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Q8C2K5

- RASL3_MOUSE

UniProt

Q8C2K5 - RASL3_MOUSE

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Protein
RAS protein activator like-3
Gene
Rasal3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as a Ras GTPase-activating protein By similarity.

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of Ras protein signal transduction Source: RefGenome
  2. positive regulation of Ras GTPase activity Source: RefGenome
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
RAS protein activator like-3
Gene namesi
Name:Rasal3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2444128. Rasal3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10411041RAS protein activator like-3
PRO_0000322567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Phosphoserine By similarity
Modified residuei187 – 1871Phosphoserine By similarity
Modified residuei190 – 1901Phosphoserine By similarity
Modified residuei259 – 2591Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C2K5.
PRIDEiQ8C2K5.

PTM databases

PhosphoSiteiQ8C2K5.

Expressioni

Gene expression databases

ArrayExpressiQ8C2K5.
BgeeiQ8C2K5.
CleanExiMM_A430107D22RIK.
GenevestigatoriQ8C2K5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123141.

Structurei

3D structure databases

ProteinModelPortaliQ8C2K5.
SMRiQ8C2K5. Positions 444-762.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 321102PH
Add
BLAST
Domaini334 – 41077C2
Add
BLAST
Domaini484 – 676193Ras-GAP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili218 – 24326 Reviewed prediction
Add
BLAST
Coiled coili931 – 101383 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG313834.
GeneTreeiENSGT00600000084217.
HOGENOMiHOG000154074.
InParanoidiQ8C2K5.
KOiK17634.
OMAiRRHFQPS.
OrthoDBiEOG7KM5S1.
TreeFamiTF105303.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8C2K5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKPECGQTMF RTFWSRSRDS SAMDPPLQSE EDSQTQPSLP SPLTSYRWHT     50
GGSGEKAAGG FRWGRFAGWG RALSHQEPMV NSQPAPRSLF RRVLSAPPKE 100
SRSNRLRFSK TLWGRHKNVA PLEPKPNPKA PEPELELVAD PDLPVAQIPE 150
PPTPDMPVWN IDGFTLLEGK LVMLGEEEGP RQIRVGSASS ENSMQAALGN 200
LKDAVRTPGK TEPEAAGSNQ VHNVRKLLKR LKEKKRAKSE LGAYTPRDGP 250
PSALGSRESL ATLSELDLGA ERDVRVWPLH PSLLGEPYCF QVTWAGGSLC 300
FSCRSSAERD RWIEDLRRQF QPSQDNVERQ EMWLTVWVHE AKGLPRATVP 350
GVRAELWLDG ALLARTAPRA GPGQLFWAER FHFEALPPAR RLSLRLRSAG 400
PAGATVGRVV LELDEVSIPR APAAGLERWF PVLGAPAGAV LRARIRVRCL 450
RVLPSERYKE LAEFLTFHYA RLCGALEPAL SAQAKEELAA AMVRVLRATG 500
RAQALVTDLG TAELARCGGR EALLFRENTL ATKAIDEYMK LVAQEYLQDT 550
LGQVVRCLCA STEDCEVDPS KCPTPELPKH QARLRDSCEE VFENIIHSYN 600
CFPAELGSVF SSWREACKAR GSEALGPRLV CASLFLRLLC PAILAPSLFG 650
LAPEHPAPGP ARTLTLIAKV IQNLANCAPF GEKEAYMAFM NSFLEDHGPA 700
MQHFLDQVAT VDADTTPSGY QGSGDLALQL AVLHVQLCTI FAELDQKTQD 750
SLEPLPTILR AIEEGRPVPV SVPMRLPRIS TQVQSSFFSG EKPGFLAPRD 800
LPKHTPLISK SQSLRSFQGA GSWASRRPDE ERPQRRPRPV LRTQSVPARR 850
PTHRRPSAGS KPRPKGSLRM GPAPCGRAWT RASASLPRKP SVPWQRQMDQ 900
PGDRYQTTGT HRPVGKLAEI QCEVAIFREA QKALSLLVES LSTQVQALKE 950
QQEHFRCQLQ DLYSRLGAGI SKLDSKGGLP SNGSHRLKSL EQRLTEMECS 1000
QDQLRDSLQS LQLLSKTPGS RSQPLPLKAP CVNGADLSMG T 1041
Length:1,041
Mass (Da):114,782
Last modified:March 1, 2003 - v1
Checksum:iDA58139782B1EEFF
GO
Isoform 2 (identifier: Q8C2K5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     132-132: E → ERSKQAMVPGVKGQLSGVSSLLQLQ

Note: No experimental confirmation available.

Show »
Length:1,043
Mass (Da):114,685
Checksum:iBB7FACC5B3C42A49
GO

Sequence cautioni

The sequence BAC30956.1 differs from that shown. Reason: Frameshift at position 11.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 2.
VSP_031931Add
BLAST
Alternative sequencei132 – 1321E → ERSKQAMVPGVKGQLSGVSS LLQLQ in isoform 2.
VSP_031932

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → M in BAC27141. 1 Publication
Sequence conflicti494 – 4941R → H in BAC27141. 1 Publication
Sequence conflicti978 – 9781G → S in BAC40689. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030797 mRNA. Translation: BAC27141.1.
AK041479 mRNA. Translation: BAC30956.1. Frameshift.
AK088449 mRNA. Translation: BAC40358.1.
AK088987 mRNA. Translation: BAC40689.1.
BC132341 mRNA. Translation: AAI32342.2.
CCDSiCCDS37556.1. [Q8C2K5-1]
RefSeqiNP_848900.2. NM_178785.3. [Q8C2K5-1]
XP_006524476.1. XM_006524413.1. [Q8C2K5-2]
UniGeneiMm.122284.
Mm.416246.

Genome annotation databases

EnsembliENSMUST00000063824; ENSMUSP00000064084; ENSMUSG00000052142. [Q8C2K5-1]
ENSMUST00000136375; ENSMUSP00000118738; ENSMUSG00000052142.
ENSMUST00000137458; ENSMUSP00000123141; ENSMUSG00000052142. [Q8C2K5-2]
GeneIDi320484.
KEGGimmu:320484.
UCSCiuc008bwu.1. mouse. [Q8C2K5-2]
uc008bwv.1. mouse. [Q8C2K5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030797 mRNA. Translation: BAC27141.1 .
AK041479 mRNA. Translation: BAC30956.1 . Frameshift.
AK088449 mRNA. Translation: BAC40358.1 .
AK088987 mRNA. Translation: BAC40689.1 .
BC132341 mRNA. Translation: AAI32342.2 .
CCDSi CCDS37556.1. [Q8C2K5-1 ]
RefSeqi NP_848900.2. NM_178785.3. [Q8C2K5-1 ]
XP_006524476.1. XM_006524413.1. [Q8C2K5-2 ]
UniGenei Mm.122284.
Mm.416246.

3D structure databases

ProteinModelPortali Q8C2K5.
SMRi Q8C2K5. Positions 444-762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000123141.

PTM databases

PhosphoSitei Q8C2K5.

Proteomic databases

PaxDbi Q8C2K5.
PRIDEi Q8C2K5.

Protocols and materials databases

DNASUi 320484.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063824 ; ENSMUSP00000064084 ; ENSMUSG00000052142 . [Q8C2K5-1 ]
ENSMUST00000136375 ; ENSMUSP00000118738 ; ENSMUSG00000052142 .
ENSMUST00000137458 ; ENSMUSP00000123141 ; ENSMUSG00000052142 . [Q8C2K5-2 ]
GeneIDi 320484.
KEGGi mmu:320484.
UCSCi uc008bwu.1. mouse. [Q8C2K5-2 ]
uc008bwv.1. mouse. [Q8C2K5-1 ]

Organism-specific databases

CTDi 64926.
MGIi MGI:2444128. Rasal3.

Phylogenomic databases

eggNOGi NOG313834.
GeneTreei ENSGT00600000084217.
HOGENOMi HOG000154074.
InParanoidi Q8C2K5.
KOi K17634.
OMAi RRHFQPS.
OrthoDBi EOG7KM5S1.
TreeFami TF105303.

Miscellaneous databases

NextBioi 396821.
PROi Q8C2K5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8C2K5.
Bgeei Q8C2K5.
CleanExi MM_A430107D22RIK.
Genevestigatori Q8C2K5.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR001849. PH_domain.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
Pfami PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEi PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiRASL3_MOUSE
AccessioniPrimary (citable) accession number: Q8C2K5
Secondary accession number(s): A3KMM0
, Q8C2A5, Q8C9R4, Q8CDB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi