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Q8C261

- NCKX5_MOUSE

UniProt

Q8C261 - NCKX5_MOUSE

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Protein

Sodium/potassium/calcium exchanger 5

Gene
Slc24a5, Nckx5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca2+ and 1 K+ to the melanosome in exchange for 4 cytoplasmic Na+ By similarity.

GO - Molecular functioni

  1. calcium, potassium:sodium antiporter activity Source: MGI
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transmembrane transport Source: MGI
  2. negative regulation of melanin biosynthetic process Source: MGI
  3. response to stimulus Source: UniProtKB-KW
  4. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Solute carrier family 24 member 5
Gene namesi
Name:Slc24a5
Synonyms:Nckx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2677271. Slc24a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 6637Extracellular Reviewed predictionAdd
BLAST
Transmembranei67 – 8721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini88 – 11124Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei112 – 13221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini133 – 1364Extracellular Reviewed prediction
Transmembranei137 – 15721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini158 – 17013Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini192 – 1943Extracellular Reviewed prediction
Transmembranei195 – 21521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini216 – 30590Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei306 – 32621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini327 – 3348Extracellular Reviewed prediction
Transmembranei335 – 35521Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini356 – 3627Cytoplasmic Reviewed prediction
Transmembranei363 – 38321Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini384 – 40017Extracellular Reviewed predictionAdd
BLAST
Transmembranei401 – 42121Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini422 – 43817Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei439 – 45921Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini460 – 47011Extracellular Reviewed predictionAdd
BLAST
Transmembranei471 – 49121Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini492 – 50110Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome Source: UniProtKB-SubCell
  3. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 501472Sodium/potassium/calcium exchanger 5PRO_0000045754Add
BLAST

Proteomic databases

PRIDEiQ8C261.

Expressioni

Tissue specificityi

Highly expressed in melanin-producing cells such as skin and eye compared to other tissues. Strongly overexpressed in melanoma cell lines. Expressed in dental tissues.2 Publications

Gene expression databases

BgeeiQ8C261.
CleanExiMM_SLC24A5.
GenevestigatoriQ8C261.

Structurei

3D structure databases

ProteinModelPortaliQ8C261.
SMRiQ8C261. Positions 84-215.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00730000110432.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ8C261.
KOiK13753.
OMAiYITIFLN.
OrthoDBiEOG776SP8.
PhylomeDBiQ8C261.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C261-1 [UniParc]FASTAAdd to Basket

« Hide

MRTKWGPTWT RRVLLLGIFW VSAYLPVRGV SLPPRLPRAT GNSTQCAVSP    50
ASEFPEGFFT KQESTDGGIV IYFLIILYMC MAISIVCDKY FLPSLEIISD 100
SLGLSQDVAG ATFMAAGSSA PELVTAFLGV FITKGDIGIS TILGSAIYNL 150
LGICAACGLL SNMVSTLSCW PLFRDCAVYA VSVGAVFGII FDNRIYWYEG 200
AGLLLIYGLY VLLLCFDTTI SRHVMKTCSP CCPCLARAME ERIEQQTLLG 250
WEDESQLFIR RQSRTDSGIF QEDSGYSQLS LSLHGLSQVS EDPPSVFSMP 300
EADLRRIFWV LSLPIITLLA LTTPDCRRKF WKNYFVITFF MSALWISAFT 350
YILVWMVTVT GETLGIPDTV MGLTLLAAGT SIPDTVTSVL VARKGKGDMA 400
ISNIVGSNVF DMLCLGLPWF IKTAFTNASA PIEVNSKGLT YITISLNISI 450
LFLFLAVHFN GWKLDRKLGV VCLVLYLGLA TLSVLYEIGI IGNNRIRGCG 500
V 501
Length:501
Mass (Da):54,984
Last modified:March 1, 2003 - v1
Checksum:iB0AFD2BE7FC7AB34
GO

Sequence cautioni

The sequence BAC24122.1 differs from that shown. Reason: Frameshift at positions 5 and 14.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401T → K in BAC24122. 1 Publication
Sequence conflicti97 – 971I → V in AAP57526. 1 Publication
Sequence conflicti120 – 1201A → G in BAC24122. 1 Publication
Sequence conflicti342 – 3421S → C in BAC24122. 1 Publication
Sequence conflicti474 – 4741V → L in BAC24122. 1 Publication
Sequence conflicti488 – 4881I → V in BAC24122. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236527 mRNA. Translation: AAP57526.1.
AB085629 mRNA. Translation: BAC24122.1. Frameshift.
AK089225 mRNA. Translation: BAC40800.1.
BC094232 mRNA. Translation: AAH94232.1.
CCDSiCCDS38226.1.
RefSeqiNP_778199.2. NM_175034.3.
UniGeneiMm.330538.

Genome annotation databases

EnsembliENSMUST00000070353; ENSMUSP00000063887; ENSMUSG00000035183.
GeneIDi317750.
KEGGimmu:317750.
UCSCiuc008mbv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236527 mRNA. Translation: AAP57526.1 .
AB085629 mRNA. Translation: BAC24122.1 . Frameshift.
AK089225 mRNA. Translation: BAC40800.1 .
BC094232 mRNA. Translation: AAH94232.1 .
CCDSi CCDS38226.1.
RefSeqi NP_778199.2. NM_175034.3.
UniGenei Mm.330538.

3D structure databases

ProteinModelPortali Q8C261.
SMRi Q8C261. Positions 84-215.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8C261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070353 ; ENSMUSP00000063887 ; ENSMUSG00000035183 .
GeneIDi 317750.
KEGGi mmu:317750.
UCSCi uc008mbv.1. mouse.

Organism-specific databases

CTDi 283652.
MGIi MGI:2677271. Slc24a5.

Phylogenomic databases

eggNOGi COG0530.
GeneTreei ENSGT00730000110432.
HOGENOMi HOG000231933.
HOVERGENi HBG054881.
InParanoidi Q8C261.
KOi K13753.
OMAi YITIFLN.
OrthoDBi EOG776SP8.
PhylomeDBi Q8C261.
TreeFami TF318759.

Miscellaneous databases

NextBioi 394160.
PROi Q8C261.
SOURCEi Search...

Gene expression databases

Bgeei Q8C261.
CleanExi MM_SLC24A5.
Genevestigatori Q8C261.

Family and domain databases

InterProi IPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view ]
PANTHERi PTHR10846. PTHR10846. 1 hit.
Pfami PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel, mouse renal divalent cation transporter (JSX)."
    Satoh J., Smith C., Romero M.F.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Cloning of a new member of Na-Ca exchanger."
    Ishibashi K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  5. Cited for: TISSUE SPECIFICITY.
  6. "Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts."
    Hu P., Lacruz R.S., Smith C.E., Smith S.M., Kurtz I., Paine M.L.
    Cells Tissues Organs 196:501-509(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNCKX5_MOUSE
AccessioniPrimary (citable) accession number: Q8C261
Secondary accession number(s): Q6XE39, Q8CJF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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