UniProtKB - Q8C255 (DPEP2_MOUSE)
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Protein
Dipeptidase 2
Gene
Dpep2
Organism
Mus musculus (Mouse)
Status
Functioni
Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).
Catalytic activityi
Hydrolysis of dipeptides.PROSITE-ProRule annotation
Cofactori
Zn2+PROSITE-ProRule annotation
Enzyme regulationi
Inhibited by L-penicillamine.1 Publication
Kineticsi
- KM=5 µM for LTD41 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 91 | Zinc 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 93 | Zinc 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 190 | Zinc 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 190 | Zinc 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 217 | SubstratePROSITE-ProRule annotation | 1 | |
Metal bindingi | 263 | Zinc 2; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 284 | Zinc 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 295 | SubstratePROSITE-ProRule annotation | 1 | |
Binding sitei | 353 | SubstratePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- dipeptidase activity Source: GO_Central
- dipeptidyl-peptidase activity Source: InterPro
- exopeptidase activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- metalloexopeptidase activity Source: InterPro
Keywordsi
Molecular function | Dipeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX). R-MMU-5423646. Aflatoxin activation and detoxification. |
Protein family/group databases
MEROPSi | M19.002. |
Chemistry databases
SwissLipidsi | SLP:000001462. |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidase 2 (EC:3.4.13.19)Alternative name(s): Membrane-bound dipeptidase 2 Short name: MBD-2 |
Gene namesi | Name:Dpep2 Synonyms:Mbd2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442042. Dpep2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000231605 | 32 – 459 | Dipeptidase 2Add BLAST | 428 | |
PropeptideiPRO_0000231606 | 460 – 478 | Removed in mature formSequence analysisAdd BLAST | 19 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 140 ↔ 219 | PROSITE-ProRule annotation | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 291 ↔ 323 | PROSITE-ProRule annotation | ||
Disulfide bondi | 428 | InterchainPROSITE-ProRule annotation | ||
Lipidationi | 459 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | Q8C255. |
PeptideAtlasi | Q8C255. |
PRIDEi | Q8C255. |
PTM databases
PhosphoSitePlusi | Q8C255. |
Expressioni
Tissue specificityi
Expressed in heart, lung, testis, spleen and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000053687. |
CleanExi | MM_DPEP2. MM_MBD2. |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.PROSITE-ProRule annotation
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000080659. |
Structurei
3D structure databases
ProteinModelPortali | Q8C255. |
SMRi | Q8C255. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4127. Eukaryota. COG2355. LUCA. |
GeneTreei | ENSGT00390000017920. |
HOGENOMi | HOG000072016. |
HOVERGENi | HBG002339. |
InParanoidi | Q8C255. |
KOi | K01273. |
OMAi | AYCRYHD. |
OrthoDBi | EOG091G09CU. |
PhylomeDBi | Q8C255. |
TreeFami | TF324523. |
Family and domain databases
CDDi | cd01301. rDP_like. 1 hit. |
InterProi | View protein in InterPro IPR000180. Dipep_AS. IPR028531. Dpep2. IPR032466. Metal_Hydrolase. IPR008257. Pept_M19. |
PANTHERi | PTHR10443. PTHR10443. 1 hit. PTHR10443:SF9. PTHR10443:SF9. 1 hit. |
Pfami | View protein in Pfam PF01244. Peptidase_M19. 1 hit. |
SUPFAMi | SSF51556. SSF51556. 1 hit. |
PROSITEi | View protein in PROSITE PS00869. RENAL_DIPEPTIDASE_1. 1 hit. PS51365. RENAL_DIPEPTIDASE_2. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C255-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSLTGLKGHW VLGHGLSVFL LVLLLLGPSQ PLIWTQTKPG FSGASTTSSI
60 70 80 90 100
PRALTKPDIS SIPTTPGNPN FPDLRDRARA LMQEFPLIDG HNDMPLVLRQ
110 120 130 140 150
FYQNGLQDAN LRNFTHGQTS LDRLKDGLVG AQFWSAYVPC QTQDRDALRL
160 170 180 190 200
TLEQIDLIRR ICASYSELEL VTSVKALNST QKLACLIGVE GGHSLDNSLA
210 220 230 240 250
VLRSFYLLGV RYLTLTHTCN TPWAETSSKG VHAFYSSVTG LTSFGEKVVA
260 270 280 290 300
EMNRLGMMVD LSHVSDAAAR RALEVSQAPV IFSHSAARAV CPNARNLPDD
310 320 330 340 350
LLQLLKKNGG IVMVTFSVGV LPCNPLANVS TVADHFDHIR SVIGSEFIGI
360 370 380 390 400
GGDYDGTKQF PQGLEDVSTY PVLIEELLRR GWNEQELQGI LRGNLLRVFR
410 420 430 440 450
QVEQVRDKSK WQSPLEDMIP EEQLDSACHS ALRPQKQHPE KNQPETPEYH
460 470
ILKFSHSKSS PHIVPSLAIV ATLLGLIV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 78 | A → T in BAE42354 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 89 | D → G in BAE42559 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 99 | R → G in BAE42559 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017852 | 1 – 93 | Missing in isoform 3. 1 PublicationAdd BLAST | 93 | |
Alternative sequenceiVSP_017853 | 1 | M → MAWHGETYCLIGGYRVYGDA PLPTPAKAEQEEKPVPRRAP KRQRVQEESDQDLGCPGAKV PRLKLKHGGKGLSRPSSVPA CSALSKM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_017854 | 176 – 179 | ALNS → VKWIYSG in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_017855 | 334 – 340 | DHFDHIR → EKGQQKHQFTPPRDTHFV in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488552 mRNA. Translation: AAP84986.1. AK089244 mRNA. Translation: BAC40810.1. AK155417 mRNA. Translation: BAE33255.1. AK170094 mRNA. Translation: BAE41559.1. AK170970 mRNA. Translation: BAE42149.1. AK171044 mRNA. Translation: BAE42209.1. AK171122 mRNA. Translation: BAE42264.1. AK171155 mRNA. Translation: BAE42280.1. AK171196 mRNA. Translation: BAE42306.1. AK171268 mRNA. Translation: BAE42354.1. AK171503 mRNA. Translation: BAE42494.1. AK171606 mRNA. Translation: BAE42559.1. |
CCDSi | CCDS22625.1. [Q8C255-2] CCDS80925.1. [Q8C255-3] CCDS80926.1. [Q8C255-1] |
RefSeqi | NP_001288133.1. NM_001301204.1. [Q8C255-1] NP_001288134.1. NM_001301205.1. [Q8C255-3] NP_795887.2. NM_176913.4. [Q8C255-2] |
UniGenei | Mm.248357. Mm.470084. |
Genome annotation databases
Ensembli | ENSMUST00000034373; ENSMUSP00000034373; ENSMUSG00000053687. [Q8C255-1] ENSMUST00000117555; ENSMUSP00000113877; ENSMUSG00000053687. [Q8C255-3] ENSMUST00000227363; ENSMUSP00000154250; ENSMUSG00000115067. [Q8C255-2] |
GeneIDi | 319446. |
KEGGi | mmu:319446. |
UCSCi | uc009nex.2. mouse. [Q8C255-3] uc009ney.2. mouse. [Q8C255-2] uc057amr.1. mouse. [Q8C255-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | DPEP2_MOUSE | |
Accessioni | Q8C255Primary (citable) accession number: Q8C255 Secondary accession number(s): Q3TAV9 Q7TQ53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | March 28, 2018 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |