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Protein

Sodium/potassium/calcium exchanger 5

Gene

Slc24a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca2+ and 1 K+ to the melanosome in exchange for 4 cytoplasmic Na+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425561. Sodium/Calcium exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Solute carrier family 24 member 5
Gene namesi
Name:Slc24a5
Synonyms:Nckx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2677271. Slc24a5.

Subcellular locationi

  • Golgi apparatustrans-Golgi network membrane By similarity; Multi-pass membrane protein By similarity
  • Melanosome By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 66ExtracellularSequence analysisAdd BLAST37
Transmembranei67 – 87Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini88 – 111CytoplasmicSequence analysisAdd BLAST24
Transmembranei112 – 132Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini133 – 136ExtracellularSequence analysis4
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 170CytoplasmicSequence analysisAdd BLAST13
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 194ExtracellularSequence analysis3
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 305CytoplasmicSequence analysisAdd BLAST90
Transmembranei306 – 326Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini327 – 334ExtracellularSequence analysis8
Transmembranei335 – 355Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini356 – 362CytoplasmicSequence analysis7
Transmembranei363 – 383Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini384 – 400ExtracellularSequence analysisAdd BLAST17
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 438CytoplasmicSequence analysisAdd BLAST17
Transmembranei439 – 459Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini460 – 470ExtracellularSequence analysisAdd BLAST11
Transmembranei471 – 491Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini492 – 501CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004575430 – 501Sodium/potassium/calcium exchanger 5Add BLAST472

Proteomic databases

MaxQBiQ8C261.
PaxDbiQ8C261.
PRIDEiQ8C261.

PTM databases

PhosphoSitePlusiQ8C261.

Expressioni

Tissue specificityi

Highly expressed in melanin-producing cells such as skin and eye compared to other tissues. Strongly overexpressed in melanoma cell lines. Expressed in dental tissues.2 Publications

Gene expression databases

BgeeiENSMUSG00000035183.
CleanExiMM_SLC24A5.
ExpressionAtlasiQ8C261. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063887.

Structurei

3D structure databases

ProteinModelPortaliQ8C261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ8C261.
KOiK13753.
OMAiTTQCVIS.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ8C261.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030245. SLC24A5.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF27. PTHR10846:SF27. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTKWGPTWT RRVLLLGIFW VSAYLPVRGV SLPPRLPRAT GNSTQCAVSP
60 70 80 90 100
ASEFPEGFFT KQESTDGGIV IYFLIILYMC MAISIVCDKY FLPSLEIISD
110 120 130 140 150
SLGLSQDVAG ATFMAAGSSA PELVTAFLGV FITKGDIGIS TILGSAIYNL
160 170 180 190 200
LGICAACGLL SNMVSTLSCW PLFRDCAVYA VSVGAVFGII FDNRIYWYEG
210 220 230 240 250
AGLLLIYGLY VLLLCFDTTI SRHVMKTCSP CCPCLARAME ERIEQQTLLG
260 270 280 290 300
WEDESQLFIR RQSRTDSGIF QEDSGYSQLS LSLHGLSQVS EDPPSVFSMP
310 320 330 340 350
EADLRRIFWV LSLPIITLLA LTTPDCRRKF WKNYFVITFF MSALWISAFT
360 370 380 390 400
YILVWMVTVT GETLGIPDTV MGLTLLAAGT SIPDTVTSVL VARKGKGDMA
410 420 430 440 450
ISNIVGSNVF DMLCLGLPWF IKTAFTNASA PIEVNSKGLT YITISLNISI
460 470 480 490 500
LFLFLAVHFN GWKLDRKLGV VCLVLYLGLA TLSVLYEIGI IGNNRIRGCG

V
Length:501
Mass (Da):54,984
Last modified:March 1, 2003 - v1
Checksum:iB0AFD2BE7FC7AB34
GO

Sequence cautioni

The sequence BAC24122 differs from that shown. Reason: Frameshift at positions 5 and 14.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40T → K in BAC24122 (Ref. 2) Curated1
Sequence conflicti97I → V in AAP57526 (Ref. 1) Curated1
Sequence conflicti120A → G in BAC24122 (Ref. 2) Curated1
Sequence conflicti342S → C in BAC24122 (Ref. 2) Curated1
Sequence conflicti474V → L in BAC24122 (Ref. 2) Curated1
Sequence conflicti488I → V in BAC24122 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236527 mRNA. Translation: AAP57526.1.
AB085629 mRNA. Translation: BAC24122.1. Frameshift.
AK089225 mRNA. Translation: BAC40800.1.
BC094232 mRNA. Translation: AAH94232.1.
CCDSiCCDS38226.1.
RefSeqiNP_778199.2. NM_175034.3.
UniGeneiMm.330538.

Genome annotation databases

EnsembliENSMUST00000070353; ENSMUSP00000063887; ENSMUSG00000035183.
GeneIDi317750.
KEGGimmu:317750.
UCSCiuc008mbv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236527 mRNA. Translation: AAP57526.1.
AB085629 mRNA. Translation: BAC24122.1. Frameshift.
AK089225 mRNA. Translation: BAC40800.1.
BC094232 mRNA. Translation: AAH94232.1.
CCDSiCCDS38226.1.
RefSeqiNP_778199.2. NM_175034.3.
UniGeneiMm.330538.

3D structure databases

ProteinModelPortaliQ8C261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063887.

PTM databases

PhosphoSitePlusiQ8C261.

Proteomic databases

MaxQBiQ8C261.
PaxDbiQ8C261.
PRIDEiQ8C261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070353; ENSMUSP00000063887; ENSMUSG00000035183.
GeneIDi317750.
KEGGimmu:317750.
UCSCiuc008mbv.1. mouse.

Organism-specific databases

CTDi283652.
MGIiMGI:2677271. Slc24a5.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ8C261.
KOiK13753.
OMAiTTQCVIS.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ8C261.
TreeFamiTF318759.

Enzyme and pathway databases

ReactomeiR-MMU-425561. Sodium/Calcium exchangers.

Miscellaneous databases

PROiQ8C261.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035183.
CleanExiMM_SLC24A5.
ExpressionAtlasiQ8C261. baseline and differential.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030245. SLC24A5.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF27. PTHR10846:SF27. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX5_MOUSE
AccessioniPrimary (citable) accession number: Q8C261
Secondary accession number(s): Q6XE39, Q8CJF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.