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Protein

Vasohibin-1

Gene

Vash1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Vasohibin-1
Gene namesi
Name:Vash1
Synonyms:Vash
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442543. Vash1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Vasohibin-1PRO_0000189981Add
BLAST

Post-translational modificationi

Ubiquitinated in vitro.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei39 – 402CleavageBy similarity
Sitei86 – 872CleavageBy similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8C1W1.
PaxDbiQ8C1W1.
PRIDEiQ8C1W1.

PTM databases

iPTMnetiQ8C1W1.
PhosphoSiteiQ8C1W1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021256.
CleanExiMM_VASH1.

Interactioni

Subunit structurei

Interacts with SVBP; the interaction enhances VASH1 solubility and secretion and prevents its ubiquitination.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021681.

Structurei

3D structure databases

ProteinModelPortaliQ8C1W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni329 – 37547Involved in heparin-binding and antiangiogenic activityBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the vasohibin family.Curated

Phylogenomic databases

eggNOGiENOG410IFRP. Eukaryota.
ENOG410ZG80. LUCA.
GeneTreeiENSGT00390000012703.
HOGENOMiHOG000007477.
HOVERGENiHBG079337.
InParanoidiQ8C1W1.
OMAiWRHVARI.
OrthoDBiEOG091G0CSJ.
TreeFamiTF329370.

Family and domain databases

InterProiIPR028131. Vasohibin.
IPR028132. Vasohibin-1.
[Graphical view]
PANTHERiPTHR15750:SF3. PTHR15750:SF3. 1 hit.
PfamiPF14822. Vasohibin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C1W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGKKVVPS GSSSASPNAA ATTTAAAAAA AAAPHSGTKR LETTEGASAQ
60 70 80 90 100
RDEEPEEEGE EDLRDGGVPF FINRGGLPVD EATWERMWKH VAKIHPDGEK
110 120 130 140 150
VALRIRGATD LPKIPIPSVP TFQPTTPVPE RLEAVQRYIR ELQYNHTGTQ
160 170 180 190 200
FFEIKKSRPL TGLMDLAKEM TKEALPIKCL EAVILGIYLT NSMPTLERFP
210 220 230 240 250
ISFKTYFSGN YFRHIVLGVN FGGRYGALGM SRREDLMYKP PAFRTLSELV
260 270 280 290 300
LDYEAAYGRC WHVLKKVKLG QCVSHDPHSV EQIEWKHSVL DVERLGREDF
310 320 330 340 350
RKELERHARD MRLKIGKGTG PPSPTKDRKK DVSSPQRAQS SPHRRNSRSE
360 370
RRPSGEKKPA EPKAMPDLSG YQIRV
Length:375
Mass (Da):41,875
Last modified:July 27, 2011 - v4
Checksum:i82F7348A17B32B6D
GO

Sequence cautioni

The sequence BAC41121 differs from that shown. Reason: Frameshift at position 27. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21P → A in BAC41121 (PubMed:16141072).Curated
Sequence conflicti157 – 1571S → G in BAC41121 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090166 mRNA. Translation: BAC41121.1. Frameshift.
AC102689 Genomic DNA. No translation available.
CCDSiCCDS49118.1.
RefSeqiNP_796328.2. NM_177354.4.
XP_011240471.1. XM_011242169.1.
UniGeneiMm.216101.

Genome annotation databases

EnsembliENSMUST00000021681; ENSMUSP00000021681; ENSMUSG00000021256.
GeneIDi105242496.
238328.
KEGGimmu:105242496.
mmu:238328.
UCSCiuc007ohx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090166 mRNA. Translation: BAC41121.1. Frameshift.
AC102689 Genomic DNA. No translation available.
CCDSiCCDS49118.1.
RefSeqiNP_796328.2. NM_177354.4.
XP_011240471.1. XM_011242169.1.
UniGeneiMm.216101.

3D structure databases

ProteinModelPortaliQ8C1W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021681.

PTM databases

iPTMnetiQ8C1W1.
PhosphoSiteiQ8C1W1.

Proteomic databases

MaxQBiQ8C1W1.
PaxDbiQ8C1W1.
PRIDEiQ8C1W1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021681; ENSMUSP00000021681; ENSMUSG00000021256.
GeneIDi105242496.
238328.
KEGGimmu:105242496.
mmu:238328.
UCSCiuc007ohx.2. mouse.

Organism-specific databases

CTDi22846.
MGIiMGI:2442543. Vash1.

Phylogenomic databases

eggNOGiENOG410IFRP. Eukaryota.
ENOG410ZG80. LUCA.
GeneTreeiENSGT00390000012703.
HOGENOMiHOG000007477.
HOVERGENiHBG079337.
InParanoidiQ8C1W1.
OMAiWRHVARI.
OrthoDBiEOG091G0CSJ.
TreeFamiTF329370.

Miscellaneous databases

ChiTaRSiVash1. mouse.
PROiQ8C1W1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021256.
CleanExiMM_VASH1.

Family and domain databases

InterProiIPR028131. Vasohibin.
IPR028132. Vasohibin-1.
[Graphical view]
PANTHERiPTHR15750:SF3. PTHR15750:SF3. 1 hit.
PfamiPF14822. Vasohibin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVASH1_MOUSE
AccessioniPrimary (citable) accession number: Q8C1W1
Secondary accession number(s): E9QKT9, Q8C394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.