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Q8C261

- NCKX5_MOUSE

UniProt

Q8C261 - NCKX5_MOUSE

Protein

Sodium/potassium/calcium exchanger 5

Gene

Slc24a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca2+ and 1 K+ to the melanosome in exchange for 4 cytoplasmic Na+ By similarity.By similarity

    GO - Molecular functioni

    1. calcium, potassium:sodium antiporter activity Source: MGI
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transmembrane transport Source: MGI
    2. negative regulation of melanin biosynthetic process Source: MGI
    3. response to stimulus Source: UniProtKB-KW
    4. sodium ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Calcium, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium/calcium exchanger 5
    Alternative name(s):
    Na(+)/K(+)/Ca(2+)-exchange protein 5
    Solute carrier family 24 member 5
    Gene namesi
    Name:Slc24a5
    Synonyms:Nckx5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2677271. Slc24a5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome Source: UniProtKB-SubCell
    3. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 501472Sodium/potassium/calcium exchanger 5PRO_0000045754Add
    BLAST

    Proteomic databases

    PRIDEiQ8C261.

    Expressioni

    Tissue specificityi

    Highly expressed in melanin-producing cells such as skin and eye compared to other tissues. Strongly overexpressed in melanoma cell lines. Expressed in dental tissues.2 Publications

    Gene expression databases

    BgeeiQ8C261.
    CleanExiMM_SLC24A5.
    GenevestigatoriQ8C261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C261.
    SMRiQ8C261. Positions 84-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 6637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini88 – 11124CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1364ExtracellularSequence Analysis
    Topological domaini158 – 17013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 1943ExtracellularSequence Analysis
    Topological domaini216 – 30590CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 3348ExtracellularSequence Analysis
    Topological domaini356 – 3627CytoplasmicSequence Analysis
    Topological domaini384 – 40017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 43817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini460 – 47011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini492 – 50110CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei471 – 49121Helical; Name=11Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    GeneTreeiENSGT00730000110432.
    HOGENOMiHOG000231933.
    HOVERGENiHBG054881.
    InParanoidiQ8C261.
    KOiK13753.
    OMAiYITIFLN.
    OrthoDBiEOG776SP8.
    PhylomeDBiQ8C261.
    TreeFamiTF318759.

    Family and domain databases

    InterProiIPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PANTHERiPTHR10846. PTHR10846. 1 hit.
    PfamiPF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8C261-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTKWGPTWT RRVLLLGIFW VSAYLPVRGV SLPPRLPRAT GNSTQCAVSP    50
    ASEFPEGFFT KQESTDGGIV IYFLIILYMC MAISIVCDKY FLPSLEIISD 100
    SLGLSQDVAG ATFMAAGSSA PELVTAFLGV FITKGDIGIS TILGSAIYNL 150
    LGICAACGLL SNMVSTLSCW PLFRDCAVYA VSVGAVFGII FDNRIYWYEG 200
    AGLLLIYGLY VLLLCFDTTI SRHVMKTCSP CCPCLARAME ERIEQQTLLG 250
    WEDESQLFIR RQSRTDSGIF QEDSGYSQLS LSLHGLSQVS EDPPSVFSMP 300
    EADLRRIFWV LSLPIITLLA LTTPDCRRKF WKNYFVITFF MSALWISAFT 350
    YILVWMVTVT GETLGIPDTV MGLTLLAAGT SIPDTVTSVL VARKGKGDMA 400
    ISNIVGSNVF DMLCLGLPWF IKTAFTNASA PIEVNSKGLT YITISLNISI 450
    LFLFLAVHFN GWKLDRKLGV VCLVLYLGLA TLSVLYEIGI IGNNRIRGCG 500
    V 501
    Length:501
    Mass (Da):54,984
    Last modified:March 1, 2003 - v1
    Checksum:iB0AFD2BE7FC7AB34
    GO

    Sequence cautioni

    The sequence BAC24122.1 differs from that shown. Reason: Frameshift at positions 5 and 14.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401T → K in BAC24122. 1 PublicationCurated
    Sequence conflicti97 – 971I → V in AAP57526. 1 PublicationCurated
    Sequence conflicti120 – 1201A → G in BAC24122. 1 PublicationCurated
    Sequence conflicti342 – 3421S → C in BAC24122. 1 PublicationCurated
    Sequence conflicti474 – 4741V → L in BAC24122. 1 PublicationCurated
    Sequence conflicti488 – 4881I → V in BAC24122. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236527 mRNA. Translation: AAP57526.1.
    AB085629 mRNA. Translation: BAC24122.1. Frameshift.
    AK089225 mRNA. Translation: BAC40800.1.
    BC094232 mRNA. Translation: AAH94232.1.
    CCDSiCCDS38226.1.
    RefSeqiNP_778199.2. NM_175034.3.
    UniGeneiMm.330538.

    Genome annotation databases

    EnsembliENSMUST00000070353; ENSMUSP00000063887; ENSMUSG00000035183.
    GeneIDi317750.
    KEGGimmu:317750.
    UCSCiuc008mbv.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Skin-deep - Issue 74 of September 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236527 mRNA. Translation: AAP57526.1 .
    AB085629 mRNA. Translation: BAC24122.1 . Frameshift.
    AK089225 mRNA. Translation: BAC40800.1 .
    BC094232 mRNA. Translation: AAH94232.1 .
    CCDSi CCDS38226.1.
    RefSeqi NP_778199.2. NM_175034.3.
    UniGenei Mm.330538.

    3D structure databases

    ProteinModelPortali Q8C261.
    SMRi Q8C261. Positions 84-215.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8C261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070353 ; ENSMUSP00000063887 ; ENSMUSG00000035183 .
    GeneIDi 317750.
    KEGGi mmu:317750.
    UCSCi uc008mbv.1. mouse.

    Organism-specific databases

    CTDi 283652.
    MGIi MGI:2677271. Slc24a5.

    Phylogenomic databases

    eggNOGi COG0530.
    GeneTreei ENSGT00730000110432.
    HOGENOMi HOG000231933.
    HOVERGENi HBG054881.
    InParanoidi Q8C261.
    KOi K13753.
    OMAi YITIFLN.
    OrthoDBi EOG776SP8.
    PhylomeDBi Q8C261.
    TreeFami TF318759.

    Miscellaneous databases

    NextBioi 394160.
    PROi Q8C261.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8C261.
    CleanExi MM_SLC24A5.
    Genevestigatori Q8C261.

    Family and domain databases

    InterProi IPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    PANTHERi PTHR10846. PTHR10846. 1 hit.
    Pfami PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel, mouse renal divalent cation transporter (JSX)."
      Satoh J., Smith C., Romero M.F.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Cloning of a new member of Na-Ca exchanger."
      Ishibashi K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    5. Cited for: TISSUE SPECIFICITY.
    6. "Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts."
      Hu P., Lacruz R.S., Smith C.E., Smith S.M., Kurtz I., Paine M.L.
      Cells Tissues Organs 196:501-509(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNCKX5_MOUSE
    AccessioniPrimary (citable) accession number: Q8C261
    Secondary accession number(s): Q6XE39, Q8CJF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3