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Protein

Probable G-protein coupled receptor 157

Gene

Gpr157

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 157
Gene namesi
Name:Gpr157
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2442046. Gpr157.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini37 – 4812CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8718ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 11911CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini141 – 16626ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini188 – 22740CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini249 – 25911ExtracellularSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini281 – 33050CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Probable G-protein coupled receptor 157PRO_0000070340Add
BLAST

Proteomic databases

PaxDbiQ8C206.
PRIDEiQ8C206.

PTM databases

PhosphoSiteiQ8C206.

Expressioni

Gene expression databases

BgeeiQ8C206.
CleanExiMM_GPR157.
ExpressionAtlasiQ8C206. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092020.

Structurei

3D structure databases

ProteinModelPortaliQ8C206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi295 – 2984Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGF4. Eukaryota.
ENOG410XSF0. LUCA.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ8C206.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ8C206.
TreeFamiTF330856.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPAPPTEL LPWERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLSIVR TTRGPSTDHL IWAFHLISWG VPLAITVAAV SLKKIGYDAS
160 170 180 190 200
DVSVGWCWIN LEAEDRVLWM LLTGKLWEML AYILLPLLYL LVRKHINRAH
210 220 230 240 250
QALSEYRPIC EGRQLQRGSS TSTADKKLVL IPLIFICLRV WSTVRFVLTL
260 270 280 290 300
CGSPAVQTPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCCPR
310 320 330
PSTQSPPGAP TPPKIGESQE SRRTPEVPST
Length:330
Mass (Da):36,344
Last modified:March 1, 2003 - v1
Checksum:iD2A1F08B4365A2DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961C → W in BAC40879 (PubMed:16141072).Curated
Sequence conflicti326 – 3305EVPST → RSAQHSGWLSSLSVLALPSW FLLQD in BAC40879 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089544 mRNA. Translation: BAC40921.1.
AK089429 mRNA. Translation: BAC40879.1.
CCDSiCCDS38977.1.
RefSeqiNP_796340.2. NM_177366.3.
UniGeneiMm.219307.

Genome annotation databases

EnsembliENSMUST00000094451; ENSMUSP00000092020; ENSMUSG00000047875.
GeneIDi269604.
KEGGimmu:269604.
UCSCiuc008vxj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089544 mRNA. Translation: BAC40921.1.
AK089429 mRNA. Translation: BAC40879.1.
CCDSiCCDS38977.1.
RefSeqiNP_796340.2. NM_177366.3.
UniGeneiMm.219307.

3D structure databases

ProteinModelPortaliQ8C206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092020.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8C206.

Proteomic databases

PaxDbiQ8C206.
PRIDEiQ8C206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094451; ENSMUSP00000092020; ENSMUSG00000047875.
GeneIDi269604.
KEGGimmu:269604.
UCSCiuc008vxj.1. mouse.

Organism-specific databases

CTDi80045.
MGIiMGI:2442046. Gpr157.

Phylogenomic databases

eggNOGiENOG410IGF4. Eukaryota.
ENOG410XSF0. LUCA.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ8C206.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ8C206.
TreeFamiTF330856.

Miscellaneous databases

ChiTaRSiGpr157. mouse.
NextBioi392915.
PROiQ8C206.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C206.
CleanExiMM_GPR157.
ExpressionAtlasiQ8C206. baseline and differential.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGP157_MOUSE
AccessioniPrimary (citable) accession number: Q8C206
Secondary accession number(s): Q8C224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.