, Kiaa1851
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2444854. Amigo3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 383364Extracellular Reviewed predictionAdd
BLAST
Transmembranei384 – 40421Helical; Reviewed predictionAdd
BLAST
Topological domaini405 – 508104Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 508489Amphoterin-induced protein 3PRO_0000014514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 40 By similarity
Disulfide bondi38 ↔ 47 By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 251 By similarity
Disulfide bondi225 ↔ 273 By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi300 ↔ 352 By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8C2S7.

PTM databases

PhosphoSiteiQ8C2S7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ8C2S7.
CleanExiMM_AMIGO3.
GenevestigatoriQ8C2S7.

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2 By similarity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082137.

Structurei

3D structure databases

ProteinModelPortaliQ8C2S7.
SMRiQ8C2S7. Positions 33-369.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6137LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13324LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17821LRR 5Add
BLAST
Repeati184 – 20724LRR 6Add
BLAST
Domaini219 – 27557LRRCTAdd
BLAST
Domaini279 – 37092Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146733.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ8C2S7.
OMAiVCLATGP.
OrthoDBiEOG7C8GHP.
PhylomeDBiQ8C2S7.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C2S7-1 [UniParc]FASTAAdd to Basket

« Hide

MAWLVLSGIL LCMLGAGLGT SDLEDVLPPA PHNCPDICIC AADVLSCAGR    50
GLQDLPVALP TTAAELDLSH NALKRLHPGW LAPLSRLRAL HLGYNKLEVL 100
GHGAFTNASG LRTLDLSSNM LRMLHTHDLD GLEELEKLLL FNNSLMHLDL 150
DAFQGLRMLS HLYLSCNELS SFSFNHLHGL GLTRLRTLDL SSNWLKHISI 200
PELAALPTYL KNRLYLHNNP LPCDCSLYHL LRRWHQRGLS ALHDFEREYT 250
CLVFKVSESR VRFFEHSRVF KNCSVAAAPG LELPEEQLHA QVGQSLRLFC 300
NTSVPATRVA WVSPKNELLV APASQDGSIA VLADGSLAIG RVQEQHAGVF 350
VCLASGPRLH HNQTLEYNVS VQKARPEPET FNTGFTTLLG CIVGLVLVLL 400
YLFAPPCRGC CHCCQRACRN RCWPRASSPL QELSAQSSML STTPPDAPSR 450
KASVHKHVVF LEPGKKGLNG RVQLAVAEDF DLCNPMGLQL KAGSESASST 500
GSEGLVMS 508
Length:508
Mass (Da):55,625
Last modified:March 1, 2003 - v1
Checksum:i31334E42F91810C5
GO

Sequence cautioni

The sequence BAC26035.1 differs from that shown. Reason: Frameshift at position 224.
The sequence BAC98266.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237004 mRNA. Translation: AAO48945.1.
AB167510 mRNA. Translation: BAD12542.1.
AK028619 mRNA. Translation: BAC26035.1. Frameshift.
AK088051 mRNA. Translation: BAC40120.1.
AK129456 mRNA. Translation: BAC98266.1. Different initiation.
CCDSiCCDS23516.1.
RefSeqiNP_796249.1. NM_177275.4.
UniGeneiMm.449806.

Genome annotation databases

EnsembliENSMUST00000085060; ENSMUSP00000082137; ENSMUSG00000032593.
GeneIDi320844.
KEGGimmu:320844.
UCSCiuc009rom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237004 mRNA. Translation: AAO48945.1 .
AB167510 mRNA. Translation: BAD12542.1 .
AK028619 mRNA. Translation: BAC26035.1 . Frameshift.
AK088051 mRNA. Translation: BAC40120.1 .
AK129456 mRNA. Translation: BAC98266.1 . Different initiation.
CCDSi CCDS23516.1.
RefSeqi NP_796249.1. NM_177275.4.
UniGenei Mm.449806.

3D structure databases

ProteinModelPortali Q8C2S7.
SMRi Q8C2S7. Positions 33-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000082137.

PTM databases

PhosphoSitei Q8C2S7.

Proteomic databases

PRIDEi Q8C2S7.

Protocols and materials databases

DNASUi 320844.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085060 ; ENSMUSP00000082137 ; ENSMUSG00000032593 .
GeneIDi 320844.
KEGGi mmu:320844.
UCSCi uc009rom.1. mouse.

Organism-specific databases

CTDi 386724.
MGIi MGI:2444854. Amigo3.
Rougei Search...

Phylogenomic databases

eggNOGi NOG146733.
GeneTreei ENSGT00530000063545.
HOGENOMi HOG000231327.
HOVERGENi HBG080231.
InParanoidi Q8C2S7.
OMAi VCLATGP.
OrthoDBi EOG7C8GHP.
PhylomeDBi Q8C2S7.
TreeFami TF326838.

Miscellaneous databases

NextBioi 397545.
PROi Q8C2S7.
SOURCEi Search...

Gene expression databases

Bgeei Q8C2S7.
CleanExi MM_AMIGO3.
Genevestigatori Q8C2S7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats."
    Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.
    J. Cell Biol. 160:963-973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Cerebellum.
  2. Ono T.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin and Thymus.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.

Entry informationi

Entry nameiAMGO3_MOUSE
AccessioniPrimary (citable) accession number: Q8C2S7
Secondary accession number(s): Q6ZPH1, Q8CEB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi