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Q8C2K5 (RASL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RAS protein activator like-3
Gene names
Name:Rasal3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1041 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a Ras GTPase-activating protein By similarity.

Sequence similarities

Contains 1 C2 domain.

Contains 1 PH domain.

Contains 1 Ras-GAP domain.

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.

Sequence caution

The sequence BAC30956.1 differs from that shown. Reason: Frameshift at position 11.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8C2K5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8C2K5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     132-132: E → ERSKQAMVPGVKGQLSGVSSLLQLQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10411041RAS protein activator like-3
PRO_0000322567

Regions

Domain220 – 321102PH
Domain334 – 41077C2
Domain484 – 676193Ras-GAP
Coiled coil218 – 24326 Potential
Coiled coil931 – 101383 Potential

Amino acid modifications

Modified residue411Phosphoserine By similarity
Modified residue1871Phosphoserine By similarity
Modified residue1901Phosphoserine By similarity
Modified residue2591Phosphoserine By similarity

Natural variations

Alternative sequence1 – 2222Missing in isoform 2.
VSP_031931
Alternative sequence1321E → ERSKQAMVPGVKGQLSGVSS LLQLQ in isoform 2.
VSP_031932

Experimental info

Sequence conflict1221L → M in BAC27141. Ref.1
Sequence conflict4941R → H in BAC27141. Ref.1
Sequence conflict9781G → S in BAC40689. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DA58139782B1EEFF

FASTA1,041114,782
        10         20         30         40         50         60 
MKPECGQTMF RTFWSRSRDS SAMDPPLQSE EDSQTQPSLP SPLTSYRWHT GGSGEKAAGG 

        70         80         90        100        110        120 
FRWGRFAGWG RALSHQEPMV NSQPAPRSLF RRVLSAPPKE SRSNRLRFSK TLWGRHKNVA 

       130        140        150        160        170        180 
PLEPKPNPKA PEPELELVAD PDLPVAQIPE PPTPDMPVWN IDGFTLLEGK LVMLGEEEGP 

       190        200        210        220        230        240 
RQIRVGSASS ENSMQAALGN LKDAVRTPGK TEPEAAGSNQ VHNVRKLLKR LKEKKRAKSE 

       250        260        270        280        290        300 
LGAYTPRDGP PSALGSRESL ATLSELDLGA ERDVRVWPLH PSLLGEPYCF QVTWAGGSLC 

       310        320        330        340        350        360 
FSCRSSAERD RWIEDLRRQF QPSQDNVERQ EMWLTVWVHE AKGLPRATVP GVRAELWLDG 

       370        380        390        400        410        420 
ALLARTAPRA GPGQLFWAER FHFEALPPAR RLSLRLRSAG PAGATVGRVV LELDEVSIPR 

       430        440        450        460        470        480 
APAAGLERWF PVLGAPAGAV LRARIRVRCL RVLPSERYKE LAEFLTFHYA RLCGALEPAL 

       490        500        510        520        530        540 
SAQAKEELAA AMVRVLRATG RAQALVTDLG TAELARCGGR EALLFRENTL ATKAIDEYMK 

       550        560        570        580        590        600 
LVAQEYLQDT LGQVVRCLCA STEDCEVDPS KCPTPELPKH QARLRDSCEE VFENIIHSYN 

       610        620        630        640        650        660 
CFPAELGSVF SSWREACKAR GSEALGPRLV CASLFLRLLC PAILAPSLFG LAPEHPAPGP 

       670        680        690        700        710        720 
ARTLTLIAKV IQNLANCAPF GEKEAYMAFM NSFLEDHGPA MQHFLDQVAT VDADTTPSGY 

       730        740        750        760        770        780 
QGSGDLALQL AVLHVQLCTI FAELDQKTQD SLEPLPTILR AIEEGRPVPV SVPMRLPRIS 

       790        800        810        820        830        840 
TQVQSSFFSG EKPGFLAPRD LPKHTPLISK SQSLRSFQGA GSWASRRPDE ERPQRRPRPV 

       850        860        870        880        890        900 
LRTQSVPARR PTHRRPSAGS KPRPKGSLRM GPAPCGRAWT RASASLPRKP SVPWQRQMDQ 

       910        920        930        940        950        960 
PGDRYQTTGT HRPVGKLAEI QCEVAIFREA QKALSLLVES LSTQVQALKE QQEHFRCQLQ 

       970        980        990       1000       1010       1020 
DLYSRLGAGI SKLDSKGGLP SNGSHRLKSL EQRLTEMECS QDQLRDSLQS LQLLSKTPGS 

      1030       1040 
RSQPLPLKAP CVNGADLSMG T 

« Hide

Isoform 2 [UniParc].

Checksum: BB7FACC5B3C42A49
Show »

FASTA1,043114,685

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030797 mRNA. Translation: BAC27141.1.
AK041479 mRNA. Translation: BAC30956.1. Frameshift.
AK088449 mRNA. Translation: BAC40358.1.
AK088987 mRNA. Translation: BAC40689.1.
BC132341 mRNA. Translation: AAI32342.2.
RefSeqNP_848900.2. NM_178785.3.
XP_006524476.1. XM_006524413.1.
UniGeneMm.122284.
Mm.416246.

3D structure databases

ProteinModelPortalQ8C2K5.
SMRQ8C2K5. Positions 285-329, 331-769.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000123141.

PTM databases

PhosphoSiteQ8C2K5.

Proteomic databases

PaxDbQ8C2K5.
PRIDEQ8C2K5.

Protocols and materials databases

DNASU320484.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063824; ENSMUSP00000064084; ENSMUSG00000052142. [Q8C2K5-1]
ENSMUST00000136375; ENSMUSP00000118738; ENSMUSG00000052142.
ENSMUST00000137458; ENSMUSP00000123141; ENSMUSG00000052142. [Q8C2K5-2]
GeneID320484.
KEGGmmu:320484.
UCSCuc008bwu.1. mouse. [Q8C2K5-2]
uc008bwv.1. mouse. [Q8C2K5-1]

Organism-specific databases

CTD64926.
MGIMGI:2444128. Rasal3.

Phylogenomic databases

eggNOGNOG313834.
GeneTreeENSGT00600000084217.
HOGENOMHOG000154074.
InParanoidQ8C2K5.
KOK17634.
OMARRHFQPS.
OrthoDBEOG7KM5S1.
TreeFamTF105303.

Gene expression databases

ArrayExpressQ8C2K5.
BgeeQ8C2K5.
CleanExMM_A430107D22RIK.
GenevestigatorQ8C2K5.

Family and domain databases

Gene3D1.10.506.10. 1 hit.
InterProIPR000008. C2_dom.
IPR001849. Pleckstrin_homology.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamPF00616. RasGAP. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEPS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio396821.
PROQ8C2K5.
SOURCESearch...

Entry information

Entry nameRASL3_MOUSE
AccessionPrimary (citable) accession number: Q8C2K5
Secondary accession number(s): A3KMM0 expand/collapse secondary AC list , Q8C2A5, Q8C9R4, Q8CDB4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot