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Q8C2K5

- RASL3_MOUSE

UniProt

Q8C2K5 - RASL3_MOUSE

Protein

RAS protein activator like-3

Gene

Rasal3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May function as a Ras GTPase-activating protein.By similarity

    GO - Molecular functioni

    1. Ras GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of Ras protein signal transduction Source: RefGenome
    2. positive regulation of Ras GTPase activity Source: RefGenome
    3. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RAS protein activator like-3
    Gene namesi
    Name:Rasal3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2444128. Rasal3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10411041RAS protein activator like-3PRO_0000322567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411PhosphoserineBy similarity
    Modified residuei187 – 1871PhosphoserineBy similarity
    Modified residuei190 – 1901PhosphoserineBy similarity
    Modified residuei259 – 2591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8C2K5.
    PRIDEiQ8C2K5.

    PTM databases

    PhosphoSiteiQ8C2K5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8C2K5.
    BgeeiQ8C2K5.
    CleanExiMM_A430107D22RIK.
    GenevestigatoriQ8C2K5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000123141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C2K5.
    SMRiQ8C2K5. Positions 444-762.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 321102PHAdd
    BLAST
    Domaini334 – 41077C2Add
    BLAST
    Domaini484 – 676193Ras-GAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili218 – 24326Sequence AnalysisAdd
    BLAST
    Coiled coili931 – 101383Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2 domain.Curated
    Contains 1 PH domain.Curated
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG313834.
    GeneTreeiENSGT00600000084217.
    HOGENOMiHOG000154074.
    InParanoidiQ8C2K5.
    KOiK17634.
    OMAiRRHFQPS.
    OrthoDBiEOG7KM5S1.
    TreeFamiTF105303.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view]
    PfamiPF00616. RasGAP. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEiPS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8C2K5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPECGQTMF RTFWSRSRDS SAMDPPLQSE EDSQTQPSLP SPLTSYRWHT     50
    GGSGEKAAGG FRWGRFAGWG RALSHQEPMV NSQPAPRSLF RRVLSAPPKE 100
    SRSNRLRFSK TLWGRHKNVA PLEPKPNPKA PEPELELVAD PDLPVAQIPE 150
    PPTPDMPVWN IDGFTLLEGK LVMLGEEEGP RQIRVGSASS ENSMQAALGN 200
    LKDAVRTPGK TEPEAAGSNQ VHNVRKLLKR LKEKKRAKSE LGAYTPRDGP 250
    PSALGSRESL ATLSELDLGA ERDVRVWPLH PSLLGEPYCF QVTWAGGSLC 300
    FSCRSSAERD RWIEDLRRQF QPSQDNVERQ EMWLTVWVHE AKGLPRATVP 350
    GVRAELWLDG ALLARTAPRA GPGQLFWAER FHFEALPPAR RLSLRLRSAG 400
    PAGATVGRVV LELDEVSIPR APAAGLERWF PVLGAPAGAV LRARIRVRCL 450
    RVLPSERYKE LAEFLTFHYA RLCGALEPAL SAQAKEELAA AMVRVLRATG 500
    RAQALVTDLG TAELARCGGR EALLFRENTL ATKAIDEYMK LVAQEYLQDT 550
    LGQVVRCLCA STEDCEVDPS KCPTPELPKH QARLRDSCEE VFENIIHSYN 600
    CFPAELGSVF SSWREACKAR GSEALGPRLV CASLFLRLLC PAILAPSLFG 650
    LAPEHPAPGP ARTLTLIAKV IQNLANCAPF GEKEAYMAFM NSFLEDHGPA 700
    MQHFLDQVAT VDADTTPSGY QGSGDLALQL AVLHVQLCTI FAELDQKTQD 750
    SLEPLPTILR AIEEGRPVPV SVPMRLPRIS TQVQSSFFSG EKPGFLAPRD 800
    LPKHTPLISK SQSLRSFQGA GSWASRRPDE ERPQRRPRPV LRTQSVPARR 850
    PTHRRPSAGS KPRPKGSLRM GPAPCGRAWT RASASLPRKP SVPWQRQMDQ 900
    PGDRYQTTGT HRPVGKLAEI QCEVAIFREA QKALSLLVES LSTQVQALKE 950
    QQEHFRCQLQ DLYSRLGAGI SKLDSKGGLP SNGSHRLKSL EQRLTEMECS 1000
    QDQLRDSLQS LQLLSKTPGS RSQPLPLKAP CVNGADLSMG T 1041
    Length:1,041
    Mass (Da):114,782
    Last modified:March 1, 2003 - v1
    Checksum:iDA58139782B1EEFF
    GO
    Isoform 2 (identifier: Q8C2K5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: Missing.
         132-132: E → ERSKQAMVPGVKGQLSGVSSLLQLQ

    Note: No experimental confirmation available.

    Show »
    Length:1,043
    Mass (Da):114,685
    Checksum:iBB7FACC5B3C42A49
    GO

    Sequence cautioni

    The sequence BAC30956.1 differs from that shown. Reason: Frameshift at position 11.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221L → M in BAC27141. (PubMed:16141072)Curated
    Sequence conflicti494 – 4941R → H in BAC27141. (PubMed:16141072)Curated
    Sequence conflicti978 – 9781G → S in BAC40689. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2222Missing in isoform 2. 1 PublicationVSP_031931Add
    BLAST
    Alternative sequencei132 – 1321E → ERSKQAMVPGVKGQLSGVSS LLQLQ in isoform 2. 1 PublicationVSP_031932

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030797 mRNA. Translation: BAC27141.1.
    AK041479 mRNA. Translation: BAC30956.1. Frameshift.
    AK088449 mRNA. Translation: BAC40358.1.
    AK088987 mRNA. Translation: BAC40689.1.
    BC132341 mRNA. Translation: AAI32342.2.
    CCDSiCCDS37556.1. [Q8C2K5-1]
    RefSeqiNP_848900.2. NM_178785.3. [Q8C2K5-1]
    XP_006524476.1. XM_006524413.1. [Q8C2K5-2]
    UniGeneiMm.122284.
    Mm.416246.

    Genome annotation databases

    EnsembliENSMUST00000063824; ENSMUSP00000064084; ENSMUSG00000052142. [Q8C2K5-1]
    ENSMUST00000136375; ENSMUSP00000118738; ENSMUSG00000052142.
    ENSMUST00000137458; ENSMUSP00000123141; ENSMUSG00000052142. [Q8C2K5-2]
    GeneIDi320484.
    KEGGimmu:320484.
    UCSCiuc008bwu.1. mouse. [Q8C2K5-2]
    uc008bwv.1. mouse. [Q8C2K5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030797 mRNA. Translation: BAC27141.1 .
    AK041479 mRNA. Translation: BAC30956.1 . Frameshift.
    AK088449 mRNA. Translation: BAC40358.1 .
    AK088987 mRNA. Translation: BAC40689.1 .
    BC132341 mRNA. Translation: AAI32342.2 .
    CCDSi CCDS37556.1. [Q8C2K5-1 ]
    RefSeqi NP_848900.2. NM_178785.3. [Q8C2K5-1 ]
    XP_006524476.1. XM_006524413.1. [Q8C2K5-2 ]
    UniGenei Mm.122284.
    Mm.416246.

    3D structure databases

    ProteinModelPortali Q8C2K5.
    SMRi Q8C2K5. Positions 444-762.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000123141.

    PTM databases

    PhosphoSitei Q8C2K5.

    Proteomic databases

    PaxDbi Q8C2K5.
    PRIDEi Q8C2K5.

    Protocols and materials databases

    DNASUi 320484.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063824 ; ENSMUSP00000064084 ; ENSMUSG00000052142 . [Q8C2K5-1 ]
    ENSMUST00000136375 ; ENSMUSP00000118738 ; ENSMUSG00000052142 .
    ENSMUST00000137458 ; ENSMUSP00000123141 ; ENSMUSG00000052142 . [Q8C2K5-2 ]
    GeneIDi 320484.
    KEGGi mmu:320484.
    UCSCi uc008bwu.1. mouse. [Q8C2K5-2 ]
    uc008bwv.1. mouse. [Q8C2K5-1 ]

    Organism-specific databases

    CTDi 64926.
    MGIi MGI:2444128. Rasal3.

    Phylogenomic databases

    eggNOGi NOG313834.
    GeneTreei ENSGT00600000084217.
    HOGENOMi HOG000154074.
    InParanoidi Q8C2K5.
    KOi K17634.
    OMAi RRHFQPS.
    OrthoDBi EOG7KM5S1.
    TreeFami TF105303.

    Miscellaneous databases

    NextBioi 396821.
    PROi Q8C2K5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8C2K5.
    Bgeei Q8C2K5.
    CleanExi MM_A430107D22RIK.
    Genevestigatori Q8C2K5.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view ]
    Pfami PF00616. RasGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEi PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiRASL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8C2K5
    Secondary accession number(s): A3KMM0
    , Q8C2A5, Q8C9R4, Q8CDB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3